基本介紹
- 中文名：洪學傳
- 國籍：中國
- 民族：漢族
- 職業：教師
- 畢業院校：天津大學
- 學位/學歷：博士學位
- 專業方向：化工
- 職務：武漢大學藥學院, 楚天學者特聘教授
- 發表論文數目：13篇（截至2019年7月）
學習簡歷,工作簡歷,業績概要,獲獎情況,研究,領域,專業方向,學術論文,
學習簡歷
1993.9 - 1997.7 天津大學攻讀套用化學系精細化工專業學士學位
1993.9 - 1997.7 天津大學攻讀管理學院技術經濟學士雙學位
1997.9 - 1999.11 天津大學免試攻讀化工學院套用化學專業碩士學位
1999.12 -2000.7 日本北海道大學藥學院和觸媒化學研究中心研修生
2001.1 - 2005.7 美國密蘇里大學哥倫比亞分校攻讀有機化學博士學位
工作簡歷
1997.9 - 1999.11 天津大學化工學院97級本科生輔導員
2005.9 - 2007.9美國愛默里大學博士後研究員
2007.10- 2010. 10AMRI, Albany, NY, USA 資深科學家
2010.10- 2011.4武漢大學藥學院, 教授
2011.5-至今武漢大學藥學院, 楚天學者特聘教授，武漢大學藥學院鄧子新院士創新團隊成員。
業績概要
2)率先發現了以手性亞碸亞胺(sulfoximine)為手性助劑的不對稱的1,4-加成反應, 使在芳香基團, 雜環共扼環的α位引入手性烷基手性中心更加容易。反應具有廣泛 的普遍性和絕對的立體選擇性。
3)在美國國立衛生研究院(NIH), Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF) 和 CV Therapeutics 的支持下, 利用這特定的化學設計, 合成了一系列具有絕對構像的抗結核病的天然或非天然化合物例如(+)-curcumeme, (+)-curcuphenol, pesudoteroxazole, erogorgiaene, colombiasin A 和 elisapterosin B及分子改造, 開發出了一些選擇性地高, 毒性小的抗結核劑。
4)發現用改進的aza-Achmatowicz 方法合成多取代吡咯。確定銠(II)催化吲哚環加成串聯反應的相對立體構像。設計, 合成了一系列具有高生物活性的天然化合物例如kopsifoline的核 心結構。
5)曾從事各類癌症藥物和肥胖症的小分子藥物等發現，合成, 研製及工業開發。其中一個臨床III藥在2009年9月得到美國FDA批准。
獲獎情況
2004Breckenridge Lyons Award for Outstanding Graduate Research, University of Missouri-Columbia.
2004Gordon Research Conference on Organic Reactions and Process Chair Award.
研究
領域
藥物化學，有機化學，分子影像(Molecular Imaging)
專業方向
1.活性天然產物的全合成
2.化學合成藥物的開發與研究
3.運用現代生物學技術進行藥物開發
4.用於腫瘤光聲成像的分子探針的研製和開發
學術論文
著作：
1.“Recent Progress in the Chemistry of 2,1-Benzothiazines”
Xuechuan Hong; Michael Harmata. Progress in Hetereocyclic Chemistry, Chapter 1, G. W. Gribble and J. A. Joule, eds, Pergamon Press, Vol 20, pp 1–43 (2008)
發表論文：
1．“Metal-free direct amidation of peptidyl thiol esters with -amino acid esters.” Hao Chen, Maomao He, Yaya Wang, Linhui Zhai, Yongbo Cui, Yangyan Li, Yan Li, Haibing Zhou*, Xuechuan Hong* and Zixin Deng, Green Chem., 2011, 13“The Intramolecular, Stereoselective Addition of Sulfoximine Carbanions to α,β-Unsaturated Esters.”Michael Harmata; Xuechuan Hong. J. Am. Chem.l Soc.2003, 125(19), 5754–5756. , 2723
2.
3. “Asymmetric Organocatalysis of [4+3] Cycloaddition Reactions.” Michael Harmata; Sunil K. Ghosh; Xuechuan Hong; Sumrit Wacharasindhu; Patrick Kirchhoefer. J. Am. Chem.l Soc. 2003, 125(8), 2058–2059.
4. “A Cycloaddition Protocol for the Assembly of the Heterocyclic Framework Associated with the Kopsifoline Alkaloids.”Xuechuan Hong; Stefan France; José M. Mejía-Oneto; Albert Padwa. Org. Lett. 2006, 8, 5141–5144.
5. “Benzothiazines in Synthesis. A Total Synthesis of Pseudopteroxazole.”Michael Harmata; Xuechuan Hong. Org. Lett. 2005, 7(16), 3581–3583.
6.“Benzothiazines in Synthesis. Toward the Synthesis of Pseudopteroxazole.”Michael Harmata; Xuechuan Hong; Charles L. Barnes. Org. Lett.2004, 6(13), 2201–2203.
7."Benzothiazines in Organic Synthesis.The Preparation of Enantiomerically Pure 4-Substituted Quinolones” Michael Harmata; Xuechuan Hong. Org. Lett. 2007, 9, 2901–2904.
8.“Benzothiazines in Synthesis. Stereoselective Synthesis of Erogorgiaene.”Michael Harmata; Xuechuan Hong;Peter R. Schreiner. J. Org. Chem.2008, 73, 1290–1296.
9. “Synthesis of 2,4-Disubstituted Pyrroles by Rearrangements of 2-Furanyl Carbamates.”Sezgin Kiren; Xuechuan Hong; Carolyn A. Leverett; Albert Padwa.Org. Lett. 2009, 11(6), 1233–1235.
10. “A dipolar Cycloaddition Approach Toward the Kopsifoline Alkaloid Framework.” Xuechuan Hong; Stefan France; Albert Padwa. Tetrahedron, 2007, 63, 5962–5976.
11. “Rhodium Carbenoid Induced Cycloadditions of Diazo Ketoamides Across Indolyl π-Bonds.”Xuechuan Hong; José M. Mejía-Oneto; Stefan France; Albert Padwa. Synlett, 2007, 775–779.
12. “Lewis Acid Promoted a-Hydroxy b-Dicarbonyl to a-Ketol Ester Rearrangement.” Xuechuan Hongıa-Oneto; Albert Padwa. Tetrahedron Lett. 2006, 47, 8387–8390.;Jose M. Mej
13. “Photodesulfonylation of Indoles Initiated by Electron Transfer from Triethylamine.”Xuechuan Hong; José M. Mejía-Oneto; Stefan France; Albert Padwa. Tetrahedron Lett.2006, 47, 2409–2412.
14. “Palladium-catalyzed Cross-coupling Reactions of a Sulfoximine with Aryl Dichlorides under Microwave Irradiation.”Michael Harmata; Xuechuan Hong. Synlett, 2007, 969–973.
國際學術會議報告
1. “Studies of the Chemistry of 2,1-Benzothiazines and an Approach to the Synthesis of Antitubercular Natural Products.” Xuechuan Hong*nd International Symposium on Organic Synthesis and Drug Development,Nanjing, China, October 14-16, 2010.. Presented at 2
2. “Benzothiazines in Synthesis. Synthesis of Enantiomerically Pure 3,4-Dihydroquinolin-2(1H)-ones.” Michael Harmata; Xuechuan Hong*. ORGN-029l presented at the 231 National Meeting of the American Chemical Society, Atlanta, GA, March 26-30, 2006.
3. "Benzothiazines in Synthesis. A Route to Chiral Cyclobutanes” Michael Harmata; Weijiang Ying and Xuechuan Hong. ORGN-515 presented at the 231 National Meeting of the American Chemical Society, Atlanta, GA, March 26-30, 2006.
4.“Benzothiazines in Synthesis. Stereoselective Synthesis of Diastereomers of Erogorgiaene.” Michael Harmata; Xuechuan Hong*. ORGN-060 presented present at the 228 National Meeting of the American Chemical Society, Philadelphia, August 22-26, 2004.
5. “Microwave-assisted N-arylation of a Sulfoximine with Aryl Chlorides.” Michael Harmata; Xuechuan Hong*. ORGN-165 presented at the 228 National Meeting of the American Chemical Society, Philadelphia, August 22-26, 2004.
6. “Towards a Synthesis of Pseudopteroxazole.” Michael Harmata; Xuechuan Hong*. Presented at the Gordon Research Conference on Organic Reactions and Processes, July 18-23, 2004.
7. “Microwave-assisted N-arylation of a Sulfoximine with Aryl Chlorides.” Michael Harmata; Xuechuan Hong*. Presented at the Gordon Research Conference on Organic Reactions and Processes, July 18-23, 2004.
8.“Benzothiazines in Synthesis. Towards Pseudopteroxazole.” Michael Harmata; Xuechuan Hong*. ORGN-061 presented at the 228National Meeting of the American Chemical Society, Philadelphia, August 22-26, 2004.
9. “Towards a Synthesis of Erogorgiaene.” Michael Harmata; Xuechuan Hong*. Paper #48 presented at the 38 Annual Midwest Regional Meeting of the American Chemical Society, Columbia, November 5-7, 2003.
博士後招聘
本研究組擬招收具有以下專業研究背景博士後1-2名：
1.活性天然化合物的全合成
2.腫瘤光聲成像的分子探針的研製和開發。
