基本介紹
人物經歷,研究方向,獲獎記錄,代表論文,
人物經歷
2011年於遼寧大學藥學院獲得學士學位。
2011-2016，隨後在北京生命科學研究所和天津大學從事博士學習，師從雷曉光教。
2016-2019，先後在北京大學化學生物學系和藥學院擔任科研助理，合作導師為雷曉光教授和黎後華教授。
2019年作為洪堡學者赴德國馬普化學生態研究所Sarah E. O'Connor 教授實驗室從事博士後研究。
2023年加入西湖大學理學院。
研究方向
洪本科博士的主要研究工作是藥用植物來源的活性天然產物的仿生化學合成和生源合成途徑的解析。通過借鑑生源假說並利用最新的合成方法學，包括有機小分子催化和碳氫活化反應，開發高效的仿生合成策略來完成藥用植物來源的活性天然產物的化學合成，包括具有神經活性的石松生物鹼和 (-)-incarviatone A, 香茶菜屬二萜和雜萜(+)-hyperforin。這些合成為後續的靶點和作用機制研究打下基礎。運用化學邏輯分析，多組學和體外瞬時表達等方法順利解析了藥用植物馬錢子中生物鹼strychnine的生源合成途徑的所有基因。同時發現兩個醯基轉移酶中一個胺基酸殘基的改變是Strychnos nux-vomica和strychnos sp. 這兩種植物分別產生strychnine和diaboline的直接原因。這為後續的strychine以及其衍生物的合成生物學研究提供了重要的基礎。
獲獎記錄
Participation in the 71 Lindau Nobel Laureate Meeting in Chemistry, 2022
Alexander von Humboldt Foundation Fellowship, 2019-2021
國家獎學金，2015
NIBS優秀研究生，2014
代表論文
1. Benke Hong, Dagny Grzech, Lorenzo Caputi, Prashant Sonawane, Carlos E. Rodríguez López, Mohamed Omar Kamileen, Néstor J. Hernández Lozada, Veit Grabe, Sarah E. O’Connor*, Biosynthesis of strychnine, Nature 2022, 607, 617-622.
• Highlighted by Bethany Halford in Chem. & Eng. News.
• Highlighted by Thoma West in Nat. Synth. 2022, 1, 581.
• Highlighted by Jonathan R. Chekan in Angew. Chem. Int. Ed. 2022, 61, e202212301.
2. Yunpeng Ji†, Benke Hong†, Ivan Franzoni, Mengyang Wang, Weiqiang Guan, Hongli Jia, Houhua Li*, Enantioselective Total Synthesis of Hyperforin and Pyrohyperforin, Angew. Chem. Int. Ed. 2022, 61, e202116136.
• Highlighted by Erick M. Carreira and Marlene Fadel in Synfacts 2022, 18, 0463.
3. Weilong Liu†, Benke Hong†, Jin Wang†, and Xiaoguang Lei*, New Strategies in the Efficient Total Syntheses of Polycyclic Natural Products, Acc. Chem. Res. 2020, 53, 2569–2586.
4. Benke Hong, Tuoping Luo, Xiaoguang Lei*, Late-Stage Diversification of Natural Products, ACS Cent. Sci. 2020, 6, 622-635.
5. Jin Wang†, Benke Hong†, Dachao Hu, Yuichiro Kadonaga, Ruyao Tang, Xiaoguang Lei*, Protecting-Group-Free Syntheses of ent-Kaurane Diterpenoids: [3+2+1] Cycloaddition/Cyclo-alkenylation Approach, J. Am. Chem. Soc. 2020, 142, 2238-2243.
• Highlighted by Erick M. Carreira and Moritz J. Classen in Synfacts 2020, 16, 0375.
6. Benke Hong†, Weilong Liu†, Jin Wang†, Jinbao Wu, Yuichiro Kadonaga, Pei-Jun Cai, Hong-Xiang Lou, Zhi-Xiang Yu, Houhua Li*, and Xiaoguang Lei*, Photoinduced skeletal rearrangements reveal radical-mediated synthesis of terpenoids, Chem 2019, 5, 1671-1681.
• Highlighted in Chem 2019, 5, 1368-1370.
• Highlighted in Synform 2020, 02, A19–A22.
7. Benke Hong, Dachao Hu, Jinbao Wu, Jing Zhang, Houhua li, Yingming Pan, Xiaoguang Lei*, Divergent Total Syntheses of (-)-Huperzine Q, (+)-Lycopladine B, (+)-Lycopladine C, and (-)-4-epi-Lycopladine D, Chem. Asian J. 2017, 12, 1557-1567.
• Selected as a Very Important Paper (VIP).
8. Benke Hong, Ting Dong, Xiaoguang Lei*, Recent advances in target identification by natural product based chemical probes, Sci. China Chem. 2016, 59, 1088-1092.
9. Benke Hong†, Chao Li†, Zhen Wang, Jie Chen, Houhua Li*, Xiaoguang Lei*, Enantioselective Total Synthesis of (−)-Incarviatone A, J. Am. Chem. Soc. 2015, 137, 11946−11949.
• Highlighted by Stu Borman in Chem. & Eng. News 2015, 93, 35.
• Highlighted as “Synfact of the Month” by Erick M. Carreira and Stefan Fischer in Synfacts 2015, 11, 1231.
10. Benke Hong†, Houhua Li†, Jinbao Wu, Jing Zhang, Xiaoguang Lei*, Total Syntheses of (−)-Huperzine Q, (+)-Lycopladines B and C, Angew. Chem. Int. Ed. 2015, 54, 1011−1015.
• Highlighted by Erick M. Carreira and Simon Krautwald in Synfacts 2015, 11, 112.
