李勤凱，男，博士，北京大學副教授。
基本介紹
- 中文名：李勤凱
- 職業：教師
- 學位/學歷：博士
- 專業方向：細胞內蛋白-蛋白相互作用
- 任職院校：北京大學
個人經歷,研究方向,學術成果,榮譽獎項,
個人經歷
2013 – 北京大學深圳研究生汽戒獄阿院，副教授
2012 – 2013 中科院重慶分院，副研究員
2009 – 2012 德島拜夜設大學附屬醫院，博士後/助理教授
2006 – 2009 德島大學，理學博士
2003 – 2006 南華大學，理學碩士
1999 – 2003 江西中醫藥大學，理學學士
研究方向
蛋白-蛋白相互作用屑記汽調控著細胞的代謝及行為學特徵。研究細胞悼故估內蛋白-蛋白相互作用及其相關信號傳導系統有助於從分子角度理解人體生理及病理過程。我們棕厚拘照的主要研究方向是充分利用交叉學科知識及手腿敬境段闡明某些關鍵蛋白的相互作用對細胞代謝及其相關疾病發生髮展的機理，從而為開發辣迎這類疾病的治療性藥物提供行之有效的策略及分子靶點。
學術成果
1. Xu Y, An X, Guo X, Habtetsion TG, Wang Y, Xu X, Kandala S,Li Q, Li H, Zhang C, Caldwell RB, Fulton DJ, Su Y, Hoda MN, Zhou G, Wu C, Huo Y*.Endothelial PFKFB3 plays a critical role in angiogenesis.Arterioscler Thromb Vasc Biol.2014 Jun;34(6):1231-9. doi: 10.1161/ATVBAHA.113.303041.
2. Dai Y, Jia Y, Chen N, Bian W,Li Q,Ma Y, Chen Y, Pei D*. Zebrafish as a model system to study toxicology.Environ Toxicol Chem. 2014 Jan; 33(1):11-7. doi: 10.1002/etc.2406.
3. Li Q*,Hosaka T, Harada N, Nakaya Y. Activation of Akt through 5-HT2A receptor ameliorates serotonin-induced degradation of insulin receptor substrate-1 in adipocytes.Mol Cell Endocrinol.2013 Jan 5; 365(1):25-35. doi: 10.1016/j.mce.2012.08.022.
4.Li Q,Hosaka T, Shikama Y, Bando Y, Kosugi C, Kataoka N, Nakaya Y, Funaki M*. Heparin-Binding EGF-Like Growth Factor (HB-EGF) Mediates 5-HT-Induced Insulin Resistance Through Activation of EGF Receptor-ERK1/2-mTOR Pathway.Endocrinology.2012 Jan; 153(1):56-68.
5. Liu Y*, Wang Z, Yin W,Li Q, Cai M, Yu J, Li H, Zhang C, Zu X. Preventive effect of Ibrolipim on suppressing lipid accumulation and increasing lipoprotein lipase in the kidneys of diet-induced diabetic minipigs.Lipids Health Dis.2011 Jul 16; 10:117.
6.Li Q*,Hata A, Kosugi C, Kataoka N, Funaki M. The density of extracellular matrix proteins regulates inflammation and insulin signaling in adipocytes.FEBS Lett.2010 Oct 8; 584(19):4145-50. Epub 2010 Sep 15.
7.Li Q, Yin W*, Cai M, Liu Y, Hou H, Shen Q, Zhang C, Xiao J, Hu X, Wu Q, Funaki M, Nakaya Y. NO-1886 suppresses diet-induced insulin resistance and cholesterol accumulation through STAT5-dependent upregulation of IGF1 and CYP7A1.J Endocrinol.2010 Jan; 204(1):47-56.
8.Li Q, Hosaka T, Jambaldorj B, Nakaya Y, Funaki M*. Extracellular matrix with the rigidity of adipose tissue helps 3T3-L1 adipocytes maintain insulin responsiveness.J Med Invest.2009 Aug; 56(3-4):142-9.
9. Liu Y*, Wang Z, Yin W,Li Q, Cai M, Zhang C, Xiao J, Hou H, Li H, Zu X. Severe insulin resistance and moderate glomerulosclerosis in a minipig model induced by high-fat/ high-sucrose/ high-cholesterol diet.Exp Anim.2007 Jan; 56(1):11-20.
10. Hu X, She M, Hou H,Li Q, Shen Q, Luo Y, Yin W*. Adiponectin decreases plasma glucose and improves insulin sensitivity in diabetic Swine.Acta Biochim Biophys Sin(Shanghai). 2007 Feb;39(2):131-6.
11. Zhang C, Yin W*, Liao D, Huang L, Tang C, Tsutsumi K, Wang Z, Liu Y,Li Q, Hou H, Cai M, Xiao J. NO-1886 upregulates ATP binding cassette transporter A1 and inhibits diet-induced atherosclerosis in Chinese Bama minipigs.J Lipid Res.2006 Sep; 47(9):2055-63.
12. Cai M, Yin W*,Li Q, Liao D, Tsutsumi K, Hou H, Liu Y, Zhang C, Li J, Wang Z, Xiao J. Effects of NO-1886 on inflammation-associated cytokines in high-fat/high-sucrose/high-cholesterol diet-fed miniature pigs.Eur J Pharmacol.2006 Jul 1; 540(1-3):139-46.
2. Dai Y, Jia Y, Chen N, Bian W,Li Q,Ma Y, Chen Y, Pei D*. Zebrafish as a model system to study toxicology.Environ Toxicol Chem. 2014 Jan; 33(1):11-7. doi: 10.1002/etc.2406.
3. Li Q*,Hosaka T, Harada N, Nakaya Y. Activation of Akt through 5-HT2A receptor ameliorates serotonin-induced degradation of insulin receptor substrate-1 in adipocytes.Mol Cell Endocrinol.2013 Jan 5; 365(1):25-35. doi: 10.1016/j.mce.2012.08.022.
4.Li Q,Hosaka T, Shikama Y, Bando Y, Kosugi C, Kataoka N, Nakaya Y, Funaki M*. Heparin-Binding EGF-Like Growth Factor (HB-EGF) Mediates 5-HT-Induced Insulin Resistance Through Activation of EGF Receptor-ERK1/2-mTOR Pathway.Endocrinology.2012 Jan; 153(1):56-68.
5. Liu Y*, Wang Z, Yin W,Li Q, Cai M, Yu J, Li H, Zhang C, Zu X. Preventive effect of Ibrolipim on suppressing lipid accumulation and increasing lipoprotein lipase in the kidneys of diet-induced diabetic minipigs.Lipids Health Dis.2011 Jul 16; 10:117.
6.Li Q*,Hata A, Kosugi C, Kataoka N, Funaki M. The density of extracellular matrix proteins regulates inflammation and insulin signaling in adipocytes.FEBS Lett.2010 Oct 8; 584(19):4145-50. Epub 2010 Sep 15.
7.Li Q, Yin W*, Cai M, Liu Y, Hou H, Shen Q, Zhang C, Xiao J, Hu X, Wu Q, Funaki M, Nakaya Y. NO-1886 suppresses diet-induced insulin resistance and cholesterol accumulation through STAT5-dependent upregulation of IGF1 and CYP7A1.J Endocrinol.2010 Jan; 204(1):47-56.
8.Li Q, Hosaka T, Jambaldorj B, Nakaya Y, Funaki M*. Extracellular matrix with the rigidity of adipose tissue helps 3T3-L1 adipocytes maintain insulin responsiveness.J Med Invest.2009 Aug; 56(3-4):142-9.
9. Liu Y*, Wang Z, Yin W,Li Q, Cai M, Zhang C, Xiao J, Hou H, Li H, Zu X. Severe insulin resistance and moderate glomerulosclerosis in a minipig model induced by high-fat/ high-sucrose/ high-cholesterol diet.Exp Anim.2007 Jan; 56(1):11-20.
10. Hu X, She M, Hou H,Li Q, Shen Q, Luo Y, Yin W*. Adiponectin decreases plasma glucose and improves insulin sensitivity in diabetic Swine.Acta Biochim Biophys Sin(Shanghai). 2007 Feb;39(2):131-6.
11. Zhang C, Yin W*, Liao D, Huang L, Tang C, Tsutsumi K, Wang Z, Liu Y,Li Q, Hou H, Cai M, Xiao J. NO-1886 upregulates ATP binding cassette transporter A1 and inhibits diet-induced atherosclerosis in Chinese Bama minipigs.J Lipid Res.2006 Sep; 47(9):2055-63.
12. Cai M, Yin W*,Li Q, Liao D, Tsutsumi K, Hou H, Liu Y, Zhang C, Li J, Wang Z, Xiao J. Effects of NO-1886 on inflammation-associated cytokines in high-fat/high-sucrose/high-cholesterol diet-fed miniature pigs.Eur J Pharmacol.2006 Jul 1; 540(1-3):139-46.
榮譽獎項
2014 深圳市孔雀計畫 (C類)
2011 Outstanding Young investigator awarded by Japan Diabetes Society (Japan)
2011 The best young researcher at Tokushima University (Japan)
2006-2009 Japanese Government (Monbukagakusho: MEXT) Scholarship (Japan)
2011 Outstanding Young investigator awarded by Japan Diabetes Society (Japan)
2011 The best young researcher at Tokushima University (Japan)
2006-2009 Japanese Government (Monbukagakusho: MEXT) Scholarship (Japan)
榮譽獎項
2014 深圳市孔雀計畫 (C類)
2011 Outstanding Young investigator awarded by Japan Diabetes Society (Japan)
2011 The best young researcher at Tokushima University (Japan)
2006-2009 Japanese Government (Monbukagakusho: MEXT) Scholarship (Japan)
2011 Outstanding Young investigator awarded by Japan Diabetes Society (Japan)
2011 The best young researcher at Tokushima University (Japan)
2006-2009 Japanese Government (Monbukagakusho: MEXT) Scholarship (Japan)
