梁興偉

梁興偉，男，博士，廣西大學教授。

基本介紹

• 中文名：梁興偉
• 學位/學歷：博士
• 職業：教師
• 專業方向：哺乳動物植入前胚胎MZT過程及相關機制
• 任職院校：廣西大學

個人經歷

2017-01至現在，廣西大學學術帶頭人，廣西高校引進海外高層次人才“百人計畫”入選者。

2017年以前先後在中科院動物所、韓國忠北國立大學、美國華盛頓州立大學從事博士後研究工作。

學術兼職

《Endocrinology》，《Human Reproduction》，《Molecular Human Reproduction》，《Reproduction》，《Protein & Cell》，《Scientific Reports》,《Oncotarget》，《Pakistan Journal of Zoology》，《The Journal of Veterinary Medical Science》，《Reproductive Toxicology》和《Journal of Cellular Physiology》雜誌的特邀審稿人。

中國動物學會細胞與分子顯微技術分會理事。

主講課程

本科生：專業英語

研究生：細胞生物學實驗技術，胚胎生物技術與操作訓練

研究方向

1，環境應激（毒物、代謝異常等）對哺乳動物卵母細胞成熟、早期胚胎髮育的影響及相關機制

2，哺乳動物植入前胚胎MZT過程及相關機制

學術成果

1，環境應激（毒物、代謝異常等）對哺乳動物卵母細胞成熟、早期胚胎髮育的影響及相關機制

2，哺乳動物植入前胚胎MZT過程及相關機制

2018至現在

1. Sui L, Nie J, Xiao P, Yan K, Zhang H, Liu JH, Zhang H, Cui KX, Lu K, Liang X.: Maternal benzo[a]pyrene exposure is correlated with the meiotic arrest and quality deterioration of offspring oocytes in mice. Reproductive toxicology. 2019;93:10-8.

2. Nie J, Sui L, Zhang H, Zhang H, Yan K, Yang X, Lu S, Lu K, Liang X.: Mogroside V protects porcine oocytes from in vitro ageing by reducing oxidative stress through SIRT1 upregulation. Aging. 2019;11(19):8362-73.

3. Nie J, Yan K, Sui L, Zhang H, Zhang H, Yang X, Lu S, Lu K, Liang X.: Mogroside V improves porcine oocyte in vitro maturation and subsequent embryonic development. Theriogenology. 2020;141:35-40

4. Xiao P, Nie J, Wang X, Lu K, Lu S, Liang X.: Melatonin alleviates the deterioration of oocytes from mice subjected to repeated superovulation. Journal of Cellular Physiology, 2019;234(8):13413-22.

5. Nie J., Xiao P., Wang X., Yang X., Xu H., Lu K., Lu S., Liang X.: Melatonin prevents deterioration in quality by preserving epigenetic modifications of porcine oocytes after prolonged culture. Aging 2018;10(12):3897-3909.

6. Xu H. Y., Geng S. S., Li T. T., Fu Q., Lu S. S., Liang X. W., Lu Y. Q., Zhang M., Yang X. G., Lu K. H.: Maturation of buffalo oocytes invitro with acetyl-l-carnitine improves cryotolerance due to changes in mitochondrial function and the membrane lipid profile. Reproduction, fertility, and development 2018;

7. Xu H. Y., Yang X. G., Lu S. S., Liang X. W., Lu Y. Q., Zhang M., Lu K. H.: Treatment with acetyl-l-carnitine during in vitro maturation of buffalo oocytes improves oocyte quality and subsequent embryonic development. Theriogenology 2018;118:80-89

8. Zhao H., Nie J., Zhu X., Lu Y., Liang X., Xu H., Yang X., Zhang Y., Lu K., Lu S.: In vitro differentiation of spermatogonial stem cells using testicular cells from Guangxi Bama mini-pig. J Vet Sci 2018;19:592-599

9. Zhu M. J., Kang Y., Xue Y., Liang X., Garcia M. P. G., Rodgers D., Kagel D. R., Du M.: Red raspberries suppress NLRP3 inflammasome and attenuate metabolic abnormalities in diet-induced obese mice. The Journal of nutritional biochemistry 2018;53:96-103

2018年以前

1. Liang X, Yang Q, Fu X, Rogers CJ, Wang B, Pan H, Zhu MJ, Nathanielsz PW, Du M: Maternal obesity epigenetically alters visceral fat progenitor cell properties in male offspring mice. The Journal of physiology 2016;594:4453-4466

2. Liang X, Yang Q, Zhang L, Maricelli JW, Rodgers BD, Zhu MJ, Du M: Maternal high-fat diet during lactation impairs thermogenic function of brown adipose tissue in offspring mice. Scientific reports 2016;6:34345

3. Yang Q#, Liang X#, Sun X, Zhang L, Fu X, Rogers CJ, Berim A, Zhang S, Wang S, Wang B, Foretz M, Viollet B, Gang DR, Rodgers BD, Zhu MJ, Du M: AMPK/alpha-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis. Cell metabolism 2016;24:542-554 (#Co-first author) （Science子刊）Science Signaling專文評述，

4. Liang XW, Cui XS, Sun SC, Jin YX, Heo YT, Namgoong S, Kim NH: Superovulation induces defective methylation in line-1 retrotransposon elements in blastocyst. Reproductive biology and endocrinology : RB&E 2013;11:69

5. Liang X, Ma J, Schatten H, Sun Q: Epigenetic changes associated with oocyte aging. Science China Life Sciences 2012;55:670-676

6. Liang XW, Ge ZJ, Wei L, Guo L, Han ZM, Schatten H, Sun QY: The effects of postovulatory aging of mouse oocytes on methylation and expression of imprinted genes at mid-term gestation. Molecular human reproduction 2011;17:562-567

7. Liang XW, Ge ZJ, Guo L, Luo SM, Han ZM, Schatten H, Sun QY: Effect of postovulatory oocyte aging on DNA methylation imprinting acquisition in offspring oocytes. Fertility and sterility 2011;96:1479-1484

8. Liang XW, Zhu JQ, Miao YL, Liu JH, Wei L, Lu SS, Hou Y, Schatten H, Lu KH, Sun QY: Loss of methylation imprint of Snrpn in postovulatory aging mouse oocyte. Biochemical and biophysical research communications 2008;371:16-21

9. Guan L, Hu X, Liu L, Xing Y, Zhou Z, Liang X, Yang Q, Jin S, Bao J, Gao H, Du M, Li J, Zhang L: bta-miR-23a involves in adipogenesis of progenitor cells derived from fetal bovine skeletal muscle. Scientific reports 2017;7:43716

10. Wang S, Liang X, Yang Q, Fu X, Zhu M, Rodgers BD, Jiang Q, Dodson MV, Du M: Resveratrol enhances brown adipocyte formation and function by activating AMP-activated protein kinase (AMPK) alpha1 in mice fed high-fat diet. Mol Nutr Food Res 2017;61

11. Li MQ, Luo AL, Zhao PW, Li TT, Geng SS, Liang XW, Xu HY, Lu YQ, Lu SS, Yang XG, Lu KH: Nanos2 is a molecular marker of inchoate buffalo spermatogonia. Animal reproduction science 2017;186:44-51

12. Meng Y, Zhang J, Zhang F, Ai W, Zhu X, Shu G, Wang L, Gao P, Xi Q, Zhang Y, Liang X, Jiang Q, Wang S: Lauric Acid Stimulates Mammary Gland Development of Pubertal Mice through Activation of GPR84 and PI3K/Akt Signaling Pathway. J Agric Food Chem 2017;65:95-103

13. Wang B, Fu X, Liang X, Deavila JM, Wang Z, Zhao L, Tian Q, Zhao J, Gomez NA, Trombetta SC, Zhu MJ, Du M: Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRalpha(+) adipose progenitors. Cell Discov 2017; 3:17036

14. Wang B, Fu X, Liang X, Wang Z, Yang Q, Zou T, Nie W, Zhao J, Gao P, Zhu MJ, de Avila JM, Maricelli J, Rodgers BD, Du M: Maternal Retinoids Increase PDGFRalpha(+) Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development. EBioMedicine 2017;18:288-299

15. Zhao J, Yang Q, Zhang L, Liang X, Sun X, Wang B, Chen Y, Zhu M, Du M: AMPKalpha1 deficiency suppresses brown adipogenesis in favor of fibrogenesis during brown adipose tissue development. Biochemical and biophysical research communications 2017;491:508-514

16. Wang S, Liang X, Yang Q, Fu X, Rogers CJ, Zhu M, Rodgers BD, Jiang Q, Dodson MV, Du M: Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) alpha1. International journal of obesity 2015;39:967-976

17. Wei S, Fu X, Liang X, Zhu MJ, Jiang Z, Parish SM, Dodson MV, Zan L, Du M: Enhanced mitogenesis in stromal vascular cells derived from subcutaneous adipose tissue of Wagyu compared with those of Angus cattle. Journal of animal science 2015;93:1015-1024

18. Wang B, Yang G, Liang X, Zhu M, Du M: Grape seed extract prevents skeletal muscle wasting in interleukin 10 knockout mice. BMC complementary and alternative medicine 2014;14:162

19. Ge ZJ, Liang XW, Guo L, Liang QX, Luo SM, Wang YP, Wei YC, Han ZM, Schatten H, Sun QY: Maternal diabetes causes alterations of DNA methylation statuses of some imprinted genes in murine oocytes. Biology of reproduction 2013;88:117

20. Ou XH, Li S, Wang ZB, Li M, Quan S, Xing F, Guo L, Chao SB, Chen Z, Liang XW, Hou Y, Schatten H, Sun QY: Maternal insulin resistance causes oxidative stress and mitochondrial dysfunction in mouse oocytes. Human reproduction 2012;27:2130-2145

21. Ma JY, Liang XW, Schatten H, Sun QY: Active DNA demethylation in mammalian preimplantation embryos: new insights and new perspectives. Molecular human reproduction 2012;18:333-340

22. Guo L, Qi ST, Miao DQ, Liang XW, Li H, Ou XH, Huang X, Yang CR, Ouyang YC, Hou Y, Sun QY, Han Z: The roles of parathyroid hormone-like hormone during mouse preimplantation embryonic development. PloS one 2012;7:e40528

23. Wang K, Jiang GJ, Wei L, Liang XW, Miao DQ, Sun SC, Guo L, Wang ZB, Lu SS: Survivin is a critical regulator of spindle organization and chromosome segregation during rat oocyte meiotic maturation. Zygote 2011;19:307-313

24. Wei L, Liang XW, Zhang QH, Li M, Yuan J, Li S, Sun SC, Ouyang YC, Schatten H, Sun QY: BubR1 is a spindle assembly checkpoint protein regulating meiotic cell cycle progression of mouse oocyte. Cell cycle 2010;9:1112-1121

25. Zhu JQ, Zhu L, Liang XW, Xing FQ, Schatten H, Sun QY: Demethylation of LHR in dehydroepiandrosterone-induced mouse model of polycystic ovary syndrome. Molecular human reproduction 2010;16:260-266

26. Lin S-L, Yan L-Y, Liang X-W, Wang Z-B, Wang Z-Y, Qiao J, Schatten H, Sun Q-Y: A novel variant of ER-alpha, ER-alpha36 mediates testosterone-stimulated ERK and Akt activation in endometrial cancer Hec1A cells. Reproductive Biology and Endocrinology 2009;7:102

27. Sun SC, Wei L, Li M, Lin SL, Xu BZ, Liang XW, Kim NH, Schatten H, Lu SS, Sun QY: Perturbation of survivin expression affects chromosome alignment and spindle checkpoint in mouse oocyte meiotic maturation. Cell cycle 2009;8:3365-3372

28. Zhu JQ, Liu JH, Liang XW, Xu BZ, Hou Y, Zhao XX, Sun QY: Heat stress causes aberrant DNA methylation of H19 and Igf-2r in mouse blastocysts. Molecules and cells 2008;25:211-215

29. Liu J, Liang X, Zhu J, Wei L, Hou Y, Chen DY, Sun QY: Aberrant DNA methylation in 5' regions of DNA methyltransferase genes in aborted bovine clones. In Journal of genetics and genomics = Yi chuan xue bao, 2008, p. 559-568

30. Liu J-H, Zhu J-Q, Liang X-W, Yin S, Safiriyu Idowu O, Hou Y, Chen D-Y, Schatten H, Sun Q-Y: Diploid parthenogenetic embryos adopt a maternal-type methylation pattern on both sets of maternal chromosomes. Genomics 2008;91:121-128

31. Lu YQ, Liang XW, Zhang M, Wang WL, Kitiyanant Y, Lu SS, Meng B, Lu KH: Birth of twins after in vitro fertilization with flow-cytometric sorted buffalo (Bubalus bubalis) sperm. Animal reproduction science 2007;100:192-196