方顯楊，男，中國科學院生物物理研究所博士，美國國立衛生研究院國立癌症研究所 博士後，清華大學生命科學學院教授、博導。
基本介紹
- 中文名：方顯楊
- 國籍：中國
- 職業：教授，博導
- 畢業院校：武漢大學
教育和工作經歷,主要研究領域與方向,代表論文,
教育和工作經歷
1998-2002： 武漢大學， 學士；
2002-2008： 中國科學院生物物理研究所， 博士；
2009-2015 ：美國國立衛生研究院國立癌症研究所 ，博士後；
2015- ：清華大學生命科學學院， 研究員、博導。
主要研究領域與方向
實驗室主要開展與人類疾病和重大生命過程密切相關的非編碼RNA的結構生物學研究，主要利用小角X射線散射(SAXS)、核磁共振(NMR)、X射線晶體學技術，並結合其它生物物理學、生物化學、計算生物學和分子生物學的方法與手段，研究與病毒、癌症、神經退行性疾病密切相關的非編碼RNA的結構與功能，及其與其它生物大分子包括蛋白質、DNA、 RNA的相互作用；同時發展基於小角X射線散射技術和其它生物物理手段聯用的整合結構生物學(Integrated Structural Biology)新方法。
代表論文
1. Xianyang Fang, Jason R. Stagno,Yuba Bhandari,Xiaobing Zuo,Yun-Xing Wang. Small-angle X-ray scattering: a bridge between RNA secondary structures and three-dimensional topological structures. Current Opinion in Structural Biology2015,30:147-160.
2. Sujay Subbayya Ithychanda, Xianyang Fang, Maradumane L. Mohan, Liang Zhu, Kalyan C. Tirupula, Sathyamangla V. Naga Prasad, Yun-Xing Wang, Sadashiva Karnik, Jun Qin. A mechanism of global shape-dependent recognition and phosphorylation of filamin by protein kinase A. Journal of Biological Chemistry 2015, 290(13):8527-38.
3. Yi Peng, Joseph E. Curtis, Xianyang Fang, and Sarah A. Woodson. Structural Model of the folded rpoS mRNA leader in complex with Hfq. Proceedings of the Naitonal Academy of Sciences2014, 111(48): 17134-9.
4. Alexander Lemak, Bin Wu, Adelinda Yee, Scott Houliston, Hsiau-Wei Lee, Aleksandras Gutmanas, Xianyang Fang, Maite Garcia, Anthony Semesi, Yun-Xing Wang, James H. Prestegard, Cheryl H. Arrowsmith. Structural characterization of a flexible two-domain protein in solution based using Small Angle X-ray Scattering and NMR Data. Structure2014, 22(12):1862-74
5. Feng-Ming James Chang, Coyne, H. Jerome, Ramirez, Ciro Alberto Cubillas, Pablo Vinuesa Fleischmann, Xianyang Fang, Zhen Ma, Dejian Ma, John D. Helmann, Alejandro García-de los Santos, Yun-Xing Wang, Charles E. Dann III, and David P. Giedroc. Cu(I)-mediated Allosteric Switching in a Copper-sensing Operon Repressor (CsoR). Journal of Biological Chemistry2014, 289(27):19204-17.
6. Xianyang Fang, Jinbu Wang, Ina P. O’Carroll, Michelle Mitchell, Xiaobing Zuo, Yi Wang, Ping Yu, Yu Liu, Jason W. Rausch, Marzena A. Dyba, Jørgen Kjems, Charles D. Schwieters, Soenke Seifert, Randall E. Winans, Norman R. Watts, Stephen J. Stahl, Paul T. Wingfield, R. Andrew Byrd, Stuart F. J. Le Grice, Alan Rein,Yun-Xing Wang. An unusual topological structure of the HIV-1 rev response element, Cell2013, 155(3): 594-605.
7. Moshe Giladi, Itay Friedberg, Xianyang Fang, Reuben Hiller, Yun-Xing Wang, Daniel Khananshvili. G503 is obligatory for dynamic coupling of regulatory domains in NCX proteins Biochemistry2012, 51(37):7313-20.
8. Moshe Giladi, Yeheskel Sasson, Xianyang Fang, Reuben Hiller, Tal Buki, Yun-Xing Wang, Joel Alan Hirsch, Daniel Khananshvili. A common Ca2+-driven interdomain module governs eukaryotic NCX regulation, PLoS One2012, 7(6): e39985.
9. George Avvakumov, John Walker, Sheng Xue, Abdellah Allali-Hassani, Abdalin Asinas, Usha Nair, Xianyang Fang, Xiaobing Zuo, Yun-Xing Wang, Keith Wilkinson, Sirano Dhe-Paganon. Two ZnF-UBP domains in isopeptidase T (USP5), Biochemistry 2012, 51(6): 1188-98.
10. Xianyang Fang, Yingang Feng, and Jinfeng Wang. Favorable contribution of the C-terminal residue K97 to the stability of a hyperthermophilic archaeal [P62A]Ssh10b, Archives of Biochemistry and Biophysics2009, 481(1):52-8.
11. Xianyang Fang, Qiu Cui, Yufeng Tong, Yingang Feng, Lu Shan, Li Huang, and Jinfeng Wang. A stabilizing a/β-hydrophobic core greatly contributes to hyperthermostability of archaeal [P62A]Ssh10b. Biochemistry2008, 47(43):11212-21.
12. Quan Luo, Xianyang Fang, Zhiwei Deng, Jinfeng Wang. NMR study of influences of D51N mutation on backbone conformation of hyperthermophilic archaeal [P62A]Ssh10b. Chemical Journal of Chinese Universities-Chinese2008,29,546-550.
