李錦銓，華中農業大學食品科學技術學院、生物醫學與健康學院教授、博士生導師、國家優秀青年科學基金獲得者。
基本介紹
- 中文名：李錦銓
- 學位/學歷：博士
- 職業：教師
- 主要成就：國家優秀青年科學基金獲得者
- 職稱：教授
- 就職單位：華中農業大學生物醫學與健康學院
教育經歷,工作經歷,研究方向,科研項目,學術兼職,授權專利,主要論文,
教育經歷
2005-2009華中農業大學/生物技術/學士
2009-2013華中農業大學/預防獸醫/博士
2011-2013 Montana state University/感染與免疫/中美聯培博士
工作經歷
2021-至今 華中農業大學 教授
2021-至今 上海噬菌體與耐藥研究所 兼職PI
2020-至今 洛克菲勒大學 噬菌體與傳染病客座研究員
2018-2020洛克菲勒大學 傳染病博士後，合作導師：Vincent A. Fischetti教授
2013-2021華中農業大學 講師、副教授
研究方向
要圍繞“超級細菌”分子致病機制、噬菌體高效殺菌機制和功能性噬菌體開展研究工作，獲批國家自然科學基金優秀青年科學基金、農業農村部農業科研傑出人才培養計畫、湖北省傑出青年科學基金支持。
1.病原菌突破血腦屏障分子機制和跨宿主傳播機制
2.人獸共患病原菌噬菌體資源庫、合成噬菌體、治療性噬菌體生產工藝
3.基於組學技術高通量篩選新型噬菌體裂解酶/噬菌肽
4.新功能噬菌體的發掘和機制研究（腫瘤微環境，治療代謝性疾病）
科研項目
1. 人獸共患病與公共衛生，國家自然科學基金優秀青年科學基金項目， 2024.01-2026.12，主持
2. 湖北省傑出青年科學基金，2023-2026，主持
3. 農業農村部農業科研傑出人才培養計畫，2021.09-2022.09，主持
4. 高效裂解耐藥大腸桿菌的非透膜劑依賴型噬菌體裂解酶作用機制研究，2021.1-2024.12，國家自然科學基金面上項目，主持
5. 噬菌體多糖解聚酶介導的腸炎沙門氏菌生物被膜消除機制，2018.1-2021.12，國家自然科學基金面上項目，主持
6.“十四五”國家重點研發計畫“豬細菌性疫病新型疫苗創製”項目子課題, 2022.11-2025.12, 國家重點研發計畫,主持
7. 豬鏈球菌2型內皮素轉化酶的致病機制研究，2016.1-2018.12，國家自然科學基金青年科學基金項目，主持
8. 耐藥梭菌噬菌體高效裂解酶的發掘和作用機制研究，2019.1-2020.12，湖北省科技創新專項（中美合作專項），主持
9. 湖北地區小龍蝦中副溶血弧菌污染狀況和污染機制研究，2015.1-2016.12，湖北省自然科學基金，主持
10. 重要食源性致病菌耐藥機制及傳播規律研究，2018.1-2021.12，國家重點研發計畫，研究骨幹
學術兼職
《Frontiers in Microbiology》主題編輯，《食品科學》、《Virulence》、《Vaccine》、《Microbiology Spectrum》、《Infection and Immunity》、《International Journal of Food Microbiology》、《Frontiers in Cellular and Infection Microbiology》、《Microorganisms》和《Viruses-Basel》等SCI期刊審稿人
授權專利
1.一種主效成分為噬菌體LPEE17和LPEK22的混合製劑及套用. CN110317793B.發明專利.2020.06.中國.1/4.
2.沙門氏菌噬菌體和噬菌體抗菌組合物及其套用. CN106497888B.發明專利. 2018.06.中國.1/8.
3.一種寬譜沙門氏菌噬菌體LPSTLL及套用.CN109825479B.發明專利.2019.02.中國.2/7.
4.一種豬鏈球菌2型10基因缺失株及套用. CN106085936B.發明專利.2019.02.中國.1/6.
5.一種區分豬鏈球菌爆發菌株和散發菌株的檢測引物和套用.CN106868143B.發明專利.2018.10.中國.1/10.
6.一種豬鏈球菌2型五基因缺失株及套用.CN105316252B.發明專利.2018.08.中國.1/7.
7.一種雞常見食源性細菌四重螢光PCR檢測試劑盒及使用方法.CN103436626B.發明專利.2015.09.中國.8/9.
8.一種豬鏈球菌2型的SS2-LAMP檢測試劑盒及套用.CN104404132B.發明專利.2016.02.中國.1/5.
9.一種高致病性嗜水氣單胞菌及套用.CN105695372B.發明專利.2018.05.中國.2/7.
10.一種無抗生素標記的嗜水氣單胞菌減毒菌及套用.CN105886429B.發明專利.2019.04.中國.2/7.
11.一種腸炎沙門氏菌噬菌體LPSE28及其在食品中的套用.CN108546685B.發明專利.2021.01.中國.1/9.
12.一種沙門氏菌噬菌體LPSE34及其在食品中的套用.CN108588037B.發明專利.2021.01.中國.1/9.
主要論文
1. Geng Zou Lijun He, Jing Rao, Zhiyong Song, Hu Du, Runze Li, Wenjing Wang, Yang Zhou, Lu Liang, Huanchun Chen, Jinquan Li. Improving the safety and efficacy of phage therapy from the perspective of phage-mammal interactions. FEMS microbiology reviews. 2023 Jul 5;47(4): fuad042.
2. Xingxing Dong, Yanjie Chao, Yang Zhou, Rui Zhou, Wei Zhang, Vincent A. Fischetti, Xiaohong Wang, Ye Feng, Jinquan Li. The global emergence of a novel Streptococcus suis clade associated with human infections. EMBO Molecular Medicine, 2021, e13810.
3. Yufan Yang, Hu Du, Geng Zou, Zhiyong Song, Yang Zhou, Hao Li, Chen Tan, Huanchun Chen, Vincent A Fischetti, Jinquan Li. Encapsulation and delivery of phage as a novel method for gut flora manipulation in situ: A review. Journal of Controlled Release, 2023,353: 634-649.
4. Zhiwei Li, Peixi Chang, Jiali Xu, Chen Tan, Xiaohong Wang, Weicheng Bei, Jinquan Li. A Streptococcus suis Live Vaccine Suppresses Streptococcal Toxic Shock-Like Syndrome and Provides Sequence Type Independent Protection. The Journal of Infectious Diseases, 2019, 219(3): 448-458.
5. Chad W Euler, Assaf Raz, Anaise Hernandez, Anna Serrano, Siyue Xu, Martin Andersson, Geng Zou, Yue Zhang, Vincent A Fischetti, Jinquan Li. PlyKp104, a Novel Phage Lysin for the Treatment of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Other Gram-Negative ESKAPE Pathogens. Antimicrobial Agents and Chemotherapy, 2023,17;67(5): e0151922.
6. Yue Zhang, Geng Zou, Md Sharifull Islam, Kun Liu, Suqiang Xue, Zhiyong Song, Yingwang Ye, Yang Zhou, Yuanguo Shi, Shaozhong Wei, Rui Zhou, Huanchun Chen, Jinquan Li. Combine thermal processing with polyvalent phage LPEK22 to prevent the Escherichia coli and Salmonella enterica contamination in food. Food Research International, 2022, 165:112454.
7. Lin Teng, Geng Zou, Yang Zhou, Jie Li, Zhiyong Song, Xingxing Dong, Zhengxin Ma, Zhijie Zheng, Huanchun Chen,Li Jinquan.Phage controlling method against novel freshwater-derived Vibrio parahaemolyticus in ready-to-eat crayfish (Procambarus clarkii). Food Research International, 2022,162:111986.
8. Yu Jin, Ke Liu, Guangqiang Li, Chengfei Li, Zhidong Xiao, Chao Yuan,Jinquan Li. In situ reduction triggers the highly sensitive detection of pesticide by classic gold nanoparticle and quantum dots nanocomposite. Analytica Chimica Acta, 2021, 1172:338679
9.Yating Guo, Jie Li, Md.Sharifull Islam, Ting Yan, Yang Zhou, Lu Liang, Ian F.Connerton, Kai Deng, Jinquan Li. Application of a novel phage vB_SalS-LPSTLL for biological control of Salmonella in foods. Food Research International, 2021, 147:110492
10.Siyue Xu, Edmondo Campisi, Jinquan Li, Vincent A. Fischetti. Decontamination of Escherichia coli O157:H7 on Fresh Romaine Lettuce Using a Novel Bacteriophage Lysin.International Journal of Food Microbiology, 2021, 341:109068
11.Sharifull Islam, Md, Xiangwei Yang, Chad W. Euler, Xueqing Han, Jiahui Liu, Isrfil Hossen, Md, Yang Zhou, Jinquan Li. Application of a novel phage ZPAH7 for controlling multidrug-resistant Aeromonas hydrophila on lettuce and reducing biofilms. Food Control, 2021, 122 :107785
12.Md. Sharifull Islam, Yang Zhou, Lu Liang, Ishatur Nime, Ting Yan, Stephan P. Willias, Md. Zakaria Mia, Weicheng Bei, Ian F. Connerton, Vincent A. Fischetti,Jinquan Li. Application of a Broad Range Lytic Phage LPST94 for Biological Control of Salmonella in Foods. Microorganisms, 2020, 8(2):247.
13.Ting Yan, Lu Liang, Ping Yin, Yang Zhou, Ashraf Mahdy Sharoba, Qun Lu, Xingxing Dong, Kun Liu, Ian F. Connerton, Jinquan Li. Application of a Novel Phage LPSEYT for Biological Control of Salmonella in Foods. Microorganisms, 2020, 8(3):400.
14.Md. Sharifull Islam, Yang Zhou, Lu Liang, Ishatur Nime, Kun Liu, Ting Yan, Xiaohong Wang, Jinquan Li. Application of a Phage Cocktail for Control of Salmonella in Foods and Reducing Biofilms. Viruses, 2019, 11(9): 841.
15.Feng Liu,Jinquan Li, Kang Yan, Huan Li, Chengfeng Sun, Shuo Zhang, Fangyan Yuan, Xiangru Wang, Chen Tan, Huanchun Chen, Weicheng Bei, Binding of Fibronectin to SsPepO Facilitates the Development of Streptococcu suis Meningitis, The Journal of Infectious Diseases, 2018, 217(6):973-982.
16.Chenxi Huang, Safiullah M. Virk, Jianchun Shi, Yang Zhou, Stephan P. Willias, Mohamed K. Morsy, Hazem E. Abdelnabby, Jie Liu, Xiaohong Wang, Jinquan Li. Isolation, Characterization, and Application of Bacteriophage LPSE1 Against Salmonella enterica in Ready to Eat (RTE) Foods.Frontiers in Microbiology, 2018, 9:1046.
17.Liping Feng, Xiaona Niu, Wen Mei, Weitian Li, Yuan Liu, Stephan P. Willias, ChaoYuan, Weicheng Bei, Xiaohong Wang, Jinquan Li. Immunogenicity and protective capacity of EF-Tu and FtsZ of Streptococcus suis serotype 2 against lethal infection. Vaccine, 2018, 36(19):2581-2588.
18.Ying Zhou, Ruonan Nie, Xiaoyue Liu, Jinghui Kong, Xiaohong Wang,Jinquan Li. GntR is involved in the expression of virulence in strain Streptococcus suis P1/7.FEMS Microbiology Letters, 2018, 365(14).
19.Xingxing Dong, Xiaohong Wang, Xingchun Chen, Zhiyun Yan, Jing Cheng, Liangliang Gao, Yuan Liu, Jinquan Li. Genetic Diversity and Virulence Potential of Staphylococcus aureus Isolated from Crayfish (Procambarus clarkii). Current Microbiology, 2017, 74(1):28-33.
20.Yang Zhou, Xingxing Dong, Zhiwei Li, Geng Zou, Li Lin, Xiaohong Wang, Huanchun Chen, Robin B. Gasser, Jinquan Li. Predominance of Streptococcus suis ST1 and ST7 in human cases in China, and detection of a novel sequence type, ST658.Virulence, 2017, 8(6):1031-1035.
21.Xingxing Dong, Zhi Li, Xiaohong Wang, Min Zhou, Li Lin, Yang Zhou, Jinquan Li. Characteristics of Vibrio parahaemolyticus isolates obtained from crayfish (Procambarus clarkii) in freshwater. International Journal of Food Microbiology, 2016:132-138.
22.魏 麟（本科生），朱方莉，周 洋，Khairy Morsy MOHAMED，袁 超，董星星，王小紅，李錦銓.噬菌體在檢測食源性病原菌中的套用研究進展.食品科學, 2018，(1):314-322.
23.呂陽（本科生），尹平，Khairy Morsy MOHAMED，高磊，袁超，周洋，邱寧，鄒璐瑤，李志，Abdelnabby HAZEM，王小紅，李錦銓.噬菌體在食品安全控制中的研究進展,食品科學, 2018,(15):240-246
24.郭浩然（本科生），許菁彥，周 洋，李子齊，邱熠鑫，魏 麟，董星星，李錦銓.噬菌體分布的廣泛性以及口服安全性，中國食品學報，2021,21(02):349-357
