基本介紹
- 中文名：王冬立
- 畢業院校：清華大學
- 學位/學歷：博士
- 專業方向：植物病理學
- 任職院校：中國農業大學
人物經歷,工作經歷,教育經歷,研究方向,發表論文,
人物經歷
工作經歷
2019.07 - 今 中國農業大學 副教授
2014.07 - 2019.06 清華大學 博士後
2008.07 - 2011.08 清華大學 科研助理
教育經歷
2001.09 - 2005.07 南京農業大學 本科
2005.09 - 2008.07 中科院微生物研究所 碩士
2011.09 - 2014.07 清華大學 博士
研究方向
研究方向為結構生物學，主要利用X-射線晶體學衍射技術，研究植物免疫相關的生物大分子複合物的結構，進而分析其作用的分子機制，為套用提供參考。
發表論文
Wang D, Zhang S, Li L, Liu X, Mei K, Wang X. Structural insights into the assembly and activation of IL-1β with its receptors. Nat Immunol 2010, 11(10): 905-911.
Li L, Wang D, Jiang Y, Sun J, Zhang S, Chen Y, Wang X. Crystal structure of human ISG15 in complex with influenza B virus NS1B. J Biol Chem 2011, 286(35): 30258-30262.
Xue X, Lu Q, Wei H, Wang D, Chen D, He G, Huang L, Wang H, Wang X. Structural basis of chemokine sequestration by CrmD, a poxvirus-encoded tumor necrosis factor receptor. PLoS Pathog 2011 7(7): e1002162.
Wang D, Huang B, Zhang S, Yu X, Wu W, Wang X. Structural basis for R-spondin recognition by LGR4/5/6 receptors. Gene Dev 2013, 27(12): 1339-1344.
Wang N, Shi X, Jiang L, Zhang S, Wang D, Tong P, Guo D, Fu L, Cui Y, Liu X, Arledge KC, Chen Y, Zhang L, Wang X. Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4. Cell Res 2013, 23(8): 986-993.
Song W, Wang Y, Wang N, Wang D, Guo J, Fu L, Shi X. Identification of residues on human receptor DPP4 critical for MERS-CoV binding and entry. Virology 2014, 471: 49-53.
Wei H, Wang D, Qian Y, Liu X, Fan S, Yin H, Wang X. Structural basis for the specific recognition of IL-18 by its alpha receptor. FEBS Lett 2014, 588(21): 3838-3843.
Yu X, Zhang S, Jiang L, Cui Y, Li D, Wang D, Wang N, Fu L, Shi X, Li Z, Zhang L, Wang X. Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27. Sci Rep 2015, 5: 13133.
Chen, W, Huang, W, Chen, T, Salawu, E, Wang, D, Lee, Y, Chang, Y, Yang, L, Sue, S, Wang, X et al. (2016) Structure and function of chicken interleukin-1 beta mutants: uncoupling of receptor binding and in vivo biological activity. Sci Rep, 6, 27729.
Zhang, S, Zhou, P, Wang, P, Li, Y, Jiang, L, Jia, W, Wang, H, Fan, A, Wang, D, Shi, X et al. (2018) Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein. Cell Rep, 24, 441-452.
Cheng, X, Zhao, Y, Jiang, Q, Yang, J, Zhao, W, Taylor, IA, Peng, YL, Wang, D* and Liu, J*. (2019) Structural basis of dimerization and dual W-box DNA recognition by rice WRKY domain. Nucleic Acids Res, doi.org/10.1093/nar/gkz113
Zhao X, Wilmen A, Wang D, Wang X, et al. Targeted Inhibition of Activated Protein C by an Exosite Antibody to Treat Hemophilia. Nat Med, in revision.
Wang S, Zhao Y, Yi L, Shen M, Wang C, Zhang X, Yang J , Peng YL, Wang D*, Liu J*. Structural basis of trehalose-6-phosphate synthase catalytic process. Biochemical J, in revision.
