李博文(遼寧師範大學講師)

李博文，男，畢業於大連理工大學生物工程學院與中國科學院大連化物所（聯合培養），研究生學歷，工學博士學位。遼寧師範大學講師、碩士生導師、研究生兼職輔導員。

教育經歷

• 大連理工大學與中國科學院大連化學物理研究所（聯合培養），研究生學歷，工學博士學位 (2016-2022)

• 遼寧師範大學，研究生學歷，理學碩士學位 (2013-2016)
• 遼寧師範大學，本科學歷，理學學士學位 (2009-2013)

研究方向

腫瘤分子生物學

蛋白翻譯後修飾

三陰性乳腺癌大器官轉移分子機制

獲獎內容

大連市新引進高層次人才-青年才俊，國家獎學金等

課題研究

• 國家自然科學基金委員會, 面上項目 “FBXL10對ERRα的調控及在乳腺癌細胞能量代謝過程中的作用機制”（No. 81872263），結題，參與；
• 國家自然科學基金委員會, 面上項目 “SYNJ2BP-COX16基因融合蛋白SUMO化修飾對腫瘤生長及轉移調控的作用與機制”（No. 82073088），在研, 參與；
• 遼寧省科研項目“七鰓鰻口腔腺中活性菌株的分離鑑定及其抗血栓作用研究”，結題，參與。
• 遼寧師範大學新進博士啟動科研項目，在研，主持。

學術成果

• Bowen Li, Shujing Li, Xiaoxia Shi, Yini Zhang, Zhiqiang Xin, Yuxi Yang, Binggong Zhao, Shuangshuang Song, Ping Ren, Huijian Wu. MZF1 activates transcriptional activity of p53 and suppresses breast cancer cell proliferation via acetyltransferase PCAF. Genes & Disease, 2022, doi:10.1016/j.gendis. 2022.11.005. (IF=7.376)
• Bowen Li, Liying Mu, Yanan Li, Kangkai Xia, Yuxi Yang, Sattout Aman, Bashir Ahmad, Shujing Li, Huijian Wu. TIMELESS inhibits breast cancer cell invasion and metastasis by down-regulating the expression of MMP9. Cancer Cell Int, 2021,21(1):38. (IF=6.435)
• Bowen Li, Meng Gou, Jianmei Han, Xiaofei Yuan, Yingying Li, Tiesong Li, Qi Jiang, Rong Xiao, Qingwei Li. Proteomic analysis of buccal gland secretion from fasting and feeding lampreys (Lampetra morii). Proteome Science, 2018,16:9. (IF=2.882)
• Mingru Zhu*, Bowen Li*, Jihong Wang, Rong Xiao. The Anti-Angiogenic Activity of a Cystatin F Homologue from the Buccal Glands of Lampetra morii. Marine Drugs, 2018,16(12):477. (共第一作者，IF=6.085)
• Xiahui Li, Shujing Li, Bowen Li, Yanan Li, Sattout Aman, Kangkai Xia, Yuxi Yang, Bashir Ahmad, Huijian Wu. Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1. NPJ Precision Oncology, 2021,5(1):20. (IF= 10.092)
• Sattout Aman, Yanan Li, Yunmeng Cheng, Yuxi Yang, Linlin Lv, Bowen Li, Kangkai Xia, Shujing Li, Huijian Wu. DACH1 inhibits breast cancer cell invasion and metastasis by down-regulating the transcription of matrix metalloproteinase 9. Cell Death Discovery, 2021,7:351. (IF=7.109)
• Yangyang Yang, Shujing Li, Bowen Li, Yanan Li, Kangkai Xia, Sattout Aman, Yuxi Yang, Bashir Ahmad, Binggong Zhao, Huijian Wu. FBXL10 promotes ERRα protein stability and proliferation of breast cancer cells by enhancing the mono-ubiquitylation of ERRα. Cancer Lett, 2021,502:108-119. (IF=9.756)
• Yangyang Yang, Xiahui Li, Bowen Li, Liying Mu, Jin Wang, Yunmeng Cheng, Yao Gu, Huijian Wu. Associations between TNFSF4 gene polymorphisms and susceptibility to autoimmune diseases in Asians: a meta-analysis. Immunol Invest, 2021,50(2-3):184-200. (IF= 3.044)
• Shujing Li, Jin Wang, Gaolei Hu, Sattout Aman, Bowen Li, Yanan Li, Kangkai Xia, Yuxi Yang, Bashir Ahmad, Miao Wang, Huijian Wu. SUMOylation of MCL1 protein enhances its stability by regulating the ubiquitin-proteasome pathway. Cell Signal, 2020,73:109686. (IF=4.850)
• Xiao Jiang, Xiaoyan Bai, Bowen Li, Yanan Li, Kangkai Xia, Miao Wang, Shujing Li, Huijian Wu. Plasma Inter-Alpha-Trypsin Inhibitor Heavy Chains H3 and H4 Serve as Novel Diagnostic Biomarkers in Human Colorectal Cancer. Disease Markers, 2019,2019:5069614. (IF=3.464)
• Jian Wang, Shujing Li, Xiahui Li, Bowen Li, Yanan Li, Kangkai Xia, Yuxi Yang, Sattout Aman, Miao Wang, Huijian Wu. Circadian protein BMAL1 promotes breast cancer cell invasion and metastasis by up-regulating matrix metalloproteinase9 expression. Cancer Cell Int, 2019,19:182. (IF=6.435)
• Zhaowei Xu, Yangyang Yang, Bowen Li, Yanan Li, Kangkai Xia, Yuxi Yang, Xiahui Li, Miao Wang, Shujing Li, Huijian Wu. Checkpoint suppressor 1 suppresses transcriptional activity of ERα and breast cancer cell proliferation via deacetylase SIRT1. Cell Death & Disease, 2018,9(5):559. (IF=9.685)
• Huan Chen, Zhaowei Xu, Xiahui Li, Yangyang Yang, Bowen Li, Yanan Li, Kangkai Xia, Jian Wang, Shujing Li, Miao Wang, Huijian Wu. α-catenin SUMOylation increases IκBα stability and inhibits breast cancer progression. Oncogenesis, 2018 Mar 13;7(3):28. (IF= 6.524)
• Zhaojun Jia, Miao Wang, Shujing Li, Xiahui Li, Xiao-yan Bai, Zhaowei Xu, Yangyang Yang, Bowen Li, Yanan Li, Huijian Wu. U-box ubiquitin ligase PPIL2 suppresses breast cancer invasion and metastasis by altering cell morphology and promoting SNAI1 ubiquitination and degradation. Cell Death & Disease, 2018 Jan 19;9(2):63. (IF=9.685)
• Xiao-yan Bai, Shujing Li, Miao Wang, Xiahui Li, Yangyang Yang, Zhaowei Xu, Bowen Li, Yanan Li, Kangkai Xia, Huan Chen, Huijian Wu. Krüppel-like factor 9 down-regulates matrix metalloproteinase 9 transcription and suppresses human breast cancer invasion. Cancer Lett, 2018,412:224-235. (IF=9.756)
• Miao Wang, Huijian Wu, Shujing Li, Zhaowei Xu, Xiahui Li, Yangyang Yang, Bowen Li, Yanan Li, Jing Guo, Huan Chen. SYNJ2BP promotes the degradation of PTEN through the lysosome-pathway and enhances breast tumor metastasis via PI3K/AKT/SNAI1 signaling. Oncotarget, 2017,8(52):89692-89706. (IF=6.359)
• Qi Jiang, Qingwei Li, Jianmei Han, Meng Gou, Yuanyuan Zheng, Bowen Li, Rong Xiao, Jihong Wang. rLj-RGD3 induces apoptosis via the mitochondrial-dependent pathway and inhibits adhesion, migration and invasion of humanHeyA8 cells via FAK pathway. International Journal of Biological Macromolecules. 2017, 96:652-668. (IF=8.025)
• Rong Xiao, Zhilin Zhang, Hongyan Wang, Yinglun Han, Meng Gou, Bowen Li, Dandan Duan, Jihong Wang, Xin Liu, Qingwei Li. Identification and characterization of a cathepsin D homologue from lampreys (Lampetra japonica). Dev Comp Immunol.2015, 49(1):149-156. (IF=3.605)
• 李博文, 勾萌, 李慶偉, 肖蓉. 七鰓鰻口腔腺蛋白質功能研究進展. 生命科學研究. 2017, 21(1): 69-78.
• 李博文, 勾萌, 肖蓉, 李慶偉. 鈉離子通道參與調節小膠質細胞的生物學功能（封面文章）. 生理學報. 2015, 67(1): 41-47.
• 段丹丹, 王紅艷, 張志林, 李博文, 趙靜, 肖蓉. 七鰓鰻組織蛋白酶D成熟肽結構域的原核表達及功能研究, 遼寧大學學報（自然科學版）. 2017, 44(2): 177-183.
• 李麗, 唐敏, 李博文, 趙靜, 肖蓉. 一株具有纖維蛋白原水解酶活性菌株的分離鑑定. 中國科技論文. 2016,11(24): 2786-2790.