沙珍霞

沙珍霞

沙珍霞,女,青島大學生命科學學院教授,博士生導師。青島大學水生生物學科負責人。

基本介紹

  • 中文名:沙珍霞
  • 學位/學歷:博士
  • 職業:教師
  • 專業方向:海洋魚類細胞生物學及免疫學
  • 任職院校:青島大學生命科學學院
個人經歷,研究方向,學術成果,

個人經歷

1997年、2006年畢業於中國海洋大學生命學院海洋生物學專業,分獲碩士、博士學位。1997年7月至2016年5月在中國水產科學研究院黃海水產研究所工作,歷任助理研究員、副研究員和研究員,研究室副主任、研究室主任,先後獲青島市創先爭優優秀共產黨員、中國水產科學院先進工作者、中國科學研究院黃海水產研究所優秀共產黨員、先進工作者、文明職工等榮譽稱號。2006年9月-2008年3月於美國Auburn大學博士後及訪問學者。2016年5月作為引進人才進入青島大學生命科學學院工作,2017年8月被聘為青島大學三層次特聘教授。現為國家海洋科學與技術國家試點實驗室海洋漁業科學與食物產出功能實驗室固定人員,中國水產學會生物技術分會專業技術委員會委員,中國海洋學會生物工程分會副秘書長,青島市微藻產業學會、青島市生物工程學會常務理事。

研究方向

海洋魚類細胞生物學及免疫學
水生生物資源利用及生物技術

學術成果

主持的國家級科研項目:
1. 國家重點研發計畫子課題-“海水魚類抗病與抗逆性狀形成的分子機理(2018YFD0900301-3)”, 2018.12-2022.12
2. 國家自然科學基金面上項目-“半滑舌鰨補體信號通路及抗菌免疫防禦機理(31572644)”,2016.01-2019.12
3. 國家自然科學基金面上項目-“半滑舌鰨miRNA表達譜構建及免疫相關性分析(31172439)”,2012.01-2015.12”
4. 863高技術計畫子課題-“海水養殖生物重要功能基因的發掘與研究(2012AA10A401-4)”,2012.01-2015.12
5. 國家自然科學基金面上項目-“斑點叉尾鮰天然免疫基因NLR和APR基因定位及抗病機制的研究(30871941)”、2009.01-2011.12
6. 863高技術計畫子課題-“重要海水養殖動物細胞工程育種技術 (2006AA10A401)”,2006.01-2010.12
7. 863高技術計畫課題-“重要海水養殖動物細胞培養技術與細胞系建立 (2006AA09Z406)”,2006.01-2009.12
8. 863高技術計畫課題-“花鱸胚胎幹細胞培養及基因打靶技術研究(2004AA626110,2004AA629180)”,2002.01-2004.10,2004.10-2005.10
代表性論文:
(1) Yang G, Xiu YJ, Chen YD, Bai L, Sha ZX. Identification and expression of complement component C8α, C8β and C8γ gene in half-smooth tongue sole (Cynoglossus semilaevis) and C8α recombinant protein antibacterial activity analysis. Fish and Shellfish Immunology, 2018, 72:658-669. SCI一區
(2) Sha ZX, Wang LQ, Sun LM, Chen YD, Zheng Y, Xin M, Li C, Chen SL. Isolation and characterization of monocyte/macrophage from peripheral blood of half smooth tongue sole (Cynoglossus semilaevis). Fish & Shellfish Immunology, 2017, 65: 256-266. SCI一區
(3) Wu SM, Zheng RK, Sha ZX and Sun CM. Genome Sequence of Pseudomonas stutzeri 273 and Identification of the Exopolysaccharide EPS273 Biosynthesis Locus. Mar. Drugs, 2017, 15, 218; doi:10.3390/md15070218. SCI二區
(4) Chen YD, Xia YT, Shao CW, Han L, Chen XJ, Yu MJ, Sha ZX. Discovery and identification of candidate sex-related genes based on transcriptome sequencing of Russian sturgeons (Acipenser gueldenstaedtii) gonads. Physiological genomics, 2016, 48(7), 464-476.
(5) Yan H, Chen YD, Zhou S, Li C, Gong GY, Chen XJ, Wang TZ, Chen SL, Sha ZX. Expression profile analysis of miR-221 and miR-222 in different tissues and head-kidney cells of Cynoglossus semilaevis, following pathogen infection. Marine Biotechnology, 2016, 18:37-48. SCI一區
(6) Zheng Y, Wang N, Sha ZX, Chen SL. Establishment of a continuous cell line from female half-smooth tongue sole (Cynoglossus semilaevis). Aquaculture Research, 2016, 47(11):3608-3615.
(7) Gong GY, Sha ZX, Chen SL Li C, Yan H., Chen YD., Wang TZ. Expression Profiling Analysis of the microRNA Response of Cynoglossus semilaevis to Vibrio anguillarum and Other Stimuli. Marine Biotechnology, 2015, 17(3): 338-52. SCI一區
(8) Xiang J, Li X, Chen Y, Lu Y, Yu MJ, Chen XJ, Zhang WT, Zeng Y, Sun LM, Chen SL, Sha ZX. Complement factor I from flatfish half-smooth tongue (Cynoglossus semilaevis) exhibited anti-microbial activities. Developmental & Comparative Immunology, 2015, 53(1): 199-209. SCI一區
(9) Zeng Y, Xiang JS, Lu Y, Chen YD, Wang TZ, Gong GY, Wang L, Li XH, Chen SL, Sha, ZX. sghC1q, a novel C1q family member from half-smooth tongue sole (Cynoglossus semilaevis): Identification, expression and analysis of antibacterial and antiviral activities. Developmental and Comparative Immunology, 2015, 48, 151-163. SCI一區
(10) Zhang X, Wang S, Chen SL, Chen Y, Liu Y, Shao CW, Wang Q, Lu Y, Gong GY, Ding SX, Sha ZX. Transcriptome analysis revealed changes of multiple genes involved in immunity in Cynoglossus semilaevis during Vibrio anguillarum infection. Fish & Shellfish Immunology, 2015, 43(1):209-218. SCI一區
(11) Sha ZX, Gong GY, Wang SL, Lu Y, Wang L, Wang QL, Chen SL. Identification and characterization of Cynoglossus semilaevis microRNA response to Vibrio anguillarum infection through high-throughput sequencing. Developmental and Comparative Immunology, 2014, 44(1):59-69. SCI一區
(12) Lu Y, Wang QL, Liu Y, Shao CW, Chen SL, Sha ZX. Gene cloning and expression analysis of IRF1 in half-smooth tongue sole (Cynoglossus semilaevis). Molecular biology reports, 2014, 41(6): 4093-4101.
(13) Li M, Wang QL, Lu Y, Chen SL, Sha ZX. Expression of NODs in channel catfish (Ictalurus punctatus) after infection with virulent Edwardsiella tarda, Aeromonas hydrophila, Streptococcus iniae and channel catfish hemorrhage reovirus. Fish & Shellfish Immunology, 2012, 33(4):1033-41. SCI一區
(14) Li M, Liu Y, Wang QL, Chen SL, Sha ZX. BIRC7 gene in channel catfish (Ictalurus punctatus): identification and expression analysis in response to Edwardsiella tarda, Streptococcus iniae and channel catfish Hemorrhage Revirus. Fish & Shellfish Immunology, 2012, 33(1):146-53. SCI一區
(15) Sha ZX, Wang QL, Liu Y, Chen SL. Identification and expression analysis of goose-type lysozyme in half-smooth tongue sole (Cynoglossus semilaevis). Fish & Shellfish Immunology, 2012, 32(1):914-921. SCI一區
(16) Sha ZX, Liu H, Wang QL, Liu Y, Lu Y, Li M, Chen SL. Channel catfish (Ictalurus punctatus) protein disulphide isomerase, PDIA6: Molecular characterization and expression regulated by bacteria and virus inoculation. Fish & Shellfish Immunology, 2012, 33(2):220-228. SCI一區
(17) Liu Y, Meng YQ, Wang QL, Sha ZX. Class II, major histocompatibility complex, transactivator (CIITA) in channel catfish: Identification and expression patterns responding to different pathogens. Molecular Biology Reports, 2012, 39(12):11041-50.
(18) Zheng Y, Wang N, Xie MS, Sha ZX, Chen SL. Establishment and characterization of a new fish cell line from head kidney of half-smooth tongue sole (Cynoglossus semilaevis). Fish Physiology and Biochemistry, 2012. 38(6): 1635-1643.
(19) Sha ZX, Luo XH, Liao XL, Wang SL, Wang QL, Chen SL. 2011. Development and characterization of 60 novel EST-SSR markers in half-smooth tongue sole (Cynoglossus semilaevis). Journal of Fish Biology. 78: 322-331.
(20) Sha ZX, Wang SL, Zhuang ZM, Wang Q, Wang Q, Li P, Ding H, Wang N, Liu ZJ, Chen SL. 2010. Generation and analysis of 10,000 ESTs from the half smooth tongue sole, Cynoglossus semilaevis Gunther and identification of microsatellite and SNP markers. Journal of Fish Biology. 76: 1190-1204.
(21) Sha ZX, Ren GC, Wang XL, Wang N, Chen SL. 2010. Development and characterization of a cell line from the embryos of half smooth tongue sole (Cynoglossus semilaevis). Acta Oceanologica Sinica. 29(2):81-87.
(22) Sha ZX, Abernathy JW, Wang SL, Li P, Kucuktas H, Liu H, Peatman E, Liu ZJ. 2009. NOD-like subfamily of the nucleotide-binding domain and leucine-rich repeat containing family receptors and their expression in channel catfish. Developmental Comparative Immunology. 33(9): 991-999. SCI一區
(23) Sha ZX, Xing SC, Shao CW, Tian YS, Liao XL., Chen SL. 2009. Isolation and characterization of 12 polymorphic microsatellite markers from ladyfish (Elops saurus Linnaeus). Conservation Genetics. 10(6): 1799-1801.
(24) Sha ZX, Xu P, Takano T, Liu H, Terhune J, Liu ZJ. 2008. The warm temperature acclimation protein Wap65 as an immune response gene: its duplicates are differentially regulated by temperature and bacterial infections. Molecular Immunology. 45(5): 1458-1469.
註:本人為第一作者、通訊或共同通訊作者論文
授權的國家發明專利:
(1)沙珍霞,陳亞東,曾艷,向晉松,路颺,陳松林,公光業,王天姿,邵長偉。2014, 一種具有免疫效果的基因,ZL 20140249584.6
(2)沙珍霞,盛軍,鄭媛,紀曉峰,王致鵬。一種殼寡糖酶變構體,ZL 201610212888.4
(3)陳松林,葉寒青,沙珍霞。魚類肌肉生長抑素MSTN基因克隆及其基因打靶載體構建,ZL200510104768.4
(4)陳松林,任國誠,沙珍霞。魚類胚胎細胞分離與培養方法,ZL200510044628.2
(5)王娜,陳松林,王賢麗,沙珍霞。一種大菱鮃腎細胞系的構建方法及套用,ZL200910016926.9
(6)陳松林,張玉喜,劉雲國,沙珍霞,田永勝,鄧寒。牙鮃抗病相關MHC基因標記及其輔助育種方法,ZL200510045555.9
(7)陳松林,李靜,田永勝,沙珍霞,王清印,莊志猛,徐建勇。半滑舌鰨雌性特異AFLP片段及遺傳性別鑑定的PCR方法,ZL200610044177.7
(8)陳松林,鄧思平,田永勝,沙珍霞,王清印。半滑舌鰨性逆轉的誘導方法,ZL2006101710173
(9)陳松林,田永勝,徐田軍,鄧寒,沙珍霞,劉本偉,季相山,於過才。魚類家系建立和抗病高產良種選育方法,ZL 200810138063.8
科研成果獎勵:
(1)2014-2015年度農業部創新團隊,2015,(等同於農業部成果一等獎,位2)
(2) 牙鮃快速生長良種培育技術的建立與套用,2014,山東省科學技術獎二等獎(位5)
(3) 牙鮃良種培育技術的建立及“鮃優1號”新品種創製和套用,2013,青島市科技進步一等獎(位4)
(4) 海水鮃鰈魚類基因資源發掘與套用,2010,山東省科學技術獎二等獎(位3)
(5) 海水養殖魚類遺傳資源發掘與推廣套用,2009,中華農業科技獎一等獎(位4)
(6) 龍鬚菜遺傳特性的研究,2000,國家海洋局海洋科技進步一等獎(位5)
(7) 重要海水養殖魚類精子和胚胎冷凍保存及種質冷凍庫建立的研究,2005.1.11,海洋創新成果獎二等獎(位3)
(8) 海水養殖魚類基因資源發掘、種質創製與套用,2009,海洋創新成果二等獎(位4)
(9)重要海水養殖魚類基因資源發掘、種質創新與套用,2009,首屆中國水產學會范蠡科學技術獎一等獎(位6)
(10)半滑舌鰨性染色體進化及性別分會和底棲適應機制研究,2015,中國水產科學研究院大漁創新獎(位5)
(11)半滑舌鰨舌鰨性別特異分子標記及遺傳性別鑑定技術的建立與套用,2009,中國水產科學研究院科技進步獎一等獎(位4)
(12)重要海水養殖魚類精子和胚胎冷凍保存及種質冷凍庫建立的研究,2005,中國水產科學研究院科技進步二等獎(位3)

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