曾進勝， 男，1964年出生。1985年畢業於江西醫學院醫療系，1994年獲中山醫科大學神經病學專業博士學位。1996年9月至1998年8月，在瑞典LUND大學Wallenberg神經科學中心從事博士後研究。2002年7月-2002年10月，在NNICU, Barnes-Jewish Hospital, Washington University in St. Louis. USA，學習腦卒中監護和急救。
現為國家重點學科--中山大學附屬第一醫院神經科主任、二級教授、一級主任醫師、博士生導師、廣東省“珠江學者”特聘教授。擔任中國神經精神疾病雜誌主編、International Journal of Stroke（中文版）主編、中國卒中雜誌副主編、中華腦血管病雜誌（電子版）副總編輯和美國stroke雜誌、國內12家專業雜誌編委和Brain Research、Cerebrovascular Diseases等雜誌特約審稿人、中華醫學會神經病學分會委員、腦血管病學組秘書、中國醫師協會神經病學分會常委、廣東省醫師協會神經病學分會主任委員、廣東省神經內科學會副主任委員、腦血管病學組組長。
2020年2月，入選國家健康科普專家庫成員名。
基本介紹
- 中文名：曾進勝
- 國籍：中國
- 民族：漢
- 出生日期：1964年
- 畢業院校：江西醫學院醫療系
- 代表作品： 主編《臨床診斷與治療方案叢書;神經內科疾病》
- 職務：中山大學附屬第一醫院神經科主任
人物簡介,醫療專長,教學工作,主要課程,實踐性教學,教學研究課題,發表論文,教學獎項,主/參編教材,科研工作,科研成果,
人物簡介
主要從事腦血管病的預防、急救、治療和康復研究，在腦卒中後神經可塑性、內源性神經幹細胞的分化和遠隔性損害研究方面具有特色。其中高血壓動脈硬化性腦梗死的病理機制及臨床系列研究和抗高血壓治療預防腦卒中的實驗研究分別獲廣東省科技進步二等獎、衛生部三等獎和廣東省醫藥衛生科技進步二等獎。曾被衛生部醫政司評為衛生部支援西部地區農村衛生工作“優秀教師”，獲國家教育部“高校青年教師獎”、廣東省回國創業青年之星“優秀獎”、國家教育部高等院校優秀青年教師“霍英東教育基金三等獎”和廣東省青年教師“南粵教壇新秀獎”、廣東省優秀教師獎、柯麟醫學獎，入選“千百十人才工程”廣東省級培養對象並獲優秀個人稱號、廣東省“珠江學者”特聘教授。承擔並完成教育部高校青年教師獎勵計畫（TRAPOYT，2002年）、國家自然科學基金（39940012, 30271485，30770764）、衛生部臨床學科重點學科建設項目（2002）、美國中華醫學會基金（CMB，00-730）、廣東省自然科學基金（990065，B30303, 2003D30301）和廣東省自然科學基金團隊項目（2000年）等多項科研項目30項。已在國內外雜誌發表論文270篇，其中SCI收錄雜誌51篇。主編專著4本，參與編寫專著20本。
醫療專長
出診時間：周四下午（名專家門診），周五上午（教授門診）。
教學工作
主要課程
課程名稱 課程類別 年學時 屆數 學生總人數
腦血管疾病與偏頭痛（英文） 七、八年制臨床醫學專業課 4學時/年 5 500
腦血管疾病新進展（中文） 研究生學位專業課 4學時/年 5 100
腦血管疾病新進展（中文） 全國高級醫師進修班 4學時/年 5 150
實踐性教學
指導實習生的教學,在查房時將神經病學的基礎理論和臨床實際緊密結合為學生進行講解. 將神經病學、神經解剖、血管解剖、康復醫學相結合，使學生掌握神經解剖、血管解剖的基礎上，學習神經病學。同時指導研究生的課題設計;對每個畢業生的論文進行審核.在實踐中對教學進行大膽改革,樹立以學生為主體的教學思想，充分發揮學生主動學習的積極性。
教學研究課題
1. 2003-2007年，第一負責人，“腦卒中專科化治療和神經可塑性研究”項目，教育部高校青年教師獎
2. 2007- 2009年，第一負責人，主持“07校級雙語課程《神經病學》”項目，中山大學醫學教務處
發表論文
1. 方燕南,曾進勝，代謝綜合徵與腦卒中.繼續醫學教育, 2005
2. 姚曉黎,李洵樺,曾進勝，提高教學能力,講好本科大課.中山大學學報論叢, 2007
3. 馮慧宇,方燕南,姚曉黎,車珠江,曾進勝，現代教育技術在神經科教學中的套用.中山大學學報論叢, 2007
4. 陳子怡, 陶玉倩, 李洵樺, 馮慧宇, 周列民, 曾進勝，以理論考核分析指導神經科見習方案調整.醫學信息, 2009
5. 李中, 王淑珍, 張成，李洵樺, 曾進勝，提高臨床神經病學見習教學質量的探索與實踐.西北醫學教育, 2009
教學獎項
① 2009年，珠江學者特聘教授
② 2008年，廣東省千百十人才優秀個人獎，廣東省柯磷醫學獎
③ 2007年，被評為廣東省南粵優秀教師
④ 2006年，被衛生部醫政司評為衛生部支援西部地區農村衛生工作“優秀教師”
主/參編教材
1. 主編《腦卒中:新理論與新實踐1》(2006年)
2. 主編《腦卒中:新理論與新實踐2》(2008年)
3. 主編《腦卒中:新理論與新實踐3》(2009年)
4. 主編《臨床診斷與治療方案叢書;神經內科疾病》(2010年)
5. 副主編《神經病學》(2009年)
6. 副主編《神經病學》（2010年）
7. 副主編《臨床專科醫師規範化培訓用書—神經病學》（2009年）
8. 參編《內科臨床手冊》(2006年)
9. 參編《神經病學》(第2版) (2007年)
10.參編《內科急症治療學》(2009年)
科研工作
課題名稱 | 課題來源 | 起止年限 | 金額(萬) | 排名 | 完成情況 |
EphB2對實驗性大腦皮層梗死後遠隔部位局部血管新生和神經可塑性的作用 | 國家自然科學基金(30770764) | 2008-2010 | 30 | 第一 | 完成 |
瀰漫性腦損害(阿爾茨海默病和精神分裂症)的腦網路研究 | 國家重點基礎研究發展計畫（973）課題（計畫課題編號：2011CB707805） | 2011-2015 | 236 | 第一 | 進行中 |
腦梗死後遠隔部位神經細胞自噬的發現、機制及調控靶點 | 國家自然科學基金-廣東省聯合重點項目 （編號：U1032005） | 2011-2013 | 190 | 第一 | 完成 |
腦梗死後遠隔部位Aβ沉積與神經細胞自噬和凋亡的調控機制 | 廣東省高等學校高層次 人才項目 | 2011-2013 | 80 | 第一 | 完成 |
帕金森病致病基因的篩查及其致病機制的研究 | 廣東省科技廳 | 2011- | 5 | 第一 | 進行中 |
腦梗死後局部腦網路早期改變模式與臨床預後 | 廣州市科技計畫項目 | 2011- | 70 | 第一 | 進行中 |
負荷劑量氯吡格雷治療中國人急性腦梗死的有效性與安全性隨機雙盲多中心臨床研究 | 橫向課題 | 2008- | 10 | 第一 | 進行中 |
施普善對高血壓大鼠腦梗死後遠隔細胞凋亡的作用研究 | 橫向課題 | 2008- | 6．0萬 | 第一 | 進行中 |
腦栓通對局灶性大腦皮層梗死後遠隔部位繼發性損害的保護作用的研究 | 橫向課題 | 2008- | 8．0萬 | 第一 | 進行中 |
科研成果
主要從事腦血管病的防治和康復機制研究，1998年回國後，在國內首先開創了腦中風監護工作。近年的主要成績有：
研究成果 獲獎等級 時間 排名
1．腦梗塞的病理機制及治療新理念 廣東省科技進步二等獎 2008 第三
2．易卒中型腎血管性高血壓大鼠模型及其套用 教育部科技進步二等獎 2007 第二
SCI收錄的部分論文(*為通信作者)
1. Jinsheng Zeng (曾進勝)*, Huang R. Stroke-prone Renovascular Hypertensive Rats.Chinese Medical Journal, 1998, 111(8):741-744
2. Jinsheng Zeng(曾進勝)*, Zhang Y, Mo J, Su Z, Huang R. Two-Kidney two-clip renovascular hypertensive rats can be used as stroke-prone rats. Stroke , 1998, 29(8):1708-1714
3. Jinsheng Zeng (曾進勝) *, Zhang Y, Mo J, Su Z, Huang R. Spontaneous stroke in renovascular hypertensive rats. Stroke, 1999, 30:696
4. Jinsheng Zeng(曾進勝), Mattsson B, Johansson BB. Are neuronal markers and neocortical graft-host interface influenced by housing conditions in rats with cortical infarct cavity? Brain Res Bull. 1999，48:165-171
5. Risedal A, Jinsheng Zeng (曾進勝), Johansson BB. Early training may exacerbate brain damage in focal brain ischemia in the rat. J Cereb Blood Flow Metab, 1999, 19:997-1004
6. Jinsheng Zeng(曾進勝), Mattsson B, Schultz M, Johansson BB, Sorensen JC. Expression of zinc positive cells and terminals in fetal homografts to adult rat neocortex depend on transplantation site and rearing conditions. Exp Neurol, 2000, 164:176-183
7. Yannan Fang, Xiaohua Chen, Hua Li, Jianwen Lin, Ruxun Huang, Jinsheng Zeng(曾進勝). A study on additional early physiotherapy after stroke and factors affecting functional recovery. Clinical Rehabilitation. 2003, 17(6):608-617
8. Jinsheng Zeng(曾進勝)*, Yu Jian, Cui Chunmei, Zhao Zhan, Hong Hua, Sheng Wenli, Tao Yuqian, Li Ling, Huang Ruxun. Cultured human embryonic neocortical cells survive and grow in infarct cavities of adult rat brains and interconnect with host brain. Chinese Medical Journal，2005, 118(4):275-280
9. Hong H, Jin-sheng Zeng(曾進勝), Kreulen DL, Kaufman DI, Chen AF. Atorvastatin ProtectsAgainst Cerebral Infarction via Inhibiting NADPH Oxidase-Derived Superoxide in Ischemic Stroke. Am J Physiol Heart Circ Physiol, 2006, 291(11):2210-2215
10. Bin Song, Chi Ma, Shoufang Gong, Zhongmin Yuan, Dan Li, Wei Liu,Wenming Li, Ruzhu Chen, Xiaonan Zhu, Jinsheng Zeng(曾進勝), Yifan Han, Mingtao Li. Extracellular signal-regulated kinases are not involved in activitydependent survival or apoptosis in cerebellar granule neurons. Neuroscience Letters, 2006, 407(8):214–218
11. Chunmei Cui, Alex F Chen, Zongpei Jiang, Qingqing Wu,Jianwen Lin, Hongmei Wen and Jinsheng Zeng(曾進勝)*. Inhibition of NAD(P)H oxidase reduces fibronectin expressionin stroke-prone renovascular hypertensive rat brain. Clinical and Experimental Pharmacology and Physiology, 2007, 34(4):304-309
12. Zhijian Liang, Jinsheng Zeng(曾進勝)*, Siren Liu, Xueying Ling,Anding Xu, Jian Yu, Li Ling. A prospective study of secondary degeneration following subcortical infarction using diffusion tensor imaging. J Neurol Neusurg Psychiat, 2007, 78(5):581-586
13. Fang Wang, Zhijian Liang, Qinghua Hou, Shihui Xin, Li Lin, Meixia He, Zhong Pei，Jinsheng Zeng(曾進勝)*. Nogo-A is involved in secondary axonal degeneration of thalamus in hypertensive rats with focal cortical infarction. Neuroscience Letters, 2007, 417 (3) :255–260
14. Zhan Zhao, Jian Yu, Songjie Liao, Li Xiong, Zhijian Liang, Li Ling, Qinghua Hou, Wenliang Zhou, Zhong Pei, Jinsheng Zeng(曾進勝)*.Delayed Decompressive Craniectomy Improves the Long term Outcome in Hypertensive Rats with Space-occupying Cerebral Infarction. Neurocritical Care, 2007, 7(3):263-269
15. Chun-Ling Liu, Song-Jie Liao, Jin-Sheng Zeng(曾進勝), Jian-Wen Lin, Chang-Xin Li，Long-Chang Xie,Xiao-Geng Shi,Ru-Xun Huang. dl-3n-butylphthalide prevents stroke via improvement of cerebral microvessels in RHRSP. Journal of the Neurological Sciences, 2007, 260(4):106–113
16. Song-Jie Liao, Li Lin, Jin-Sheng Zeng(曾進勝), Ru-Xun Huang, Keith MChannon., Alex F Chen. Endothelium-Targeted Transgenic Gtp-Cyclohydrolase I Overexpression Inhibits Neointima Formation In Mouse Carotid Artery. Clinical and Experimental Pharmacology and Physiology, 2007, 34(12):1260-6.
17. Meixia He, Shihui Xing, Bo Yang, Liqun Zhao, Ying Hai, Zhijian Liang, Wenliang Zhou, Jinsheng Zeng(曾進勝)*, Zhong Pei. Ebselen attenuates oxidative DNA damage and enhances its repair activity in the thalamus after focal cortical infarction in hypertensive rats. Brain Research, 2007, 1181:83-92
18. Zhijian Liang, Jinsheng Zeng(曾進勝)*, Cuimei Zhang, Sirun Liu, Xueying Ling, Anding Xu, Li Ling, Fang Wang, Zhong Pei. Longitudinal Investigations on the Anterograde and Retrograde Degeneration in the Pyramidal Tract following Pontine Infarction with Diffusion Tensor Imaging. Cerebrovascular Diseases, 2008, 25(3):209-216
19. Li Ling, Qinghua Hou, Shihui Xing, Jian Yu, Zhong Pei, Jinsheng Zeng(曾進勝)*. Exogenous kallikrein enhances neurogenesis and angiogenesis in the subventricular zone and the peri-infarction region and improves neurological function after focal cortical infarction in hypertensive rats. Brain Research, 2008, 1206(4):89-97
20. Yining Huang, Yan Cheng, Jiang Wu, Yansheng Li, En Xu, Zhen Hong, Zhengyi Li, Weiwei Zhang, Meiping Ding, Xuguang Gao, Dongsheng Fan, Jinsheng Zeng(曾進勝), Kasing Wong, Chuanzhen Lu, Jiangxi Xiao, Chen Yao. Cilostazol as an alternative to aspirin after ischaemic stroke: a randomised, double-blind, pilot study. Lancet Neurol, 2008, 7(6): 494–99.
21. Shihui Xing, Ling Chen, Xi Chen, Zhong Pei, Jinsheng Zeng(曾進勝) * Jinru Li. Excessive blinking as an initial manifestation of juvenile Huntington’s disease from a Chinese family. Neurological Science, 2008, 29:275–277
22. Shihui Xing, Yangdong He, Li Ling, Qinghua Hou, Jian Yu, Jinsheng Zeng(曾進勝)*,Zhong Pei. Blockade of EphB2 enhances neurogenesis in the subventicular zone and improves neurological function after cerebral cortical infarction in hypertensive rats. Brain Research, 2008, 1230:237-246.
23. Zhongwei Zhang, Laijing Song, Quanfei Meng, Ziping Li, Boning Luo, Zhong Pei, Jinsheng Zeng(曾進勝). Segmented echo planar MR imaging of the brachial pexus with inversion recovery magnetization preparation at 3.0T. Journal of Magnetic Resonance Imaging , 2008, 28(2):440–444
24. Yuhua Fan, Liangfu Zhu, Songjie Liao, Jinsheng Zeng(曾進勝)*. Anxiety disorders mimic recurrent transient ischemic attacks: Two case reports. American Journal of Case Report. 2008, 9(4):196-199
25. Li Ling, Xiaoshun He, Jinsheng Zeng(曾進勝)*. In-Hospital Cerebrovascular Complications following orthotopic Liver Transplantation. BMC Neurology, 2008, 8:52
26. Jian Yu, Jinsheng Zeng(曾進勝)*, Yangdong He, Zhan Zhao, Chunmei Cui, Li Xiong, Meixia He, Zhijian Liang, Hua Hong, Wenli Sheng, Yannan Fang, Ruxun Huang, Ramond Cheung. Exogenous epidermal growth factor improves early neurological function and promotes endogenous subependymal neural stem cells differentiation to astrocytes in adult hypertensive rats after neocortical infarction. Clinical and Experimental Pharmacology and Physiology, 2009, 36, 539–546
27. Yongjing Su, Xiaoyan Zhang, Jinsheng Zen(曾進勝)*, Zhong Pei, Raymond Tak Fai Cheung, Qiuping (Pearl) Zhou, Li Ling, Jian Yu, Jianling Tan, Zhenlu Zhang. New-onset constipation at acute stage after first stroke： incidence, risk factors, and impact on the stroke outcome. Stroke, 2009,40(4):1304-9.
28. Yuhua Fan, Songjie Liao, Jian Yu, Li Ling, Qinghua Hou, Shihui Xing, Jinsheng Zeng(曾進勝)*. Idiopathic hypertrophic cranial pachymeningitis manifested by transient ischemic attack. Medical Science Monitor, 2009; 15(12): CS 178 - 181
29. Zhijian Liang, Jinsheng Zeng(曾進勝)*, Cuimei Zhang, Sirun Liu, Xueying Ling, Fang Wang, Li Ling, Qinghua Hou, Shihui Xing, Zhong Pei. Progression of pathological changes in the middle cerebellar peduncle by diffusion tensor imaging correlate with lesser motor gains after pontine infarction. Neurorehabilitation and Neural Repair, 2009, 23(7):692-698
30. Li Ling, Jinsheng Zeng(曾進勝)*, Zhong Pei, Raymond Tak Fai Cheung, Qinghua Hou, Shihui Xing, Jian Yu. Neurogenesis and angiogenesis in ipsilateral thalamus with secondary damage in adult hypertensive rats following focal cortical infarction. Journal of Cerebral Blood flow and Metabolism, 2009, 29:1538–1546
31. Li Ling, Liangfu Zhu, Jinsheng Zeng(曾進勝)*, Songjie Liao, Jian Yu, Zhiyun Yang, Zhijian Liang. Pontine infarction with pure motor hemiparesis or hemiplegia. BMC Neurology, 2009, 15;9:25
32. Jian Sun, Yannie Oi Yan Soo , Wynnie Wai Man Lam, Ka Sing Wong, Jin Sheng Zeng, Yu Hua Fan. Different distribution patterns of cerebral microbleeds in acute ischemic stroke patients with and without hypertension. Eur Neurol, 2009, 62:298–303
33. Song-Jie Liao, Jian-Wen Lin, Zhong Pei, Chun-Ling Liu, Jin-sheng Zeng(曾進勝), Ru-Xun Huang. Enhanced angiogenesis with dl-3n-butylphthalide treatment after focal cerebral ischemia in RHRSP. Brain Res, 2009, 1289:69-78.
34. Jia Zhao, Ling Li, Chen Ling, Jie Li, Ji-Yan Pang, Yong-Cheng Lin, Jie Liu, Ruxun Huang, Guan-Lei Wang, Zhong Pei and Jinsheng Zeng(曾進勝). Marine compound Xyloketal B protects PC12 cells against OGD-induced cell damage. Brain Res, 2009, 1302:240-247.
35. Qinghua Hou, Li Ling, Fang Wang, Shihui Xing, Zhong Pei, Jinsheng Zeng(曾進勝)*. Endostatin expression in neurons during the early stage of cerebral ischemia is associated with neuronal apoptotic cell death in adult hypertensive rat model of stroke. Brain Research, 2010, 1311:182-188
36. Mei-xiaHe, Wan-liYang, Ming-mingZhang, Ya-junLian, Hai-yingHua, Jin-sheng Zeng(曾進勝), Li-rongZhang. Association between interleukin-6 gene promoter -572C/G polymorphism and the risk of sporadic Alzheimer's disease. Neurol Sci, 2010, 31(2):165-8.
37. Xi-lin Lu, Xiao-li Yao, Zhiyong Liu, Heng Zhang, Wei Li, Zhenxing Li, Guan-Lei Wang, Jiyan Pang, Yongcheng Lin, Zhongliang XuLing Chen, Zhong Pei Jinsheng Zeng(曾進勝)*. Protective effects of xyloketal B against MPP+-induced neurotoxicity in Caenorhabditis elegans and PC12 cells. Brain Res, 2010, 1332:110-9.
38. Li Xiong, Jian Yu, Songjie Liao, Shihui Xing, Zhan Zhao, Jinsheng Zeng(曾進勝)*. Mechanisms of secondary damage to the thalamic nucleus and substantia nigra in an adult hypertensive rat model following middle cerebral artery occlusion Neural Regen Res, 2010, 5(11):853-858
39. Yusheng Zhang, Shihui Xing, Jian Zhang, Jingjing Li, Chuo Li, Zhong Pei and Jinsheng Zeng(曾進勝)*. Reduction of β-amyloid deposits by γ-secretase inhibitor is associated with the attenuation of secondary damage in the ipsilateral thalamus and sensory functional improvement after focal cortical infarction in hypertensive rats. Journal of Cerebral Blood flow and Metabolism, 2011, 31(2):572-9
40. Chuo Li, Xueying Ling, Sirun Liu, Anding Xu, Yusheng Zhang, Shihui Xing, Zhong Pei and Jinsheng Zeng*(曾進勝). Early detection of secondary damage in ipsilateral thalamus after acute infarction at unilateral corona radiata by diffusion tensor imaging and magnetic resonance spectroscopy. BMC Neurology. 2011, 11:49.
41. Jing-Jing Li, Shi-Hui Xing, Jian Zhang, Hua Hong, Yi-Liang Li, Chao Dang, Yu-Sheng Zhang, Chuo Li, Yu-Hua Fan, Jian Yu, Zhong Pei and Jin-Sheng Zeng*(曾進勝). Decrease of tight junction integrity in the ipsilateral thalamus during the acute stage after focal infarction and ablation of the cerebral cortex in rats. Clinical and Experimental Pharmacology and Physiology. 2011,38:776–782.
42. Zhang J, Zhang Y, Li J, Xing S, Li C, Li Y, Dang C, Fan Y, Yu J, Pei Z and Jin-Sheng Zeng*(曾進勝). Autophagosomes accumulation is associated with β-amyloid deposits and secondary damage in the thalamus after focal cortical infarction in hypertensive rats. J Neurochem. 2012;120(4):564-73.
43. Xing S, Zhang Y, Li J, Zhang J, Li Y, Dang C, Li C, Fan Y, Yu J, Pei Z and Jin-Sheng Zeng*(曾進勝). Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction. Autophagy. 2012;8(1):63-76.
44. Zhang J, Zhang Y, Xing S, Liang Z and Jin-Sheng Zeng*(曾進勝). Secondary neurodegeneration in remote regions after focal cerebral infarction: a new target for stroke management? Stroke. 2012;43(6):1700-5.
45. Li C, Ling X, Liu S, Xu A, Zhang Y, Xing S, Pei Z and Jin-Sheng Zeng*(曾進勝). Abnormalities of magnetic resonance spectroscopy and diffusion tensor imaging are correlated with executive dysfunction in patients with ischemic leukoaraiosis. J Clin Neurosci. 2012;19(5):718-22.
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