牛彥，女，博士，北京大學藥學院副教授，碩士生導師。
基本介紹
- 中文名：牛彥
- 職業：教師
- 畢業院校：北京大學
- 學位/學歷：博士
- 專業方向：藥物先導化合物的發現和最佳化、活性小分子構效關係研究
- 任職院校：北京大學藥學院
- 職稱：副教授
個人經歷,主講課程,研究方向,學術成果,代表性論文,中國專利,榮譽獎項,
個人經歷
2015.9 - 2016.9 德國康斯坦茨大學化學生物學與藥理學系,訪問學者
2013.8 - 今北京大學藥學院,藥物化學系,副教授肯少和,碩士生導煉墓市禁師;
2007.8 - 2013.7北京大學立樂估藥學院,藥物化學系,講師;
2002.9 - 2007.7北阿戲敬您京大學藥學院,化學生物學專業,博士;
1998.9 - 2002.7北京大學藥學院,藥學專業,本習龍套科。
主講課程
《背厚束藥物化學》、《藥物化學進展》、《計算機輔助藥物設計》。
研究方向
1.藥物先導化合物的去套發現和最佳化；
2.基於靶標結構的藥物分子設計與化學合成；
3.活性小分子構效關係研究
學術成果
代表性論文
Gang Yan, Lina Hao, Yan Niu*, Wenjie Huang, Wei Wang, Fengrong Xu, Lei Liang, Chao Wang, Hongwei Jin, Ping Xu*, 2-Substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamides as BACE1 inhibitors: Synthesis, biological evaluation and docking studies, European Journal of Medicinal Chemistry, 2017
Jing Sun, Yan Niu*, Chao Wang, Hao Zhang, Bingyu Xie, Fengrong Xu, Hongwei Jin, Yihong Peng, Lei Liang, Ping Xu*, Discovery of 3-benzyl-1,3-benzoxazine-2,4-dione analogues as allosteric mitogen-activated kinase kinase (MEK) inhibitors and anti-enterovirus 71 (EV71) agents, Bioorganic & Medicinal Chemistry, 2016
Qi Sun, Bo Xu, Yan Niu*, Fengrong Xu, Lei Liang, Chao Wang, Jiapei Yu, Gang Yan, Wei Wang, Hongwei Jin*, Ping Xu*. Synthesis, Bioactivity, Docking and Molecular Dynamics Studies of Furan-Based Peptides as 20S Proteasome Inhibitors. ChemMedChem, 2015
Peng Liu,Yan Niu,* Chao Wang, Qi Sun, Yaya Zhai, Jiapei Yu,Jing Sun, Fengrong Xu, Gang Yan, Wenjie Huang, Lei Liang, Ping Xu*, 4-Oxo-1,4-dihydroquinoline-3-carboxamides as BACE-1 inhibitors: synthesis, biological evaluation and docking studies,European Journal of Medicinal Chemistry.2014
Chao Wang, Hao Zhang, Fengrong Xu,Yan Niu*, Yun Wu, Xin Wang, Yihong Peng,Jing Sun, Lei Liang and Ping Xu* , Substituted 3-Benzylcoumarins as Allosteric MEK1 Inhibitors: Design, Synthesis and Biological Evaluation as Antiviral Agents,Molecules,2013
Yan Niu, Haifei Gao, Fengrong Xu, Lei Liang, Peng Liu, Chao Wang, Guanyu Yang, Qi Sun, Ping Xu*, Design, synthesis and in vitro biological evaluation of 3-styrylbenzimidamides as potential BACE1 inhibitors,Letters in Drug Design & Discovery, 2013
Yan Niu, Haifei Gao, Fengrong Xu, Chao Wang, Peng Liu, Guanyu Yang, Qi Sun,Ping Xu*, Synthesis, in vitro biological evaluation and molecular docking studies of benzimidamides as potential BACE1 inhibitors,Chem Biol Drug Des,2012
Yan Niu, Chao Ma, Hongwei Jin, Fengrong Xu, Haifei Gao, Peng Liu, Yongjian Li, Chao Wang, Guanyu Yangand Ping Xu*, The Discovery of Novel b-Secretase Inhibitors: Pharmacophore Modeling, Virtual Screening, and Docking Studies,Chem Biol Drug Des,2012
Dong Wang, Liguo Yang, Jingjing Su,Yan Niu, Xiaoping Lei, Juan Xiong, Xiaohua Cao, Yinghe Hu, Bing Mei, Jin-Feng Hu,Attenuation of neurodegenerative phenotypes in Alzheimer-like presenilin1/presenilin 2 conditional double knockout mice by EUK1001, a promising derivative of xanomeline,Biochemical and Biophysical Research Communications,2011
Yan Niu,Yuehua Wang,Xiaomin Zou,Xiaoming Yang,Chao Ma,Yang Lü,Bo Zhou,Yue Yuan,Guanhua Du andPing Xu*.Synthesis and preliminary evaluation of peptidomimetic inhibitors of human β-secretase.European Journal of Medicinal Chemistry.2010
Bo Zhou,Yan Niu, Xiao-Min Zou, Feng-Rong Xu, Yue Yuan, Chao Wang, Hai-Fei Gao, Peng Liu, Ping Xu*, Structure-based design of hexahydropyrimidin-5-ols as novel non-peptidic β-secretase inhibitors,Journal of Chinese Pharmaceutical Sciences, 2010
Wen Si, Xuliang Zhang,Yan Niu, Huiting Yu, Xiaoping Lei, Huanxin Chen, Xiaohua Cao, A novel derivative of xanomeline improves fear cognition in aged mice,Neuroscience Letters, 2010
Yihui Cui, Dong Wang, Wen Si, Wen Lu,Yan Niu, Xiaoping Lei, Yinhe Hu, Xiaohua Cao*, Enhancement of memory function in aged mice by a novel derivative of xanomeline,Cell Research, 2008
中國專利
(1) 徐萍，彭宜紅，王超，牛彥，張浩，許鳳榮，具有MEK抑制功能的化合物及其製備方法與套用，中國
(2) 徐萍，牛彥，高海飛，許鳳榮，具有β-分泌酶抑制功能的化合物及其製備方法與套用，中國
榮譽獎項
1.2008年,藥學院第八屆青年教師教學演示競賽,二等獎
2.2009年,北京大學醫學部,優秀教師獎
3.2010年,北京大學優秀班主任,二等獎
Chao Wang, Hao Zhang, Fengrong Xu,Yan Niu*, Yun Wu, Xin Wang, Yihong Peng,Jing Sun, Lei Liang and Ping Xu* , Substituted 3-Benzylcoumarins as Allosteric MEK1 Inhibitors: Design, Synthesis and Biological Evaluation as Antiviral Agents,Molecules,2013
Yan Niu, Haifei Gao, Fengrong Xu, Lei Liang, Peng Liu, Chao Wang, Guanyu Yang, Qi Sun, Ping Xu*, Design, synthesis and in vitro biological evaluation of 3-styrylbenzimidamides as potential BACE1 inhibitors,Letters in Drug Design & Discovery, 2013
Yan Niu, Haifei Gao, Fengrong Xu, Chao Wang, Peng Liu, Guanyu Yang, Qi Sun,Ping Xu*, Synthesis, in vitro biological evaluation and molecular docking studies of benzimidamides as potential BACE1 inhibitors,Chem Biol Drug Des,2012
Yan Niu, Chao Ma, Hongwei Jin, Fengrong Xu, Haifei Gao, Peng Liu, Yongjian Li, Chao Wang, Guanyu Yangand Ping Xu*, The Discovery of Novel b-Secretase Inhibitors: Pharmacophore Modeling, Virtual Screening, and Docking Studies,Chem Biol Drug Des,2012
Dong Wang, Liguo Yang, Jingjing Su,Yan Niu, Xiaoping Lei, Juan Xiong, Xiaohua Cao, Yinghe Hu, Bing Mei, Jin-Feng Hu,Attenuation of neurodegenerative phenotypes in Alzheimer-like presenilin1/presenilin 2 conditional double knockout mice by EUK1001, a promising derivative of xanomeline,Biochemical and Biophysical Research Communications,2011
Yan Niu,Yuehua Wang,Xiaomin Zou,Xiaoming Yang,Chao Ma,Yang Lü,Bo Zhou,Yue Yuan,Guanhua Du andPing Xu*.Synthesis and preliminary evaluation of peptidomimetic inhibitors of human β-secretase.European Journal of Medicinal Chemistry.2010
Bo Zhou,Yan Niu, Xiao-Min Zou, Feng-Rong Xu, Yue Yuan, Chao Wang, Hai-Fei Gao, Peng Liu, Ping Xu*, Structure-based design of hexahydropyrimidin-5-ols as novel non-peptidic β-secretase inhibitors,Journal of Chinese Pharmaceutical Sciences, 2010
Wen Si, Xuliang Zhang,Yan Niu, Huiting Yu, Xiaoping Lei, Huanxin Chen, Xiaohua Cao, A novel derivative of xanomeline improves fear cognition in aged mice,Neuroscience Letters, 2010
Yihui Cui, Dong Wang, Wen Si, Wen Lu,Yan Niu, Xiaoping Lei, Yinhe Hu, Xiaohua Cao*, Enhancement of memory function in aged mice by a novel derivative of xanomeline,Cell Research, 2008
中國專利
(1) 徐萍，彭宜紅，王超，牛彥，張浩，許鳳榮，具有MEK抑制功能的化合物及其製備方法與套用，中國
(2) 徐萍，牛彥，高海飛，許鳳榮，具有β-分泌酶抑制功能的化合物及其製備方法與套用，中國
榮譽獎項
1.2008年,藥學院第八屆青年教師教學演示競賽,二等獎
2.2009年,北京大學醫學部,優秀教師獎
3.2010年,北京大學優秀班主任,二等獎
