基本介紹
- 中文名：王巍
- 國籍：中國
- 民族：漢族
- 職業：教師
- 畢業院校：武漢大學
- 學位/學歷：博士/大學
- 專業方向：基於多組分反應的多肽、擬肽合成藥物化學研究
- 職務：副教授
- 主要成就：針對蛋白蛋白相互作用運用多組分化學和基於結構藥物綜合設計的抗癌藥物發現
人物經歷,主講課程,研究方向,主要貢獻,
人物經歷
學習簡歷
2005 獲武漢大學理學博士學位
2000 獲武漢大學化學系學士學位
2000 獲武漢大學化學系學士學位
工作簡歷
2011-至今 武漢大學藥學院
2008-2011 美國匹茲堡大學(University of Pittsburgh) 博士後
2006-2008 美國南伊利諾斯大學 (Southern Illinois University Carbondale) 博士後
2005-2006 上海無錫藥明康德新藥開發有限公司高級研究員
2008-2011 美國匹茲堡大學(University of Pittsburgh) 博士後
2006-2008 美國南伊利諾斯大學 (Southern Illinois University Carbondale) 博士後
2005-2006 上海無錫藥明康德新藥開發有限公司高級研究員
主講課程
研究生課程：新藥研發與申報
本科生課程：計算機輔助藥物設計
研究方向
融合合成化學和計算機輔助藥物設計技術開展針對抗病毒藥物和腫瘤蛋白相互作用靶點的藥物設計和發現工作，開展對功能蛋白結構域到活性小分子的“翻譯”研究，主要針對蛋白蛋白相互作用進行相應功能小分子的藥物設計與合成
2. 新有機合成反應，新試劑與新技術(特別是不對稱合成反應技術)在藥物合成的套用。
3. 建設多組分反應的化合骨架資料庫，開發新型多組分反應化學骨架，建立快速構建化合物庫的合成能力。
4. 利用生命科學研究成果，特別是最新細胞內信號傳導，通路以及相關結構生物學研究進展，開展生物活性分子化合物的設計。
5. 合作開展套用基於錨點骨架和基於結構的藥物設計，尋找和發現新先導物，充分利用在蛋白蛋白相互作用調節劑中的經驗，直接考慮化合物與靶點蛋白或核酸三維結構匹配和電子分布匹配進行相應設計，脫離傳統盲目組合化學合成，利用多組分反應研究基礎進行構效關係，進行先導物的結構最佳化和化學合成。
6. 利用獨特多組分反應合成的化學骨架發散型的化合物庫，利用國內外各種細胞篩選平台合作進行高通量篩選研究
主要貢獻
主持
1） 主持武漢大學引進人才科研啟動經費，2012.1 – 2014.12;
2） 國家自然科學青年基金，2013.1-2015.12
參加多項校級，省部級課題。
學術論文
1. Enantioselective inhibition of reverse transcriptase (RT) of HIV-1 by non racemic indole-based trifluoropropanoates developed by asymmetric catalysis using recyclable organocatalysts, Xin Han, Wenjie Ouyang, Bin Liu, Wei Wang*, Bo Tian , Shuwen Wu *, Hai-Bing Zhou*, Organic Biomolecular Chemistry, 2013, , 2013, 11, 8463-8475
2. N-Butyl-2,4-dinitro-anilinium p-toluenesulfonate as a highly active and selective esterification catalyst, Narsimha Sattenapallya, Wei Wang, Huimin Liu, and Yong Gao*, Tetrahedron Letters, 2013, 54(48), 6665-6668
3. Esterification Catalysis by Pyridinium p-Toluenesulfonate Revisited Modification with a Lipid Chain for Improved Activities and Selectivities, Wei Wang, Huimin Liu, Shaoyi Xu, and Yong Gao, Synthetic Communications, 2013, 43(21), 2906-2912
4. P53-Mdm2 Active Benzimidazol-2-ones, Wei Wang, Haiping Cao, Siglinde Wolf, Miguel S. Camacho-Horvitz, Tad Holak, and Alexander Dömling, Bioorganic & Medicinal Chemistry, 2013, 21, 14, 3982-3995
5. Chemisty & Biology of Multicomponent Reactions, Alexander Dömling, Wei Wang#, Kan Wang# , (equally contribution) Chemical Reviews, 2012, 112 (6), pp 3083–3135
6. Enabling Large-Scale Design, Synthesis and Validation of Small Molecule Protein-Protein Antagonists, D. Koes, K. Khoury, Y. Huang, Wei Wang, M. Bista, G. M. Popowicz, S. Wolf , T. A. Holak, A. Dömling, C.J. Camacho, Plos One, 2012 , 7(3), e32839
7. Polycyclic Compounds by Ugi−Pictet−Spengler Sequence, Wei Wang, Sarah Ollio, Alexander Dömling, The Journal of Organic Chemistry, 2011, 76 (2), 637–644, (Selected by Synfact, 2011, 4, 376)
8. Two Strategies for the Development of Mitochondrial-Targeted Small Molecule Radiation Damage Mitigators, Jean-Claude M. Rwigema, Barbara Beck, Wei Wang, Alexandaer Doemling, Michael W. Epperly, Donna Shields, Darcy Franicola, Tracy Dixon, Marie-Celine Céline Frantz, Peter Wipf, Yulia Tyurina, Valerian Kagan, Hong Wang, and Joel S. Greenberger, International Journal of Radiation Oncology*Biology*Physics, 2011, 80(3), 860-868
9. Structures of Low Molecular Weight Inhibitors Bound to MDMX and MDM2 Reveal New Approaches for p53-MDMX/MDM2 Antagonist Drug Discovery, G. M. Popowicz, A. Czarna, S. Wolf, K. Wang, Wei Wang, A. Dömling, T. A. Holak, Cell Cycle, 2010, 9(6), 1104 – 1111.
10. Polycyclic indole alkaloid-type compounds by MCR, Wei Wang, Eberhardt Herdtweck , Alexander Dömling, Chemical Communications, 2010, 46, 770-772.
11. Bacillamide C and Derivatives: The Convergent Approach, Wei Wang, Shannon Joyner, Kareem Andrew Sameer Khoury, Alexander Dömling, Organic Biomolecular Chemistry, 2010, 8, 529-532.
12. Rapid and efficient hydrophilicity tuning of p53/MDM2 antagonists, Stuti Srivastava, Barbara Beck, Wei Wang, Ania Czarna, Tad Holak, Alexander Dömling, Journal of Combinatorial Chemistry, 2009, 11 (4), pp 631–639
13. Efficient Synthesis Of Arrays Of Amino Acid Derived Ugi Products With Subsequent Amidation, Wei Wang, Alexander Dömling, Journal of Combinatorial Chemistry, 2009, 11 (3), p 403-409
14. A Fast and Efficient Approach to Small Molecular Weight Protein-Protein Interaction Antagonists Using MCR Chemistry. BarbaraBeck, StutiSrivastava, WeiWang, KanWang, AnnaCzarna, TadA.Holak, LidioMeireles, CarlosCamacho, BaluRaghavan, BillyW.Day and AlexanderDömling, In MCR 2009; Mironov, M. A., Ed.; Advances in Experimental Medicine and Biology, 2011, Volume 699, 82.
15. Progress in biscalixarene research, Zheng, Qin; Gong, Shuling.; Zhang, Chunlei; Wang, Wei; Chen, Yuanyin, Progress in Chemistry (In Chinese) 2007, 19, (5), 722-734,.
16. The Effect of Hydrogen bonds in the Reaction of Phenols with Epoxy in the Presence of Nano CaCO3, Wei Wang, Shuling Gong*, Yuanyin Chen, Supramolecular Chemistry，2006, 18(4)311-315.
17. Fibriform One-dimentional Hydrogen-bonded Network Composed of 1,2-alt Calix[4]arene Tetra Acetic Acid, Wei Wang, Shuling Gong*, Yuanyin Chen, Jianpin Ma, New Journal of Chemistry, 2005, 29:1390-1392.
18. Preparation and Characterization of Biscalix[4]arene with Alkyne-containing Spacer, Wang Wei, Gong Shuling, Meng Lingzhi, Chen Yuanyin*, Chemical Journal of Chinese Universities, 2005, 26(8): 1467-1470. (In Chinese)
19. Solid-Phase Microextraction of Aromatic Amines with Amide Bridged Calix[4]arenes Coated Fiber, Wei Wang, Shuling Gong*, Qihua Cao, Yuanyin Chen, Xiujuan Li, and Zhaorui Zeng, Chromatography, 61(1-2):85-80 2005.
20. Diamide bridged calix[8]arenes, Li Jun, Wang Wei, Gong Shuling, Chen Yuanyin*, Wu Xiaojun, Synlett, 2004, (2): 332-334.
21. Characteristics and Applications of Amide Bridged Calix[4]arene Solid-Phase Microextration Fiber, Xiujuan Li, Shuling Gong, Wei Wang, Zhaorui Zeng*, Chinese Journal of Chromatography, (In Chinese), 2004, 22(5) 472-475
22. Nano CaCO3: An unique condensation agent for the preparation of monosubstituted calix[4]arene by ring-opening reaction, Gong SL*, Wang Wei, Fang Pengfei, Chen Yuanyin, Chinese Chemical Letters, 2003, 14 (1): 20-21 JAN.
23. Nano CaCO3: playing a special role in the monofunctionalization of calixarenes by epoxides, Gong SL*, Wang Wei, Chen Yuanyin, Meng Lingzhi, Wan Tao, New Journal of Chemistry, 2002, 26 (12): 1827-1830.
24. Novel fiber coated with amide bridged-calix[4]arene used for solid-phase microextraction of aliphatic amines, Xiujuan Li, Zhaorui Zeng*, Jingjing Zhou, Shuling Gong, Wei Wang, Yuanyin Chen, Journal of Chromatography A, 2004, 1041(1-2): 1-9.
國際國內學術會議及報告:
1. Nov, 2011, 全國藥物化學學術會議分會報告, 針對蛋白蛋白相互作用運用多組分化學和基於結構藥物綜合設計的抗癌藥物發現
2. Jun 2009, Invitation to The Combinatorial Chemistry Gordon Research (including Gordon-Kenan Research Seminar ) , Peptidomimetic, Natural Product Library and Anti-Cancer Drug Discovery Using MCR Products With Subsequent Amidation
交流報告：
May 2010, Postdoc Data & Dine Symposium, University of Pittsburgh
Nov 2009, Joint Organic Group Meetings in the University of Pittsburgh Combinatorial Chemistry Center
Mar 2008, Study of Novel Catalysts for Biodiesel Production, Oak Ridge National Laboratory
Jun 2004, Invitation of The Academic Forum for Chinese Doctoral Candidates, Beijing
