李宗金(南開大學醫學院教授)

李宗金 ，男 ，南開大學醫學院教授。主要從事幹細胞治療，人胚胎幹細胞的分化，組織工程，腫瘤幹細胞及分子影像學的研究

基本介紹

• 中文名：李宗金
• 國籍：中國
• 職業：大學教授
• 畢業院校：南開大學

教育經歷

博士後史丹福大學 2005-2009　

博士中國協和醫科大學 2000-2005
學士白求恩醫科大學 1989-1994

工作經歷

2009-至今南開大學醫學院
2005-2009史丹福大學放射系，分子影像中心

學術兼職

1．2009-至今 Circulation Research 雜誌審稿人
2. 2009-至今 Peer Reviewer for the American Heart Association
3. 2010 Stem Cells International客座主編
4. 2010-至今 自然科學基金面上項目評審
5. 2010-2012 American Journal of Nuclear Medicine and Molecular Imaging編委
6. 2912-2014 中國組織工程研究雜誌執行編委
7. 2012- 高等學校博士學科點專項科研基金網路評審專家
8. 2012- 教育部學位中心“省市優秀碩士學位論文評選”通訊評議評審專家

研究方向

主要從事幹細胞治療，人胚胎幹細胞的分化，組織工程，腫瘤幹細胞及分子影像學的研究，在國際上率先套用胚胎幹細胞來源的內皮細胞用於缺血性心臟病的治療。同時，套用納米脂質體聯合分子影像技術靶向腫瘤幹細胞的研究也得到了較高的評價。包括在Nature Methods, Circulation, J Am Coll Cardiol, Stem Cells, Caner Res，Stroke, Biomaterials等雜誌發表論文40餘篇，其中SCI論文36篇，被引用超過800次。

參與了3部專著的撰寫，申請了2項發明專利。研究工作先後獲得多項獎勵，包括：2007年美國血管生物學學會優秀青年科學家獎、2008年美國心臟病學會優秀青年科學家獎、2009年史丹福大學心血管研究所優秀青年科學家獎、Mitzi and William Blahd, MD 啟動基金第一名等。

1) 國家重大科學研究計畫項目973（項目編號：2011CB964903） 2011-2015
經費：￥4,620,000，為研究骨幹，經費來源：科技部。研究課題“多潛能幹細胞特異性誘導分化及其表觀遺傳學調控在治療糖尿病中的套用基礎研究”，子課題“在體胰島組織和腎上皮組織幹細胞歸巢、複製、分化的示蹤新技術與新方法”。研究內容: 建立 MSC和ESC在小動物的分子影像監測技術，利用分子影像技術，評價 MSC和ESC在糖尿病和腎功能衰竭中的作用; 建立大動物模型，引進 PET，MRI等分子影像技術，監測其在大動物體內功能的改變。
2)國家自然科學基金（項目批准號：31071308） 2011-2013
經費：￥370，000，項目主持人，經費來源：國家自然科學基金委。研究課題“非病毒微載體重編程心臟幹細胞為誘導多能幹細胞(iPSC)的研究”。

3) 2010年度高等學校博士學科點專項科研基金.經費：￥60,000，為研究骨幹，經費來源：教育部。研究課題“非病毒微載體重編程心臟幹細胞為誘導多能幹細胞的研究”。
4）天津套用基礎與前沿技術研究計畫（自然科學基金）重點項目 2012-2014
經費：￥200，000，項目主持人，經費來源：天津科委。
5）國家教育部留學回國人員科研啟動金
經費：￥35，000，項目主持人，經費來源：教育部。

專利

1. 具有腫瘤靶向、體內示蹤和治療作用的脂質體藥物組合物及製備方法，第一發明人
2. 具有腫瘤靶向、體內示蹤和治療作用的人胚胎幹細胞來源的內皮細胞, 第一發明人

講授課程

1．病理生理學
2．幹細胞生物學

榮譽獎勵

2006 美國心臟學會(AHA)牆報前10名
2006-2007 史丹福大學博士後基金
2007 美國血管生物學會Jay D. Coffman優秀青年科學家獎
2008 第57屆美國心臟病學會(ACC)優秀青年科學家獎
2008 ACCF/Bristol-Myers Squibb Travel Award, 美國心臟病學會(ACC)
2008 史丹福大學醫學院心血管病研究所，優秀青年科學家獎
2008 國際幹細胞學會 (ISSCR) Travel Award
2008 Mitzi and William Blahd, MD 啟動基金第一名, 美國核醫學會
2009 Journal of Cellular Biochemistry, 2009年106卷第2期封面文章
2010 發表在 Stroke, 2010, 41(3):516-23 的文章被F1000選中.
2012 南開大學第四屆良師益友提名獎

主要貢獻

1. Su W, Wang L, Zhou M, Tong L, Liu Z, Hu S, Liu F, Liu Y, Yan F, Kong D, Han Z, WuJC, Xiang R, Li Z*. Human Embryonic Stem Cell-derived Endothelial Cells as Cellular Delivery Vehicles for Targeting Therapy of Breast Cancer. Submitted
2. Jia X, Xie X, Feng G, YaoX, Lü H, Mao L, Zhao Q, Che Y, Han Z, XuY, Li Z*, Kong D*. Bone marrow-derived cells can acquire renal stem cells properties and ameliorate ischemia-reperfusion induced acute renal injury. BMC Nephrology. 2012 in press. (IF, 2.2)
3. Daadi MM, Hu S, Klausner J, Li Z, Sofilos M, Sun G, Wu JC, Steinberg GK. Imaging Neural Stem Cell Graft-Induced Structural Repair in Stroke. Cell Transplantation. 2012 in press. (IF, 6.2)
4. Lu D, Chen S, Tan X, Li N, Liu C, Li Z, Liu Z, Stupack DG, Reisfeld RA, Xiang R. Fra-1 Promotes Breast Cancer Chemosensitivity by Driving Cancer Stem Cells from Dormancy. Cancer Res, 2012, 72(14): 3451-6.Link (IF, 8.2)
5. Wang L, Su W, Liu Z, Zhou M, Chen S, Chen Y, Lu D, Liu Y, Yan F, Zheng Y, Han Z, Kong D, WuJC, Xiang R*, Li Z*. CD44 Antibody Targeted Liposomes for Molecular Imaging and Therapy of Hepatocellular Carcinoma. Biomaterials. 2012, 33(20): 5107-5114Link(IF, 7.8)
6. Wang L, Chen S, Zhang M, Chen Y, Su W, Liu Y, Lu D, Li S, Yang Y, Li Z, Qu P, Hu H, Xiang R. Legumain Serves as a Biomarker for the Diagnosis and Prognosis of Human Ovarian Cancer. J of Cell Biochem. 2012, 113(8): 2679-86. Link(IF, 3.1)
7. Zhou M, Wang L, Su W, Tong L, Liu Z, Liu Y, Yan F, Zheng Y, Zhao H, Xiang R*, Li Z*. Assessment of Therapeutic Efficacy of Liposomal Nanoparticles Mediated Gene Delivery by Molecular Imaging for Cancer Therapy. J Biomed Nanotechnol. 2012, 8(5): 742-750. Link(IF, 4.2)
8. Feng G, Cui J, Zheng Y, Han Z, Xu Y*,Li Z*. Identification, Characterization and Biological Significance of Very Small Embryonic-Like Stem Cells (VSELs) in Regenerative Medicine. Histol Histopathol. 2012, 27(7): 827-833. PMID: 22648539 Link. (IF, 2.5)
9. Zhang J, Jia X, Xu Z, Ding F, Zhou X, Fu H, Liu Y, Ou L, Li Z, Kong D. Improved Mesenchymal Stem Cell Survival in Ischemic Heart Through Electroacupuncture. Chin J Integr Med. 2012, DOI: 10.1007/s11655-012-1101-3. Link. (IF, 0.799)
10.Zhang Z, Yin J, Zhang C, Liang N, Bai N, Chang A, Liu Y, Li Z, Tan X, Li N, Lv D, Xiang R, Tian Y, Liu C. Activating transcription factor 4 increases chemotherapeutics resistance of human hepatocellular carcinoma. Cancer Biology & Therapy, 2012, 13(6) 435-442. Link(IF, 2.9)
11. Hu S, Huang M, Nguyen P, Gong Y, Li Z, Jia F, Lan F, Liu J, Nag D, Robbins RC, Wu JC. Novel MicroRNA Pro-survival Cocktail for Improving Engraftment and Function of Cardiac Progenitor Cell Transplantation. Circulation. 2011, 124: S27-S34. Link (IF, 14.8) (Top 3 advances in AHA Basic Cardiovascular Sciences in 2011)
12. Li Z, Hu S, Ghosh Z, Han Z, Wu JC. Functional Characterization and Expression Profiling of Human Induced Pluripotent Stem Cell- and Embryonic Stem Cell-Derived Endothelial Cells. Stem Cells Dev. 2011, 20(10): 1701-1710. Link(IF, 4.8)
13. Su W, Zhou M, Zheng Y, Fan Y, Han Z, Kong D, Zhao RC, Wu JC, Xiang R*, Li Z*. Bioluminescence reporter gene imaging characterize human embryonic stem cell-derived teratoma formation. J Cell Biochem. 2011, 112: 840–848. Link. (IF, 3.1)
14. Wang Y, Wang Yanming, Wang L, Che Y, Li Z*, Kong D*. Preparation and evaluation of magnetic nanoparticles for cell labeling. Journal of Nanoscience and Nanotechnology. 2011, 11: 3749-3756. Link(IF, 1.9)
15.Xie X, Hiona A, Lee A, Cao F, Huang M, Li Z, Cherry A, Pei X, Wu JC. Effects of Long Term Culture on Human Embryonic Stem Cell Aging. Stem Cells Dev. 2011; 20(1): 127-38. Link (IF, 4.8)
16. S, Huang M, Li Z, Jia F, Ghosh Z, Lijkwan M, Sun N, Fasanaro P, Wang X, Martelli R, Robbins RC, Wu JC. MicroRNA-210 as a Novel Therapy for Treatment of Ischemic Heart Disease. Circulation. 2010, 122:S124-S131. Link. (IF, 14.8)
17.Wilson KD, Sun N, Huang M, Zhang WY, Lee AJ, Li Z, Wang SX, Wu JC. Effects of Ionizing Radiation on Self Renewal and Pluripotency of Human Embryonic Stem Cells. Cancer Research. 2010, 70(13): 5539-48. Link(IF, 8.2)
18.Huang NF, Niiyama H, Peter C, De A, Natkunam Y, Fleissner FA, Li Z, Rollins M, Wu JC, Gambhir SS, Cooke JP. Embryonic Stem Cell-Derived Endothelial Cells Incorporate into the Ischemic Hindlimb and Restore Perfusion. Arteriosclerosis, Thrombosis, and Vascular Biology. 2010, 30:915-922. Link (IF, 7.2)
19.Jia F, Wilson KD, Sun N, Gupta DM, Huang M, Li Z, Kay MA, Longaker MT, Wu JC. A Simple Non-viral Minicircle Vector for Deriving Human iPS Cells. Nature Methods. 2010, 7(3): 197-199. Link. (IF, 20.7)
20.DaadiDM, DavisA, Arac A, Li Z, MaagAL, Batnagar R, SunG, WuJC, Steinberg GK. Human Neural Stem Cell Grafts Modify Microglial Response and Enhance Axonal Sprouting In Neonatal Hypoxic-Ischemic Brain Injury. Stroke. 2010, 41(3): 516-23.Link (IF, 7.0) (selected by F1000)
21. Wilson KD, Smith B, Kraft D, Jia F, Xie X, Huang M, Hoyt G, Chu P, Robbins RC, Weissman IL, Gambhir SS, Wu JC. Functional and Transcriptional Characterization of Human Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Myocardial Infarction. PLoS ONE. 2009, 4(12): e8443. Link(IF, 4.4)
22.J, Huang NF, Wilson KD, Velotta JB, Huang M, Li Z, Robbins RR, Cooke JP, Wu JC. nAChRs Mediate Human Embryonic Stem Cell-Derived Endothelial Cells: Proliferation, Apoptosis, and Angiogenesis. PLoS ONE. 2009, 4(9): e7040. Link (IF, 4.4)
23.Huang M, Chen ZY, Jia F, Li Z, Kay MA, Wu JC. Novel minicircle vector for cell based gene therapy in murine myocardial infarction. Circulation. 2009, 120:S230-S237 Link(IF, 14.8)
24.Daadi DM, Li Z, Arac A, GrueterBA, Sofilos M, Malenka RC, Wu JC, Steinberg GK. Molecular and Magnetic Resonance Imaging of Human Embryonic Stem Cell-Derived Neural Stem Cell Grafts in Ischemic Rat Brain. Molecular Therapy. 2009, 17(7): 1282–1291.Link. (IF, 7.1)
25.Lee A, Huang M, Chung J, Chu P, Yang P, Rosenberg J, Robbins RC, Wu JC. Imaging Survival and Function of Transplanted Cardiac Stem Cells. Journal of the American College of Cardiology. 2009, 53(14):1229–40. Link (IF,14.3)
26, Han Z, Wu JC*. Transplantation of Human Embryonic Stem Cell-Derived Endothelial Cells for Vascular Diseases. J of Cell Biochem. 2009, 106:194-199. (Journal cover, invited review) Link(IF, 3.5)
27.Xie X, Chan KS, Cao F, Hang M, Li Z, Lee A, Weissman I, Wu JC. Imaging of STAT3 Signaling Pathway During Mouse Embryonic Stem Cell Differentiation. Stem Cell and Development. 2009; 18(2): 205-14. Link(IF, 4.8)
28.Huang M, Chan D, Jia F, Xie X, Li Z, Robbins RC, Chen X, Giaccia A, Wu JC. Short Hairpin RNA Interference Therapy for Ischemic Heart Disease. Circulation.2008; 118: s226-233. Link(IF, 14.8)
29.#Wilson KD, #Li Z, Wager R, Yue P, Tsao P, Nestorova G, Huang M, Hirschberg D, Yock PG, Quertermous D, Wu JC. Transcriptome alteration in the diabetic heart by rosiglitazone: Implications for cardiovascular mortality. PLoS ONE. 2008, 3(7): e2609. (#Co-first author) Link(IF, 4.4)
30. Suzuki Y, Huang M, Cao F, Xie X, Connolly AJ, Yang PC, Wu JC. Comparison of reporter gene and iron particle labeling for tracking fate of human embryonic stem cells and differentiated endothelial cells in living subjects. Stem Cells. 2008, 26(4): 864-873. Link(IF, 7.9)
31 Wu JC, Sheikh AY, Kraft D, Cao F, Xie XY, Patel M, Gambhir SS, Robbins RC, Cooke JP, Wu JC. Differentiation, survival, and function of embryonic stem cell derived endothelial cells for ischemic heart disease. Circulation.2007; 116: I46-I54.Link (IF, 14.4)
32.Xie X, Cao F, Sheikh AY, Li Z, Connolly AJ, Pei X, Li RK, Robbins RC, Wu JC. Genetic modification of embryonic stem cells with VEGF enhances cell survival and improves cardiac function. Cloning and Stem Cells. 2007; 9(4): 553-567 Link(IF, 2.9)
33.Cao F, Drukker M, Lin S, Sheikh AY, Xie X, Li Z, Connolly AJ, Weissman IL, Wu JC.. Molecular imaging of embryonic stem cell misbehavior and suicide gene ablation. Cloning and Stem Cells. 2007; 9(1): 107-17. Link(IF, 2.9)
34.Lin S, Xie X, Patel MR, Yang YH, Li Z, Cao F, Gheysens O, Zhang Y, Gambhir SS, Rao JH, Wu JC. Quantum dot imaging for embryonic stem cells. BMC Biotechnol. 2007; 7(1): 67 Link (Featured in Nanowerk). (IF, 2.9)
35.Chang GY, Cao F, Krishnan M, Huang M, Li Z, Xie X, Sheikh AY, Hoyt G, Robbins RC, Hsiai T, Schneider MD, Wu JC. Positron emission tomography imaging of conditional gene activation in the heart. J Mol Cell Cardiol. 2007; 43(1):18-26. (Journal cover) Link(IF, 5.5)
著作:
1. Yizhou Zheng, Deling Kong and Zongjin Li* (2011). Non-invasive Imaging of Human Embryonic Stem Cells Derived Endothelial Cells Using Reporter Genes, Methodological Advances in the Culture, Manipulation and Utilization of Embryonic Stem Cells for Basic and Practical Applications, Craig Atwood (Ed.), ISBN: 978-953-307-197-8, InTech, (*correspondence author) Link
2. Hu S, Lavinghousez P, Li Z, Wu JC (2011). Differentiation of endothelial cells from hES cells and hiPS cells, Human Embryonic and Induced Pluripotent Stem Cells, Ye, Kaiming; Jin, Sha (Eds.) ISBN 978-1-61779-266-3, Humana Press. Link
3. Tong L, Zhao H, He Z, Li Z (2012). Current Perspectives on Molecular Imaging for Tracking Stem Cell Therapy "Medical Imaging in Clinical Practice", Erondo OF (Eds) ISBN InTech.