王平，教授，博士生導師，辦公地點位於生科院生命醫學研究所。通訊地址位於上海市閔行區東川路500號生命科學學院。研究方向為細胞信號傳導、炎性細胞遷移的分子機制、腫瘤及幹細胞中關鍵蛋白的調控機制。畢業於復旦大學生命科學學院生物系。
基本介紹
- 中文名：王平
- 國籍：中國
- 職業：教授，博士生導師
- 畢業院校：復旦大學生命科學學院
- 性別：男
- 學位：教授，博士生導師
人物經歷,主要貢獻,科研方向,科研項目,科研論文,獲獎記錄,
人物經歷
1997年畢業於復旦大學生命科學學院生物系， 獲理學學士學位；
2002年7月畢業於中科院上海細胞與生化研究所，獲分子細胞生物學博士學位；
2003年到2008年先後在美國明尼蘇達大學、康地涅克大學及耶魯大學藥學系做博士後研究。
2008年7月受聘於華東師範大學， 任教授及博士生導師。
2002年7月畢業於中科院上海細胞與生化研究所，獲分子細胞生物學博士學位；
2003年到2008年先後在美國明尼蘇達大學、康地涅克大學及耶魯大學藥學系做博士後研究。
2008年7月受聘於華東師範大學， 任教授及博士生導師。
主要貢獻
科研方向
細胞信號傳導
(1) 炎症信號傳導：炎性細胞如中性粒細胞發生定向遷移的分子機制；血管內皮細胞在炎症發生中的作用及調控機制；炎症過程中白細胞與血管內皮細胞黏附的分子機制；炎症相關重大疾病。
(2) 腫瘤信號傳導：腫瘤發生髮展及轉移中的重要調控蛋白（如AKT/Myc/PTEN/KLFs等）的翻譯後修飾如泛素化及類泛素化、磷酸化及乙醯化以及與腫瘤發生的關係。
(3)幹細胞信號傳導：幹細胞乾性維持及分化過程中關鍵蛋白的翻譯後修飾如泛素化、磷酸化及乙醯化調控。
(1) 炎症信號傳導：炎性細胞如中性粒細胞發生定向遷移的分子機制；血管內皮細胞在炎症發生中的作用及調控機制；炎症過程中白細胞與血管內皮細胞黏附的分子機制；炎症相關重大疾病。
(2) 腫瘤信號傳導：腫瘤發生髮展及轉移中的重要調控蛋白（如AKT/Myc/PTEN/KLFs等）的翻譯後修飾如泛素化及類泛素化、磷酸化及乙醯化以及與腫瘤發生的關係。
(3)幹細胞信號傳導：幹細胞乾性維持及分化過程中關鍵蛋白的翻譯後修飾如泛素化、磷酸化及乙醯化調控。
科研項目
項目類別 | 批准號 | 項目名稱 | 資助時間與金額 | 本人任務 |
973計畫 | 2012CB910404 | GPCR配體的高通量篩選及信號轉導機理研究 | 2012.1-2016.12（340萬） | 課題組長 |
973計畫 | 2010CB529700 | 炎症過程中細胞間相互作用的信號轉導機制及其套用研究 | 2012.1-2014.12（160萬） | 課題骨幹 |
國家自然科學基金優秀青年基金 | 31222037 | 細胞遷移與信號傳導 | 2013.1-2015.12（100萬） | 主持 |
國家自然科學基金面上項目 | 31171338 | PIP5K1C參與中性粒細胞極性及運動的信號傳導機制研究 | 2012.1-2015.12（30萬） | 主持 |
國家自然科學基金面上項目 | 30971521 | SCP1去磷酸化PIPKIγ90調控細胞遷移的機制與功能研究 | 2012.1-2012.12（30萬） | 主持 |
國家自然科學基金青年項目 | 30800587 | b-Arrestins/PIPKIs結合調控GPCR相關信號通路的機制和功能研究 | 2009.1-2011.12（25萬） | 主持 |
教育部“新世紀優秀人才計畫” | NCET-10-0387 | 腫瘤抑制因子SCF-FBW7新功能的研究 | 2011.1-2014.12（50萬） | 主持 |
上海市”科技啟明星計畫“ | 09QA1*4*01 900 | 細胞遷移重要蛋白PIPKIg90去磷酸化機制及功能研究 | 2009.7-2011.06（15萬） | 主 |
科研論文
1. Xiao N, Li H, Luo J, Wang R, Chen H, Chen J,Wang P.Ubiquitin-Specific Protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFa-induced cancer cell migration.Biochem. J.(2012) 441,979-986
2. Wang Q, Xu X, Li J, Liu J, Gu H, Zhang R, Chen J, Kuang Y, Fei J, Jiang C, Wang P, Pei D, Ding S, Xie X. Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells. Cell Res. 2011 Jul 5. doi: 10.1038/cr.2011.108.
3. Wenwen Xu *, Ping Wang *#, Bj?rn Petri, Yong Zhang, Wenwen Tang, Le Sun, Holger Kress, Tom Mann, Yan Shi, Paul Kubes & Dianqing Wu#. Important Roles of PIP5K1C in Neutrophil Recruitment Immunity2010 33(3): 340-50 (Co-corresponding author)
4. Li C, Yang Z, Li Z, Ma Y, Zhang L, Zheng C, Qiu W, Wu X, Wang X, Li H, Tang J, Qian M, Li D, Wang P, Luo J, Liu M. Maslinic acid suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating RANKL-mediated NF-kappaB and MAPK signaling pathways. J Bone Miner Res. 2010 Sep 2.
5. Liu N, Li H, Li S, Shen M, Xiao N, Chen Y, Wang Y, Wang W, Wang R, Wang Q, Sun J, Wang P. The Fbw7/hCDC4 tumor suppressor targets pro-proliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs. J Biol Chem. 2010 285(24):18858-67. (Corresponding author)
6. Wang Z, Kumamoto Y, Wang P, Gan X, Lehmann D, Smrcka AV, Cohn L, Iwasaki A, Li L, Wu D. Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5. J Biol Chem.2009 Oct 16; 284(42):28599-606.
7. Wang Z, Liu B, Wang P, Dong X, Fernandez-Hernando C, Li Z, Hla T, Li Z, Claffey K, Smith JD, Wu D. Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice. J Clin Invest. 2008 Jan 2;118(1):195-204
8. Ping Wang, Jing Nie and Duanqing Pei. The hemopexin domain of MT1-MMP is not required for its activation of proMMP2 on cell surface, but essential for MT1-MMP mediated invasion in 3-D type I collagen. J Biol Chem. 2004 Dec 3;279(49):51148-51155，
9. Ping Wang, Xing Wang and Duanqing Pei. Mint-3 regulates the retrieval of internalized MT5-MMP to plasma membrane by binding to its carboxyl end motif EWV. J Biol Chem. 2004 May 7;279 (19):20461-20470.
10. Ping Wang, Tortorella M, England K, Malfait AM, Thomas G, Arner L, Pei D. Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (aggrecanase-1) in the trans-Golgi network. J Biol Chem. 2004, April 9, 279(15):15434-15440.
11. Ping Wang*, Hua Gao*, Yanxiang Ni, Beibei Wang, Yalan Wu, Linhua Qin, Lan Ma, Gang Pei. b-arrestin 2 functions as a GPCR-activated regulator of oncoprotein Mdm2. J Biol Chem. 2003 Feb 21; 278(8):6363-6370.
12. Ping Wang, Ya-Lan Wu, Xin Ge, and Gang Pei. Subcellular localization of beta-arrestins is determined by their intact N domain and the nuclear export signal at the C terminus. J Biol Chem. 2003 Mar 28;278(13):11648-11653.
13. Ping Wang *, Ya-Lan Wu*, Tian-Hua Zhou, Yue Sun and Gang Pei (2000), Identification of alternative splicing variants of the b subunit of human Ca/calmodulin-dependent protein kinase II with different activities. FEBS Letters 475 (2000) 107-110.
14. Kun Ling*, Ping Wang*, Jian Zhao*, Ya-Lan Wu, Zhijie Cheng, Guo-Xiang Wu, Wei Hu, Lan Ma and Gang Pei. (1999) Five-transmembrane domains appear sufficient for a G protein-coupled receptor: Functional five-transmembrane domain chemokine receptors. Proc. Natl. Acad. Sci. USA. 1999 July. 96: 7922-7927.
15. Jian Qiu, Ping Wang, Qing Jing, Wenbo Zhang, Xiaoyu Li, Yongping Zhong, Gang Sun, Gang Pei and Yizhang Chen. (2001) Rapid Activation of ERK1/2 Mitogen-Activated Protein Kinase by Corticosterone in PC12 Cells. Biochemical and Biophysical Research Communications287, 1017–1024.
16. Liguang Lou, Tianhua Zhou, Ping Wang, and Gang Pei. (1999). Modulation of Ca /Calmodulin-Dependent Protein Kinase II Activity by Acute and Chronic Morphine Administration in Rat Hippocampus: Differential Regulation of alpha and beta Isoforms. Molecular Pharmacology, 1999, 55:557–563.
17. Qing Jing, Sun-Mei Xin, Wen-Bo Zhang, Ping Wang, Yong-Wen Qin, Gang Pei.( 2000). Lysophosphatidylcholine Activates p38 and p42/44 Mitogen-Activated Protein Kinases in Monocytic THP-1 Cells, but Only p38 Activation Is Involved in Its Stimulated Chemotaxis. Circ Res. 2000;87:52-59.)
18. Jian Zhao, Lan Ma, Ya-lan Wu, Ping Wang, Wei Hu and Gang Pei (1998). Chemokine Receptor CCR5 functionally couples to inhibitory G protein and undergoes desensitization. Journal of Cellular Biochemistry 1998, 71:36-45.* co-first author
4. Li C, Yang Z, Li Z, Ma Y, Zhang L, Zheng C, Qiu W, Wu X, Wang X, Li H, Tang J, Qian M, Li D, Wang P, Luo J, Liu M. Maslinic acid suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating RANKL-mediated NF-kappaB and MAPK signaling pathways. J Bone Miner Res. 2010 Sep 2.
5. Liu N, Li H, Li S, Shen M, Xiao N, Chen Y, Wang Y, Wang W, Wang R, Wang Q, Sun J, Wang P. The Fbw7/hCDC4 tumor suppressor targets pro-proliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs. J Biol Chem. 2010 285(24):18858-67. (Corresponding author)
6. Wang Z, Kumamoto Y, Wang P, Gan X, Lehmann D, Smrcka AV, Cohn L, Iwasaki A, Li L, Wu D. Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5. J Biol Chem.2009 Oct 16; 284(42):28599-606.
7. Wang Z, Liu B, Wang P, Dong X, Fernandez-Hernando C, Li Z, Hla T, Li Z, Claffey K, Smith JD, Wu D. Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice. J Clin Invest. 2008 Jan 2;118(1):195-204
8. Ping Wang, Jing Nie and Duanqing Pei. The hemopexin domain of MT1-MMP is not required for its activation of proMMP2 on cell surface, but essential for MT1-MMP mediated invasion in 3-D type I collagen. J Biol Chem. 2004 Dec 3;279(49):51148-51155，
9. Ping Wang, Xing Wang and Duanqing Pei. Mint-3 regulates the retrieval of internalized MT5-MMP to plasma membrane by binding to its carboxyl end motif EWV. J Biol Chem. 2004 May 7;279 (19):20461-20470.
10. Ping Wang, Tortorella M, England K, Malfait AM, Thomas G, Arner L, Pei D. Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (aggrecanase-1) in the trans-Golgi network. J Biol Chem. 2004, April 9, 279(15):15434-15440.
11. Ping Wang*, Hua Gao*, Yanxiang Ni, Beibei Wang, Yalan Wu, Linhua Qin, Lan Ma, Gang Pei. b-arrestin 2 functions as a GPCR-activated regulator of oncoprotein Mdm2. J Biol Chem. 2003 Feb 21; 278(8):6363-6370.
12. Ping Wang, Ya-Lan Wu, Xin Ge, and Gang Pei. Subcellular localization of beta-arrestins is determined by their intact N domain and the nuclear export signal at the C terminus. J Biol Chem. 2003 Mar 28;278(13):11648-11653.
13. Ping Wang *, Ya-Lan Wu*, Tian-Hua Zhou, Yue Sun and Gang Pei (2000), Identification of alternative splicing variants of the b subunit of human Ca/calmodulin-dependent protein kinase II with different activities. FEBS Letters 475 (2000) 107-110.
14. Kun Ling*, Ping Wang*, Jian Zhao*, Ya-Lan Wu, Zhijie Cheng, Guo-Xiang Wu, Wei Hu, Lan Ma and Gang Pei. (1999) Five-transmembrane domains appear sufficient for a G protein-coupled receptor: Functional five-transmembrane domain chemokine receptors. Proc. Natl. Acad. Sci. USA. 1999 July. 96: 7922-7927.
15. Jian Qiu, Ping Wang, Qing Jing, Wenbo Zhang, Xiaoyu Li, Yongping Zhong, Gang Sun, Gang Pei and Yizhang Chen. (2001) Rapid Activation of ERK1/2 Mitogen-Activated Protein Kinase by Corticosterone in PC12 Cells. Biochemical and Biophysical Research Communications287, 1017–1024.
16. Liguang Lou, Tianhua Zhou, Ping Wang, and Gang Pei. (1999). Modulation of Ca /Calmodulin-Dependent Protein Kinase II Activity by Acute and Chronic Morphine Administration in Rat Hippocampus: Differential Regulation of alpha and beta Isoforms. Molecular Pharmacology, 1999, 55:557–563.
17. Qing Jing, Sun-Mei Xin, Wen-Bo Zhang, Ping Wang, Yong-Wen Qin, Gang Pei.( 2000). Lysophosphatidylcholine Activates p38 and p42/44 Mitogen-Activated Protein Kinases in Monocytic THP-1 Cells, but Only p38 Activation Is Involved in Its Stimulated Chemotaxis. Circ Res. 2000;87:52-59.)
18. Jian Zhao, Lan Ma, Ya-lan Wu, Ping Wang, Wei Hu and Gang Pei (1998). Chemokine Receptor CCR5 functionally couples to inhibitory G protein and undergoes desensitization. Journal of Cellular Biochemistry 1998, 71:36-45.* co-first author
獲獎記錄
1. 2012年 基金委優秀青年基金計畫支出；
2. 2011年 上海市‘曙光學者’人才計畫；
3. 2010年 教育部新世紀人才計畫；
4. 2009年 上海市‘青年科技啟明星’人才計畫；
5. 2006年 AHA Postdoctoral fellowship；
6. 2000年 中科院地奧獎學金；
7. 1999年 中科院偉華獎學金。
2. 2011年 上海市‘曙光學者’人才計畫；
3. 2010年 教育部新世紀人才計畫；
4. 2009年 上海市‘青年科技啟明星’人才計畫；
5. 2006年 AHA Postdoctoral fellowship；
6. 2000年 中科院地奧獎學金；
7. 1999年 中科院偉華獎學金。
