楊潔是天津市醫科大學基礎醫學院教授。
基本介紹
- 中文名：楊潔
- 國籍：中國
- 民族：漢族
- 職業：天津市醫科大學基礎醫學院教授
- 畢業院校：中山醫科大學
簡歷,研究方向,職務學術,
簡歷
1997年7月-1998年12月 中山醫科大學 生化教研室 (講師)
研究方向
細胞因子及其信號傳導通路調控機制的研究和疾病發生的關係。
職務學術
現任天津醫科大學基礎醫學院院長、免疫學教研室副主任、國家教育部"免疫微環境與疾病重點實驗室"副主任、國家衛生部有突出貢獻中青年專家、國家教育部“新世紀人才支持計畫”天津市“131人才”第一層次人選、天津市"細胞與分子免疫學重點實驗室"副主任、天津市特聘教授、天津市優秀教師、病原生物學與免疫學教授，擔任天津市免疫學會秘書長、天津市國際生物治療學會會員、國際RNA學會會員、中國免疫學會終身會員、中國細胞生物學會會員、中華醫學會醫學細胞生物學常務委員、中華微生物與免疫學會青年委員會副主委、臨床生物化學與分子生物學理事、天津市生化與分子生物學理事、中華微生物學與免疫學雜誌編委、中國檢驗醫學雜誌（英文版）編委、中國腫瘤臨床（英文版）編委、醫學分子生物學雜專編委、醫學參考報編委。近五年，楊潔教授承擔科研項目20多項，科研經費400餘萬人民幣，包括 “863”課題1項、國家自然科學基金2項、多項國際合作項目，發表學術論文38篇，其中SCI收錄論文10餘篇，第一作者或通訊作者6篇，累計影響因子高於76，單篇影響因子最高達11.502。SCI收錄
1. Yang J, Aittomaki S, Pesu M, Carter K, Saarinen J, Kalkkinen N, Kieff E, Silvennoinen O. Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. EMBO J. 2002 Sep 16;21(18):4950-4958. (IF:8.993)
2. Aittomaki S, Yang J, Scott EW, Simon MC, Silvennoinen O. Distinct functions for signal transducer and activator of transcription 1 and PU.1 in transcriptional activation of Fc gamma receptor I promoter.Blood. 2002 Aug 1;100(3):1078-1080. (IF:10.555)
3. Ungureanu D, Vanhatupa S, Kotaja N, Yang J,Aittomaki S, Janne OA, Palvimo JJ, Silvennoinen O. PIAS proteins promote SUMO-1 conjugation to STAT1. Blood. 2003 Nov 1;102(9):3311-3313. (IF:10.555)
4. Paukku K, Yang J,Silvennoinen O. Tudor and nuclease-like domains containing protein p100 function as coactivators for signal transducer and activator of transcription 5. Mol Endocrinol. 2003 Sep;17(9):1805-1814. (IF:5.257)
5. Aittomaki S, Yang J, Scott EW, Simon MC, Silvennoinen O. Molecular basis of Stat1 and PU.1 cooperation in cytokine-induced Fcgamma receptor I promoter activation. Int Immunol. 2004 Feb;16(2):265-274. (IF:3.403)
6. Valineva T, Yang J,Palovuori R, Silvennoinen O. The transcriptional co-activator protein p100 recruits histone acetyltransferase activity to STAT6 and mediates interaction between the CREB-binding protein and STAT6. J Biol Chem. 2005 Apr 15;280(15):14989-14996. (IF:5.328).
7. Valineva T, Yang J,Silvennoinen O. Characterization of RNA helicase A as component of STAT6-dependent enhanceosome. Nucleic Acids Res. 2006;34(14):3938-3946. (IF:7.479)
8. Wang Y, Yang J, Gao Y, Dong LJ, Liu S, Yao Z. Reciprocal Regulation of 5alpha-Dihydrotestosterone, Interleukin-6 and Interleukin-8 During Proliferation of Epithelial Ovarian Carcinoma. Cancer Biol Ther. 2007 Mar 1;6(6): 864-871 (IF:2.711)
9. Shaw N, Zhao M, Cheng C, Xu H, Saarikettu J, Li Y, Da Y, Yao Z, Silvennoinen O, Yang J, Liu ZJ, Wang BC, Rao Z. The multifunctional human p100 protein 'hooks' methylated ligands. Nat Struct Mol Biol. 2007 Aug;14(8):779-784. (IF:12.273)
10. Yang J,Valineva T, Hong J, Bu T, Yao Z, Jensen ON, Frilander MJ, Silvennoinen O. Transcriptional co-activator protein p100 interacts with snRNP proteins and facilitates the assembly of the spliceosome. Nucleic Acids Res. 2007; 35(13):4485-4494. （IF:7.479）
11. Li H, Wang Y, Gao Y, Shao J, Zhao X, Deng W, Liu Y, Yang J, Yao Z. Effects of Raf kinase inhibitor protein expression on metastasis ans progression of human epithelial ovarian cancer. Mol. Cancer Res. 2008;6(6): 917-928 (IF:4.162)
12. Wang Y, Liu Y, Han R, Yang J, Zhi Z, Zhang Y, Yao Z, Gao W, Shwn Z. Temporal evolution of soluble Fas and Fas ligand in patients with orthotopic liver transplantation. Cytokine. 2008; 41(3): 240-243 (IF:3.123
13. Li H, Wang Y, Gao Y, Zhao X, Liu Y, Sun B,Yang J, Yao Z. Effects of raf kinase inhibitor protein expression on metastasis and progression of human breast cancer. Mol. Cancer Res. 2009;7(6): 832-840 (IF:4.162)
14. Yang J, Wang Y, Gao Y, Shao J, Zhang X, Yao Z. Reciprocal regulation of 17β-estradiol, interleukin-6 and interleukin-8 during growth and progression of epithelial ovarian cancer. Cytokine 2009;46(3): 382-391 (IF:3.123)
15. Saarikettu J, Ovod V, Vuoksio M, Grönholm J,Yang J, Silvennoinen O. Monoclonal antibodies against human Tudor-SN. Hybridoma (Larchmt). 2010 Jun;29(3):231-236 (IF:0.284)
16. Liu X, Dong L, Zhang X, Wang B, Wang X, Li H, He J, Ge L, Yao Z, Jing X, Yang J. Identification of p100 protein target promoters by chromatin immunoprecipitation Guided Ligation and Selection (ChIP-GLAS). Cell. Mol. Immunology 2010，8(1)：88-91. (IF :2.765)
17. Wang X, Liu X, Fang J, Lu Y, He J, Yao X, Yao Z, Yang J. Coactivator p100 protein enhances STAT6-dependnent transcriptional activation but has no effect on STAT1-mediated gene transcription. Anat. Rec. 2010; 293(6): 1010-1016 (IF:1.49)
18. Wang Z, Shao J, Zhou Q, Liu J, Zhu Y, Yang J, Wei M. The -251A>T polymorphism of interleukin-8 is associated with longer mechanical ventilation and hospital staying after coronary surgery. Cytokine. 2010; 50(3): 268-272 (IF:3.123)
19. Gao X, Ge L, Shao J, Su C, Zhao H, Saarikettu J, Yao X, Yao Z, Silvennoinen O, Yang J. Tudor-SN interacts with and co-localizes with G3BP in stress granules under stress conditions. FEBS Lett. 2010; 584: 3525-3532（IF:3.541）
20. Zhang G, Jing X, Wang X, Shi W, Sun P, Su C, Zhu M, Yang Z, Yao Z, Yang J. Contribution of the proinflammatory cytokine IL-18 in the formation of human nasal polyps [J]. Anat Rec (Hoboken). 2011，294(6):953-960 （IF:1.49）
21. Dong L, Zhang X, Fu X, Zhang X, Gao X, Zhu M, Wang X, Yang Z, Jensen ON, Saarikettu J, Yao Z, Silvennoinen O, Yang J. PTB-associated splicing factor (PSF) functions as a repressor of STAT6-mediated Ig epsilon gene transcription by recruitment of HDAC1.J Biol Chem. 2011 Feb 4;286(5):3451-9.（IF:5.328）
