戴亮亮(西北工業大學醫學研究院副教授)

戴亮亮，男，博士，西北工業大學醫學研究院副教授。

基本介紹

• 中文名：戴亮亮
• 學位/學歷：博士
• 職業：教師
• 專業方向：生物醫學工程,材料科學與工程,藥學
• 任職院校：西北工業大學

個人經歷

工作經歷 Work Experience

2018/07-至今： 西北工業大學，醫學研究院，副教授

教育經歷 Education Experience

2015/09-2018/06 重慶大學，生物醫學工程專業，博士，導師：蔡開勇

2012/09-2015/06 重慶大學，生物學專業，碩士，導師：蔡開勇

研究方向

（1）生物功能性納米藥物遞送系統的構建與抗腫瘤效應評價；

（2）功能納米控釋系統介導腫瘤生物/免疫治療的機制研究；

（3）腫瘤微環境的分子調控干預策略。

學術成果

Academic Achievements

代表性論文：

2021年

[15] Liangliang Dai*, Xiang Li, Xinmin Zheng, Zhenxiang Fu, Mengjiao Yao, Siyu Meng, Jiangong Zhang, Binbin Han, Quanli Gao, Jing Chang, Kaiyong Cai*, Hui Yang*. TGF-β blockade-improved chemo-immunotherapy with pH/ROS cascade-responsive micelle via tumor microenvironment remodeling. Biomaterials. 2021, 276, 121010. (IF: 12.479)

[14] Xinmin Zheng, Pan Zhang, Zhenxiang Fu, Siyu Meng, Liangliang Dai*, Hui Yang*. Applications of nanomaterials in tissue engineering. RSC Adv, 2021, 11, 19041–19058. (IF: 3.361)

[13] Zhang Yuan, Chuanchuan Lin, Liangliang Dai*, Ye He, Jinwei Hu, Kun Xu, Bailong Tao, Peng Liu*, Kaiyong Cai*. Near‐infrared light‐activatable dual‐action nanoparticle combats the established biofilms of methicillin‐resistant staphylococcus aureus and its accompanying inflammation. Small. 2021, 2007522. (IF: 13.281)

2020年

[12] Liangliang Dai, Xiang Li, Mengjiao Yao, Peiyun Niu, Xichen Yuan, Ke Li, Maowen Chen, Zengxiang Fu, Xianglong Duan, Haibin Liu, Kaiyong Cai*, Hui Yang*. Programmable prodrug micelle with size-shrinkage and charge-reversal for chemotherapy-improved IDO immunotherapy. Biomaterials. 2020, 241, 119901. (IF: 12.479)

[11] Ke Li, Lu Lu, Chencheng Xue, Ju Liu, Ye He, Jun Zhou, Zengzilu Xia, Liangliang Dai*, Kaiyong Cai*. Polarization of tumor-associated macrophage phenotype via porous hollow iron nanoparticles for tumor immunotherapy in vivo. Nanoscale. 2020, 12, 130-144. (IF: 7.79，HCP)

2019年

[10] Liangliang Dai, Xiang Li, Xianglong Duan, Menghuan Li, Peiyun Niu, Huiyun Xu, Kaiyong Cai, Hui Yang. A pH/ROS cascade-responsive charge-reversal nanosystem with self-amplified drug release for synergistic oxidation-chemotherapy. Advanced Science. 2019, 6, 1801807. (IF: 16.806)

[9] 戴亮亮，劉軍傑，周駿，羅忠，蔡開勇。回響性納米藥物遞送系統構建及腫瘤治療研究[J]，醫用生物力學，2019年S1期

2018年

[8] Liangliang Dai, Ke Li, Menghuan Li, Xiaojing Zhao, Zhong Luo, Lu Lu, Yanfeng Luo, Kaiyong Cai. Size/Charge changeable acidity‐responsive micelleplex for photodynamic‐improved PD‐L1 immunotherapy with enhanced tumorpenetration. Advanced Functional Materials. 2018, 28, 1707249. (IF: 18.808)

2017年

[7] Liangliang Dai, Ruisi Cai, Menghuan Li, Zhong Luo, Yonglin Yu, Weizhen Chen, Xinkun Shen, Yuxia Pei, Xiaojing Zhao, Kaiyong Cai. Dual-targeted cascade-responsive prodrug micelle system for tumor therapy in vivo. Chemistry of Materials. 2017, 29, 6976-6992. (IF: 9.811)

2016年

[6] Liangliang Dai, Yonglin Yu, Zhong Luo, Menghuan Li, Weizhen Chen, Xinkun Shen, Feng Chen, Qiang Sun, Qingfeng Zhang, Hao Gu, Kaiyong Cai. Photosensitizer enhanced disassembly of amphiphilic micelle for ROS-response targeted tumor therapy in vivo. Biomaterials. 2016, 104, 1-17. (IF: 12.479)

[5] Liangliang Dai, Junjie Liu, Zhong Luo, Menghuan Li, Kaiyong Cai. Tumor therapy: Targeted drug delivery systems. Journal of Materials Chemistry B. 2016, 4. 6758-6772. (IF: 6.311)

[4] Liangliang Dai, Qingfeng Zhang, Xinkun Shen, Qiang Sun, Caiyun Mu, Hao Gu, Kaiyong Cai. A pH-responsive nanocontainer based on hydrazone-bearing hollow silica nanoparticles for targeted tumor therapy. Journal of Materials Chemistry B. 2016, 4, 4594-4604. (IF:6.311)

2015年以前

[3] Liangliang Dai, Qingfeng Zhang, Jinghua Li, Xinkun Shen, Caiyun Mu, Kaiyong Cai. Dendrimerlike mesoporous silica nanoparticles as pH-responsive nanocontainers for targeted drug delivery and bioimaging. ACS Applied Materials & Interfaces. 2015, 7, 7357-7372. (IF: 9.229)

[2] Liangliang Dai, Qingfeng Zhang, Hao Gu, Kaiyong Cai. Facile synthesis of yolk-shell silica nanoparticles for targeted tumor therapy. Journal of Materials Chemistry B. 2015, 3, 8303-8313. (IF: 6.311, Hot Paper)

[1] Liangliang Dai, Jinghua Li, Beilu Zhang, Junjie Liu, Zhong Luo, Kaiyong Cai. Redox-responsive nanocarrier based on heparin end-capped mesoporous silica nanoparticles for targeted tumor therapy in vitro and in vivo. Langmuir. 2014, 3, 7867-7877. (IF: 3.882)

代表性項目：

（1）主持國家自然科學基金青年科學基金項目，功能化MOF納米反應器“雙重飢餓”腫瘤治療及機制研究（2021.01-2023.12）；

（2）主持陝西省高校科協青年人才托舉計畫，程式性膠束控釋系統化療/腫瘤免疫聯合治療研究（2021.01-2022.12）；

（3）主持陝西省自然科學基金青年項目，自增強藥物釋放膠束控釋系統的構建及抑瘤機制研究（2019.01-2020.12）；

（4）主持中央高校基本科研業務費，具有電荷反轉/自增強藥物釋放特性的膠束遞送系統構建及抗腫瘤機制研究（2018.01-2020.12）