景鍵,男,博士,南京大學生命科學學院教授、博士生導師。景鍵以國際著名模式動物海兔為對象,研究行為的神經機制,並將此模式動物第一次引進中國,在南京大學建立了相應的實驗平台。
基本介紹
- 中文名:景鍵
- 畢業院校:美國伊利諾伊大學
- 學位/學歷:博士
- 專業方向:神經生物學
- 任職院校:南京大學
人物經歷,學術兼職,研究領域,主要文章,學術影響,主要成就,個人基金,教學情況,
人物經歷
1983-1987, 北京大學生物學系學生。研究方向神經病理學(大鼠海馬的缺血和缺氧)
1987-1989, 北京神經外科研究所,研究助理
1989-1992, 美國杜克(Duke)大學,研究助理。研究方向:神經生物學(動物模型系統)
1992-1998, 美國伊利諾伊大學(University of Illinois)生理系,博士研究生(Ph.D.)
1998-2001, 美國西奈山(Mount Sinai)醫學院,博士後
2002-2013,美國西奈山(Mount Sinai)醫學院神經科學系, 助理教授
2012-至今:南京大學生命科學學院,研究員
學術兼職
Academic Editor: PLOS ONE (2015-present)
美國神經科學學會會員
中國神經科學學會第六屆感覺和運動分會委員會委員
研究領域
行為/系統和細胞神經科學(Behavioral/Systems and Cellular Neuroscience) – 利用動物模型系統研究行為的神經機理 (Studying neural basis of behavior using model systems): 感覺運動整合(sensorimotor integration), 運動協調(movement coordination), 神經調節(neuromodulation), 行為和環路可塑性(behavioral and circuit plasticity); 動機 (motivation), 覺醒 (arousal), 決策(decision making) 等的神經機制
主要文章
編著
Jing J, Ed, Network Functions and Plasticity: Perspectives from Studying Neuronal Electrical Coupling in Microcircuits, Academic Press, London, UK, 2017
論文
Checco J.W., Zhang G., Yuan W-D., Le Z-W., Jing J. *, Sweedler J.V.* , Aplysia allatotropin-related peptide and its newly identified d-amino acid–containing epimer both activate a receptor and a neuronal target, J. Biol. Chem. , 293 , 16862−16873, (2018).Checco J.W., Zhang G., Yuan W-D., Yu K., Yin S-Y., Roberts-Galbraith R.H., Yau P.M., Romanova E.V., Jing J. * , Sweedler J.V. * , Molecular and physiological characterization of a receptor for D‑amino acid-containing neuropeptides, ACS Chem. Biol. , 13 , 1343-1352, (2018).Zhang G., Yuan W-D., Vilim F.S., Romanova E.V., Yu K., Yin S-Y., Le Z-W., Xue Y-Y., Chen T-T., Chen G-K., Chen S-A., Cropper E.C., Sweedler J.V., Weiss K.R., Jing J. * , Newly identified Aplysia SPTR-Gene Family-Derived Peptides: localization and function, Aplysia, ACS Chem. Neurosci. , 9 , 2041-2053, (2018).Zhang G., Vilim F.S., Liu D-D, Romanova E.V., Yu K., Yuan W-D., Xiao H., Chen T-T., Alexeeva V.Y., Yin S-Y., Chen S-A., Cropper E.C., Sweedler J.V., Weiss K.R., Jing J. * , Discovery of leucokinin-like neuropeptides that modulate a specific parameter of feeding motor programs in the molluscan model, Aplysia, J. Biol. Chem. , 292 , 18775−18789, (2017).Livnat I., Tai H-C., Jansson E. T., Bai L., Romanova E.V., Chen T-T., Yu K., Chen S-A., Zhang Y., Wang Z-Y., Liu D-D., Weiss K.R., Jing J. * , Sweedler J.V. * , A D-amino acid-containing neuropeptide discovery funnel, Anal. Chem. , 88 , 11868−11876, (2016).Siniscalchi M.J., Cropper E.C., Jing J., Weiss K.R., Repetition priming of motor activity mediated by a central pattern generator: the importance of extrinsic vs. intrinsic program initiators, J. Neuro physiol. ,116 , 1821–1830, (2016).Yang C-Y., Yu K., Wang Y., Chen S-A., Liu D-D., Wang Z-Y., Su Y-N., Yang S-Z., Chen T-T., Livnat I., Vilim F.S., Cropper E.C., Weiss K.R., Sweedler J.V., Jing J. * , Aplysia locomotion: network and behavioral actions of GdFFD, a D-amino acid-containing neuropeptide, PloS One , 11 , e0147335, (2016). Jing J. * , Alexeeva V.Y., Chen S-A., Yu K., Due M.R., Tan L-N., Chen T-T., Liu D-D., Cropper E.C., Vilim F.S., Weiss K.R., Functional characterization of a vesicular glutamate transporter in an interneuron that makes excitatory and inhibitory synaptic connections in a molluscan neural circuit, J. Neurosci., 35 , 9137–9149, (2015).Wu J-S., Wang N, Siniscalchi M.J., Perkins M.H., Zheng Y-T., Yu W., Chen S-A., Jia R-N., Gu J-W., Qian Y-Q., Ye Y., Vilim F.S., Cropper E.C., Weiss K.R., Jing J. * , Complementary interactions between command-like interneurons that function to activate and specify motor programs, J. Neurosci., 34, 6510–6521, (2014). (Featured in THIS WEEK IN THE JOURNAL )Bai L., Livnat I., Romanova E.V., Alexeeva V.Y., Yau P.M., Vilim F.S., Weiss K.R., Jing J. * , Sweedler J.V. *, Characterization of GdFFD, a D-amino acid-containing neuropeptide that functions as an extrinsic modulator of the Aplysia feeding circuit, J. Biol. Chem. , 288 , 32837–32851, (2013).Sasaki K., Cropper E.C., Weiss K.R., Jing J. * , Functional differentiation of a population of electrically coupled heterogeneous elements in a microcircuit, J. Neurosci., 33, 93-105, (2013). (Featured in THIS WEEK IN THE JOURNAL )Jing J. * , Sweedler J.V., Cropper E.C., Alexeeva V., Park J.H., Romanova E., Xie F., Dembrow N.C., Ludwar B.C., Weiss K.R., Vilim F.S., Feedforward compensation mediated by the central and peripheral actions of a single neuropeptide discovered using representational differences analysis, J. Neurosci., 30, 16545-16558, (2010). On the COVER of Dec 8 issue of J Neurosci.Sasaki K., Brezina V., Weiss K.R., Jing J.* , Distinct inhibitory neurons exert temporally specific control over activity of a motoneuron receiving concurrent excitation and inhibition, J. Neurosci., 29, 11732-11744, (2009). (Featured in THIS WEEK IN THE JOURNAL and FACULTY OF 1000 BIOLOGY )Jing J. * , Vilim F.S., Cropper E.C., Weiss K.R., Neural analog of arousal: persistent conditional activation of a feeding modulator by serotonergic initiators of locomotion, J. Neurosci., 28, 12349-12361, (2008).Jing J. * , Vilim F.S., Horn C., Alexeeva V.Y., Hatcher N.G., Sasaki K., Yashina I., Zhurov Y., Kupfermann I., Sweedler J.V., Weiss K.R., From hunger to satiety: reconfiguration of a feeding network by Aplysia neuropeptide Y, J. Neurosci., 27, 3490–3502, (2007). (Recommended by FACULTY OF 1000 BIOLOGY )Jing J. * , Weiss K.R., Generation of variants of a motor act in a modular and hierarchical motor network, Curr. Biol., 15, 1712–1721, (2005). (Featured in BBC NEWS and Eurek Alert!)Jing J. * , Cropper E.C., Hurwitz I., Weiss K.R., The construction of movement with behavior-specific and behavior-independent modules, J. Neurosci., 24, 6315-6325, (2004).Jing J. * , Gillette R., Directional avoidance turns encoded by single interneurons and sustained by multifunctional serotonergic cells, J. Neurosci., 23, 3039-3051, (2003).
學術影響
1、2010年12月的《Feedforward compensation mediated by the central and peripheral actions of a single neuropeptide discovered using representational differences analysis》文章成為J Neurosci(神經科學雜誌)期刊封面;
2、5篇論文(通訊作者)被新聞媒介(BBCNews)和專家專欄( Faculty of 1000 Biology,2篇, J Neurosci-”This Week in The Journal” 3篇)做了重點介紹。
自1989年以來,共發表53篇研究論文,11 篇綜述論文,(第一作者:24;通訊作者:25)。其中:在高影響雜誌發表的研究論文:21篇 J Neurosci (影響因子:7.869),1篇 Current Biology (影響因子 : 10.445),1篇 J Biol Chem (影響因子 : 5.023),15篇 J Neurophysiol (影響因子 : 3.607)。引用情況 : 14 研究論文(第一或通訊作者,1999-2011):引用了493 次(截止2014年2月 )。其中:Jing and Weiss 2001, J Neurosci,引用 95次。
主要成就
一、應邀成為多個學術期刊(J Neurosci, Trends Neurosci, J Neurophysiol, J Comp Physiol, Peptides等)和 美國國家自然科學基金(NSF)審稿人;
二、應邀在三個國際會議作了專題報告;
三、為2013年美國神經科學學會(SFN)年會成功組織了題為《電偶聯和微環路:網路運作和可塑性》的研討會。
個人基金
1998-2012: 在美國開展的系統且有獨創性的科研工作為成功地申請美國國立衛生研究院(NIH)的基金(主要研究者: Weiss博士,研究者:景鍵)提供了重要的技術支撐。
2012年12月入職南京大學後,利用模式動物海兔構思了一個神經生物學課題,並撰寫了國家自然科學基金面上項目的基金申請,於2013年8月成功獲得資助(87萬;2014年1月到2017年12月)
教學情況
承擔南京大學生命科學學院本科生《神經生物學》課程,4學時/周。