基本介紹
- 中文名：李祥敏
- 學位/學歷：博士
- 專業方向：動物傳染病的感染與免疫機制和新型疫苗
- 任職院校：華中農業大學動物科學技術學院動物醫學院
- 職稱：副教授
人物經歷,教育經歷,工作經歷,研究方向,主要成就,論文類,科研項目,獲獎記錄,
人物經歷
教育經歷
1995.09 - 1999.06，河南農業大學，獸醫衛生檢驗專業畢業，農學學士
1999.09 - 2004.06， 華中農業大學，預防獸醫學專業畢業，農學博士
工作經歷
2008.12-至今，華中農業大學教授、博士生導師
2004.06-2008.12，華中農業大學 講師
研究方向
動物傳染病的感染與免疫機制和新型疫苗的研究。
主要成就
論文類
1. Qian S, Fan W, Liu T, Wu M, Zhang H, Cui X, Zhou Y, Hu J, Wei S, Chen H, Li X*, Qian P*. Seneca Valley Virus suppresses host type I interferon production by targeting adaptor proteins MAVS, TRIF, and TANK for cleavage. J Virol. 2017 May 31. pii: JVI.00823-17.
2. Zhang H, Wen W, Hao G, Hu Y, Chen H, Qian P, Li X*. Phylogenetic and genomic characterization of a novel atypical porcine pestivirus in China. Transbound Emerg Dis. 2017 Jul 14.
3. Wenchun Fan, Mengge Wu, Suhonh Qian, Yun Zhou, Huanchun Chen, Xiangmin Li*, Ping Qian*. TRIM52 inhibits Japanese Encephalitis virus replication by degrading the viral NS2A. Sci Rep. 2016 Sep 26; 6: 33698.
4. Qian S, Fan W, Qian P, Chen H, Li X*. Isolation and full-genome sequencing of Seneca Valley virus in piglets from China, 2016. Virol J. 2016 Oct 19; 13(1): 173.
5. Huawei Zhang, Haixue Zheng, Ping Qian, Jinfang Xu, Xi Yang, Rui Zhou, Huanchun Chen, Xiangmin Li*. Induction of systemic IFITM3 expression does not effectively control foot-and-mouth disease viral infection in transgenic pigs. Veterinary Microbiology. 15 August 2016, Volume 191, Pages 20–26.
6. Fan W, Qian S, Qian P, Li X*. Antiviral activity of luteolin against Japanese encephalitis virus. Virus Res. 2016 Jul 15; 220: 112-6.
7. Fan W, Zhang D, Qian P, Qian S, Wu M, Chen H, Li X*. Swine TRIM21 restricts FMDV infection via an intracellular neutralization mechanism. Antiviral Res. 2016 Mar; 127: 32-40.
8. Qian P, Zhi X, Wang B, Zhang H, Chen H, Li X*. Construction and immune efficacy of recombinant pseudorabies virus expressing PrM-E proteins of Japanese encephalitis virus genotype І. Virol J. 2015 Dec 10; 12: 214.
9. Zhang H, Qian P, Peng B, Shi L, Chen H, Li X*. A novel subunit vaccine co-expressing GM-CSF and PCV2b Cap protein enhances protective immunity against porcine circovirus type 2 in piglets. Vaccine. 2015 May 15; 33(21): 2449-56.
10. Qian S, Fan W, Qian P, Zhang D, Wei Y, Chen H, Li X*. Apigenin restricts FMDV infection and inhibits viral IRES driven translational activity. Viruses. 2015 Mar 31; 7(4): 1613-26.
11. Zhang H, Qian P, Liu L, Qian S, Chen H, Li X*. Virus-like particles of chimeric recombinant porcine circovirus type 2 as antigen vehicle carrying foreign epitopes. Viruses. 2014 Dec 5; 6(12): 4839-55.
12. Li X, Zhu Q, Cao Q, Chen H, Qian P*. Japanese encephalitis virus upregulates the expression of SOCS3 in mouse brain and Raw264.7 Cells. Viruses. 2014 Nov 10; 6(11): 4280-93.
13. Xu J, Qian P, Wu Q, Liu S, Fan W, Zhang K, Wang R, Zhang H, Chen H, Li X*. Swine interferon-induced transmembrane protein, sIFITM3, inhibits foot-and-mouth disease virus infection in vitro and in vivo. Antiviral Res. 2014 Sep;109: 22-9.
14. Cao QS, Li XM, Zhu QY, Wang DD, Chen HC, Qian P*. Isolation and molecular characterization of genotype 1 Japanese encephalitis virus, SX09S-01, from pigs in China. Virol J. 2011 Oct 14; 8: 472.
科研項目
1. 塞內卡病毒（SVA）3C蛋白抑制I型干擾素產生的分子機制（國家自然基金面上項目，2018.01-2021.12）.
2.病原誘導天然免疫應答及其調控機制（十三五重點研發項目. 2016.07-2020.12）
3. 酮戊二酸脫氫酶（OGDH）在TRIM15調控IFN-β信號通路中的功能及機制研究（國家自然基金面上項目，2016.01-2019.12）.
4. 微生態製劑對高架網床生態養豬促進作用與套用（校自主科技創新基金項目--標誌性成果培育， 2016.01-2018.12）
獲獎記錄
湖北省科技進步一等獎2項。
