樊立宏，男，醫學博士、研究員、主任醫師，博士研究生導師，西安交通大學第二附屬醫院運營管理部副主任。
基本介紹
- 中文名：樊立宏
- 學位/學歷：博士
- 職業：教師
- 專業方向：股骨頭壞死的發病及修復機制研究
- 任職院校：西安交通大學
個人經歷,研究方向,學術成果,
個人經歷
中國醫師協會肩肘外科分會委員，中國醫師協會骨關節炎工作委員會執行委員，中國醫促會骨科專業委員會脊柱內鏡學組委員，陝西省關節外科分會關節鏡學組委員，陝西省脊柱外科分會青年委員。
多次赴台灣陽明大學幹細胞研究中心、澳大利亞Nepean醫院、美國德克薩斯州關節置換中心、德國柏林AMEOS醫院等著名醫療機構研修學習。受邀在2015世界關節成型大會、亞洲關節年會做專題演講及壁報交流。
研究方向
股骨頭壞死的發病及修復機制研究
生物醫用材料及幹細胞的骨軟骨修復
關節疾病與運動損傷的修復及功能重建
學術成果
主持研究課題:
1. PPAR-γ通路在股骨頭壞死病理機制中的作用研究（西安交通大學校長科研基金）
2. 骨髓基質幹細胞複合異種脫細胞神經基質構建組織工程神經的研究（中央高校基本科研業務費-自由探索項目）
3. HIF-1α和BMP-7基因共轉染骨髓間充質幹細胞移植治療股骨頭壞死的實驗研究（國家自然科學基金-青年項目）
4. 基於3D微結構列印技術構建摻鋰β-TCP複合骨髓間充質幹細胞的成血管成骨能力研究（中央高校基本科研業務費-學科交叉項目）
5. 3D微結構列印摻鋰β-TCP複合microRNA-21轉染骨髓間充質幹細胞治療股骨頭壞死的實驗研究（國家自然科學基金-面上項目81572145，57萬）
6. miR-210修飾的BMMSCs來源外泌體複合可注射水凝膠激活PI3K/Akt通路治療激素性股骨頭壞死（國家自然科學基金-面上項目81772355，55萬）
7. miR-21修飾的BMMSCs外泌體修復激素性股骨頭壞死的機制研究（2017年院人才培養專項科研基金 RC（GG）201705, 6萬）
8. miR-21修飾的間充質幹細胞外泌體調控PTEN/Akt通路修復激素性股骨頭壞死的作用及機制研究（2018年陝西省社會發展基金 2018SF-052，6萬）
學術及科研成果：
Fan LH, Wang KZ, Cheng B, Wang CS, Dang XQ. Anti-apoptotic and neuroprotective effects of Tetramethylpyrazine following spinal cord ischemia in rabbits.BMC Neurosci. 2006
Die J, Wang K, Fan L, Jiang Y, Shi Z. Rosuvastatin preconditioning provides neuroprotection against spinal cord ischemia in rats through modulating nitric oxide synthase expressions.Brain Res. 2010
Liu C, Shi Z, Fan L, Zhang C, Wang K, Wang B. Resveratrol improves neuron protection and functional recovery in rat model of spinal cord injury.Brain Res.
Fan L, Wang K, Shi Z, Die J, Wang C, Dang X. Tetramethylpyrazine protects spinal cord and reduces inflammation in a rat model of spinal cord ischemia-reperfusion injury.J Vasc Surg. 2011
Fan L, Dang X, Shi Z, Zhang C, Wang K. Hydroxysafflor yellow A protects PC12 cells against the apoptosis induced by oxygen and glucose deprivation.Cell Mol Neurobiol. 2011
Fan L, Dang X, Wang K. Comparison between bipolar hemiarthroplasty and total hip arthroplasty for unstable intertrochanteric fractures in elderly osteoporotic patients.PLoS One. 2012;
You W, Gao H, Fan L, Duan D, Wang C, Wang K. Foxc2 regulates osteogenesis and angiogenesis of bone marrow mesenchymal stem cells.BMC Musculoskelet Disord. 2013
Tian L, Wen Q, Dang X, You W, Fan L, Wang K. Immune response associated with Toll-like receptor 4 signaling pathway leads to steroid-induced femoral head osteonecrosis.BMC Musculoskelet Disord. 2014 Jan
Feng M, Zhang R, Gong F, Yang P, Fan L, Ni J, Bi W, Zhang Y, Wang C, Wang K. Protective effects of necrostatin-1 on glucocorticoid-induced osteoporosis in rats. J Steroid Biochem Mol Biol. 2014 Sep
You W, Fan L, Duan D, Tian L, Dang X, Wang C, Wang K. Foxc2 over-expression in bone marrow mesenchymal stem cells stimulates osteogenic differentiation and inhibits adipogenic differentiation.Mol Cell Biochem. 2014 Jan;
Fan L, Yu Z, Li J, Dang X, Wang K. Schwann-like cells seeded in acellular nerve grafts improve nerve regeneration. BMC Musculoskelet Disord. 2014 May
Fan L, Li J, Yu Z, Dang X, Wang K. The hypoxia-inducible factor pathway, prolyl hydroxylase domain protein inhibitors, and their roles in bone repair and regeneration.Biomed Res Int. 2014;
Fan L, Yu Z, Li J, Dang X, Wang K. Immunoregulation Effects of Bone Marrow-Derived Mesenchymal Stem Cells in Xenogeneic Acellular Nerve Grafts Transplant.Cell Mol Neurobiol. 2014 Jun 17.
Fan L, Li J, Yu Z, Dang X, Wang K. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Prevents Steroid-Associated Osteonecrosis of the Femoral Head in Rabbits by Promoting Angiogenesis and Inhibiting Apoptosis. PLoS One. 2014
Zhang C, Ma J, Fan L, Zou Y, Dang X, Wang K, Song J. Neuroprotective effects of safranal in a rat model of traumatic injury to the spinal cord by anti-apoptotic, anti-inflammatory and edema-attenuating. Tissue Cell. 2015 Jun;
Yu Z, Fan L, Li J, Ge Z, Dang X, Wang K. Lithium chloride attenuates the abnormal osteogenic/adipogenic differentiation of bone marrow-derived mesenchymal stem cells obtained from rats with steroid-related osteonecrosis by activating the β-catenin pathway.Int J Mol Med. 2015
Fan L, Zhang C, Yu Z, Shi Z, Dang X, Wang K. Transplantation of hypoxia preconditioned bone marrow mesenchymal stem cells enhances angiogenesis and osteogenesis in rabbit femoral head osteonecrosis. Bone. 2015
Zefeng Yu，Lihong Fan（*），Jia Li，Zhaogang Ge，Xiaoqian Dang，Kunzheng Wang（*），Lithiumprevents rat steroid-related osteonecrosis of the femoral head by β-catenin activation，Endocrine，2016
Li, Jia，Ge, Zhaogang，Fan, Lihong，Wang, Kunzheng，Protective effects of molecular hydrogen on steroid-
induced osteonecrosis in rabbits via reducing oxidative stress and apoptosis.，BMC Musculoskelet Disord，2017
Pei JP, Fan LH（*）, Nan K1, Li J, Dang XQ, Wang KZ. HSYA alleviates secondary neuronal death through attenuating oxidative stress, inflammatory response, and neural apoptosis in SD rat spinal cord compression injury.J Neuroinflammation. 2017 May
Pei J, Fan L, Nan K, Li J, Shi Z, Dang X, Wang K. Excessive Activation of TLR4/NF-κB Interactively Suppresses the Canonical Wnt/β-catenin Pathway and Induces SANFH in SD Rats.Sci Rep. 2017 Sep
授權國家發明專利：
1. 雙層仿生頸椎間盤假體及其製造方法 [發明專利] CN200510041794.7
2. 一種複合種子細胞的組織工程神經的製備方法 [發明專利] CN201310364793.0
