方澤民(安徽大學生命科學學院副教授)

方澤民，男，博士，現為安徽大學生命科學學院副教授。

基本介紹

• 中文名：方澤民
• 職業：教師
• 學位/學歷：博士
• 專業方向：生命科學

研究方向

1.新穎性質新型工業用酶的發現及製備
2.芳香族化合物誘導及真菌互作過程中的真菌漆酶差異表達調控機制

科研項目

1.安徽省教育廳自然科學基金重大項目，“Hsp70家族成員ThHspA1功能研究”（KJ2017ZD04）
2.國家自然科學基金，“共培養條件下灰蓋鬼傘菌漆酶Lcc9表達的轉錄調控機制”(31300044)
3.教育部高等學校博士學科點專項科研基金（新教師類），“真菌相互作用過程中灰蓋鬼傘菌Lcc9功能研究”(20133401120010)
4.國家863計畫子課題，“遠海大型生物全新天然產物的發現及藥物先導化合物的最佳化”(2013AA092901)
5.安徽省自然科學基金，“真菌相互作用誘導漆酶表達核心轉錄因子研究”(1308085QC46)
6.安徽省教育廳自然科學基金重點，“乙醇耐受的新型真菌漆酶篩選”(KJ2013A022)
7.安徽大學人才引進啟動基金

發表文章

1.Zhang YF, Xu Y, Fang W, Wang XT, Fang ZM*, Xiao YZ.Pseudoruegeriamarinistellae sp. nov.,isolated from an unidentified starfish in Sanya, China.Antonie van Leeuwenhoek, 2017, 110, 187-194 (*Corresponding author)

2.Zhang YF, Tang PP, Xu Y, Fang W, Wang XT, Fang ZM*, Xiao YZ*.Lutimaribactermarinistellae sp. nov., isolated from a starfish.Int J Sys EvoMicrob, 2016, 66: 3675-3680, doi: 10.1099/ijsem.0.001251. (*Corresponding author)

3.Fang W, Yang Y, Zhang XX, Yin Q, Zhang XB, Wang XT, Fang ZM*, Xiao YZ*. Improve ethanol tolerance of β-glucosidase Bgl1A by semi-rational engineering for the hydrolysis of soybean isoflavone glycosides. J Biotechnol, 2016, 227,64-71. (*Corresponding author)

4.Chen L, Yi XM, Deng FJ, Fang W, Zhang XC, Wang XT, Fang ZM*, Xiao YZ. A novel ethanol-tolerant laccase, Tvlac, from Trametes versicolor. Biotech Lett, 2016, 38:471-476. (*Corresponding author)

5.He C, Li J, Li W, Xue Y, Fang ZM, Fang W, Zhang XC, Wang XT, Xiao YZ. Structures of PspAG97A α-glucoside hydrolase reveal a novel mechanism for chloride induced activation. J StruBiol, 2016, 196: 426-436

6.Li W, Fan H, He C, Zhang XC, Wang XT, Yuan J, Fang ZM, Fang W, Xiao YZ. PspAG97A: a halophilic α-glucoside hydrolase with novel substrate specificity from glycoside hydrolase family 97. J MicrobiolBiotechnol,2016, 26(11): 1933-1942

7.Li W, Xue Y, Li J, Yuan J, Wang X, Fang W, Fang Z*, Xiao Y. A cold-adapted and glucose-stimulated type II α-glucosidase from a deep-sea bacterium Pseudoalteromonas sp. K8. Biotech Lett, 2016, 38:345-349. (*Corresponding author)

8.Yang Y, Zhang X, Yin Q, Fang W, Fang Z, Wang X, Zhang X, Xiao Y. A mechanism of glucose tolerance and stimulation of GH1 β-glucosidases. Sci Rep, 2015. 5:17296 DOI: 10.1038/srep17296

9.Wang J, Zhang Y, Xu Y, Fang W, Wang X,Fang Z*, Xiao Y*. Genome sequence of a laccase producing fungus Trametes sp. AH28-2. J Biotechnol, 2015, 216, 167-168. (*Corresponding author)

10.Fang Z, Liu X, Chen L, Shen Y, Zhang X, Fang W, Wang X, Bao X, Xiao Y. Identification of a laccase Glac15 from Ganodermalucidum 77002 and its application in bioethanol production. Biotech Biofuel, 2015, 8:54 DOI 10.1186/s13068-015-0235-x

11.Fang W, Song R, Zhang X, Zhang X, Zhang X, Wang X, Fang Z*, Xiao Y*. Characterization of a novel β-glucosidase from Gongronella sp. W5 and its application in the hydrolysis of soybean isoflavone glycosides. J Agric Food Chem2014, 62, 11688-11695. (*Corresponding author)

12.Fang ZM, Zhou P, Chang F, Yin Q, Fang W, Yuan J, Zhang XC, Xiao YZ. Structure-based rational design to enhance the solubility and thermostability of a bacterial laccase Lac15. 2014, PLoS ONE 9(7): e102423. doi:10.1371/journal.pone.0102423

13.Fang ZM*, Li JJ*, Wang Q, Fang W, Peng H, Zhang XC, XiaoYZ. A novelesterase from a marine metagenomic library exhibiting salt tolerance ability. J MicrobiolBiotechnol, 2014, 24(6), 771-780. (* co-first author)

14.Pan K, Zhao NN, Yin Q, Zhang TW, Xu XL, Fang W, Hong YZ, Fang ZM*, Xiao YZ. Induction of laccase Lcc9 from Coprinopsis cinereaby fungal coculture and its application on indigo dye decolorization. BioresourTechnol, 2014, 162: 45-52. (*Corresponding author)

15.Fang W*,Fang ZM*, Liu ZM, Yuan J, Zhang XC, Peng H, Hong YZ, Xiao YZ. Phylogenetic analysis of bacterial community in the gut of American cockroach (Periplanetaamericana). ActaMicrobiologicaSinica, 2013, 53: 984-994. (* co-first author)

16.Fang ZM*, Li TL*, Chang F, Zhou P, Fang W, Hong YZ, Zhang XC, Peng H, Xiao YZ. A new marine bacterial laccase with chloride-enhancing, alkaline-dependent activity and dye decolorization ability. BioresourTechnol, 2012, 111: 36-41. (* co-first author)

17.Fang W*,Fang ZM*, Zhou P, Chang F, Hong YZ, Zhang XC, Peng H, Xiao YZ. Evidence for lignin oxidation by the giant panda fecal microbiome. PLoS ONE, 2012, 7(11): e50312. (* co-first author)

18.Fang ZM, Li TL, Chang F, Zhou P, Fang W, Hong YZ, Zhang XC, Peng H, Xiao YZ. A bacterial laccase from marine microbial metagenome exhibiting chloride tolerance and dye decolorization ability. ApplMicrobiolBiotechnol, 2011, 89: 1103-1110.

19.Liu JJ, Zhang XC, Fang ZM, Fang W, Peng H, Xiao YZ. The 184th residue of β-glucosidaseBgl1B plays an important role in glucose tolerance. J BiosciBioeng, 2011, 112: 447-450.

20.GeHH, Xu PS, Xu Y, Fang ZM, Xiao YZ. Purification, crystallization and preliminary crystallographic analysis of recombinant Lac15 from a marine microbial metagenome. ActaCryst F, 2011, 67: 956-958.

21.Fang ZM, Fang W, Liu JJ, Hong YZ, Peng H, Zhang XC, Sun BL, Xiao YZ. Cloning and characterization of a β-glucosidase from marine microbial metagenome with excellent glucose tolerance. J MicrobiolBiotechnol, 2010, 20: 1351-1358.