林古法，中科院上海生命科學研究院博士，同濟大學生命科學與技術學院教授，博士生導師。
基本介紹
- 中文名：林古法
- 畢業院校：中科院上海生命科學研究院
- 學位/學歷：博士
- 職務：博士生導師
人物經歷,研究領域,論文論著,
人物經歷
本科就讀上海醫科大學，畢業後曾任青島大學醫學院附屬醫院住院醫師。研究生就讀中科院上海生命科學研究院師從丁小燕研究員，獲發育生物學博士學位。博士後合作導師為英國巴斯大學JMW Slack教授。曾任美國明尼蘇達大學研究助理、助理教授。現為同濟大學生命科學與技術學院教授、脊柱脊髓損傷再生修復教育部重點實驗室（同濟大學）研究員。
研究領域
實驗室研究方向為器官再生機理及誘導哺乳動物器官再生的途徑。
主要研究內容為爪蛙、蠑螈與小鼠動物器官再生的細胞及分子生物學、表觀遺傳及代謝調控機制。此外，實驗室亦致力於利用誘導多能幹細胞（iPSC）探討多能前體細胞移植在器官損傷修復與再生中的套用前景。實驗室已建立了三維培養誘導類肢芽器官及獲取肢芽前體細胞、通過移植含有胚胎肢芽前體細胞和生長因子組合的凝膠纖維蛋白骨架（fibrin scaffold）建立了誘導斷肢再生的技術方法，可以促進小鼠斷趾再生。
論文論著
Book Chapters:
1.Chen Y, Lin G. (2014). Xenopus model for regeneration. XenopusDevelopment, Edited by Kubiak J & Kloc M. Willy-Blackwell Publishing. corresponding author
2.Leng H, Lin G and Chen Y. (2013). Cellular Origins of Amphibian Regeneration. Progenitor Cells: Biology, Characterization and Potential Clinical Applications, Edited by Horton P. and Lawrence B. Nova Publishers, New York (book chapter).corresponding author
Peer-reviewed publications:
1. Tai X, Xue S, Zhang C, Liu Y, Chen J, HanY, Lin G*, Zhang C*. Pharmacological evaluation of MRAP proteins on Xenopusneural melanocortin signaling. J Cell Physiol. 2021 Jan 31. doi:10.1002/jcp.30306. PMID: 33521982.
2. Xu H, Zhang H, Fang Y, Yang H, Chen Y,Zhang C, Lin G*. Activation of the Melanocortin-4 receptor signaling by a-MSH stimulates nerve-dependent mousedigit regeneration. Cell Regeneration, 2021 May 3;10(1):19. doi:10.1186/s13619-021-00081-9.
3. Li L, Zheng J, Xu Y, Kuang Z, Zhang C, LiN, Lin G*, Zhang C*. Pharmacological modulation of dual melanocortin-4 receptorsignaling by melanocortin receptor accessory proteins in the tetrapod XenopusLaevis. J Cell Physiol. 2021;236:5980-5993. https://doi.org/10.1002/jcp.30280.
4. Shen J, Hu L, Yang L, Zhang M, Sun W, LuX, Lin G, Huang C, Zhang X, Chin YE. (2020) Reversible Acetylation ModulatesDishevelled-2 Puncta Formation in Canonical Wnt Signaling Activation. SigTransduct Target Ther. 06 July 2020.
5. Lin G*, Chen Y. Limb regeneration under check by thenervous system. (2018) Chinese J Cell Biol. DOI: 10.11844/cjcb.2018.11.0202. correspondingauthor. Review.
6.Zhang M, ChenY, Xu H, Yang L, Yuan F, Li L, Xu Y, Chen Y*, Zhang C*, and Lin G* (2018).Melanocortin receptor 4 (Mc4r) signaling regulates vertebrate limbregeneration. Dev Cell.2018.46: 397-409. *corresponding author
7.Zhang M, YangL, Yuan F, Chen Y, and Lin G*. Dicer inactivation stimulates limb regenerationability in Xenopus laevis. Wound Repair and Regeneration. 2018. 26:46-53.*corresponding author
8.ChenY, Xu H, Lin G*. Generation of iPSC-derivedlimb progenitor-like cells for stimulating phalange regeneration in the adultmouse Cell Discovery 2017 (3), 17046; doi:10.1038/celldisc.2017.46.*corresponding author
9.Lin H, Zhu X,Chen G, Song L, Gao L, Khand A, Chen Y, Lin G* and Tao Q*. KDM3A-mediateddemethylation of histone H3 lysine 9 facilitates the chromatin binding ofNeurog2 during neurogenesis. Development 2017, 144:3674-3685. *correspondingauthor
10. Pai, V.P.,Lemire, J.M., Chen, Y., Lin, G., and Levin, M. (2015). Local and long-rangeendogenous resting potential gradients antagonistically regulate apoptosis andproliferation in the embryonic CNS. Int J Dev Biol. 2015, 59:327-340.
11. Pai V, LemireJM, Pare JF, Lin G, Chen Y and Levin M. (2015)Endogenous gradients of resting potential instructively pattern neural tissuevia Notch signalling. J. Neurosci. 35: 4366–4385.
12. Shi X, Jai R,Zirbes K, Gong W, Lin G, Kyba M,Thomson J, Koyano-Nakagawa N and Garry D. (2014). Cooperative interaction ofEtv2 and Gata2 regulates the development of endothelial and hematopoieticlineages Dev. Biol. 389, 208–218..
13. Lin G*, Chen Y.* and Slack JMW. (2013). Imparting regenerative capacity to limbs byprogenitor cell transplantation. Dev. Cell 24: 41-51 * equal contributor. correspondingauthor. (F1000prime recommended: http://f1000.com/prime/717971589?bd=1&ui=22057)
14. Lin G, Chen Y. and Slack JMW. (2012). Transgenic analysis ofsignaling pathways required for Xenopustadpole spinal cord and muscle regeneration. Anat. Rec. 295:1532-1540. correspondingauthor.
15. Chen Y, Lin G, Chen Y, Fok A and Slack JMW.(2012). Micro-computed tomography forvisualizing limb skeletal regeneration in young Xenopus frogs. Anat. Rec. 295: 1562-1565.
16. Lin G and Slack JMW. (2008). Requirement for Wnt and FGFsignaling in Xenopus tadpole tailregeneration. Dev Biol. 316: 323-335.
17. Slack JMW, Lin G and Chen Y. (2008). The Xenopus tadpole: a new model forregeneration research. Cell Mol Life Sci. 65: 54-63.
18. Lin G, Chen Y andSlack JMW. (2007). Regeneration of neural crest derivatives in the Xenopus tadpole tail. BMC DevBiol 7, 56.
19. Chen Y, Lin, G. and Slack, J. M. (2006).Control of muscle regeneration in the Xenopustadpole tail by Pax7. Development 133, 2303-13.
20. Lin G, Geng X, Chen Y, Qu B, Wang F, Hu R and Ding X. (2003). T-box bindingsite mediates the dorsal activation of myf-5 in Xenopus gastrula embryos. DevDyn 226, 51-8.
21. Wu K, Weng Z, Lin G,Wu X, Li F and Zhang Y. (2005). The effect ofbreast cancer specific gene 1 in the prognosis of breast cancer. ChineseJournal of Surgery. 43:294-7 (in Chinese).
22. Wu K, Weng Z, Lin G, Yin M, Qian H, Zhang Y, Ding X.(2004). Significance of breast cancer specific gene 1 expression in breastcancer. Shanghai Medical Journal. 27:193-5 (in Chinese).
23. Lin G, Geng X, Chen Y, Qu B, Wang F, Hu R and Ding X. (2003).T-box binding site mediates the dorsal activation of myf-5 in Xenopus gastrula embryos. DevDyn 226, 51-8.
24. Geng X, Xiao L,Lin G, Hu R, Wang JH, Rupp RA andDing X. (2003). Lef/Tcf-dependent Wnt/beta-catenin signaling during Xenopus axis specification. FEBSLett 547, 1-6.
25. Chen Y, Lin G, Hu R, Chen Y and Ding X. (2003). Activin/Nodalsignals mediate the ventral expression of myf-5 in Xenopus gastrula embryos. Biochem Biophys Res Commun 310,121-7. equal contributor.
26. Wu K, Weng Z,Tao Q, Lin G, Wu X, Qian H, Zhang Y,Ding X, Jiang Y, Shi YE. (2003). Stage-specific expression of breastcancer-specific gene gamma-synuclein. Cancer Epidemiol Biomarkers Prev.12: 920-5.
