湯亞傑於2005年從美國麻省理工學院(MIT)學成回國，現任“發酵工程教育部重點實驗室（湖北工業大學）”主任，主要從事“發酵工程”領域的教學科研工作，聚集天然產物生物製造，致力於解決實驗室的生物技術成果產業化的瓶頸問題。應邀出任發酵工程領域學術期刊“Bioprocess and Biosystems Engineering (Springer)”Associate Editor (副主編)。先後入選全國傑出專業技術人才、“萬人計畫”科技創新領軍人才、“新世紀百千萬人才工程”國家級人選。
基本介紹
- 中文名：湯亞傑
- 國籍：中國
- 民族：漢族
- 出生地：湖北省武穴市
- 出生日期：1973年10月
- 職務：湖北工業大學學科建設辦公室主任
研究興趣,學術獎勵,學術榮譽,學術兼職,發明專利,代表性論文,
研究興趣
以國家戰略需求產品抗腫瘤藥物為導向，致力於生物化工領域天然產物生物製造的研究。以具有良好抗腫瘤活性的天然產物為目標，採用合成生物學的思路，高效製備具有成藥前景的藥物前體，並深入理解天然產物人工合成的調控機制，為天然產物生物製造提供新思路、新理論和新方法。
學術獎勵
1. 湖北省科技進步一等獎(2014)
2. 教育部自然科學一等獎(2014)
3. 湖北省自然科學二等獎(2011)
4. 上海市自然科學二等獎(2010)
5. 教育部自然科學一等獎(2004)
學術榮譽
1. 全國傑出專業技術人才(2014)
2. “萬人計畫”科技創新領軍人才(2014)
3. “新世紀百千萬人才工程”國家級人選(2009)
學術兼職
1. Associate Editor: Bioprocess and Biosystems Engineering (Springer) (2012-)
2. Advisory Board: Biotechnology Journal (Wiley)(2012-)
3.湖北省食品質量安全抽檢監測專家委員會·副主任委員 (2014-)
發明專利
1.Ya-Jie Tang. 4′-Demthylepipodophyllotoxin Derivative, Preparation Method and Use Thereof (US 8569309B2)
2. Ya-Jie Tang, Wei Zhao. 4′-Demthylepipodophyllotoxin Derivative, Preparation Method and Use Thereof II (US 8796279B2)
3. 湯亞傑 李冬生 孔國平. 一種塊菌多糖的製備方法 (ZL200610166504.6)
4. 湯亞傑 王冠 劉瑞桑 李冬生. α-雄烷醇的製備及含量檢測方法 (ZL200810000570.5)
5. 湯亞傑 李冬生 朱麗雯. 促進靈芝次生代謝產物合成的細胞培養方法 (ZL 200810001055.9)
6. 湯亞傑 張偉 李冬生. 一種促進靈芝酸和靈芝多糖生物合成的靈芝細胞培養方法(ZL200810002772.3)
7. 湯亞傑 徐小玲 李冬生. 4′-去甲基表鬼臼酸的製備和分離方法 (ZL200810002773.8)
8. 湯亞傑 李艷 李冬生. 將鬼臼毒素轉化為鬼臼酸和鬼臼苦素的方法 (ZL200810002774.2)
9. 湯亞傑 張偉. 促進靈芝酸和靈芝多糖生物合成的發酵方法(ZL 200810007833.5)
10. 湯亞傑 柳巧寧. 中間補料發酵生產塊菌活性菌絲體和塊菌多糖的方法 (ZL 200810172343.0)
11. 湯亞傑 李園園. 具抗腫瘤活性的羊毛甾烷型三萜化合物及製備方法和套用(ZL 200810184588.5)
12. 湯亞傑, 趙巍. 4′-去甲基表鬼臼毒素衍生物及其合成方法和套用. (ZL 201010156798.0)
13.湯亞傑,趙巍.4′-去甲基表鬼臼毒素衍生物及其合成方法和套用.(PCT/2010/CN/8569309)
14. 湯亞傑, 趙巍. 4-(2,3,5,6-四甲基吡嗪-1-基)-4′-去甲表鬼臼毒素的生物轉化及分離純化方法. (ZL 201010159753.9)
15. 湯亞傑 李園園. 腦苷脂的製備、純化及含量檢測方法 (ZL 201010268280.6)
16. 湯亞傑 白佳珂. 硫取代鬼臼類衍生物及其合成方法和套用 (ZL 201110106180.8)
17. 湯亞傑 白佳珂. 硫取代鬼臼類衍生物及其生物轉化和分離純化方法 (ZL 201110106192.0)
18. 湯亞傑 肖黎. 具有抗腫瘤活性的酯化鬼臼類衍生物及其製備方法和用途(ZL201210374710.1)
19. 湯亞傑 肖黎. 具抗腫瘤活性的氮取代鬼臼類衍生物及其製備方法和用途(ZL 201210374359.6)
20.湯亞傑 陳露 趙巍. 具抗腫瘤活性的醯胺取代鬼臼類衍生物及其製備方法和用途(ZL201310292277.1)
代表性論文
1. Ya-Xuan Zhang, Wei Zhao, Ya-Jie Tang*. Multilevel induction of apoptosis by microtubule-interfering inhibitors 4β-S-aromatic heterocyclic podophyllum derivatives causing multi-fold mitochondrial depolarzation and PKA signaling pathways in HeLa cells.Oncotarget (In press) 2016 (IF=6.359) ( with equal contribution to this work)
2. Jun-Han Yu, Li-Wen Zhu, Shi-Tao Xia, Hong-Mei Li, Ya-Ling Tang, Xin-Hua Liang, Tao Chen, Ya-Jie Tang*. Combinatorial optimization of CO2 transport and fixation to improve succinate production by promoter engineering. Biotechnology and Bioengineering (In press) 2016 ( with equal contribution to this work)
3. Kai-Zhi Jia, Quan Zhang, Lin-Yang Sun, Yang-Hua Xu, Hong-Mei Li, Ya-Jie Tang*. Clonostachys rosea demethiolase STR3 controls the conversion of methionine into methanethiol. Scientific Reports 2016, 6:21920 (IF=5.578)
4. Quan Zhang, Kai-Zhi Jia, Shi-Tao Xia, Yang-Hua Xu, Rui-Sang Liu, Hong-Mei Li, Ya-Jie Tang*. Regulating ehrlich and demethiolation pathways for alcohols production by the expression of ubiquitin-protein ligase gene HUWE1. Scientific Reports 2016, 6:20828 ( with equal contribution to this work)
5. Rui-Sang Liu, Guang-Huai Jin, Deng-Rong Xiao, Hong-Mei Li, Feng-Wu Bai*, Ya-Jie Tang*. Screening of the key volatile organic compounds of Tuber melanosporum fermentation by aroma sensory evaluation combination with principle component analysis. Scientific Reports 2015, 5:17954. ( with equal contribution to this work)
6. Li-Wen Zhu, Lei Zhang, Li-Na Wei, Hong-Mei Li, Zhan-Peng Yuan, Tao Chen, Ya-Ling Tang, Xin-Hua Liang, Ya-Jie Tang*. Collaborative regulation of CO2 transport and fixation during succinate production in Escherichia coli. Scientific Reports 2015, 5:17321 ( with equal contribution to this work)
7. Deng-Rong Xiao, Rui-Sang Liu, Long He, Hong-Mei Li, Ya-Ling Tang, Xin-Hua Liang, Tao Chen, Ya-Jie Tang*. Aroma improvement by repeated freeze-thawed treatment during Tuber melanosporum fermentation. Scientific Reports 2015, 5:17120 ( with equal contribution to this work)
8. Wei Zhao, Yong Yang, Ya-Xuan Zhang, Hong-Mei Li, and Ya-Jie Tang*. Fluoride-containing podophyllum derivatives exhibit antitumor activities through enhancing mitochondrial apoptosis pathway by increasing the expression of caspase-9 in HeLa cells. Scientific Reports 2015, 5:17175 ( with equal contribution to this work)
9. Jian-Long Li, Wei Zhao, Chen Zhou, Ya-Xuan Zhang, Hong-Mei Li, Ya-Ling Tang, Xin-Hua Liang, Tao Chen, Ya-Jie Tang*. Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: 4β-S-aromatic heterocyclic podophyllum derivatives display antitumor activity. Scientific Reports 2015, 5:14814 ( with equal contribution to this work)
10. Wei Zhao, Jia-Ke Bai, Hong-Mei Li, Tao Chen, Ya-Jie Tang*. Tubulin structure-based drug design for the development of novel 4β-sulfur-substituted podophyllum tubulin inhibitors with anti-tumor activity. Scientific Reports 2015, 5:10172.
11. Ya-Jie Tang*, Rui-Sang Liu, Hong-Mei Li. Current progress on Tuber submerged fermentation: a promising alternative for its fruiting bodies. Applied Microbiology and Biotechnology 2015, 99: 2041-2053. ( with equal contribution to this work)
12. Li Xiao, Wei Zhao, Hong-Mei Li, Duan-Ji Wan, Dong-Sheng Li, Tao Chen, Ya-Jie Tang*. Design and synthesis of the novel DNA topoisomerase II inhibitors: esterification and amination substituted 4′-demethylepipodophyllotoxin derivates with anti-tumor activity by activating ATM/ATR signaling pathways.European Journal of Medicinal Chemistry 2014, 80: 267-277. ( with equal contribution to this work)
13. Wei Zhao, Xiao-Hua Wang, Hong-Mei Li, Shi-Hua Wang, Tao Chen, Zhan-Peng Yuan, Ya-Jie Tang*. Isolation and characterization of polysaccharides with the anti-tumor activity fromTuber fruiting bodies and fermentation system. Applied Microbiology and Biotechnology 2014, 98:1991-2002. ( with equal contribution to this work)
14. Wei Zhao, Lu Chen, Hong-Mei Li, Duan-Ji Wan, Dong-Sheng Li, Tao Chen, Zhan-Peng Yuan*, Ya-Jie Tang*. A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4′-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation. Bioorganic & Medicinal Chemistry 2014, 22:2998-3007. ( with equal contribution to this work)
15. Huai Wang, Li-Jun Tang, Ya-Jie Tang*, Zhan-Peng Yuan*. SAR analysis and biological studies of synthesized podophyllum derivates obtained by N linkage modification at C-4 position. Bioorganic & Medicinal Chemistry 2014, 22: 6183-6192.
16. Wei Zhao, Dan-Dan Chai, Hong-Mei Li, Tao Chen, Ya-Jie Tang*. Significance of metal ion supplementation in the fermentation medium on the structure and anti-tumor activity of Tuber polysaccharides produced by Tuber submerged fermentation. Process Biochemistry 2014, 49: 2030-2038. ( with equal contribution to this work)
17. Dao-Cheng Li, Rui-sang Liu, Hong-Mei Li, Zhan-Peng Yuan, Tao Chen, Ya-Jie Tang*. Ranking the significance of fermentation condition on the volatile organic compounds of Tuber melanosporum fermentation system by combination of head-space solid phase microextraction and chromatographic fingerprint similarity analysis. Bioprocess and Biosystems Engineering 2014, 37(3):543-552.
18. Li-Wen Zhu, Xiao-Hong Li, Lei Zhang, Hong-Mei Li, Jian-Hua Liu, Zhan-Peng Yuan, Tao Chen, Ya-Jie Tang*. Activation of glyoxylate pathway without the activation of its related gene in succinate-producing engineered Escherichia coli. Metabolic Engineering 2013, 20:9-19. ( with equal contribution to this work)
19. Rui-Sang Liu, Huan Zhou, Hong-Mei Li, Zhan-Peng Yuan, Tao Chen, Ya-Jie Tang*. Metabolism of L-methionine linked to the biosynthesis of volatile organic sulfur-containing compounds during the submerged fermentation of Tuber melanosporum.Applied Microbiology and Biotechnology 2013, 97:9981-9992. ( with equal contribution to this work)
20. Yuan-Yuan Li, Ping Liu, Yang Tang, Hong-Mei Li, Ya-Ling Tang, Xin-Hua Liang, Ya-Jie Tang*. Novel cerebrosides isolated from the fermentation mycelia of Tuber indicum.Helvetica Chimica Acta2013, 96:702-709.
21. Jia-Ke Bai, Wei Zhao, Hong-Mei Li, Ya-Jie Tang*. Novel biotransformation process of podophyllotoxin to 4β-sulfur-substituted podophyllum derivates with anti-tumor activity by Penicillium purpurogenum Y.J. Tang. Current Medicinal Chemistry 2012, 19:927-936.
22. Rui-Sang Liu, Dao-Cheng Li, Hong-Mei Li, Ya-Jie Tang*. Evaluation of aroma active compounds in Tuber fruiting bodies by gas chromatography-olfactometry in combination with aroma reconstitution and omission test. Applied Microbiology and Biotechnology 2012, 94:353-363.
23. Wei Zhao, Hong-Mei Li, Duan-Ji Wan, Ya-Jie Tang*. Manipulation of heterogeneity product in 4′-demethylepipodophyllotoxin biotransformation process by using yeast extract as nitrogen source. Applied Microbiology and Biotechnology 2012, 93:107-115.
24. Yuan-Yuan Li, Guan Wang, Hong-Mei Li, Jian-Jiang Zhong, Ya-Jie Tang*. Volatile organic compounds from Tuber melanosporum fermentation system. Food Chemistry 2012, 135:2628-2637.
25. Ping Liu, Hong-Mei Li, Ya-Jie Tang*. Comparison of free amino acids and 5’-nucleotides between Tuber fermentation mycelia and natural fruiting bodies.Food Chemistry 2012,132:1413-1419.
26. Yang Tang, Hong-Mei Li, Ya-Jie Tang*. Comparison of sterol composition between Tuber fermentation mycelia and natural fruiting bodies.Food Chemistry 2012,132:1207-1213.
27. Li-Wen Zhu, Cheng-Cheng Wang, Rui-Sang Liu, Hong-Mei Li, Duan-Ji Wan, Ya-Jie Tang*. Actinobacillus succinogenes ATCC 55618 fermentation medium optimization for the production of succinic acid by response surface methodology. BioMed Research International Volume2012, Article ID626137, 9 pages doi:10.1155/2012/626137.
28. Wei Zhao, Hong-Mei Li, Ya-Ling Tang, Xin-Hua Liang, Duan-Ji Wan, Ya-Jie Tang*. Optimization of a biotransformation process to produce 4-(2, 3, 5, 6-tetramethylpyrazine-1)-4′-demethylepipodophyllotoxin. Process Biochemistry 2012, 47:1522-1531.
29. Ya-Jie Tang*, Guan Wang, Yuan-Yuan Li, Hong-Mei Li, Yang Tang, Ping Liu. Quantitative determination for the major volatile organic compounds of Tuber melanosporum fermentation system by distillation-solid phase extraction-gas chromatography.Food Analytical Methods 2012,5:651-658.
30. Xiu-Ji Liu, Rui-Sang Liu, Hong-Mei Li, Ya-Jie Tang*. Lycopene production from synthetic medium by Blakeslea trispora NRRL 2895 (+) and 2896 (-) in a stirred-tank fermenter. Bioprocess and Biosystems Engineering 2012, 35:729-749.
31. Jin-Feng Wang, Xiu-Ji Liu, Rui-Sang Liu, Hong-Mei Li, Ya-Jie Tang*. Optimization of the mated fermentation process for the production of lycopene by Blakeslea trispora NRRL 2895 (+) and NRRL 2896 (-). Bioprocess and Biosystems Engineering 2012, 35:553-564.
32. Cheng-Cheng Wang, Li-Wen Zhu, Hong-Mei Li, Ya-Jie Tang*. Performance analyses of a neutralizing agent combination strategy for the production of succinic acid by Actinobacillus succinogenes ATCC 55618. Bioprocess and Biosystems Engineering 2012, 35:659-664.
33. Ping Liu, Yuan-Yuan Li, Hong-Mei Li, Duan-Ji Wan, Ya-Jie Tang*. Determination of the nucleosides and nucleobases in Tuber samples by dispersive solid-phase extraction combined with liquid chromatography–mass spectrometry. Analytica Chimica Acta 2011, 687:159-167.
34. Ya-Jie Tang*, Wei Zhao, Hong-Mei Li. Novel tandem biotransformation process for the biosynthesis of a novel compound 4-(2, 3, 5, 6-tetramethylpyrazine-1)-4′-demethylepipodophyllotoxin. Applied and Environmental Microbiology 2011, 77:3023-3034.
35. Wei Zou, Li-Wen Zhu, Hong-Mei Li, Ya-Jie Tang*. Significance of CO2 donor on the production of succinic acid by Actinobacillus succinogenes ATCC 55618. Microbial Cell Factories 2011, 10:87.
36. Yang Tang, Yuan-Yuan Li, Hong-Mei Li, Duan-Ji Wan, Ya-Jie Tang*. Comparison of lipid content and fatty acid composition between Tuber fermentation mycelia and natural fruiting-bodies. Journal of Agricultural and Food Chemistry 2011, 59:4736-4742.
37. Ya-Jie Tang*, Wei Zhang, Rui-Sang Liu, Li-Wen Zhu, Jian-Jiang Zhong. Scale-up study on the fed-batch fermentation of the medicinal mushroom Ganoderma lucidum for the hyperproduction of ganoderic acid and Ganoderma polysaccharides in stirred-tank bioreactor.Process Biochemistry 2011, 46: 404-408.
38. Rui-Sang Liu, Ya-Jie Tang*. Tuber melanosporum fermentation medium optimization by Plackett-Burman design coupled with Draper-Lin small composite design and desirability function. Bioresource Technology 2010, 101:3139-3146.
39. Rui-Sang Liu, Ya-Jie Tang*. Quantitative analysis for the effect of plant oil and fatty acid on Tuber melanosporum culture by uniform design combined with partial least squares regression.Applied Microbiology and Biotechnology 2010, 87: 1689-1697.
40. Li-Wen Zhu, Jian-Jiang Zhong, Ya-Jie Tang*. Multi-fed batch culture integrated with three-stage light irradiation and multiple additions of copper ions for the hyperproduction of ganoderic acid and Ganoderma polysaccharides by the medicinal mushroom Ganoderma lucidum.Process Biochemistry 2010, 45:1904-1911.
41. Ya-Jie Tang*, Li-Wen Zhu. Improvement of ganoderic acid and Ganoderma polysaccharide biosynthesis by Ganoderma lucidum fermentation under the inducement of Cu. Biotechnology Progress 2010, 26:417-423.
42. Li-Wen Zhu, Ya-Jie Tang*. Significance of protein elicitor isolated from Tuber melanosporum on the production of ganoderic acid and Ganoderma polysaccharides by Ganoderma lucidum.Bioprocess and Biosystems Engineering 2010, 33: 999-1005.
43. Ya-Jie Tang*, Xiao-Ling Xu, Jian-Jiang Zhong. A novel biotransformation of 4´-demethylepipodophyllotoxin to 4´-demethylepipodophyllic acid by Bacillus fusiformis CICC 20463, Part II: Process Optimization. Bioprocess and Biosystems Engineering 2010, 33:237-246.
44. Qiao-Ning Liu, Rui-Sang Liu, Yi-Hua Wang, Zhi-Yuan Mi, Dong-Sheng Li, Jian-Jiang Zhong, Ya-Jie Tang*. Fed-batch fermentation of Tuber melanosporum for the hyperproduction of mycelia and bioactive Tuber polysaccharides. Bioresource Technology 2009, 100:3644-3649.
45. Yan Li, Yuan-Yuan Li, Zhi-Yuan Mi, Dong-Sheng Li, Ya-Jie Tang*. Novel biotransformation process of podophyllotoxin to produce podophyllic acid and picropodophyllotoxin by Pseudomonas aeruginosa CCTCC AB93066, Part II: Process Optimization. Bioresource Technology 2009, 100:2271-2277.
46. Ya-Jie Tang*, Wei Zhang, Jian-Jiang Zhong. Performance analyses of a pH-shift and DO-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum. Bioresource Technology 2009, 100:1852-1859.
47. Ya-Jie Tang*, Guan Wang, Yuan-Yuan Li, Jian-Jiang Zhong. Fermentation condition outweighed truffle species in affecting volatile organic compounds analyzed by chromatographic fingerprint system. Analytica Chimica Acta 2009, 647: 40-45.
48. Ya-Jie Tang*, Xiao-Ling Xu, Jian-Jiang Zhong. A novel biotransformation of 4´-demethylepipodophyllotoxin to 4´-demethylepipodophyllic acid by Bacillus fusiformis CICC 20463. Process Biochemistry 2009, 44:572-577.
49. Ya-Jie Tang*, Yan Li, Jian-Jiang Zhong. Novel biotransformation process of podophyllotoxin to produce podophyllic acid and picropodophyllotoxin by Pseudomonas aeruginosa CCTCC AB93066, Part I: Process Development. Bioprocess and Biosystems Engineering 2009, 32:663-671.
50. Ya-Jie Tang*, Hong-Mei Li, Jean-François P. Hamel. Significance of pH and temperature on the production of heat-shock protein glycoprotein 96 by MethA tumor cell suspension culture in stirred-tank bioreactors. Bioprocess and Biosystems Engineering2009, 32:267-276.
51. Ya-Jie Tang*, Hong-Mei Li, Jean-François P. Hamel. Effect of dissolved oxygen tension and agitation rate on the production of heat-shock protein glycoprotein 96 by MethA tumor cell suspension culture in stirred-tank bioreactors. Bioprocess and Biosystems Engineering2009, 32:475-484.
52. Yuan-Yuan Li, Zhi-Yuan Mi, Yang Tang, Guan Wang, Dong-Sheng Li, Ya-Jie Tang*. Lanostanoids isolated from Ganoderma lucidum mycelium cultured by submerged fermentation. Helvetica Chimica Acta2009, 92:1586-1593.
53. Ya-Jie Tang*, Ling-Li Zhu, Rui-Sang Liu, Hong-Mei Li, Dong-Sheng Li, Zhi-Yuan Mi. Quantitative response of cell growth and Tuber polysaccharides biosynthesis by medicinal mushroom Chinese truffle Tuber sinense to metal ion in culture medium. Bioresource Technology 2008, 99:7606-7615.
54. Guan Wang, Yuan-Yuan Li, Dong-Sheng Li, Ya-Jie Tang*. Determination of 5α-androst-16-en-3α-ol in truffle fermentation broth by solid-phase extraction coupled with gas chromatography-flame ionization detector/electron impact mass spectrometry. Journal of Chromatography B 2008, 870:209-215. ( with equal contribution to this work)
55. Li-Wen Zhu, Jian-Jiang Zhong, Ya-Jie Tang*. Significance of fungal elicitors on the production of Ganoderma polysaccharides and ganoderic acid by submerged fermentation of medicinal mushroom Ganoderma lucidum. Process Biochemistry 2008, 43:1359-1370.
56. Rui-Sang Liu, Dong-Sheng Li, Hong-Mei Li, Ya-Jie Tang*. Response surface modeling the significance of nitrogen source on the cell growth and Tuber polysaccharides production by submerged cultivation of Chinese truffle Tuber sinense. Process Biochemistry 2008, 43:868-876.
57. Ya-Jie Tang*, Ling-Li Zhu, Dong-Sheng Li, Zhi-Yuan Mi, Hong-Mei Li. Significance of inoculation density and carbon source on the mycelial growth and Tuber polysaccharides production by submerged fermentation of Chinese truffleTuber sinense. Process Biochemistry2008, 43:576-586.
58. Wei Zhang, Ya-Jie Tang*. A novel three-stage light irradiation strategy in the submerged fermentation of medicinal mushroom Ganoderma lucidum for the efficient production of ganoderic acid and Ganoderma polysaccharides. Biotechnology Progress 2008, 24:1249-1261.
59. Ya-Jie Tang*, Li-Wen Zhu, Hong-Mei Li, Dong-Sheng Li. Submerged culture of mushroom in bioreactors - challenges, current state-of-the-art, and future prospects. Food Technology and Biotechnology 2007, 45(3):221-229. (Invited Review)
60. Ya-Jie Tang*, Hong-Mei Li, Jean-Francois P. Hamel. Suspension culture process of MethA tumor cell for the production of heat-shock protein glycoprotein 96: process optimization in spinner flasks. Biotechnology Progress2007, 23 (6):1363-1377.
61. Ya-Jie Tang*, Ryo Ohashi, Jean-Francois P. Hamel. Perfusion culture of hybridoma cell for hyperproduction of IgG2a monoclonal antibody in a wave bioreactor-perfusion culture system. Biotechnology Progress 2007, 23:255-264.
62. Ya-Jie Tang, Jian-Jiang Zhong*. Modeling the kinetics of cell growth and ganoderic acid production in liquid static cultures of medicinal mushroom Ganoderma lucidum. Biochemical Engineering Journal 2004, 21:259-264.
63. Ya-Jie Tang, Jian-Jiang Zhong*. Role of oxygen supply in submerged fermentation of Ganoderma lucidum for production of Ganoderma polysaccharide and ganoderic acid. Enzyme and Microbial Technology 2003, 34: 478-484.
64. Ya-Jie Tang, Jian-Jiang Zhong*. Scale-up of a liquid static culture process for hyperproduction of ganoderic acid by the medicinal mushroom Ganoderma lucidum. Biotechnology Progress 2003, 19:1842-1846.
65. Ya-Jie Tang, Jian-Jiang Zhong*. Exopolysaccharide biosynthesis and related enzyme activities of the medicinal fungus, Ganoderma lucidum, grown on lactose in a bioreactor. Biotechnology Letters 2002, 24: 1023-1026.
66. Ya-Jie Tang, Jian-Jiang Zhong*. Fed-batch fermentation of Ganoderma lucidum for hyperproduction of polysaccharide and ganoderic acid. Enzyme and Microbial Technology2002, 31: 20-28.
