人物經歷
教育經歷
2004/09-2008/06:華中師範大學,化學學院,化學/生物學雙學位,學士
2008/09-2013/06:中山大學,藥學院,藥物化學,博士
工作經歷
2013/07-2016/09:暨南大學,藥學院,講師
2016/10-2023/09:暨南大學,藥學院,副教授
2017/08-2017/11:新加坡南洋理工大學,環境生命科學工程中心,訪問學者
2023/10-至今:暨南大學,藥學院,教授
研究方向
抗菌及抗細菌生物膜藥物的發現與機制研究
新型核酸靶向性抗感染藥物研究
講授課程
《藥物化學》(本科生)
《藥物化學實驗》(本科生)
《創新藥物設計與研究綜合大實驗》(本科生)
《生物醫藥綜合實驗基本技能》(本科生)
《微生物藥物學》(研究生)
學術成果
代表性科研項目
(1)國家自然科學基金面上項目(82273765),C-di-GMP G-四鏈體誘導劑偶聯NO供體的細菌生物膜抑制及分散雙功效藥物研究(2023/01-2026/12)
(2)國家自然科學基金青年基金項目(81402774),基於一葉鹼胺基酸軛合物設計合成靶向突變型IHD1抗膠質瘤藥物研究(2015/01-2017/12)
(3)廣州市珠江科技新星項目(201806010116),新型木豆素類廣譜抗菌劑的發現與靶點研究(2018/04-2021/03)
(4)廣東省自然科學基金面上項目(2019A1515011801),靶向細菌信號分子c-di-GMP的新型細菌生物膜抑制劑研究(2019/10-2022/09)
(5)暨南大學科研培育與創新基金面上項目(21617478),基於細菌生物膜耐藥的抗慢性感染藥物設計與合成(2017/01-2018/12)
代表性論文和專著
(1) Hai-Tao Yu, Jie-Jiao Liu, Qian-Wen Lin, Jnu Liu, Si-Ming Yu*,Ping-Hua Sun*, Jing Lin*. Glutathione-Responsive SulfurDioxide-Releasing Dendronized Chitooligosaccharide Polymer for EffectiveTreatment of Multidrug-Resistant Bacterial Infection. Chemical Engineering Journal,2023, 474: 145316.
(2) ZhuoyingLiang, WenkangLiu, ZiqiangWang, PeilianZheng, WeiLiu, JianfuZhao, YunlongZhong, YanZhang, JingLin*, WeiXue*, SimingYu*, Near-infrared laser-controlled nitric oxide-releasing goldnanostar/hollow polydopamine Janus nanoparticles for synergistic elimination ofmethicillin-resistant Staphylococcus aureus and wound healing.Acta Biomaterialia, 2022, 143: 428-444.
(3) Chan Shan, Jing Lin, Jin-QiangHou, Shuo-Bin Chen, Ai-Chun Chen, Tian-Miao Ou*, Jia-Heng Tan, Ding Li,Lian-Quan Gu, Zhi-Shu Huang*. Chemical Intervention of the NM23-H2Transcriptional Programme on c-MYC via a Novel Small Molecule. Nucleic Acids Research, 2015, 15(6): 744-754.
(4) Qian-Wen Lin, Jin-Qiang Lu, Ye-Si Huang, Jie-Jiao Liu, Wei-MinChen*, Jing Lin*.Cyclic Diguanylate G-Quadruplex Inducer-Nitric Oxide Donor Conjugate as aBifunctional Antibiofilm Agent and Antibacterial Synergistagainst Pseudomonas aeruginosa with a Hyperbiofilm Phenotype.Journal of Medicinal Chemistry, 2023,66(17):11927-11939.
(5) Teng-Fei Xuan, Zi-Qiang Wang, Jun Liu,Hai-Tao Yu, Qian-Wen Lin, Wei-Min Chen*, Jing Lin*. Design and Synthesisof Novel c-di-GMP G-Quadruplex Inducers as Bacterial Biofilm Inhibitors.Journal of Medicinal Chemistry, 2021, 64 (15): 11074-11089.
(6) Zhi-Ying Miao, Xiao-Yi Zhang, Ming-Han Yang, Yong-Jun Huang, Jing Lin*, Wei-Min Chen*.3-Hydroxypyridin-4(1H)-one Derivatives as Pqs Quorum Sensing InhibitorsAttenuate Virulence and Reduce Antibiotic Resistance in Pseudomonas aeruginosa.Journal of Medicinal Chemistry, 2023, 66(23): 15823-15846.
(7) Yuan-Yuan Wang, Xiao-Yi Zhang, Xiao-Lin Zhong, Yong-Jun Huang, Jing Lin*, and Wei-Min Chen*. Design and Synthesis of 3‑Hydroxy-pyridin-4(1H)‑ones−CiprofloxacinConjugates as Dual Antibacterial and Antibiofilm Agents against Pseudomonas aeruginosa. Journal of Medicinal Chemistry, 2023,66, 2169-2193.
(8) Jun Liu, Jin-Song Hou, Yi-QunChang, Li-Jun Peng, Xiao-Yi Zhang, Zhi-Ying Miao, Ping-HuaSun*, Jing Lin*, and Wei-MinChen*. New Pqs Quorum Sensing System Inhibitor as an Antibacterial Synergistagainst Multidrug-Resistant Pseudomonas aeruginosa. Journal of Medicinal Chemistry, 2022, 65(1): 688-709.
(9) Jun Liu, Jin-Song Hou, Yi-Bin Li, Zhi-Ying Miao, Ping-Hua Sun*, Jing Lin*, Wei-Min Chen*. Novel2-Substituted 3-Hydroxy-1,6-dimethylpyridin-4(1H)-ones as Dual-Acting BiofilmInhibitors of Pseudomonas aeruginosa. Journal of Medicinal Chemistry, 2020, 63(19):10921-10945.
(10) Tian-Miao Ou, Jing Lin, Yu-Jing Lu, Jin-Qiang Hou, Jia-Heng Tan, Shu-Han Chen, Zeng Li,Yan-Ping Li, Ding Li, Lian-Quan Gu*, Zhi-Shu Huang*. Inhibition of Cell Proliferation by QuindolineDerivative SYUIQ-05 through its Preferential Interaction with c-myc PromoterG-Quadruplex. Journal of Medicinal Chemistry, 2011, 54: 5671-5679.
代表性專利
(1)苯並噻唑類化合物及其在製備細菌生物膜抑制劑中的套用,中國發明專利,已授權,專利號:ZL201910162777.0。
(2)含有苯並噻唑類化合物的螢光探針在檢測細菌信使分子c-di-GMP中的套用,中國發明專利,已授權,專利號:ZL 201910598487.0。
(3)木豆素結構類似物及其在製備抗菌藥物中的套用,中國發明專利,已授權,專利號:ZL201410570796.4。