楊利峰，女，博士，中國農業大學動物醫學院副教授、博士生導師。
基本介紹
- 中文名：楊利峰
- 出生日期：1980年7月
- 學位/學歷：博士
- 任職院校：中國農業大學
- 性別：女
研究方向,擔任職務,學術成果,科研項目,發表論文,
研究方向
主要從事獸醫病理學的教學與研究工作，研究方向為傳染性海綿狀腦病致病的分子機制及診斷方法的研究。在Prion疾病中，錯誤摺疊蛋白蓄積機制及其引起神經元損傷的分子機制方面做了較深入系統的研究。
擔任職務
現任中國畜牧獸醫學會獸醫病理學分會第九屆理事會副理事長兼秘書長、中國藥學會毒性病理專業委員會委員、中國獸醫協會標準化技術委員會委員、中國獸醫協會實驗動物獸醫分會委員、中國獸醫病理學家、國家科技專家庫專家、中國無公害農產品評審委員會評審專家、北京市優秀人才評審專家、中國實驗動物學會會員、中國藥學會會員；擔任《實驗動物科學》期刊第七屆編委會委員、Cellular and Molecular Life Sciences、Oncotarget、Neurobiology of Diseases、Scientific Reports、Journal of Alzheimer diseases、 Frontiers neuroscience、 Frontiers in cellular neuroscience 等雜誌評審；《中國實驗動物學報》、《中國比較醫學雜誌》、《遺傳》、《中國農業科學》、《實驗動物科學》雜誌特約審稿人。
學術成果
科研項目
作為項目主持人，已承擔國家及省部級科研課題21項，獲批國家發明專利6項（均為第一完成人）；獲得教育部成果鑑定2項（第三完成人）；
發表論文
在國內外知名期刊上發表學術論文150餘篇， SCI收錄期刊論文80篇。以第一作者及通訊作者發表SCI收錄期刊論文38篇；出版教材、著（譯）作15部，累計900餘萬字。其代表論文有：
1.Syed Zahid Ali Shah, Zhao De Ming, Tariq Hussain, Naveed Sabir and Lifeng Yang*. Regulation of MicroRNAs-Mediated Autophagic Flux: A New Regulatory Avenue for Neurodegenerative Diseases with Focus on Prion Diseases. Frontiers in Aging Neuroscience.2018,Online. IF:4.602（通訊作者）
2.Mengyu Lai，Hao Yao, Syed Zahid Ali Shah, Wei Wu, Di Wang, Ying Zhao, Lu Wang, Xiangmei Zhou, Deming Zhao, Lifeng Yang* . The NLRP3-Caspase 1 inflammasome negatively regulates autophagy via TLR4-TRIF in Prion peptide-infected microglia. Frontiers in Aging Neuroscience. 2018,Online. IF:4.602（通訊作者）
3.Chaosi Li, Di Wang, Wei Wu, Wei Yang, Ying Zhao, Yuhan Duan, Wang Lu, Xiangmei Zhou, Deming Zhao, Lifeng Yang*. DLP1-dependent mitochondrial fragmentation and redistribution mediate prion-associated mitochondrial dysfunction and neuronal death. Aging Cell, 2018 Feb;17(1). IF: 6.714（通訊作者）
4.Syed Zahid Ali Shah, Deming Zhao, Tariq Hussain and Lifeng Yang*. Role of the AMPK Pathway in Promoting Autophagic Flux via Modulating Mitochondrial Dynamics in Neurodegenerative Diseases: Insight into Prion Diseases. Ageing Research Reviews . 2017 Nov;40:51-63. IF: 8.084（通訊作者）
5.Syed Zahid Ali Shah, Deming Zhao, Tariq Hussain, Lifeng Yang*.The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases. Frontiers in aging neuroscience. 2017 May 1;9:120. IF: 4.504（通訊作者）
6.Wei Yang， Li-feng Yang， Zhi-qi Song, Syed Zahid Ali Shah, Yong-yong Cui, Chao-si Li, Hua-fen Zhao, Hong-li gao, Xiang-mei Zhou, and De-ming Zhao*. PRAS40 alleviates neurotoxic prion peptide-induced apoptosis via mTOR-AKT signaling, CNS Neuroscience & Therapeutics. 2017 May;23(5):416-427. IF: 4.061（共同第一作者）
7.Syed Zahid Ali Shah#, Deming Zhao，Giulio Taglialatela, Sher Hayat Khan, Tariq Hussain, Haodi Dong, Mengyu Lai, Xiangmei Zhou and Lifeng Yang*. Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration,and Behavioral Deficits in Prion-Infected Hamsters, Neurotherapeutics. 2017 Apr;14(2):463-483. IF:5.615（通訊作者）
8.Syed Zahid Ali Shah, Tariq Hussain, Deming Zhao, and Lifeng Yang*. A Central Role for Calcineurin in Protein Misfolding Neurodegenerative Diseases, Cellular and Molecular life Science. 2017 Mar;74(6):1061-1074. IF:5.788（通訊作者）
9.Chunyu Wang, Deming Zhao， Syed Zahid Ali Shah, Wei Yang, Chaosi Li, and Lifeng Yang* . Proteome Analysis of Potential Synaptic Vesicle Cycle Biomarkers. Molecular Neurobiology. 2017 Sep;54(7):5177-5191. IF:6.190（通訊作者）
10.Khan SH， Zhao D，Shah SZ, Hassan MF, Zhu T, Song Z, Zhou X, Yang L*. Parkin Overexpression Ameliorates PrP106-126-Induced Neurotoxicity via Enhanced Autophagy in N2a Cells .Cellular and Molecular Neurobiology. 2017 May, 37:717–728. IF:2.939（通訊作者）
11.Li Chaosi, Syed Zahid Ali Shah, Zhao Deming, Lifeng Yang*. Role of Retromer Complex in Neurodegenerative Diseases. Frontiers in Aging Neuroscience. 2016 Mar 1;8:42. IF:4.725（通訊作者）
12.Ting Zhu，Deming Zhao，Zhiqi Song, Zhen Yuan, Chaosi Li, Yunsheng Wang, Xiangmei Zhou, Xiaomin Yin, Muhammad Farooque Hassan, Lifeng Yang*. HDAC6 alleviates prion peptide-mediated neuronal death via modulating PI3K-Akt-mTOR pathway. Neurobiology of Aging. 2016 Jan;37:91-102.IF: 5.22 （通訊作者）
13.Syed Zahid Ali Shah, Deming Zhao，Khan SH, Lifeng Yang*. Unfolded Protein Response Pathways in Neurodegenerative Diseases. Journal of Molecular Neuroscience. 2015 Dec;57(4):529-37.IF:2.891（通訊作者）
14.Yongyao Fu， Deming Zhao, Bo Pan, Jihong Wang, Yongyong Cui, Fushan Shi, Chunyu Wang, Xiaoming Yin, Xiangmei Zhou, Lifeng Yang*. Proteomic analysis of protein expression throughout disease progression in a mouse model of Alzheimer’s disease. J Alzheimers Dis. 2015 Aug 11;47(4):915-26.IF:4.365（通訊作者）
15.Yunsheng Wang， Deming Zhao， Bo Pan, Zhiqi Song, Syed Zahid Ali Shah , Xiaomin Yin, Xiangmei Zhou, Lifeng Yang *. Death receptor 6 and caspase 6 regulate Prion Peptide -induced axonal degeneration in rat spinal neurons. Journal of Molecular Neuroscience. 2015 Aug;56(4):966-76. IF:2.891（通訊作者）
16.Zhiqi Song, Deming Zhao, Huajia Zhao, Lifeng Yang*. NRSF：an angel or a devil in Neurogenesis and neurological diseases. Journal of molecular neuroscience. 2015 May;56(1):131-44. IF:2.891（通訊作者）
17.Zhu Lin，Deming Zhao ， Yunsheng Wang, Wei Zhao, Xiaomin Yin, Xiangmei Zhou, Zhongqiu Zhang, Lifeng Yang *. Downregulation of Beta-soluble NSF Attachment Protein (β-SNAP): Proteomics-based Identification in Early-stage Prion Disease. Neurodegenerative Diseases. 2015;15(4):193-201. IF:3.454（通訊作者）
18.Zhen Yuan, Lifeng Yang, Baian Chen, Ting Zhu, Mohammad Farooque Hassan, Xiaomin Yin, Xiangmei Zhou, Deming Zhao*. Protein misfolding cyclic amplification (PMCA) induces the conversion of recombinant prion protein to PrP oligomers causing neuronal apoptosis. Journal of Neurochemistry. 2015 Jun;133(5):722-9. IF:4.244（共同第一作者）
19.Syed Zahid Ali Shah#, Deming Zhao#, Lifeng Yang*. Regulatory Mechanisms of Endoplasmic Reticulum Resident IP3 Receptors. Journal of Molecular Neuroscience. 2015 Aug;56(4):938-48. IF:2.891（通訊作者）
20.Bo Pan， Lifeng Yang, Jin Wang, Yunsheng Wang , Jihong Wang, Xiangmei Zhou, Xiaomin Yin,Zhongqiu Zhang, Deming Zhao*. c-Abl tyrosine kinase mediates neurotoxic prion peptide-induced neuronal apoptosis via regulating mitochondrial homeostasis. Molecular Neurobiology. 2014, Apr;49(2):1102-16. IF:5.535（共同第一作者）
