田景奎

田景奎

主要從事生物醫藥信息工程與創新藥物研究工作。近3年來，開展了圓錐鐵線蓮、青蒿、銀杏葉和紅豆杉等10餘種藥用植物的活性酶誘導實驗，並研製出智慧型活性酶誘導儀；進而運用蛋白質組、基因組和生物信息學技術對銀杏葉、圓錐鐵線蓮和紅豆杉等進行了活性成分生物合成機理的研究；開展了三維組織晶片的系統研究，進行了晶片構建和複雜信號處理研究，為新藥篩選和作用機制研究奠定了基礎；從20餘種藥用植物中分離得到500多個化合物，其中70多個新化合物，對新化合物中特有的抗腫瘤、抗結核和抗炎活性成分進行了作用機制探討；開展了創新藥物研究，獲得臨床批件2項，在研新藥和健康相關產品10餘項。正在承擔國家自然科學基金、新藥創製國家重大科技專項、浙江省重大科技專項、浙江省傑出青年基金和教育部博士點基金等項目。已在國內外重要刊物發表文章70餘篇，其中SCI收錄30餘篇。

基本介紹

  • 中文名：田景奎
  • 畢業院校：中國協和醫科大學
  • 學位/學歷：博士
  • 專業方向：生物醫藥信息工程、系統生物學、天然藥物開發
  • 職務：醫療健康信息工程技術研究所副所長
科研項目,出版著作,獎勵榮譽,專利成果,研究成果,

科研項目

1.浙江省國際科技合作“一帶一路”專項，浙江-馬來西亞傳統藥物聯合研究中心，在研
2.國家新藥創製重大專項，基於臍融透皮給藥關鍵技術的中藥新藥*** ，在研
3.國家自然基金，維藥野胡蘿蔔子中Daucusol的定向分離及其抗腫瘤耐藥作用機理的研究，結題
4.國家自然基金，基於紫外誘導圓錐鐵線蓮葉綠體內抗腫瘤香豆素生物合成關鍵酶與關鍵基因研究，結題
5.浙江省自然基金重點項目，桑葉中抗BmNPV活性的Diels-Alder加合物的誘導及其生物合成機制研究，結題
6.教育部科學技術重點項目，基於紫外誘導桑葉中Diels-Alder加合物生物合成關鍵基因、關鍵酶及其套用研究，結題
7.國家新藥創製重大專項，抗腫瘤中藥新藥***的臨床前研究（滾動），結題
8.國家新藥創製重大專項，抗結核中藥新藥***的臨床前研究（滾動），結題
9.教育部博士點基金，基於亞細胞水平紫外誘導圓錐鐵線蓮香豆素生物合成機制的研究，結題
10.浙江省自然基金傑出青年基金，基於光酶誘導銀杏葉中抗氧化活性成分的生物合成機制研究，結題

出版著作

孔令義，田景奎等。天然藥物化學，化學工業出版社，2018.5
楊世林，田景奎等。天然產物化學研究，科學技術出版社，2010.10

獎勵榮譽

田景奎，張琳，馬勝林，等。中藥新藥辛萸貼片研究，浙江省科技進步三等獎，2010年

專利成果

1. 從中藥圓錐鐵線蓮中分離純化活性成分金色醯胺醇酯的方法，ZL2010106063805，2014.01.29
2.一種墨旱蓮提取物的製備方法及用途，ZL201101845891, 2013.01.23
3.一種治療偏頭痛的中藥複方製劑及其製備方法，ZL2010106063839, 2012.04.25
4. 運用活性酶誘導技術提高黃花蒿中青蒿素含量的方法，ZL201010186313, 2012.01.11
5. 一種細梗香草皂苷A的製備方法及其用途，CN201510505992.8, 2015.08.18
6.一種防治高血脂的重要組合物及其製備方法，CN201510755417.3, 2015.11.05
7.一種東革阿里提取物及其製備方法，CN20150906420.0, 2015.12.07
8.一種防治家蠶BmNPV病的誘導桑葉及其用途， CN201710252959.8, 2017.04.18

研究成果

  1. Guan QJ, Yu JJ, Zhu W, Yang BX, Li YH, Zhang L, Tian JK*. RNA-Seq transcriptome analysis of the Morus alba L. leaves exposed to high-level UV-B with and without dark treatment. Gene 2018, 645:60-68
  2. Han HT, Chou CC, Li RY, Liu JY, Zhang L, Zhu W, Hu J, Yang BX, Tian JK*. Chalcomoracin is a potent anticancer agent through triggering oxidative stress via a mitophagy-dependent mechanism. Sci. Rep. 2018, 8(1): 9566
  3. Zhu W, Zheng W, Hu XJ, Xu XB, Zhang L, Tian JK*. Variations of metabolites and proteome in Lonicera japonica Thunb. buds and flowers under UV radiation. BBA-Proteins and Proteom. 2017, 1865(4): 404-413.
  4. Ren YN, Xu XB, Zhang QL, Lu YZ, Li XM, Zhang L, Tian JK*. Isolation, characterization, and in rats plasma pharmacokinetic study of a new triterpenoid saponin from Dianthus superbus. Arch. Pharm. Res. 2017, 40(2): 159-167.
  5. Hashiguchi A.*, Hitachi K., Zhu W., Tian JK, Tsuchida K., Komatsu S. Mung bean (Vigna radiata (L.)) coat extract modulates macrophage functions to enhance antigen presentation: A proteomic study. J. Proteomics 2017, 161: 26-37.
  6. Zhang DD, Gao CX, Li RY, Zhang L, Tian JK. TEOA, a triterpenoid from Actinidia eriantha induces autophagy in SW620 cells via endoplasmic reticulum stress and ROS-dependent mitophagy. Arch. Pharm. Res. 2017, 40(5): 579-591.
  7. Hu J#, Zhu W#, Yaohan Li, Guan QJ, Haijian Yan, Yu JJ, Fu ZR, Lu XM, Tian JK*. SWATH-based quantitative proteomics reveals the mechanism of enhanced Bombyx mori nucleopolyhedrovirus-resistance in silkworm reared on UV-B treated mulberry leaves. Proteomics 2017, 17(13-14): 1600383.
  8. Wang X, Zhu W, Hashiguchi A, Nishimura M, Tian JK, Komatsu S*. Metabolic profiles of flooding-tolerant mechanism in early-stage soybean responding to initial stress. Plant Mol. Biol. 2017, 94: 669-685.
  9. Hashiguchi A.*, Zhu W., Tian JK, Komatsu S.* Proteomics and metabolomics-driven pathway reconstruction of mung bean for nutraceutical evaluation. BBA-proteins and proteom. 2017, 1865(8): 1057-1066.
  10. Feng HJ, Yang YL, Sun SC, Li YJ, Zhang L, Tian JK, Zhu QH, Feng ZL, Zhu HQ*, Sun J*. Molecular analysis of caffeoyl residues related to pigmentation in green cotton fibers. J. Exp. Bot. 2017, 68(16): 4559-4569.
  11. Yang BX, Guan QJ, Tian JK*, Komatsu S. Transcriptomic and proteomic analyses of leaves from Clematis terniflora DC. under high level of ultraviolet-B irradiation followed by dark treatment. J. Proteomics 2017, 150: 323-340.
  12. Hu J, Wang J, Li SX, Yang BX, Gong MH, Li XM, Zhang L, Tian JK*. Phytochemical compositions, antioxidant and antimicrobial activities analysis of extracts from Vaccinium bracteatum Thunb. leaves. J. Appl. Bot. Food Qual. 2016, 89: 150-155.
  13. Yang BX, Wang X, Gao CX, Chen M, Guan QJ, Tian JK*, Komatsu S. Proteomic and Metabolomic Analyses of Leaf from Clematis terniflora DC. Exposed to High-Level Ultraviolet B Irradiation with Dark Treatment. J. Proteome Res. 2016, 15: 2643-2657.
  14. Zheng W, Lu XH, Fu ZR, Zhang L, Li XM, Xu XX, Ren YN, Lu YZ, Fu HW, Tian JK*. Identification of candidate synovial membrane biomarkers after Achyranthes aspera treatment for rheumatoid arthritis. BBA-Protein and Proteom. 2016, 1864: 308-316.
  15. Li MZ, Yang BX, Chen QY, Zhu W, Ma J, Tian JK*. The complete chloroplast genome sequence of Clematis terniflora DC. (Ranunculaceae). Mitochondrial DNA Part A 2016, 27(4): 2470-2472.
  16. Chen QY, Feng X, Li MZ, Yang BX, Gao CX, Zhang L, Tian JK. The complete chloroplast genome sequence of Fatsia japonica (Apiales: Araliaceae) and the phylogenetic analysis. Mitochondrial DNA Part A 2016, 27(4): 3050-3051.
  17. Zhu W, Xu XB, Tian JK, Zhang L, Komatsu S. Proteomic Analysis of Lonicera japonica Thunb. Immature Flower Buds Using Combinatorial Peptide Ligand Libraries and Polyethylene Glycol Fractionation. J. Proteome Res. 2016, 15: 166-181.
  18. Xu XB, Gao BB, Guan QJ, Zhang DD, Ye XH, Zhou L, Tong GX, Li H, Zhang L, Tian JK*, Huang JY. Metabolomic profile for the early detection of coronary artery disease by using UPLC-QTOF/MS. J. Pharm. Biomed. Anal 2016, 129: 34-42.
  19. Shen LQ, Guan QJ, Amin A, Zhu W, Li MZ, Li XM, Zhang L, Tian JK*. Complete plastid genome of Eriobotrya japonica Thunb. Lindl and comparative analysis in Rosaceae. SpringerPlus 2016, 5: 2036
  20. Zheng W, Komatsu S, Zhu W, Zhang L, Li XM, Cui L, Tian JK*. Response and Defense Mechanisms of Taxus chinensis leaves under UV-A Radiation are Revealed Using Comparative Proteomics and Metabolomics Analyses. Plant & Cell Physiol. 2016, 57(9): 1839-1853.
  21. Chen ZZ, Zhou X, Hu BY, Li WY, Chen GY, Zhang Y, Tian JK, Zhang L, Li M, Jiang HL. Tissue distribution of capilliposide B, capilliposide C and their bioactive metabolite in mice using liquid-tandem mass spectrometry. Biomed. Chromatogr. 2016, e3895.
  22. Gao CX, Yang BX, Zhang DD, Chen M, Tian JK*. Enhanced metabolic process to indole alkaloids in Clematis terniflora DC. after exposure to high level UV-B irradiation follow by the dark. BMC Plant Biol. 2016, 16: 231
  23. Zheng W, Li XM, Zhang L, Zhang YZ, Lu XP, Tian JK*. Improved metabolites of pharmaceutical ingredient grade Ginkgo biloba and the correlated proteomics analysis. Proteomics 2015, 15(11): 1868-1883.
  24. Xu JK, Lu XH, Zhu W, Yang BX, Zhang L, Tian JK*. Two new eudesmane-type glucopyranosides from the fruits of Daucus carota L. Nat. Prod. Res. 2015, 29(20): 1903-1908.
  25. Xu CJ, Yang BX, Zhu W, Li XM, Tian JK, Zhang L. Characterization of polyphenol constituents in leaves of Linderae aggregate and their antioxidant activities. Food Chem. 2015, 186: 83-89.
  26. Yang Y, Zhang LH, Yang BX, Tian JK, Zhang L* .Aurantiamide acetate suppresses the growth of malignant gliomas in vitro and in vivo through activating autophagy. J. Cell. Mol. Med. 2015, 19(5): 1055-1064.
  27. Fu ZZ, Han HT, Liu N, Xu XB, Zhu W, Gong MH, Zhang L, Tian JK*. Two new eudesmane sesquiterpenoids from Daucus carota L. Phytochem. Lett., 2015, 14: 35-38.
  28. Liu XB, Yang BX, Zhang L, Lu YZ, Gong MH, Tian JK*. In vivo and in vitro the anti-inflammatory and antinociceptive activities of the ethanol extract fraction and aurantiamide acetate from Clematis terniflora DC. J. Ethnopharmacol. 2015,134(3): 1018-1023.
  29. Zhu W, Hu J, Wang X, Tian JK*, Komatsu S. Organ-specific analysis of Mahonia using Gel-free/Label-free proteomic technique. J. Proteome Res. 2015, 14(6): 2669-2685.
  30. Zhu W, Yang BX, Komatsu S, Lu XP, Li XM, Tian JK*. Gel-Free Quantitative Proteomic Analysis of Catharanthus roseus Seedlings with Induction of Indole Alkaloids. Front. Plant Sci. 2015, 6: 582。

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