李宏亮，博士，雲南大學醫學院助理研究員。
基本介紹
- 中文名：李宏亮
- 國籍：中國
- 畢業院校：中山大學
- 學位/學歷：博士
研究方向,代表論文,科研項目,
研究方向
神經藥理（學習記憶方向）和腫瘤藥理學
代表論文
1. Li, Hongliang, Chen, Shuxian, Liu, Jia, Guo, Xiaopeng, Xiang,Xudong; Dong, Tianqi; Ran, Pengzhan; Li, Qian; Zhu, Bei; Zhang, Xiyu; Wang, Dan; Xiao, Chunjie; Zheng,Shangyong*, Long non-coding RNA PVT1-5 promotes cell proliferation by regulating miR-126/SLC7A5 axis in lung cancer. Biochem Biophys Res Commun, 2018, 495(3): 2350-2355.
2.Li HL，Wang XD，Zhou YF，Su QB, Chen ZF, Chen ZJ, Li JL, Chen XM, Hou XY, Xie W, Xin S, Zhou LM, Huang M. Association of LEPR and ANKK1 gene polymorphisms with weight gain in epilepsy patients receiving valproic acid. International Journal of Neuropsychopharmacology 2015; DOI: 10.1093/ijnp/pyv021.
3. Xu GL，Li HL(co-fist author)，He JC，Feng EF，Shi PP，Liu YQ，Liu CX. Comparative pharmacokinetics of swertiamarin in rats after oral administration of swertiamarin alone, Qing Ye Dan tablets and co-administration of swertiamarin and oleanolic acid. Journal of Ethnopharmacology, 149 (2013) 49–54.
4. Li HL, He JC, Bai M, Song QY, Feng EF, Rao GX, Xu GL. Determination of the plasma pharmacokinetic and tissue distributions of swertiamarin in rats by liquid chromatography with tandem mass spectrometry. Arzneimittelforschung, 62 (2012)138-144.
5. Li HL, Peng XJ, He JC, Feng EF, Xu GL, Rao GX. Development and validation of a LC-ESI-MS/MS method for the determination of swertiamarin in rat plasma and its application in pharmacokinetics. Journal of Chromatography B, 879 (2011) 1653–1658.
6. Bai M, Li HL, He JC, He GH, Feng EF, Liu YQ, Shi PP, Xu GL. Development and validation of an LC-ESI-MS/MS method for the quantitation of hemslecin A in rhesus monkey plasma and its application in pharmacokinetics. Biomedical Chromatography, 28(2014) 385-390.
7. Liu YQ, Li HL, He JC, Feng EF, Rao GX, Xu GL. Development and validation of a high-performance liquid chromatography coupled with ultraviolet detection method for the determination of isocorydine in rat plasma and its application in pharmacokinetics. Drug Research, 63(2013) 558-563.
科研項目
1.國家自然科學基金，81860638，基於Dectin-1/TLR4/GSK3β信號軸協同調控神經免疫和突觸可塑性改善學習記憶的藥理新機制，主持。
2.雲南省科技廳面上項目，2017FB138，灰樹花β-葡聚糖調控AMPA及固有免疫受體Dectin-1對AD模型小鼠記憶和認知的作用研究，主持。
3.雲南省教育廳基金，2016ZZX014，野生菌灰樹花中活性成分調控AMPA/Dectin 1受體對AD模型小鼠的作用研究，主持。
4.雲南大學中青年骨幹教師培養計畫（2018年），人才培養計畫。
