林俊生，男，華僑大學分子藥物所教授，有關Connexi43的研究已由紐西蘭和英國投資贊助開發新產品。
基本介紹
- 中文名：林俊生
- 國籍：中國
- 職業：教師
- 性別：男
- 職稱：華僑大學分子藥物所教授
發明經歷,學習經歷,工作經歷,發明專利,學術論文,
發明經歷
開發和鑑定的抗Connexin50單克隆抗體已由美國Zymed公司推向市場．本人論文被指定為該產品套用的主要指導檔案(Zymed research products 2000-2001, P66) 。
發明專利（基因重組成纖維細胞生長因子-8a）已獲中國國家知識產權局正式授權。
基因重組卵泡刺激素卵 (FSH) 已申請發明專利，正在更新。
學習經歷
◆1994-1997 博士(生物化學與分子生物學) 紐西蘭奧克蘭大學生物學院
◆1990-1991 工商管理畢業文憑 澳大利亞Regent商學院
◆1978-1983 醫學士 福建醫大
工作經歷
2007- 華僑大學分子藥物所教授
2006- “長江學者”評審專家
2002-2006 紐西蘭皇家科學院Wallaceville研究中心資深科學家
2003- 福建檢驗檢疫局客座高級研究員
2001- 福建醫大客座教授
2001- 福建省骨科研究所副所長
2001-2002 紐西蘭皇家農牧研究院Wallaceville研究中心科學家(生物工程)
1999-2000 紐西蘭奧克蘭大學醫學院教學研究員(生物醫學)
1997-1999 紐西蘭奧克蘭大學醫學院博士後(分子生物學)
1991-1993 澳大利亞皇家阿爾弗王子醫院整形外科醫師 (新南威爾斯註冊)
1988-1989 福建醫大附屬第一醫院總住院醫師
1983-1987 福建醫大附屬第一醫院住院醫師
發明專利
· 基因重組成纖維細胞生長因子-8a （FGF8a）（ZL01109400.1中國）
· Recombinant ovine follicle-stimulating hormone （522256, is renewing 紐西蘭）
· Aptamer to ovine FSH alpha (in processing紐西蘭）
學術論文
代表性論文：
Journal articles:
Fidler, A. E., Lin, J, S., Lun, S., Ng Chie, W., Western, A., Stent, V., and McNatty, K. P. (2003) Production of biologically active tethered ovine FEHba by the methylotrophic yeast Pichia pastoris. Journal of Molecular Endocrinology, 30, 213-225
Law, L.Y., Lin, J.S., Becker, D.L., and Green, C.R. (2002 Dec) Knockdown of connexin43-mediated regulation of the zone of polarizing activity in the developing chick limb leads to digit truncation. Dev Growth Differ. 44(6):537-47.
Wright, C. S., Becker, D.L., Lin, J.S., Warner, A.E. and Hardy, K. (2001) Stage specific and differential expression of gap junctions in the mouse ovary points to connexin specific roles in follicular regulation. Reproduction, 121(1): 77-88
Eckert, R., Donaldson P., Lin, J S., Bond, J., Green C. Adams B., Merriman-Smith R., Tunstall M., and Kistler J. (2000). Gating of gap junction channels and hemichannels in the lens: a role in cataract? Current Topics in Membranes. 49:343-356.
Kistler, J; Merriman-Smith, R., Young, M., Gonen, T., Cowan, D., Chee, K-S., Lin, J S; Green, C; Hasiler, L., Engel, A. and Donaldson, P. (1999). Molecular solutions to lens transparency. NZ BioScience 7, 35-37
Lin, J.S., Eckert, R., Kistler, J., and Donaldson, P., (1998). Spatial differences in gap junction gating in the lens are a consequence of connexin cleavage. European Journal of Cell Biology. 76, 236-250.
Lin, J.S., Fitzgerald, S., Dong, Y., Knight, C. Donaldson, P., and Kistler, J. (1997). Processing of the gap junction protein connexin50 in the ocular lens is accomplished by calpain. European Journal of Cell Biology. 73, 141-149.
Book Chapters:
Becker, D L., Lin, J S. and Green, C R., (1999) Pluronic gel as a means of antisense delivery. In Antisense technology in the central nervous system., Edited by Leslie, R A., Hunter, A J., and Robertson, H A., Oxford University press, New York, pp149-157.
Green, C.R., Law, L.Y., Lin, J.S. and Becker. D.L. (2000). Spatiotemporal depletion of connexins using antisense oliogonucleotides. In Connexin Methods and Protocols. Part I Chapter 10, Edited by Bruzzone, R. and Giaume, C., Humana Press, New Jersey, pp175-185.
Kistler, J., Lin, J.S., Bond, J., Green, C., Eckert, R., Merriman, R., Tunstall, M. and Donaldson, P. (1999) Connexins in the lens: are they to blame in diabetic cataractogenesis? In Gap junction-mediated intercellular signalling in health and disease. Edited by Gilula, N.B. John Wiley & Sons Ltd, London, pp97-112.
Selected Conference Proceedings:
Lin, J. M., Watson, M., Callon, K., Lin, J., S., Grey, A., B., Naot, D., Reit I., and Cornish, F. (2005) FGF-8 Is Anabolic to Bone. Australian and New Zealand Bone and Mineral Society Annual Meeting
Lin, J. S., Western A., Lun, S., Hudson N., Bauer, E., Ng Chie, W. and McNatty, K. (2004) Production of tethered ovine FSHβα from insect cells. Queenstown Molecular Biology meeting, NZ.
Lin, J. S., Zhang, W., Law, L.Y., Stott, N. S. and Green, C.R. (2000). Upregulation of connexin43 by recombinant fibroblast growth factor (rFGF) 8a and its functional implications. Molecular Biology of the Cell, 11 (Supplement): pp225a.
Lin, J. S., Zhang, W., Law, L.Y., Stott, N. S. and Green, C.R. (2000). Connexin43 gap junction modulation of chondrogenic differentiation. Cell Biology International, 24: pp934.
