杜宇昊，博士，武漢大學化學與分子科學學院 , 副教授。
基本介紹
- 中文名：杜宇昊
- 職業：教師
- 學位/學歷：博士
- 專業方向：化學生物學 有機化學 表觀遺傳學
- 任職院校：武漢大學化學與分子科學學院
人物經歷,學術成果,
人物經歷
2012.4-至今,武漢大學,化學與分子科學學院,副教授
2010.9-2011.12,Wake Forest University,博士後,合作導師:Lindsay R. Comstock
2009-2010 Univerity of Virginia，訪問學者，導師：Lin Pu
2007-2008法國University of Grenoble 3，聯合培養，導師：Jean-Francois Constant
2004.9–2010.7,武漢大學,有機化學,博士,導師:周翔教授
2000.9–2004.7,武漢大學,化學,學士,導師:周翔教授
學術成果
一直從事化學生物學的研究，在小分子探針、修飾核酸、蛋白抑制劑領域有著紮實的工作基礎和經驗積累。所在實驗室為教育部長江學者特聘教授、科技部973首席科學家、國家傑出青年基金獲得者周翔教授主持的核酸化學生物學實驗室。在博士期間就從事與核酸分子探針的研究，接著在青年基金《新型可誘導DNA甲基轉移酶和組蛋白甲基轉移酶抑制劑的設計合成，構效關係和活性研究》及面上項目《DNA中甲基、羥甲基、醛基胞嘧啶多位點檢測及胞嘧啶羥甲基修飾的方法研究》的資助下，開展了獨立研究工作。
發表論文：
(1) Liu, Yinong ; Zhong, Cheng ; He, Zhiyong ; Rao, Shuang; Su, Haomiao; Wu, Fan; Fu, Boshi; Wu, Jinjun; Song, Yanyan; ; Zhou, Xiang; Du, Yuhao; Reversible photoregulation of DNA B-Z transition by a photochromic nucleoside.Sensors and Actuators B: Chemical2018，2151-2154.
(2) Rao, Shuang ; Chen, Yuqi; Hong, Tingting; He, Zhiyong; Guo, Shan; Lai Han; Guo, Ge; ; Zhou, Xiang; Du, Yuhao; Simultaneous and Sensitive Detection of Multisite 5-Methylcytosine Including Non-CpG Sites at Single-5mC-Resolution.Anal. Chem.2017, 88(21), 10547~10551.
(3) He, Zhiyong ; Chen, Yuqi; Wang, Yafen; Wang, Jiaqi; Mo, Jing; Fu, Boshi; Wang, Zijing; ; Zhou, Xiang; Du, Yuhao; A rapidly photo-activatable light-up fluorescent nucleoside and its application in DNA base variation sensing.Chem Commun (Camb)2016, 52(55), 8545~8548.
(4) Hendrick, Charles E; Frye, Krysta S; Comstock, Lindsay R; Du, Yuhao, Fluorescent DNA labeling by N-mustard analogues of S-adenosyl-L-methionine.ChemBioChem2012, 13(15), 2225~2233.
(5) Zhou, Xiang; Du, Yuhao; Targeting non-B-form DNA in living cells.Chem. Rec.2013, 13(4), 371~384.
(6) Turlington, Mark; Ostrum, Samuel G; Santosh, Vishaka; Du, Yuhao; Wren, Kathryne; Lin, Tony; Sabat, Michal; Pu, Lin; From highly enantioselective catalytic reaction of 1,3-diynes with aldehydes to facile asymmetric synthesis of polycyclic compounds.J. Am. Chem. Soc.2011, 133(30), 11780~11794.
(7) Weng, Xiaocheng; Huang, Jing; Zhang, Dan; Ma, Heng; Chen, Du, Yuhao, Dong; Zhou, Xiang ; Constant, Jean-Francois; Oligonucleotide-selenide conjugate: synthesis and its inducible sequence-specific alkylation of DNA.Bioorg. Med. Chem.2010, 18(11), 4149-4153.
(8) Zhang, Dan; Chen, Wei; Zhang, Ming; Zhou, Yangyang; Zhou, Du, Yuhao , Xiang; Cationic N-confused porphyrin derivative as a better molecule scaffold for G-quadruplex recognition.Bioorg. Med. Chem.2010, 8(3), 1111~11168.
(9) Turlington, Mark; Zhou, Xiang; Pu, Lin; Du, Yuhao; Highly enantioselective addition of linear alkyl alkynes to linear aldehydes.Tetrahedron Letters2010, 51(38), 5024~5027.
(10) Huang, Jing; Weng, Xiaocheng; Zhou, XiangDu, Yuhao; Specific Recognition of DNA by Small Molecules.Current Medicinal Chemistry2010, 17(2), 173~189
