李光鵬

1981. 9---1985. 7，就讀於山東大學生物系動物胚胎學專業，獲理學學士；1987. 9---1990. 7，在東北農業大學生物工程系動物解剖與組織胚胎學專業學習，獲理學碩士；1995. 9---1998. 12 東北農業大學生物工程系動物解剖與組織胚胎學專業， 理學博士。

基本介紹

• 中文名：李光鵬
• 國籍：中華人民共和國
• 民族：漢
• 出生地：山東省青島市
• 出生日期：1963.12
• 畢業院校：山東大學

個人簡介

男，漢族，山東青島人，1963年12月生，博士，教育部長江學者特聘教授。現任內蒙古大學實驗動物研究中心主任、生命科學學院副院長、生殖生物學及生物技術教育部重點實驗室主任。省部共建國家重點實驗室負責人。1985年7月獲山東大學生物系動物學專業理學學士。分別於1990年7月和1998年12月在東北農業大學獲得動物解剖與組織胚胎學專業理學碩士和博士學位。1998年12月至2000年7月在中國科學院動物研究所計畫生育國家重點實驗室作博士後研究，副研究員。自2000年7月至2003年2月，先後在美國科羅拉多州立大學動物繁殖與生物工程實驗室，猶他州立大學動物乳品和獸醫科學係為訪問學者。2003年3月至2007年10月任猶他州立大學動物、乳品和獸醫科學系研究助理教授。於2007年5月以教育部長江學者特聘教授身份受聘於內蒙古大學實驗動物研究中心。

工作經歷

1985.07-1987.09 哈爾濱，東北林業大學野生動物系，助教；

1990.07-1992.11 哈爾濱，黑龍江科學院自然資源研究所動物研究室，助理研究員；

1992.12-1996.05 哈爾濱，東北農業大學生物工程系動物組織胚胎學教研室，講師；

1996.05-1998.12 哈爾濱，東北農業大學生物工程系動物組織胚胎學教研室，副教授；

1998.12-2000.07 北京，中國科學院動物研究所計畫生育國家重點實驗室，博士後, 副教授；

2000.07-2001.06 美國科羅拉多州立大學動物繁殖與生物工程實驗室，訪問學者；

2001.06-2001.12 美國猶他州立大學, 動物, 乳品和獸醫科學系, 訪問學者；

2002.01-現在 美國猶他州立大學, 動物,乳品和獸醫科學系, 研究助理教授。

獲獎情況

2005度國家自然科學獎二等獎：陳大元，孫青原，李光鵬，李勁松，朱子玉。哺乳動物有性和無性生殖的實驗胚胎學研究。

主要學術成就

1.世界上首例克隆騾子--2003 年3匹克隆騾問世，成果發表於 ?科學? 雜誌。

2.2000年獲得世界上首例初級卵母細胞核移植後的哺乳動物個體--兔。

3.2001 年獲得世界上首例次級卵母細胞紡錘體交換後的哺乳動物個體--小鼠。

4.1998年獲得世界上第二例胚胎細胞克隆豬。

5.數百頭克隆牛的創造者。

6.異種克隆大熊貓的主要參入者. 1999年度國家十大科技新聞之一。

7.共發表論文70多篇, 其中SCI 論文28篇；主編及參編學術著作4部; 參與翻譯專著一部。

研究方向：

動物克隆；核質關係；減數分裂調控; 幹細胞研究；轉基因動物。

發表論著與論文：

自1990年至今，共在國內外學術期刊上發表論文70多篇, 其中SCI 論文28篇；主編及參編學術著作4部; 參與翻譯專著一部。

著作：

1.主編：“發育生物學原理與胚胎工程” 黑龍江科學技術出版社 1995；

2. 副主編：“受精生物學----受精機制與生殖工程”。（陳大元主編；孫青原，李光鵬 副主編）。科學出版社 2001；

3. 參編：“哺乳動物胚胎學” （秦鵬春主編）。科學出版社 2001；

4. White KL, Woods GL, Vanderwall DK, Li GP, Bunch TD. Cloning the Equine. In: Epigenetic Risks of Cloning. Edited by Akio Inui, 2006. pp 59-70. CRC Press, Taylor & Francis Group, Boca Raton, Florida, USA；

5. 參譯: “小鼠胚胎操縱實驗指南”. (孫青原, 陳大元 主譯). 化學工業出版社. 2006。

近幾年主要研究論文:

1.Ying Liu, Guang-Peng Li, Benjamin R. Sessions, Lee F. Rickords, Kenneth L. White and Thomas D. Bunch. Nicotine Induces Multinuclear Formation and Causes Aberrant Embryonic Development in Bovine. Mol Reprod Dev. 2007, in press.

2.Liu Y, Li GP, White KL, Rickords LF, Sessions BR, Aston KI, Bunch TD. Nicotine alters bovine oocyte meiosis and affects subsequent embryonic development. Mol Reprod Dev. 2007 Apr 17; [Epub ahead of print], PMID: 17440977 [PubMed - as supplied by publisher].

3.Pate BJ, White KL, Winger QA, Rickords LF, Aston KI, Sessons BR, Li GP, Campbell KD, Weimer B, Bunch TD. 2007. Specific integrin subunits in bovine oocytes, including novel sequences for alpha 6 and beta 3 subunits. Mol Reprod Dev. 2007 May;74(5):600-7.

4.Liu Y, Li GP, Rickords LF, White KL, Sessions BR, Aston KI, Bunch TD. Effect of nicotine on in vitro maturation of bovine oocytes. Anim Reprod Sci. 2006 Nov 26; [Epub ahead of print] PMID: 17178443 [PubMed - as supplied by publisher]

5.Kenneth I. Aston, Guang-Peng Li, Brady A. Hicks, Benjamin R. Sessions, Barry J. Pate, Douglas S. Hammon, Thomas D. Bunch and Kenneth L. White. 2006. The developmental competence of bovine nuclear transfer embryos derived from cow versus heifer cytoplasts. Animal Reproduction Science. Animal Reprod Science. 95(3-4):234-243.

6.Guang-Peng Li, Thomas D. Bunch, Kenneth L. White, Lee Rickords, Ying Liu and Benjamin R. Sessions. 2006. The denuding and centrifugation of maturing bovine oocytes alters oocyte spindle integrity and the ability of cytoplasm to support parthenogenetic and nuclear transfer embryo development. Mole Reprod Dev. 73: 446-451.

7.Aston KI, Li GP, Hicks BA, Sessions BR, Pate BJ, Hammon D, Bunch TD and White KL. 2006. Effect of the time interval between fusion and activation on nuclear state and development in vitro and in vivo of bovine somatic nuclear transfer embryos. Reproduction 131:45-51.

8.Guang-Peng Li, Ying Liu, Thomas D. Bunch, Kenneth L. White, Kenneth I. Aston. 2005. Asymmetric division of spindle microtubules and microfilaments during bovine meiosis from metaphase I to metaphase III. Mol. Reprod. Dev. 71: 220-226.

9.G-P Li, Y Liu, KL White, TD Bunch. 2005. Cytogenetic analysis of diploidy in cloned bovine embryos using an improved air dry caryotyping method. Theriogenology. 2005 Jun;63(9):2434-2444.

10.White KL, Woods GL, Vanderwall DK, Li GP, Sessions BR, Bunch TD. 2004. Why clone horses and mules? Lessons learned from the successful births of cloned mules from a horse. IEEE Engineering in medicine and Biology Magazine 23 (2): 32-36.

11.Guang-Peng Li, Thomas D. Bunch, Kenneth L. White, Kenneth I. Aston, Lora N. Meerdo, Barry J. Pate, Benjamin R. Sessions. 2004. Development, chromosomal composition and allocation of inner cell mass and trophectoderm of bovine nuclear transfer blastocysts after culture in conditioned media. Mol Reprod Dev 68:189-197.

12.Guang-Peng Li, Kenneth L. White and Thomas D. Bunch. 2004. Review of enucleation methods and procedures used in animal cloning: state of the art. Cloning and Stem Cells 6:5-14.

13.G-P Li, White KL, Aston KI, Meerdo LN, Bunch TD. 2004. Conditioned medium increases the polyploid cell composition of bovine somatic cell nuclear transferred blastocysts. Reproduction 127: 221-228.

14. Dirk K. Vanderwall, Gordon L. Woods, Kenneth I. Aston, Thomas D. Bunch, Guanpeng Li, Lora N. Meerdo and Kenneth L. White. 2004. Cloned horse pregnancies produced using adult cumulus cells. Reproduction, Fertility and Development 16(7) 675–679.

15.Guang-Peng Li, G. E. Seidel, Jr. and E. L. Squires. 2004. Improved cleavage of bovine ICSI ova cultured in heparin-containing medium. Theriogenology 61(6): 1077-1084.

16.Woods GL, White KL, Vanderwall DK, Li GP, Aston KI, Bunch TD, Meerdo LN, Pate BJ. 2003. A mule cloned from fetal cells by nuclear transfer. Science 301(5636):1063. Epub 2003 May 29.

17.G -P Li, G. E. Seidel Jr., and E. L. Squires. 2003. Intracytoplasmic sperm injection of bovine oocytes with stallion spermatozoa. Theriogenology, 59:1143-1155.

18.Guangpeng Li, Dayuan Chen, Lian Li, Zhiming Han, GE Seidel Jr. 2002. Rabbit cloning: improved fusion rates using cytochalasin B in the fusion buffer. Mol Reprod Dev 61(2):187-191.

19.Guang-Peng Li, Da-Yuan Chen, Li Lian, Qing-Yuan Sun, Min-Kang Wang. Ji-Song Li, Zhi-Ming Han. 2001. Viable rabbits derived from reconstructed oocytes by germinal vesicle transfer after intracytoplasmic sperm injection (ICSI). Mol Reprod Dev 58:180-185.

20.Guang-Peng Li, Da-Yuan Chen, Li Lian, Qing-Yuan Sun, Min-Kang Wang. 2001. Mouse-rabbit germinal vesicle transfer reveals that factors regulating oocytes meiotic progression are not species-specific in mammals. J Exp Zool 289:322-329.

21.Guangpeng Li, Lian Li, Minkang Wang, Dayuan Chen. 2001. Maturation of the reconstituted oocytes by germinal vesicle transfer in rabbits and mice. Theriogenology 56:855-866.

22.Wang MK, Chen DY, Liu JL, Li GP, Sun QY. 2001. In vitro fertilization of mouse oocytes reconstructed by transfer of metaphase II chromosomes results in live births. Zygote 9:9-14.

23.Wang MK, Liu JL, Li GP, Lian L, Chen DY. 2001. Sucrose pretreatment for enucleation: An efficient and non-damage method for removing the spindle of the mouse MII oocyte. Mol Reprod Dev 58:432-436.

24.Guang-Peng Li, Jing-He Tan, Qing-Yuan Sun, Qing-Gang Meng, Kui-Zhong Yue, Xin-Sen Sun, Zi-Yi Li, Hong-Bin Wang, Li-Bin Xu. 2000. Cloned piglets born after nuclear transplantation of embryonic blastomeres into porcine oocytes matured in vivo. Cloning, 2(1): 45-52.

25.Chen DY, Sun QY, Liu JL, Li GP, Lian L, Wang MK, Han ZM, Song XF, Li JS, Sun Q, Chen YC, Zhang YP and Ding B. 1999. The giant panda (Ailuropoda melanoleuca) somatic nucleus can dedifferentiate in rabbit ooplasm and support early development of the reconstructed egg. Science in China (Series C), 42:346-353.

26.Li Guang-Peng, Meng QG, Wei P, Yu YS, Chang ZL, Tan JH. 2001. Effects of cycloheximide (CHX) on in vitro maturation of porcine oocytes. Acta Zoologica Sinica 47(6): 684-690.

27.Li GP, Lian L, Lian Y, Chen DY. 2001. Reproduction engineering of domestic cat and nondomestic felid species. Zoological Research 22:413-420.

28.Li GP, Lan GC, Liu Y, Yu YS, Sun XS, Ma SF, Tan JH. 2000. Interspecific nuclear transfer between mouse and pig. Zoological Research 21:416-418.

29.Li GP. Lan GC, Ma SF, Tan JH. The behavior of the cell membrane of porcine oocytes matured in vitro in the electric field. Acta Anatomica Sinica, 2000, 21:145-148.

30.Li GP, Meng QG, Wei P, Tan JH. Technical modifications of in vitro maturation of porcine oocytes. Chinese Journal of Veterinary Science, 2000, 12: 32-35.

31.Li GP Cai SX, Xu LB, Tan JH. 2000. Studies on the early development of mouse tetraploid embryos produced by electrofusion. Developmental & Reproductive Biology, 7(1): 17-23.