朱斌，男，1985年12月生，湖北宜昌人，博士，西北農林科技大學副教授、博士生導師，中國水產學會魚病專業委員會會員。
基本介紹
- 中文名：朱斌
- 出生地：湖北宜昌
- 出生日期：1985年12月
- 職業：教師
- 畢業院校：西北農林科技大學
- 學位/學歷：博士
- 專業方向：水生生物學
人物經歷,研究方向,開設課程,學術成果,科研項目,學術論文,發明專利,
人物經歷
2012.9-2015.6，西北農林科技大學水生生物學專業獲博士學位；
2009.9-2012.6，西北農林科技大學水生生物學專業獲碩士學位；
2005.9-2009.6，西北農林科技大學水產養殖學專業獲學士學位。
2015.7至今，入選西北農林科技大學“青年英才計畫”留校任教。
研究方向
主要從事水產動物病害防控研究，具體研究內容包括：（1）水產納米載藥系統的開發套用；（2）水產疫苗的分子設計和開發套用；（3）水產疫苗免疫分子機制研究。
開設課程
承擔本科生《水產動物免疫學》、《魚類藥理學》、《水產動物病害學》和研究生《水生動植物疾病診治及防控》等課程教學任務。
學術成果
主要圍繞水產動物新型疫苗的創製及其分子免疫作用機制開展研究，現已獲批主持國家和省部級等科研項目10餘項。目前發表SCI論文50餘篇，累計影響因子超過200。以第一作者或通訊作者在《Nanotoxicology》、《Journal of Nanobiotechnology》、《Antiviral Research》、《Vaccine》、《Cellular Signalling》、《Fish & Shellfish Immunology》和《Science of The Total Environment》等期刊發表SCI論文37篇，總影響因子超過130，其中包括中科院大類1區論文13篇、2區論文13篇，TOP期刊論文26篇。獲批國家發明專利2項。
科研項目
（1）陝西省自然科學基礎研究計畫-面上項目（2019JM-035），碳納米管載鯉春病毒血症病毒DNA疫苗系統靶向免疫作用研究，2019.1-2020.12。
（2）廣東省水生經濟動物良種繁育重點實驗室開放基金，碳納米管載鱖DNA疫苗系統免疫效果研究，2018.06-2019.12。
（3）西北農林科技大學青年英才培育計畫“卓越新星”資助（2452018029）：水產動物納米靶向抗病研究，2018.01-2020.12。
（4）西北農林科技大學動物科技學院“博領青年學者”項目資助，2018.01-2019.12。
（5）陝西省博士後科研配套資助項目：2017.06-2019.06。
（6）中央高校基本科研業務費（2452017078）：碳納米管載鯉春病毒血症病毒疫苗系統靶向免疫作用研究，2017.01-2020.01。
（7）農業部漁用藥物創製重點實驗室開放課題（201602）：碳納米管載鱖ISKNV疫苗系統研究，2017.01-2018.12。
（8）國家自然科學基金-青年基金（31602204）：碳納米管載草魚呼腸孤病毒DNA疫苗系統靶向免疫機制研究，2017.01-2019.12。
（9）陝西省自然科學基礎研究計畫-青年人才項目（2016JQ3016）：靶向甘露糖受體的草魚出血病碳納米管載體疫苗系統基礎研究，2016.01-2017.12。
（10）陝西省博士後科學基金二等資助（2016BSHEDZZ114）：碳納米管載嗜水氣單胞菌疫苗系統靶向免疫作用機制研究，2016.03-2017.12。
（11）中國博士後科學基金特別資助（2016T90956）：碳納米管載藥系統靶向抗病毒和靶向免疫作用機制研究，2016.03-2017.12。
（12）西北農林科技大學優博論文獲得者留校基金（A213021620）：2016.01- 2018.12。
（13）中國博士後科學基金面上資助金一等資助（2015M580888）：碳納米管載藥系統靶向抗草魚呼腸孤病毒研究，2015.09-2017.07。
（14）西北農林科技大學“青年英才計畫”（Z111021510）：碳納米管載藥靶向抗草魚呼腸孤病毒研究，2015.09-2020.09。
學術論文
（*通訊作者）
（1）Hu Yang, Chen Wei-Chao, Shen Yu-Feng, Zhu Bin*, Wang Gao-Xue*. Synthesis and antiviral activity of a new arctigenin derivative against IHNV in vitro and in vivo. Fish & Shellfish Immunology. 2019. (Accepted) (IF="3.298，Top期刊，中科院農林科學1區)
（2）Zhao Zhao, Zhang Chen, Jia Yi-Jun, Qiu De-Kui, Lin Qiang, Li Ning-Qiu, Huang Zhi-Bin, Fu Xiao-Zhe, Wang Gao-Xue*, Zhu Bin*. Immersion vaccination of Mandarin fish Siniperca chuatsi against infectious spleen and kidney necrosis virus with a SWCNTs-based subunit vaccine. Fish & Shellfish Immunology. 2019, 92:133-140. (IF="3.298，Top期刊，中科院農林科學1區)
（3）Shen Yu-Feng, Hu Yang, Zhu Bin*, Wang Gao-Xue*. Antiviral activity of anisomycin against spring viraemia of carp virus in epithelioma papulosum cyprini cells and zebrafish. Virus Research. 2019, 268:38-44. (IF="2.736，中科院醫學3區)
（4）Hu Yang, Chen Wei-Chao, Shen Yu-Feng, Zhu Bin*, Wang Gao-Xue*. Synthesis and antiviral activity of coumarin derivatives against infectious hematopoietic necrosis virus. Bioorganic & Medicinal Chemistry Letters. 2019, 29(14):1749-1755. (IF="2.448，中科院醫學3區)
（5）Hu Yang, Liu Lei, Li Bo-Yang, Shen Yu-Feng, Wang Gao-Xue*, Zhu Bin*. Synthesis of arctigenin derivatives against infectious hematopoietic necrosis virus. European Journal of Medicinal Chemistry. 2019, 163:183-194. (IF="4.833，Top期刊，中科院醫學2區)
（6）Zhang Chen, Zhao Zhao, Li Jian, Song Kai-Ge, Hao Kai, Wang Jin, Wang Gao-Xue, Zhu Bin*. Bacterial ghost as delivery vehicles loaded with DNA vaccine induce significant and specific immune responses in common carp against spring viremia of carp virus. Aquaculture. 2019, 504:361-368. (IF="3.022，Top期刊，中科院農林科學2區)
（7）Huang Ai-Guo, Tu Xiao, Qi, Xiao-Zhou, Ling Fei, Zhu Bin*, Wang Gao-Xue*. Gardenia jasminoides Ellis inhibit white spot syndrome virus replication in red swamp crayfish Procambarus clarkii. Aquaculture. 2019, 504:239-247. (IF="3.022，Top期刊，中科院農林科學2區)
（8）Shen Yu-Feng, Hu Yang, Zhang Zhao, Liu Lei, Chen Cheng, Tu Xiao, Wang Gao-Xue*, Zhu Bin*. Saikosaponin D efficiently inhibits SVCV infection in vitro and in vivo. Aquaculture. 2019, 504:281-290. (IF="3.022，Top期刊，中科院農林科學2區)
（9）Hu Yang, Shen Yu-Feng, Li Bo-Yang, Wang Gao-Xue*, Zhu Bin*. Evaluation on the antiviral activity of ribavirin against infectious hematopoietic necrosis virus in epithelioma papulosum cyprini cells. Virus Research. 2019, 263:73-79. (IF="2.736，中科院醫學3區)
（10）Zhu Song, Luo Fei, Li Jian, Zhu Bin*, Wang Gao-Xue*. Biocompatibility assessment of single-walled carbon nanotubes using Saccharomyces cerevisiae as a model organism. Journal of Nanobiotechnology. 2018, 16(1):44. (IF="5.345，Top期刊，中科院工程技術1區)
11）Zhang Chen, Li Lin-Han, Wang Jin, Zhao Zhao, Li Jian, Tu Xiao, Huang Ai-Guo, Wang Gao-Xue*, Zhu Bin*. Enhanced protective immunity against spring viremia of carp virus infection can be induced by recombinant subunit vaccine conjugated to single-walled carbon nanotubes.Vaccine. 2018, 36(42):6334-6344. (IF="3.269，Top期刊，中科院醫學2區)
12）Chen Wei-Chao, Liu Lei, Shen Yu-Feng, Hu Yang, Ling Fei, Wang Gao-Xue*, Zhu Bin*. A new coumarin derivative plays a role in rhabdoviral clearance by interfering glycoprotein function during the early stage of viral infection. Cellular Signalling. 2018, 51:199-210. (IF="3.388，中科院生物2區)
13）Chen Wei-Chao, Hu Yang, Liu Lei, Shen Yu-Feng, Wang Gao-Xue*, Zhu Bin*. Synthesis and in vitro activities evaluation of arctigenin derivatives against spring viraemia of carp virus. Fish & Shellfish Immunology. 2018, 82:17-26. (IF="3.298，Top期刊，中科院農林科學1區)
14）Shen Yu-Feng, Liu Lei, Feng Cheng-Zhang, Hu Yang, Chen Cheng, Wang Gao-Xue*, Zhu Bin*. Synthesis and antiviral activity of a new coumarin derivative against spring viraemia of carp virus. Fish & Shellfish Immunology. 2018, 81:57-66. (IF="3.298，Top期刊，中科院農林科學1區)
15）Zhang Chen, Zhao Zhao, Liu Gao-Yang, Li Jian, Wang Gao-Xue*, Zhu Bin*. Immune response and protective effect against spring viremia of carp virus induced by intramuscular vaccination with a SWCNTs-DNA vaccine encoding matrix protein. Fish & Shellfish Immunology. 2018, 79:256-264. (IF="3.298，Top期刊，中科院農林科學1區)
（16）Shan Li-Peng, Chen Xiao-Hui, Ling Fei, Zhu Bin*, Wang Gao-Xue*.Targeting Heat Shock Protein 70 as an antiviral strategy against grass carp reovirus infection. Virus Research. 2018, 247:1-9. (IF="2.736，中科院醫學3區)
（17）Chen Cheng, Shen Yu-Feng, Hu Yang, Liu Lei, Chen Wei-Chao, Wang Gao-Xue*, Zhu Bin*. Highly efficient inhibition of spring viraemia of carp virus replication in vitro mediated by bavachin, a major constituent of Psoralea corlifonia Lynn. Virus Research. 2018. 255:24-35. (IF="2.736，中科院醫學3區)
（18）Zhu Bin*, Zhu Song, Li Jian, Wang Gao-Xue. The developmental toxicity, bioaccumulation and distribution of oxidized single walled carbon nanotubes in Artemia salina. Toxicology Research. 2018. 79:256-264. (IF="1.593，中科院環境科學與生態學3區)
（19）Zhu Song, Luo Fei, Chen Weichao, Zhu Bin*, Wang Gao-Xue*. Toxicity evaluation of graphene oxide on cysts and three larval stages of Artemia salina. Science of The Total Environment. 2017, 595:101-109. (IF="5.589，Top期刊，中科院環境科學與生態學2區)
（20）Liu Lei, Hu Yang, Shen Yu-Feng, Wang Gao-Xue*, Zhu Bin*. Evaluation on antiviral activity of coumarin derivatives against spring viraemia of carp virus in epithelioma papulosum cyprini cells. Antiviral Research. 2017, 144:173-185. (IF="4.130，中科院醫學2區)
（21）Hao Kai, Chen Xiao-Hui, Qi Xiao-Zhou, Yu Xiao-Bo, Du En-Qi, Ling Fei, Zhu Bin*, Wang Gao-Xue*. Protective immunity of grass carp induced by DNA vaccine encoding capsid protein gene (vp7) of grass carp reovirus using bacterial ghost as delivery vehicles. Fish & Shellfish Immunology. 2017, 64:414-425. (IF="3.298，Top期刊，中科院農林科學1區)
（22）Zhang Chen, Zhao Zhao, Zha Ji-Wei, Wang Gao-Xue*, Zhu Bin*. Single-walled carbon nanotubes as delivery vehicles enhance the immunoprotective effect of a DNA vaccine against spring viremia of carp virus in common carp. Fish & Shellfish Immunology. 2017, 71:191-201. (IF="3.298，Top期刊，中科院農林科學1區)
（23）Liu Lei, Tu Xiao, Shen Yu-Feng, Chen Wei-Chao, Zhu Bin*, Wang Gao-Xue*. The replication of spring viraemia of carp virus can be regulated by reactive oxygen species and NF-κB pathway. Fish & Shellfish Immunology. 2017, 67:211-217. (IF="3.298，Top期刊，中科院農林科學1區)
（24）Zhu Song, Luo Fei, Zhu Bin*, Wang Gao-Xue*. Mitochondrial impairment and oxidative stress mediated apoptosis induced by α-Fe2O3nanoparticles in Saccharomyces cerevisiae. Toxicology Research. 2017, 6:719-728. (IF="1.593，中科院環境科學與生態學3區)
（25）Zhu Song, Luo Fei, Zhu Bin*, Wang Gao-Xue*. Toxicological effects of graphene oxide on Saccharomyces cerevisiae. Toxicology Research. 2017, 6:535-543. (IF="1.593，中科院環境科學與生態學3區)
（26）Yu Xiao-Bo, Chen Xiao-Hui, Ling Fei, Hao Kai, Wang Gao-Xue*, Zhu Bin*. Moroxydine hydrochloride inhibits grass carp reovirus replication and suppresses apoptosis in Ctenopharyngodon idella kidney cells. Antiviral Research. 2016, 131:156-165. (IF="4.130，中科院醫學2區)
（27）Wang Yuan, Liu Guang-Lu, Li Dong-Liang, Ling Fei, Zhu Bin*, Wang Gao-Xue*. The protective immunity against grass carp reovirus in grass carp induced by a DNA vaccination using single-walled carbon nanotubes as delivery vehicles. Fish & Shellfish Immunology. 2015, 47:732-742. (IF="3.298，Top期刊，中科院農林科學1區)
（28）Zhu Bin, Liu Guang-Lu, Ling Fei, Song Lin-Sheng, Wang Gao-Xue*. Development toxicity of functionalized carbon nanotubes on rare minnow embryos and larvae. Nanotoxicology. 2015. 9(5):579-590. (IF="7.913，Top期刊，中科院醫學1區)
（29）Zhu Bin, Liu Guang-Lu, Ling Fei, Wang Gao-Xue*. Carbon nanotube-based nanocarrier loaded with ribavirin against grass carp reovirus. Antiviral Research. 2015, 118:29-38. (IF="4.130，中科院醫學2區)
（30）Zhu Bin, Liu Guang-Lu, Liu Lei, Ling Fei, Wang Gao-Xue*. Assessment of trifloxystrobin uptake kinetics, developmental toxicity and mRNA expression in rare minnow embryos. Chemosphere. 2015, 120:447-455. (IF="5.108，Top期刊，中科院環境科學與生態學2區)
（31）Zhu Bin, Liu Guang-Lu, Gong Yu-Xin, Ling Fei, Wang Gao-Xue*. Protective immunity of grass carp immunized with DNA vaccine encoding the vp7 gene of grass carp reovirus using carbon nanotubes as a carrier molecule. Fish & Shellfish Immunology. 2015, 42(2):325-334. (IF="3.298，Top期刊，中科院農林科學1區)
（32）Zhu Bin, Liu Guang-Lu, Gong Yu-Xin, Ling Fei, Song Lin-Sheng, Wang Gao-Xue*. Single-walled carbon nanotubes as candidate recombinant subunit vaccine carrier for immunization of grass carp against grass carp reovirus. Fish & Shellfish Immunology. 2014, 41(2):279-293. (IF="3.298，Top期刊，中科院農林科學1區)
（33）Zhu Bin, Gong Yu-Xin, Liu Lei, Li Dong-Liang, Wang Yuan, Ling Fei, Wang Gao-Xue*. Toxic effects of triazophos on rare minnow (Gobiocypris rarus) embryos and larvae. Chemosphere. 2014, 108:46-54. (IF="5.108，Top期刊，中科院環境科學與生態學2區)
（34）Zhu Bin, Liu Lei, Li Dong-Liang, Ling Fei, Wang Gao-Xue*. Developmental toxicity in rare minnow (Gobiocypris rarus) embryos exposed to Cu, Zn and Cd. Ecotoxicology and Environmental Safety. 2014, 104:269-277. (IF="4.527，中科院環境科學與生態學3區)
（35）Zhu Bin, Liu Lei, Gong Yu-Xin, Ling Fei, Wang Gao-Xue*. Triazole-induced toxicity in developing rare minnow (Gobiocypris rarus) embryos. Environmental Science and Pollution Research. 2014, 21(23): 13625-13635. (IF="2.914，中科院環境科學與生態學3區)
（36）Zhu Bin, Liu Tian-Qiang, Hu Xue-Gang, Wang Gao-Xue*. Developmental toxicity of 3,4-dichloroaniline on rare minnow (Gobiocypris rarus) embryos and larvae. Chemosphere. 2013, 90(3):1132-1139. (IF="5.108，Top期刊，中科院環境科學與生態學2區)
（37）Zhu Bin, Wu Zong-Fan, Li Jun, Wang Gao-Xue*. Single and joint action toxicity of heavy metals on early developmental stages of Chinese rare minnow (Gobiocypris rarus). Ecotoxicology and Environmental Safety. 2011, 74(8): 2193- 2202. (IF="4.527，中科院環境科學與生態學3區)
發明專利
（1）王高學, 朱斌, 劉廣路, 凌飛. 碳納米管載體免注射疫苗、製備方法及其在製備水產免疫苗種中的套用, 2016.01, 中國, 授權號ZL. 201310482649.7.
（2）王高學, 劉廣路, 朱斌, 凌飛. 碳納米管載抗病毒藥物複合物、製備方法及其在水產養殖無病毒攜帶苗生產中的套用, 2016.01, 中國, 授權號ZL. 201310482759.3.
