李和東，男，博士，研究員，博士生導師；中國科學院動物研究所細胞運動與肌肉收縮課題組組長。
基本介紹
- 中文名：李和東
- 國籍：中國
- 民族：漢
- 職業：博士，研究員，博士生導師
簡歷：,研究領域：,獲獎及榮譽：,代表論著：,
簡歷：
1996年於中國科學院上海生物化學研究所獲得博士學位。其後在美國 University of Massachusetts Medical School 從事研究工作，先後擔任博士後（Post-doctoral research fellow），講師（Instructor），和研究助理教授（Research assistant professor）。2008年底入選中國科學院“百人計畫”，2009年起擔任中國科學院動物研究所研究員，博士生導師。
長期從事肌球蛋白結構與功能的研究。首次構建了具有單頭結構的平滑肌肌球蛋白，證明了雙頭結構是平滑肌肌球蛋白調節的基礎。首次提出了尾部抑制假說（Tail-inhibition model）解釋非典型性肌球蛋白Va調節的機理。這一假說已被廣泛接受，並成為研究其他肌球蛋白調節的基礎。曾獲得美國心臟學會（American Heart Association）的博士後研究資助 （post-doctoral fellowship, 1999-2001）和科學家發展研究經費 （Scientist Development Grant, 2004 - 2008）。近年來取得的研究成果主要發表於國際核心學術期刊，包括J. Biol. Chem., PNAS, Cell 等。
研究領域：
目前的研究重點包括：1）非典型性肌球蛋白功能的調節；2）肌球蛋白運動與馬達蛋白運動的關係；3）昆蟲特有肌球蛋白的結構與功能；4）平滑肌收縮的調節機理。
獲獎及榮譽：
美國心臟學會博士後資助-1999-2001(American Heart Association post-doctoral fellowship, 1999-2001)和科學家發展研究經費 (Scientist Development Grant, 2004 - 2008)。
代表論著：
Xiang-dong Li*, Hyun Suk Jung, Qizhi Wang, Reiko Ikebe, Roger Craig, and Mitsuo Ikebe (2008) The globular tail domain puts on the brake to stop the ATPase cycle of the myosin Va. Proceedings of the National Academy of Sciences USA 105: 1140-1145(*corresponding author. This paper has been citied in “Faculty of 1000”).
Wang, Z., Edwards, J. G., Riley, N., Provance, D. W., Jr., Karcher, R., Li, X. D., Davison, I. G., Ikebe, M., Mercer, J. A., Kauer, J. A. and Ehlers, M. D. (2008) Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity. Cell 135, 535-548
Osamu Sato, Xiang-dong Li, and Mitsuo Ikebe (2007) Myosin Va becomes a low duty ratio motor in the inhibited form. Journal of Biological Chemistry 282:13228-13239.
Xiang-dong Li*, Hyun Suk Jung, Katsuhide Mabuchi, Roger Craig, and Mitsuo Ikebe (2006) The globular tail domain of myosin Va functions as an inhibitor of the myosin Va motor. Journal of Biological Chemistry 281:21789-21798 (* corresponding author. ).
Xiang-dong Li, Reiko Ikebe, and Mitsuo Ikebe (2005) Activation of Myosin Va function by melanophilin, a specific docking partner of Myosin Va. Journal of Biological Chemistry 278: 29435-29441.
Xiang-dong Li, Katsuhide Mabuchi, Reiko Ikebe, and Mitsuo Ikebe (2004) Ca2+ induced activation of ATPase activity of myosin Va is accompanied with a large conformational change. Biochemical and Biophysical Research Communications 315: 538-545.
Xiang-dong Li and Mitsuo Ikebe. (2003) Two functional heads are required for full activation of smooth muscle myosin. Journal of Biological Chemistry 278: 29435-29441.
Yu Chen, Norio Takizawa, Jessica L Crowley, Sang W. Oh, Cheryl L. Gatto, Taketoshi Kambara, Osamu Sato, Xiang-dong Li, Mitsuo Ikebe, and Elizabeth J. Luna (2003) F-actin and myosin II binding domains in supervillin. Journal of Biological Chemistry ?278:46094-46106
Xiang-dong Li, Junya Saito, Reiko Ikebe, Katsuhide Mabuchi, and Mitsuo Ikebe (2000) The interaction between the regulatory light chain domains on two heads is critical for regulation of smooth muscle myosin. Biochemistry 39(9): 2254-2260.
Xiang-dong Li, Troy E. Rhodes, Reiko Ikebe, Taketoshi Kambara, Howard D. White and Mitsuo Ikebe (1998) Effects of mutations in the g-phosphate binding site of myosin on its motor function. Journal of Biological Chemistry 273(42): 27404-27411.
