稀土元素的生物化學反應和有關細胞化學過程的干預

科研成果

序號	標題	類型	作者
1	A proteomic investigation into the human cervical cancer cell line HeLa treated with dicitratoytterbium (III) complex	期刊論文	Shen, Liming\|Ni, Jiazuan\|Liu, Qiong\|Hong, Guangyan\|
2	氯化鑭抑制前列腺癌細胞DU145的生長和遷移	期刊論文	黃健\|王夔\|張天藍\|王芃\|
3	Effects of lanthanum on calcium-activated K+ currents and its kinetics in MC3T3 cells	期刊論文	Yang,P.\|Zhang,L.\|
4	Gadolinium-promoted cell cycle progression with enhanced S-phase entry via activation of both ERK and PI3K signaling pathways in NIH 3T3 cells	期刊論文	Li, Jin-Xia\|Wang, Kui\|Fu, Li-Juan\|Yang, Xiao-Gai\|
5	Lanthanum citrate induces anoikis of Hela cells	期刊論文	Ni, Jiazuan\|Zheng, Xiaona\|Su, Xiange\|
6	Gadolinium-induced oxidative stress triggers endoplasmic reticulum stress in rat cortical neurons	期刊論文	Yang X\|Huang H\|Du L\|Feng X\|Wang K\|Xia Q\|
7	Lanthanum Suppresses Osteoblastic Differentiation Via Pertussis Toxin-Sensitive G Protein Signaling in Rat Vascular Smooth Muscle Cells	期刊論文	Zhang, Tian-Lan\|Gou, Bao-Di\|Huang, Jian\|Wang, Kui\|Wang, Li-Wen\|Shi, Yan-Ling\|
8	Uptake of diterbium transferrin, a potential multi-photon-excited microscopy probe, into human leukemia K562 cells via a transferrin-receptor-mediated process	期刊論文	Wang, Kui\|Yuan, Lan\|Du, Ping\|Yang, Xiao-Gai\|
9	高氯酸鐿對大鼠背根神經元細胞毒性及膜上鉀通道的影響	期刊論文	李卓玉\|楊頻\|杜正清\|武文杰\|
10	Gadolinium-promoted precipitation of calcium phosphate is associated with profibrotic activation of RAW 264.7 macrophages	期刊論文	Zhang,T.-L.\|Bian,S.\|Wang,K.\|Gou,B.-D.\|
11	稀土的生物效應及醫藥套用：細胞無機化學研究	學術專著	王夔\|
12	核磁共振法研究大腸桿菌細胞內La~(3+)與鈣調蛋白的相互作用	期刊論文	李勤\|王夔\|楊曉達\|楊秦\|劉會雪\|
13	Biochemical effects of gadolinium chloride in rats liver and kidney studied by H-1 NMR metabolomics	期刊論文	Li Weisheng\|Liao Peiqiu\|Li Xiaojing\|Wei Lai\|Wu Huifeng\|Wu Yijie\|Pei Fengkui\|Ni Jiazuan\|
14	Endothelial cell and macrophage regulation of vascular smooth muscle cell calcification modulated by cholestane-3 beta, 5 alpha, 6 beta-triol	期刊論文	Liu, Hongmei\|Yuan, Lan\|Xu, Shanjin\|Wang, Kui\|
15	La3+ binds to BiP/GRP78 and induces unfolded protein response in HepG2 cells	期刊論文	Kui Wang\|Zaiquan Li\|Xiaoda Yang\|Chenxi Shen\|
16	Brain-derived neurotrophic factor protects neurons from GdCl 3-induced impairment in neuron-astrocyte co-cultures	期刊論文	Yuan,L.\|Yang,X.\|Xia,Q.\|Wang,K.\|Feng,X.\|
17	檸檬酸鑭誘導腫瘤細胞凋亡的研究	期刊論文	劉瓊\|倪嘉纘\|蘭子堯\|沈立明\|
18	La3+誘導鈣調蛋白與鼠腦組織鈣調蛋白親合蛋白結合的研究	期刊論文	王夔\|楊曉達\|徐崑\|
19	檸檬酸釓對宮頸癌細胞作用的蛋白質組學研究	期刊論文	劉建軍\|李艷暉\|劉瓊\|周國衛\|倪嘉纘\|
20	Lanthanum chloride suppresses hydrogen peroxide-enhanced calcification in rat calcifying vascular cells	期刊論文	Gou, Bao-Di\|Shi, Yan-Ling\|Zhang, Tian-Lan\|Wang, Kui\|Shi, Yu\|
21	上槽泄露導致雙向電泳凝膠高分子量區域垂直拖尾	期刊論文	任小虎\|蘭子堯\|沈立明\|劉瓊\|
22	Metabolic profiling of serum from gadolinium chloride-treated rats by H-1 NMR spectroscopy	期刊論文	Ni, Jiazuan\|Liao, Peiqiu\|Wu, Huifeng\|Li, Xiaojing\|Pei, Fengkui\|Zhang, Xiaoyu\|Wei, Lai\|Wu, Yijie\|
23	Lanthanum Enhances in vitro Osteoblast Differentiation via Pertussis Toxin-sensitive Gi Protein and ERK Signaling Pathway	期刊論文	Lan Yuan\|Tian-Lan Zhang*\|Jian Huang\|Xi Wang\|
24	Enhancement of fluorescence of terbium and transferring-bound diterbium by HEPES.	期刊論文	Ping Du\|Ke-Ning Xu\|Lan Yuan\|Xiao-Gai Yang\|Hou-Nan Wu\|
25	Metal binding discrimination of the calmodulin Q 41C /K 75C mutant on Ca2+ and La3+	期刊論文	X Yang\|K Xu \|K Wang\|
26	Duality of effect of La3+ on mitochondrial permeability transition pore depending on the concentration	期刊論文	Yang, Xiaoda\|Liu, Huixue\|Zhao, Yuebin\|Wang, Kui\|Dong, Shuai\|
27	Effects of ytterbium on outward K+ currents in NIH3T3 cell	期刊論文	Zhang,L.\|Yang,P.\|Chen,M.\|
28	Mastoparan/Mastoparan X altered binding behavior of La3+ to calmodulin in ternary complexes	期刊論文	Yang, Qin\|Wang, Kui\|Yang, Xiaoda\|Hu, Jian\|
29	Metal-amyloid-beta peptide interactions: a preliminary investigation of molecular mechanisms for Alzheimer's disease	期刊論文	Jiao Yong\|Yang Pin\|
30	從細胞無機化學的角度看鑭系元素化合物作為診療藥物的安全性問題	期刊論文	楊曉改\|王夔\|
31	Enhancement of lanthanum (iii) on sodium currents in acutely isolated hippocampal CA1 neurons of rat	期刊論文	Du,H.\|Yang,P.\|
32	Gadolinium promoted proliferation and enhanced survival in human cervical carcinoma cells	期刊論文	Li, Jin-Xia\|Yang, Xiao-Da\|Zhang, Ying\|Yang, Xiao-Gai\|Wang, Kui\|Fu, Li-Juan\|
33	Cytoskeleton reorganization and FAK phosphorylation are involved in lanthanum (III)-promoted proliferation and differentiation in rat osteoblasts	期刊論文	Huang, Jian\|Wang, Xi\|Zhang, Tianlan\|Wang, Kui\|
34	檸檬酸鑭對肝癌HepG2細胞抗失巢凋亡的影響	期刊論文	鄭小娜\|蘇湘鄂\|
35	Comparative proteomics analysis of lanthanum citrate complex-induced apoptosis in HeLa cells	期刊論文	Shen LiMing\|Ni JiaZuan\|Liu Qiong\|
36	Metabonomic Studies on Intact Livers and Liver Extracts from Rats Treated with Neodymium Nitrate	期刊論文	Pei Feng-Kui\|Liu Wei\|Li Xiao-Jing\|Wu Yi-Jie\|Wei Lai\|Ni Jia-Zuan\|Liao Pei-Qiu\|
37	Lanthanum Chloride promoted proliferation with enhanced S-phase entry and inhibited K currents of NIH 3T3 cells	期刊論文	Liping Zhang \|Pin Yang\|Zhuoyu Li\|
38	Impaired mitochondrial function and oxidative stress in rat cortical neurons: Implications for gadolinium-induced neurotoxicity	期刊論文	Yuan,L.\|Xia,Q.\|Wang,K.\|Feng,X.\|Yang,X.\|
39	Crystallization at Multiple Sites inside Particles of Amorphous Calcium Phosphate	期刊論文	Tang RK\|Liao JW\|Wang CG\|Gou BD\|Huang J\|Wang K\|
40	Gadolinium triggers unfolded protein responses (UPRs) in primary cultured rat cortical astrocytes via promotion of an influx of extracellular Ca2+	期刊論文	Yang XD\|Xia Q\|Feng XD\|Huang HF\|Wang K\|Yuan L\|
41	Studies on the acute biochemical effects of Nd(NO3)(3) by nuclear magnetic resonance-based metabonomics	期刊論文	Ni Jia-Zuan\|Pei Feng-Kui\|Liao Pei-Qiu\|Wei, Lai\|Li Wei-Sheng\|Wu Yi-Jie\|Zhang Xiao-Yu\|Li Xiao-Jing\|
42	檸檬酸鐿誘導肝癌細胞HepG2凋亡作用及蛋白質表達變化研究	期刊論文	沈立明\|倪嘉纘\|劉瓊\|蘭子堯\|李娜\|
43	Proteomic analysis of lanthanum citrate-induced apoptosis in human cervical carcinoma SiHa cells	期刊論文	Liu, Qiong\|Shi, Lei\|Sun, Xiaohong\|Shen, Liming\|Lan, Ziyao\|Ni, Jiazuan\|
44	稀土藥用研究的動向和問題	期刊論文	王夔\|楊曉達\|楊曉改\|
45	Detection of Nano Eu2O 3 in Cells and Study of its Biological Effects	期刊論文	Pin Yang\|Xueping Zhou\|Yingqi Li\|Zhuoyu Li\|
46	Gadolinium-containing bioparticles as an active entity to promote cell cycle progression in mouse embryo fibroblast NIH3T3 cells	期刊論文	Liu,J.-C.\|Wang,K.\|Li,J.-X.\|Yang,X.-G.\|

項目摘要

我國稀土資源豐富、套用日益廣泛，研究逐漸深入，追蹤到一些基礎問題，亟待解決。本項目擬通過細胞和分子層次上相互聯繫的系統研究，闡明稀土化合物促細胞增殖作用以及與之相關的細胞分化和凋亡的本質，並在此基礎上研究對腫瘤、動脈硬化的發生髮展過程的干預方式和化學機理，揭示稀土在上述疾病防治中套用的基礎和條件。此外，研究闡明極低劑量的稀土的作用和毒性表現，揭示活性和毒性間的關聯，確定稀土作用的濃度末點（endpoint），為修正安全計量標準提供依據，為稀土套用的安全性提供基礎和條件。本項目還將通過對稀土生物無機化學水平的提高，促進細胞無機化學學科發展。另外還將對極低劑量金屬毒理學研究的思路和方法有所貢獻。

稀土元素的生物化學反應和有關細胞化學過程的干預

基本介紹

科研成果

項目摘要

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