楚楚，女，博士，中共黨員，浙江工業大學藥學院副教授、碩士生導師。長期從事中藥活性成分及功能因子篩選及開發及中藥質量標準建立方向研究工作。
基本介紹
教育背景,工作履歷,教授課程,育人成果,科研項目,所獲榮譽,代表性論文,代表性專利,科研獲獎,社會兼職,
教育背景
2005 - 2010 中國藥科大學，中藥學院，碩博連讀
2001 - 2005 中國藥科大學，中藥學院，本科
2015/09 - 2016/09 哥本哈根大學，訪問學者
2015/04 澳門大學，中藥質量鑑定技術研修班
2006/09 - 2008/09 香港浸會大學，中醫藥學院，訪問學者
工作履歷
2014 - 浙江工業大學，藥學院，副教授
2010 - 2014 浙江工業大學，藥學院，講師
教授課程
《中藥鑑定學》2011年
《中藥製劑分析》2012年-2019年
《藥用拉丁語》2011年
《中藥學專業綜合實驗》2014年
育人成果
（1）指導研究生魏蒙蒙獲第一屆全國藥學專業學位論文優秀學位論文（2018年）。
（2）指導研究生劉彩婧獲校優秀碩士論文（2020年）。
（3）指導研究生魏蒙蒙、劉彩婧。本科生王萍獲省優秀畢業生；指導研究生江璐依、張歡、連琳敏、李璟獲校優秀畢業生。
（4）指導中藥學專業本科生江璐依獲得全國製藥工程徵文比賽一等獎（2017年）。
（5）指導中藥學專業本科生江璐依、揭小康、徐祥、黃歡獲全國中醫藥高等教育技能大賽——2017年第二屆中藥學類專業學生知識技能大賽優勝獎（2017年）。
（6）指導中藥學專業本科生張慶、楊婷媛、賴雲楓獲全國中醫藥高等教育技能大賽——2015年首屆中藥學類專業學生知識技能大賽優勝獎（2015年）。
科研項目
（1）國家自然科學基金面上項目.基於多維篩選和代謝組學的決明子治療代謝綜合徵藥效物質及整合作用機制研究.2021-2024.
（2）國家自然科學基金青年科學基金項目.CD47細胞膜親和色譜線上液相色譜質譜聯用系統的建立及其在溫鬱金抗肝癌活性成分篩選中的套用. 2016-2018.
（3）浙江省自然科學基金一般項目.新型雜化納米花酶微反應器-毛細管電泳線上篩選體系的構建及其在白芍酪氨酸酶抑制劑篩選中的套用. 2020-2022.
（4）天然藥物活性組分與藥效國家重點實驗室開放基金.2021-2022.
（5）浙江省錢江人才計畫項目.化學成分群-螢光顯微特徵譜的建立及其在鐵皮石斛質量控制研究的套用. 2012-2013.
（6）浙江省教育廳一般項目.中藥配方顆粒中活性成分的新型提取分析技術研究. 2019-2020.
（7）浙江省教育廳一般項目.現代顯微術結合液質聯用技術對中藥品質的快速評定. 2011-2012.
（8）正大青春寶藥業有限公司.青春寶抗衰老片物質基礎和質量標準研究. 2012-2015.
（9）杭州胡慶余堂藥業有限公司.沉香曲質量標準研究. 2017-2018.
（10）杭州胡慶余堂藥業有限公司.香茶菜產地趁鮮加工炮製規範研究. 2019-2021.
（11）浙江普洛家園藥業有限公司.AP20015毛細管電泳檢測方法的開發和檢測. 2020-2021.
（12）浙江省中藥現代化專項項目.紅參微米粉體製備技術的產業化. 2011-2012.
所獲榮譽
（1）浙江工業大學優秀教師（2020年）。
（2）浙江工業大學藥學院優秀班主任（2019年）。
（3）浙江工業大學優秀畢業論文指導教師（2012年）。
（4）浙江工業大學第九屆青年教師教學技能比賽優秀獎（2014年）。
（5）浙江工業大學藥學院第八屆青年教師教學技能比賽一等獎（2014年）。
代表性論文
(1) Chu Chu, Yaping Zang, Fei Yang, Yanfang Zou, Jiaxu Li, EHu Liu, Tao Yi, Jizhong Yan, Shengqiang Tong*. A simple and sensitive preconcentration strategy by coupling salting-out assisted liquid-liquid extraction with online three-step stacking for the determination of potent anti-tumour compound vinblastine and its precursor in biological samples by capillary electrophoresis. J. Chromatogr. A. 2022,1664,462794.
(2)Linmin Lian, Yaping Zang, Fei Yang, E-Hu Liu, Jizhong Yan, Shengqiang Tong *, Chu Chu *. Online preconcentration methodology that realizes over 2000-fold enhancement by integrating the free liquid membrane into electrokinetic supercharging in capillary electrophoresis for the determination of trace anionic analytes in complex samples. Microchem. J. 2022, 174: 107033.
(3)Chu Chu, Jing Li, Fei Yang, Ke Yang, Bingrui Liu, Shengqiang Tong, Jizhong Yan*, Suhong Chen*. A novel high-resolution monophenolase/diphenolase/radical scavenging profiling for the rapid screening of natural whitening candidates from Peaonia lactiflora root and their mechanism study with molecular docking. J. Ethnopharmacol. 2022,282,114607. DOI:10.1016/j.jep.2021.114607.
(4)Fei Yang, Luyi Jiang, HuiMao, Yanfang Zou, Chu, Chu*. Establishment of deep eutectic solvent assisted matrix solid-phase dispersion extraction for the determination of four flavonoids in Scutellariae Radix based on the concept of quality by design. J. AOAC Int. 2021,104(6): 1681-1689.
(5)Chu Chu, Luyi Jiang, Hui Mao, Jizhong Yan*. A simple and environmentally-friendly method by pipette-tip matrix solid-phase dispersion microextraction coupled with high-performance liquid chromatography for the simultaneous determination of lignans and terpenes. Sustain. Chem. Pharm. 2021, 20: 100384.
(6)Chu Chu, Caijing Liu, Fei Yang, Linmin Lian, Jing Li, Hui Mao, Jizhong Yan*. A dual preconcentration method by combining micro matrix solid-phase dispersion extraction with field-enhanced sample injection and micelle to cyclodextrin stacking for sensitive analysis of neutral coumarins. Electrophoresis. 2021, 42(9): 1102-1107.
(7)Chu Chu, Huan Zhang, Hui Mao, Caijing Liu, Luyi Jiang,Linmin Lian, Jing Li, Jiaming Zhu, Wei Chen, Jizhong Yan*. Simultaneous determination of seven compounds in Chinese patent medicines Chenxiangqu by matrix solid-phase dispersion coupled with ultra high performance liquid chromatography and quadrupole time-of-flight mass spectrometry. J. Sep. Sci. 2020, 43(14): 2869-2879.
(8)Chu Chu, Linmin Lian, Caijing Liu, Jing Li, Hui Mao, Luyi Jiang, Jizhong Yan*. Online preconcentration by electrokinetic supercharging for sensitive determination of berberine and jatrorrhizine in biological samples. Biomed. Chromatogr. 2020, 34(6): e4824.
(9)Caijing Liu, Jing Li, Lidan Zhu, Linmin Lian, Luyi Jiang, Hanbing Li, Jizhong Yan, Chu Chu*. A sensitive two-step stacking by coupling field-enhanced sample injection and micelle to cyclodextrin stacking for the determination of neutral analytes. J. Chromatogr. A, 2020, 1618: 460854.
(10)Chu Chu *, Jing Li, Shan Wang, Lvnan Weng, Luyi Jiang, Huan Zhang,Cai jing Liu, and Jizhong Yan*. A Simple and Sensitive Dispersive Micro-Solid-Phase Extraction Coupled with High-Performance Liquid Chromatography for Quantification of Honokiol and Magnolol in Complex Matrices. J. AOAC Int. 2020, 103(5): 1406–1411.
(11)Chu Chu, Shan Wang; Luyi Jiang, Caijing Liu, Huan Zhang, Jizhong Yan. Microwave-assisted ionic liquid-based micelle extraction combined with trace-fluorinated carbon nanotubes in dispersive micro-solid-phase extraction to determine three sesquiterpenes in roots of Curcuma wenyujin. Phytochem. Anal. 2019, 30(6): 700-709.
(12)Qiu Yan Wang, Xin Dong, Juan Yang, Xiao Ting Zhen, LiHong Ye, Chu Chu*, Bin Wang, YuHan Hu, Hui Zheng, Jun Cao*. Solid acids assisted matrix solid-phase disp ersion microextraction of alkaloids by capillary electrophoresis coupled with quadrupole time-of-flight mass spectrometry. J. Sep. Sci. 2019, 42(23): 3579-3588
(13)Chu Chu, Caijing Liu, Luyi Jiang, Linmin Lian, Jing Li, Hanbing Li, Huawei Lv, Jizhong Yan. On-line synergistic stacking in capillary zone electrophoresis featuring field-amplified sample stacking and micelle to cyclodextrin stacking in the determination of two alkaloids in complicated matrix samples. J. Sep. Sci. 2019, 42(18): 3009-3015.
(14)Chu Chu, Tuo Li, H.A. Pedersen, K.T. Kongstad, Jizhong Yan, Dan Staerk.Antidiabetic constituents of Dendrobium officinale as determined by high-resolution profiling of radical scavenging and alpha-glucosidase and alpha-amylase inhibition combined with HPLC-PDA-HRMS-SPE-NMR analysis. Phytochem. Lett. 2019, 31: 47-52.
(15)Chu Chu, Shan Wang, Huan Zhang, Caijing Liu, Luyi Jiang, Yiping Tang, Jizhong Yan. A sensitive dispersive micro solid-phase extraction coupled with high performance liquid chromatography for determination of three flavonoids in complex matrics by using crab shell as a sorbent. Electrophoresis, 2019, 40(9): 1298-1305.
(16)Qing Li,Luyi Jiang, Huan Zhang, Mengmeng Wei, Chu Chu*; Yan, Jizhong. Modified Magnetic Nanoparticle-Based Solid-Phase Extraction for the Determination of Trace Amounts of Aflatoxins B-1 and B-2 in Chinese Patent Medicines: The Use of Fupuganmao Granules as a Case Study. J. AOAC Int. 2019, 102(3): 761-766.
(17) Luyi Jiang, Jie Wang, Huan Zhang, Caijing Liu, Yiping Tang, Chu Chu*. New Vortex-Synchronized Matrix Solid-Phase Dispersion Method for Simultaneous Determination of Four Anthraquinones in Cassiae Semen. Molecules, 2019, 24(7): 1312.
(18)Chu Chu, Mengmeng Wei, Caijing Liu, Hanbing Li, Jun Cao, Jizhong Yan*. Over 1000-fold improvement in an online preconcentration of trace anionic compounds by capillary electrophoresis with ionic liquid micelle-based three-step stacking. Anal. Chim. Acta, 2018, 1044: 191-197
(19)Mengmeng Wei,Caijing Liu,Huan Zhang, Luyi Jiang, Jizhong Yan, Chu Chu*. Molecular-sieve-based matrix solid-phase extraction combined with field-amplified sample stacking in capillary electrophoresis for the determination of three organic acids in a complex solid matrix. J. Sep. Sci. 2018, 41(19): 3742-3750.
(20)Mengmeng Wei,Chu Chu*, Shan Wang,Jizhong Yan. Quantitative analysis of sesquiterpenes and comparison of three Curcuma wenyujin herbal medicines by micro matrix solid phase dispersion coupled with MEEKC. Electrophoresis, 2018, 39(8): 1119-1128.
(21)Chu Chu, Mengmeng Wei,Shan Wang, Liqiong Zheng, Zheng He, Jun Cao*, Jizhong Yan*. Micro-matrix solid-phase dispersion coupled with MEEKC for quantitative analysis of lignans in Schisandrae Chinensis Fructus using molecular sieve TS-1 as a sorbent.J. Chromatogr. B, 2017, 1063: 174-179.
代表性專利
(1)楚楚，王珊，江璐依，唐誼平，顏繼忠。一種蜂蜜中黃酮類成分的含量測定方法。ZL201910108126.3, 2021-10-15
(2)楚楚，劉彩婧，連琳敏，李璟，顏繼忠。一種基於FASS-MCDS 線上富集測定生物鹼含量的方法。ZL201910340784.5，2021-06-01
(3)楚楚，王珊，顏繼忠。一種溫鬱金中倍半萜成分的提取富集方法。ZL201910078215.8, 2021-06-29
(4)楚楚，江璐依，唐誼平，顏繼忠.一種測定蒽醌類成分含量的方法。ZL201810947817.8, 2021-02-02
(5)楚楚，魏蒙蒙，劉彩婧，顏繼忠。基於FESI-sweeping-MSS聯用線上富集測定痕量有機陰離子的方法。ZL201810118606.3, 2020-02-21
(6)楚楚，李清，魏蒙蒙，王珊，顏繼忠。一種同時測定中成藥中黃麴黴素B1，B2含量的方法。ZL201710123086.0, 2019-10-29
(7)楚楚，鄭麗瓊，魏蒙蒙，顏繼忠。一種五味子中木脂素類有效成分的提取檢測方法。ZL201610929146.3, 2019-7-26
(8)楚楚，李行諾，顏繼忠，章詩迪，宋敏。一種提取製備苯甲醯芍藥苷和苯甲醯芍藥內酯苷的方法，ZL201410144187.2, 2016-04-13
(9)楚楚。一種從生脈方中分離製備5-羥甲基糠醛的方法，ZL201410456332.0, 2016-09-14
(10)楚楚，顏繼忠，童勝強，章詩迪。一種五味子中木脂素單體的提取分離製備方法，ZL201310429192.3, 2015-10-28
(11)楚楚，顏繼忠，章詩迪，童勝強，李行諾。五味子中木脂素單體的提取分離製備方法，ZL201310431854.0, 2014-4-22
科研獲獎
童勝強，顏繼忠，單偉光，楚楚，多樣化洗脫逆流色譜製備性分離手性化合物，第二屆浙江省自然科學學術獎，三等獎，2012.
童勝強，顏繼忠，程冬萍，楚楚，李行諾，浙江省藥學會科學技術獎，二等獎，2017.
社會兼職
國家自然科學基金評審專家，廣東省科技廳評審專家，Analytical Chimica Acta, Journal of Chromatography A，Food Chemistry等SCI期刊審稿專家。
