皮榮標

人物經歷

1993年籃應於江西中醫學院獲得藥學學士學位，1999年於中山（醫科）大學獲得藥理學碩士學位，2002年於中山大學醫學院獲得藥理學博士學位。曾多次到境外，包括香港科技大鞏己陵滲學（2002）、紐西蘭奧克蘭大學（2005）和美國耶魯大學醫學院（2009）開展博士後研究或合作研究。擔任多個基金評審專家（包括國家自然科學基金面上項目、廣東省自然科學基金、廣東省科技計畫和廣州市科技局科技計畫）及廣東省食品藥品管理局藥品註冊審評專家。

研究方向

1.中樞神經系統重大疾病（如腦缺血和阿爾茨海默氏病等）的分子機制；

2.治療神經系統疾病的“單分子多靶點”藥物的研究開發。

教授課程

本科生：藥理學，藥理學實驗，藥物發展史

研究生：分子藥理學，藥理學進展，治療重大疾病藥物研酷舟設捆究進展

社會兼職

J Pharmaceutics、Frontier Med Chem 和藥學研究的編委並在多個國內外重要學術刊物，如中山大學學報（醫學版）、生物物理學學報、Chinese Medicine、Neuroscience、J Med Chem、Neuroscientists、J Pineal Res、Apoptosis、Biochimica et Biophysica Acta(BBA) -Molecular Basis of Disease、Eur J Med Chem、BMC Lett及恥探講J Alzheimer Dis等擔任特邀審稿人。

學術成果

科研項目

1.國家自然科學基金：基於丙烯醛的新型散發性AD大鼠和食蟹猴模型的建立、鑑定和標準化。№81671264，2017.1-2020.12.

2.高等學校基本科研業務費中山大學重點培育項目：小分子化合物誘導星形膠質細胞重編程為功能性神經元的研究。№15ykjc08b.2015.9-2017.9；

3.廣東省科技計體提陵劃國際合作項目：廣東省（中山大學—香港理工大學）抗失智創新藥物聯合實驗室。№2013B051000038.2014.1-2016.12；

4.國家自然科學基金：Nrf2/ARE的新功能——促進海馬成體神經發生及其BDNF依賴性機制。№31371070，2014.1-2017.12；

5.科技部中意科技聯委2013-2015項目：新型多靶點抗阿爾茨海默氏病藥物的開發。№ MAE-M00705\CN13MO9，2013.1-2015.12；

6．廣東省科技計畫國際合促晚店作項目：新型多靶點抗阿爾茨海默氏埋舉記病候選藥物的開發研究。№ 2012B050300015，2013.1-2014.12；

7.高等學校基本科研業務費.新型化合物ZSU07012多靶點抗阿爾茨海默氏病作用研究。高校基本科研業務費中山大學青年教師培育項目，2010.6-2013.6，№ 10ykpy23;

8．國家自然科學基金與香港研究資助局聯合項目：新型他克林-米諾環素二聚體：多靶點防治老年性痴呆症的分子機制及其結構最佳化(大陸方負責人)；№ 30731160617，2008.1-2010.12.

論著專利

已發表的研究文章 (*通訊作者):

2016(11)

1.Ziwei Chen, Maria Digiacomo, Yalin Tua, Qiong Gua, Shengnan Wanga, Xiaohong Yang, Jiaqi Chua, Qiuhe Chen, Yifan Han, Jingkao Chen, Giulia Nesi, Simona Sestito, Marco Macchia, Simona Rapposelli*,Rongbiao Pi*.Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease.Eur J Med Chem.2016 Sep 17;125:784-792.

2.Tu YL, Chen QH, Wang SN, Uri A, Yang XH, Chu JQ, Chen JK, Luo BL, Chen XH, Wen SJ*,Pi RB*. Discovery of Lipoic acid-4-Phenyl-1H-pyrazole Hybrids as Novel Bifunctional ROCK Inhibitors with Antioxidant Activity. RSC Advances, 2016, 6, 58516–58520.

3.Wang SN, Li Q, Jing MH, Alba E, Yang XH, Sabaté R, Han YF,Pi RB, Lan WJ, Yang XB, Chen JK. Natural Xanthones from Garcinia mangostana with Multifunctional Activities for the Therapy of Alzheimer's Disease. Neurochem Res. 2016 Jul;41(7):1806-17.

4.Luo M, Liu Q, He M, Yu Z,Pi R, Li M, Yang X, Wang S, Liu A. Gartanin induces cell cycle arrest and autophagy and suppresses migration involving PI3K/Akt/mTOR and MAPK signalling pathway in human glioma cells. J Cell Mol Med. 2016 Aug 5. doi: 10.1111/jcmm.12937. [Epub ahead of print] PubMed PMID: 27491646.

5.Gao XY, Wang SN, Yang XH, Lan WJ, Chen ZW, Chen JK, Xie JH, Han YF,Pi RB, Yang XB. Gartanin Protects Neurons against Glutamate-Induced Cell Death in HT22 Cells: Independence of Nrf-2 but Involvement of HO-1 and AMPK. Neurochem Res. 2016 May 9; 41(9):2267-77.

6.Yang X, Wang S, Ouyang Y, Tu Y, Liu A, Tian Y, He M,Pi RB*. Garcinone D, a natural xanthone promotes C17.2 neural stem cell proliferation: Possible involvement of STAT3/Cyclin D1 pathway and Nrf2/HO-1 pathway. Neurosci Lett. 2016 May 10;626:6-12.

7.Chen ZW, Liu A, Liu Q, Chen J, Li WM, Chao XJ, Yang Q, Liu PQ, Mao ZX,Pi RB*. MEF2D Mediates the Neuroprotective Effect of Methylene Blue Against Glutamate-Induced Oxidative Damage in HT22 Hippocampal Cells. Mol Neurobiol. 2016 Mar 3. [Epub ahead of print] PubMed PMID: 26941101.

8.Chen M, Liu Q, Tan M, Wen S,Pi R*, Lin D*. Synthesis and biological evaluation of n-butylphthalide derivatives as anti-platelet aggregation agents. Nat Prod Res. 2016 Feb 15:1-4. [Epub ahead of print] PubMed PMID: 26878162.

9.Chu J, Tu Y, Chen J, Tan D, Liu X,Pi R*. Effects of melatonin and its analogues on neural stem cells. Mol Cell Endocrinol. 2016 Jan 15;420:169-79.

10.He XX*, Yang XH, Ou RY, Ouyang Y, Wang SN, Chen ZW, Wen SJ,Pi RB*. Synthesis and evaluation of multifunctional ferulic and caffeic acid dimers for Alzheimer's disease. Nat Prod Res. 2016 Aug 17:1-4. [Epub ahead of print] PubMed PMID: 27531418.

11.楊曉紅;王勝男;劉慶余;歐陽穎;李民;皮榮標*.Nrf2通過上調自噬促進C17．2神經幹細胞的增殖.中山大學學報（醫學科學版）, 2016; 37(4):481-9.

2015(9)

12.Digiacomo M, Chen Z, Wang S, Lapucci A, Macchia M, Yang X, Chu J, Han Y,Pi R*, Rapposelli S§. Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD.Bioorg Med Chem Lett. 2015 Feb15;25(4):807-10.IF 2.331

13.He M, Luo M, Chen S, Li K, Zheng M, Weng Y, Pi R, Liu A. Combined treatment of fasudil and glutamate decreased the viability of human glioblastoma cells by excitotoxicity through NMDAR in vitro. Int J Clin Exp Med. 2015 Oct 15;8(10):18434-40.

14.Chen M, Tan M, Jing M, Liu A, Liu Q, Wen S, Chen Z, Chao X, He X, Ramassamy C, Gao Y,Pi R（皮榮標）*. Berberine protects homocysteic acid-induced HT-22 cell death: involvement of Akt pathway.Metab Brain Dis. 2015 Feb;30(1):137-42. IF2.398

15.Shen W, Wang L, Pi R, Li Z, Rikang Wang. L-F001, a multifunctional ROCK inhibitor prevents paraquat-induced cell death through attenuating ER stress and mitochondrial dysfunction in PC12cells. Biochem Biophys Res Commun. 2015 Aug 28;464(3):794-9.

16.Zeng P, Pi RB, Li P, Chen RX, Lin LM, He H, Zhou SY. Fasudil hydrochloride, a potent ROCK inhibitor, inhibits corneal neovascularization after alkali burns in mice. Mol Vis. 2015 Jun 12;21:688-98.

17.Huang Q, Ma X, Zhu DL, Chen L, Jiang Y, Zhou L, Cen L, Pi R, Chen X. Total glucosides of peony attenuates experimental autoimmune encephalomyelitis in C57BL/6 mice. J Neuroimmunol. 2015 Jul 15;284:67-73.

18.Jiang Y, Liu Y, Zhu C, Ma X, Ma L, Zhou L, Huang Q, Cen L, Pi R, Chen X. Minocycline enhances hippocampal memory, neuroplasticity and synapse-associated proteins in aged C57 BL/6 mice. Neurobiol Learn Mem. 2015 May;121:20-9.

19.Chen Z, Mao X, Liu A, Gao X, Chen X, Ye M, Ye J, Liu P, Xu S, Liu J, He W, Lian Q, Pi R*. Osthole, a natural coumarin improves cognitive impairments and BBB dysfunction after transient global brain ischemia in C57 BL/6J mice: involvement of Nrf2 pathway. Neurochem Res. 2015 Jan;40(1):186-94.

20.陳舒；羅銘；劉安民；何明亮；陳美惠；皮榮標。法舒地爾對C1 7．2小鼠神經幹細胞增殖分化的影響及機制研究。中華神經醫學雜誌；2015；14（3）：244-248.

2014 (10 )

21.Chen X, Gao J, Jiang Y, Huang P, Xie Y,Pi R（皮榮標）, Zhu S, Yao M. Determination of newly synthesized lipoic acid-niacin dimer in rat plasma by UPLC/electrospray ionization tandem mass spectrometry: assay development, validation and application to a pharmacokinetic study.Biomed Chromatogr.2014 Feb;28(2):213-7.IF 1.662

22.Liu Z, Zhu D, Luo B, Zhang N, Liu Q, Hu Y,Pi R（皮榮標）, Huang P, Wen S. Mildcu(i)-catalyzed cascade reaction of cyclic diaryliodoniums, sodium azide, andalkynes: efficient synthesis of triazolophenanthridines.Org Lett. 2014 Nov7;16(21):5600-3.IF6.324

23.Chen M H, Liu Q, Liu A M,Pi R（皮榮標）*. Simply combining fasudil and lipoic acid in a novel multitargeted chemical entity potentially useful in central nervous system disorders.RSC ADVANCES, 2014,4(70):37266-37269.IF3.708

24.Wang L, Wang R, Jin M, Huang Y, Liu A, Qin J, Chen M, Wen S,Pi R（皮榮標）, Shen W. Carvedilol attenuates 6-hydroxydopamine-induced cell death in PC12 cells:involvement of Akt and Nrf2/ARE pathways.Neurochem Res. 2014 Sep;39(9):1733-40.IF 2.551

25.Chao XJ, Chen ZW, Liu AM, He XX, Wang SG, Wang YT, Liu PQ, Ramassamy C, Mak SH, Cui W, Kong AN, Yu ZL, Han YF,Pi RB（皮榮標）*. Effect of tacrine-3-caffeic acid, a novel multifunctional anti-Alzheimer's dimer, against oxidative-stress-inducedcell death in HT22 hippocampal neurons: involvement of Nrf2/HO-1 pathway.CNS NeurosciTher. 2014 Sep;20(9):840-50.IF3.784

26.Li L, Tuo J, Xie Y, Huang M, Huang M,Pi R（皮榮標）, Hu H. Preparation, transportation mechanisms and brain-targeting evaluation in vivo of a chemical delivery system exploiting the blood-cerebrospinal fluid barrier.JDrugTarget. 2014Sep;22(8):724-31.IF 2.723

27.Zhu D, Liu M, Yang Y, Ma L, Jiang Y, Zhou L, Huang Q,Pi R（皮榮標）, Chen X. Ginsenoside Rd ameliorates experimental autoimmune encephalomyelitis in C57BL/6mice.J Neurosci Res. 2014 Sep;92(9):1217-26.IF 2.729

28.Zhu D, Wu Y, Wu B, Luo B, GanesanA, Wu FH,Pi R（皮榮標）, Huang P, Wen S.Three-component Pd/Cu-catalyzed cascade reactions of cyclic iodoniums, alkynes, and boronic acids: an approach to methylidenefluorenes.Org Lett. 2014 May 2;16(9):2350-3.IF6.324

29.Sun X, Zhang P,Pi R（皮榮標）, Zhou Y, Deng X, Xie Z, Liao Q. Determination oftacrine-6-ferulic acid in rat plasma by LC-MS/MS and its application topharmacokinetics study.Biomed Chromatogr. 2014 Oct;28(10):1352-9.IF 1.662

30.Huang Y, Qin J, Chen M, Chao X, Chen Z, Ramassamy C,Pi R（皮榮標）, Jin M. Lithium prevents acrolein-induced neurotoxicity in HT22 mouse hippocampal cells.Neurochem Res. 2014 Apr;39(4):677-84.IF 2.551

2013 (14)

31. Ouyang Y, Chen Z, Tan M, Liu A, Chen M, Liu J, Pi R, Fang J. Carvedilol, a third-generation β-blocker prevents oxidative stress-induced neuronal death and activates Nrf2/ARE pathway in HT22 cells. Biochem Biophys Res Commun. 2013 Nov 29;441(4):917-22.

32.Daqian Zhu, Qi Liu, Bingling Luo, Meihui Chen,Rongbiao Pi, Peng Huang, Shijun Wen. Synthesis of Carbazoles via One-Pot Copper-Catalyzed Amine Insertion into Cyclic Diphenyleneiodoniums as a Strategy to Generate a Drug-Like Chemical Library. Advanced Synthesis & Catalysis. 2013，355（11-12）2172–2178.

33.Tan M, Ouyang Y, Jin M, Chen M, Liu P, Chao X, Chen Z, Chen X, Ramassamy C, Gao Y*,Pi R*. Downregulation of Nrf2/HO-1 pathway and activation of JNK/c-Jun pathway are involved in homocysteic acid-induced cytotoxicity in HT-22 cells. Toxicol Lett. 2013 Aug 27;223(1):1-8.

34.Zhu D, Chen M, Li M, Luo B, Zhao Y, Huang P, Xue F, Rapposelli S,Pi R*, Wen S*. Discovery of novel N-substituted carbazoles as neuroprotective agents with potent anti-oxidative activity. Eur J Med Chem. 2013 Aug 9;68C:81-88.

35.Zhao ZM, Sun ZH, Chen MH, Liao Q, Tan M, Zhang XW, Zhu HD,Pi RB, Yin S. Neuroprotective polyhydroxypregnane glycosides from Cynanchum otophyllum. Steroids.2013 Oct;78(10):1015-20.

36.Jiang Y, Zou Y, Chen S, Zhu C, Wu A, Liu Y, Ma L, Zhu D, Ma X, Liu M, Kang Z,Pi R, Peng F, Wang Q, Chen X. The anti-inflammatory effect of donepezil onexperimental autoimmune encephalomyelitis in C57 BL/6 mice. Neuropharmacology. 2013 Oct;73:415-24.

37.Jiang Y, Wu A, Zhu C,Pi R, Chen S, Liu Y, Ma L, Zhu D, Chen X. The protective effect of berberine against neuronal damage by inhibiting matrix metalloproteinase-9 andlaminin degradation in experimental autoimmune encephalomyelitis. Neurol Res. 2013 May;35(4):360-8.

38.Huang Y, Jin M,Pi R*, Zhang J, Chen M, Ouyang Y, Liu A, Chao X, Liu P, Liu J,Ramassamy C, Qin J*. Protective effects of caffeic acid and caffeic acid phenethyl ester against acrolein-induced neurotoxicity in HT22 mouse hippocampal cells. Neurosci Lett.2013 Feb 22;535:146-51.

39.Huang YJ, Jin MH,Pi RB*, Zhang JJ, Ouyang Y, Chao XJ, Chen MH, Liu PQ, Yu JC, Ramassamy C, Dou J, Chen XH, Jiang YM, Qin J*. Acrolein induces Alzheimer's disease-like pathologies in vitro and in vivo. Toxicol Lett. 2013 Mar 13;217(3):184-91.

40.Zhao ZY, Luan P, Huang SX, Xiao SH, Zhao J, Zhang B, Gu BB,Pi RB, Liu J. Edaravone protects HT22 neurons from H2O2-induced apoptosis by inhibiting the MAPK signaling pathway. CNS Neurosci Ther. 2013 Mar;19(3):163-9.

41.Chen X, Chen S, Jiang Y, Zhu C, Wu A, Ma X, Peng F, Ma L, Zhu D, Wang Q,Pi R. Minocycline reduces oxygen-glucose deprivation-induced PC12 cell cytotoxicity via matrix metalloproteinase-9, integrin β1 and phosphorylated Akt modulation. Neurol Sci. 2013 Aug;34(8):1391-6.

42.Yu SS, Cai Y, Ye JT,Pi RB, Chen SR, Liu PQ, Shen XY, Ji Y. Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF-κB-dependent transcriptional activity. Br J Pharmacol. 2013 Jan;168(1):117-28.

43.Doggui S, Belkacemi A, Paka GD, Perrotte M,Pi R, Ramassamy C. Curcumin protects neuronal-like cells against acrolein by restoring Akt and redox signaling pathways. Mol Nutr Food Res. 2013 Sep;57(9):1660-70.

44.王觀峰，姚敏，李文立，鄒秀蘭，鄒玉平，皮榮標.硫辛酸煙酸二聯體對丙烯醛損傷ARPE-19細胞的保護作用[J].眼科新進展,2013,02:106-109.

2012 (7)

45.Huang WY, Chao XJ, Ouyang Y, Liu AM, He XX, Chen MH, Wang LH, Liu J, Yu SW, Rapposelli S,RB Pi*. Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer Against Alzheimer's Disease, Prevents Oxidative Stress-Induced Neuronal Death Through Activating Nrf2/ARE/HO-1 Pathway in HT22 Cells. CNS Neurosci Ther. 2012 Nov;18(11):950-1.

46.Chao X, He X, Yang Y, Zhou X, Jin M, Liu S, Cheng Z, Liu P, Wang Y, Yu J, Tan Y, Huang Y, Qin J, Rapposelli S,RB Pi*. Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease. Bioorg Med Chem Lett. 2012 Oct 15;22(20):6498-502.

47.Xiao O, Xie ZL, Lin BW, Yin XF,RB Pi*, Zhou SY*. Minocycline inhibits alkali burn-induced corneal neovascularization in mice. PLoS One. 2012;7(7):e41858.

48.Chen X, Ma L, Jiang Y, Chen S, Zhu C, Liu M, Ma X, Zhu D, Liu Y, Peng F, Wang Q,Pi R. Minocycline up-regulates the expression of brain-derived neurotrophic factor and nerve growth factor in experimental autoimmune encephalomyelitis. Eur J Pharmacol. 2012 Jul 5;686(1-3):124-9.

49.Xuexuan Mao, Jiaotao Ye, Shiyou Zhou,Rongbiao Pi*, Juan Dou, Lingquan Zang, XiaojuanChao, XiaohongChen, Wenming Li, Mengfei Liu, Peiqing Liu. The effects of chronic copper exposure on the amyloid protein metabolisim associated genes' expression in chronic cerebral hypoperfused rats. Neurosci Lett. 2012. Jun 14;518(1):14-8.

50.Cai Y, Yu SS, Chen SR,Pi RB, Gao S, Li H, Ye JT, Liu PQ. Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6. FEBS Lett. 2012 Mar 23;586(6):866-74.

51.Pi R*, Mao X, Chao X, Cheng Z, Liu M, Duan X, Ye M, Chen X, Mei Z, Liu P, Li W*, Han Y*. Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo. PLoS One. 2012;7(2):e31921.

2011 ( 2 )

52.Zhang H, Mak S, Cui W, Li W, Han R, Hu S, Ye M,Pi R*, Han Y*. Tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway. Neurochem Int. 2011 Dec;59(7):981-8.

53.Mao X, Yin W, Liu M, Ye M, Liu P, Liu J, Lian Q, Xu S,Pi R*. Osthole, a natural coumarin, improves neurobehavioral functions and reduces infarct volume and matrix metalloproteinase-9 activity after transient focal cerebral ischemia in rats. Brain Res. 2011 Apr 18;1385:275-80.

2010 ( 5 )

54.Ma X, Jiang Y, Wu A, Chen X,Pi R, Liu M, Liu Y. Berberine attenuates experimental autoimmune encephalomyelitis in C57 BL/6 mice. PLoS One. 2010 ;5(10):e13489.

55.Mei Liu, Xiaomeng Ma, Xiaohong Chen, Ying Jiang, Aimin Wu, Fuhua Peng, Yingying Liu,Rongbiao Pi. Ischemic preconditioning partially suppresses andpostpones integrin αVβ3 mRNA expression followingtransient global cerebral ischemia in C57BL/6mice. Neural Regen Res. 2010;5(23):1782-1786.

56.Xiaohong Chen,Rongbiao Pi, Yan Zou, Xueqiang Hu, Mei Liu, Xiaomeng Ma, Xuexuan Mao. Attenuation of experimental autoimmune encephalomyelitis in C57 BL/6 mice by osthole, a natural coumarin. Eur J Pharmcol. 2010; 629(1-3):40-6.

57.Xiao-hong Chen, Zhu-zhen Lin, An-min Liu, Jian-tao Ye, Yan Luo, Yu-yan Luo, Xue-xuan Mao, Pei-qing Liu,Rong-biao Pi*. The orally combined neuroprotectiveeffects of sodium ferulate and borneol against transient global ischemia in C57 BL/6J mice. J Pharm Pharmacol. 2010, 62(7): 1–9.

58.Xiaohong Chen,Rongbiao Pi, Mei Liu, Xiaomeng Ma, Ying Jiang, Aimin Wu, Xuexuan Mao, Xueqiang Hu. Minocycline ameliorates experimental autoimmune encephalomyelitis in C57 BL/6 mice through up-regulating the expression of BDNF and NGF. J Neuroimmunol. 2010, 226(1-2):104-9.

2009以前(12)

59.Ye JT,Pi RB*(co corresponding author), Mao XX, Chen XH, Qin J, Xu SW, Liu PQ. Alterations in mRNA expression of BACE1, cathepsin B, and glutaminyl cyclase in mice ischemic brain. Neuroreport. 2009; 20(16):1456-60.

60.Chen X, Hu X, Zou Y,Pi R, Liu M, Wang T, Zheng X, Liu M, Lin M, Liu P, Tao L. Combined treatment with minocycline and prednisone attenuates experimental autoimmune encephalomyelitis in C57 BL/6 mice. J Neuroimmunol. 2009; 210(1-2):22-9.

61.Mei Z, Zhang F, Tao L, Zheng W, Cao Y, Wang Z, Tang S, Le K, Chen S,Pi R*(co corresponding author), Liu P. Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates beta-amyloid deposition through upregulating alpha-secretase in vivo and in vitro. Neurosci Lett. 2009; 452(2):90-5.

62.Chen X, Lan X, Mo S, Qin J, Li W, Liu P, Han Y,Pi R*. p38 and ERK, but not JNK, are involved in copper-induced apoptosis in cultured cerebellar granule neurons. Biochem Biophys Res Commun. 2009; 379(4):944-8.

63.Zhang F, Zheng W,Pi R,Mei Z, Bao Y, Gao J, Tang W, Chen S, Liu P. Cryptotanshinone protects primary rat cortical neurons from glutamate-induced neurotoxicity via the activation of the phosphatidylinositol 3-kinase/Akt signaling pathway. Exp Brain Res. 2009; 193(1):109-18.

64.RZ Lin, XH Chen, WM LI, YF Han, PQ Liu,RB Pi*. Effects of metal ions on the expression of APP and BACE1 in PC12 cells: Blocking by Curcumin. Neurosci Lett，2008；440（3）:344-347.

65.藍秀健，葉敏忠，劉培慶，余劍平，皮榮標*.銅對低鉀誘導大鼠小腦顆粒神經元凋亡的保護.中山大學學報（醫學版）. 2008；29（2）：154-158.

66.林竹貞,藍明雄,姚美村,鐘國平,劉培慶，皮榮標*.冰片對阿魏酸鈉在小鼠血漿和腦區中分布的影響.中草藥. 2008; 39（4）：551-556.

67.Janusz Lipski, Carthur K Wan, Ji-Zhong Bai,Rongbiao Pi, Dong Li, David F Donnelly. Neuroprotective potential of ceftriaxone in in vitro models of stroke. Neuroscience, 2007；146(2):617-29.

68.Wenming Li,Rongbiao Pi, Hugh H.N. Chan, Hongjun Fu, Nelson T.K. Lee, Hing Wai Tsang, Yongmei Pu, Donald C. Chang, Jialie Luo, Keming Xiong, Zhiwang Li, Chaoying Li, Hong Xue, Paul R. Carlier, Yuanping Pang, Karl W.K. Tsim, Mingtao Liand Yifan Han.Novel Dimeric AChE Inhibitor Bis(7)-tacrine, but not Donepezil, Prevents Glutamate-induced Neuronal Apoptosis by Blocking NMDA Receptors. J Biol Chem, 2005, 280(18):18179-88.

69.Rongbiao Pi, Wenming Li, Nelson T.K. Lee, Hugh H.N. Chan, Yongmei Pu, Ling Nga Chan, Nikolaus J Sucher, Donald C. Chang, Mingtao Li, Yifan Han. Minocycline Prevents Glutamate-induced Apoptosis of Cerebellar Granule Neurons by Differential Regulation of p38 and Akt Pathways. J. Neurochem,2004, 91(5): 1219-1230.

70.Rongbiao Pi, Wei Yin, Suqiu Zheng, Pengxin Qiu, Jian Zhou, Wei Guo, Tao Su, and Guangmei Yan. Adenoviral mediated transfer of TIMP-3 partially prevents glutamate-induced cell death in primary cultured cortical neurons of the rat.Brain Res Mol Brain Res, 2004, 127(1-2):136-139.

已發表綜述（*通訊作者）：

1.Qiu-He Chen,Rong-Biao Piand Jing-Kao Chen. Pharmacology of Rhein and Advancement in the Synthesis of Its Derivatives. Current Traditional Medicine. 2016; 2(1):59-69.DOI:10.2174/2215083802666160620131215

2.何淼,皮榮標,黃文勇.糖尿病視網膜病變的動物模型及藥理研究進展[J].中華實驗眼科雜誌,2015,33(1): 87-92. DOI: 10.3760/ cma.j.issn.2095-0160.2015.01.019

3.陳曉婷，陳秋荷，塗亞林，皮榮標*.血清和糖皮質激素調節激酶1在CNS疾病中的作用研究新進展.藥學研究, 2016; 35(10):559-568.

4.陳秋荷，塗亞林，皮榮標，陳景考.大黃酸及其衍生物的藥理作用研究進展.藥學研究, 2016; 35(10):559-568.

5.Ronggui Guan, Xiaoyu Xu, Meihui Chen, Haiyan Hu, Hu Ge, Shijun Wen*, Shiyou Zhou*,Rongbiao Pi*. Advances in the Studies of Roles of Rho/Rho-kinase in Diseases and the Development of Its Inhibitors. Eur J Med Chem. 2013 Dec;70:613-22.

6.Chen M, Liu A, Ouyang Y, Huang Y, Chao X,Pi R*. Fasudil and its analogs: a new powerful weapon in the long war against central nervous system disorders? Expert Opin Investig Drugs. 2013 Apr;22(4):537-50.

7.陳美惠，劉安民，巢曉娟，皮榮標*. Rho激酶抑制劑法舒地爾對中樞神經系統疾病作用及其結構改造的研究進展[J].中國新藥雜誌,2013,01:59-67.

8.董雪姣，姜伊鳴，於暕辰，皮榮標*.川芎嗪衍生物及其藥理活性研究進展[J].中南藥學,2012,04:294-299.

9.Chen X, Ma X, Jiang Y,Pi R, Liu Y, Ma L. The prospects of minocycline in multiple sclerosis. J Neuroimmunol. 2011 Jun;235(1-2):1-8. Epub 2011 May 11.

10.Ye M, Fu S,Pi R*, He F. Neuropharmacological and pharmacokinetic properties of berberine: a review of recent research. J Pharm Pharmacol. 2009; 61(7):831-7.

11.劉夢菲，阮志，皮榮標*.新靶點谷氨醯胺醯基環化酶治療阿爾茨海默病的新進展[J].中國藥學雜誌,2009,13:965-967.

12.徐海俠，謝琦，皮榮標.阿爾茨海默病澱粉樣斑塊的活體MR可視化成像研究進展.國際醫學放射學雜誌. 2009; 32(6):529-532.

13.葉敏忠，成志毅，皮榮標*.基於他克林的多靶位乙醯膽鹼酯酶抑制劑的研究進展.中國藥理學通報；2008；24（12）：1145-1149.

14.葉敏忠，成志毅，皮榮標*. “雜交”與“橋聯”——以他克林衍生物為代表探討開發多靶點抗阿爾茨海莫氏病藥物的新策略[A].中國藥理學會.藥學發展前沿論壇及藥理學博士論壇論文集[C].中國藥理學會:,2008:12.

15.納鑫,汪雪蘭,皮榮標*.川芎嗪的中樞神經藥理作用研究進展，中國中藥與臨床藥理雜誌. 2008; 19（1）：77-80。

16.毛雪璇，皮榮標*. Morris水迷宮影響因素新進展.中國行為科學雜誌，2008,17(8):152-154.

17.林竹貞，皮榮標*.嚙齒類腦缺血動物模型的研究進展.中國神經精神疾病雜誌，2007，33（9）：574-576.

18.李瑩瑩，藍秀建，朱振宇，皮榮標*.魚藤酮誘導的帕金森病動物模型的研究進展.中南藥學. 2007; 5(1):52-56.

19.藍秀建，李瑩瑩，葉敏忠，皮榮標.肝豆狀核變性中的神經系統變性與銅毒性的綜述.中山大學學報論叢. 2007, 27(3):182-187.

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