徐曉鵬，男， 博士，中山大學生命科學學院副教授、博士生導師。
基本介紹
- 中文名：徐曉鵬
- 畢業院校：中山大學
- 學位/學歷：博士
- 專業方向：海洋生物病原分子生物學等
- 任職院校：中山大學
研究方向,個人經歷,講授課程,學術成果,承擔課題,論文專著,專利,
研究方向
海洋生物病原分子生物學、海洋動物分子免疫學。包括病毒功能基因及其致病機理、病毒與宿主的相互作用、病毒疫苗開發、模式動物抗病毒免疫、先天免疫調控機制、microRNA調控網路等。
個人經歷
畢業於中山大學生命科學學院獲博士學位，2018-2019年在美國哈佛醫學院做公派訪問學者。
講授課程
本科生：《分子生物學》、《分子生物學實驗》、《魚類轉基因實驗技術》
研究生：《模式動物實驗操作技術》、《海洋生物免疫學》
學術成果
承擔課題
1.國家自然科學基金面上項目，31772881，細胞膜NF-κB（mNF-κB）信號通路及其介導的凡納濱對蝦抗真菌免疫調控機制，2018.01-2021.12，主持。
2.國家自然科學基金面上項目，31572649，凡納濱對蝦Vago信號通路的調控機制及其在抗病毒免疫中的作用，2016.01-2019.12，主持。
3.國家自然科學基金面上項目，31270048，腫大細胞病毒感染細胞的膜外貼附內皮細胞現象的機制和功能，2013.01-2016.12，主持。
4.國家自然科學青年基金項目，30901114，腫大細胞病毒VP23R和VP48R基因的致病機理，2010.01-2012.12，主持。
5. 973計畫項目（子課題），2012CB1144029，海水養殖動物主要病毒性疫病爆發機理與免疫防治的基礎研究，2012.01-2016.12，主持。
6.廣東省自然科學基金，2017A030313190，偽基底膜結構（VMBM）誘導腫大細胞病毒感染魚類脈管系統病變的分子機制，2017.05-2020.05,主持。
7.廣東省自然科學基金, 2014A030313125，凡納濱對蝦類干擾素調節因子（IRF-like）在核酸誘導抗病毒免疫反應中的作用, 2015.01-2018.01,主持。
8.中國博士後科學基金特別資助，201003369，傳染性脾腎壞死病毒VP23R和VP48R基因的致病機理，2010.10-2012.10，主持。
9.中國博士後基金，20080440788，傳染性脾腎壞死病毒（ISKNV）VP48R基因的致病機理，2008.12-2010.12，主持。
10.廣州市產學研重大專項，156100077，草魚出血症血清抗體免疫監控平台技術研究與套用， 2015.01-2017.12，主持。
11.珠江科技新星專項，2011J2200067,魚類疫苗自動注射機的研發與套用，2011.11-2014.10，主持。
12.高校基本科研業務費青年教師重點培育項目，17lgzd27，對蝦細胞膜NF-κB（mNF-κB）信號通路的鑑定及其調控機制，徐曉鵬，2017.05-2018.12，主持。
13.高校基本科研業務費青年教師培育項目，傳染性脾腎壞死病毒VP15R和VP008R的致病機理，編號：11lgpy24，2010.12-2013.12，主持。
論文專著
近年來以通訊作者和第一作者在病毒學或免疫學領域知名期刊J. Virol., J. Immunol.和Virology上發表多篇論文，包括一篇Virology雜誌的封面文章。
1.Linwei Yang, Shengwen Niu, Jiefeng Gao, Hongliang Zuo, Jia Yuan, Shaoping Weng, Jianguo He*, Xiaopeng Xu*.A single WAP domain (SWD)-containing protein with antiviral activity from Pacific white shrimp Litopenaeus vannamei Fish Shellfish Immunol. 2018,73:167-174. （通訊作者）
2.Hongliang Zuo, Jia Yuan, Shengwen Niu, Linwei Yang, Shaoping Weng, Jianguo He*, Xiaopeng Xu*. A molting-inhibiting hormone-like protein from Pacific white shrimp Litopenaeus vannamei is involved in immune responses. Fish Shellfish Immunol. 2018,72:544-551. （通訊作者）
3.Qianhui Liang, Jiefu Zheng, Hongliang Zuo, Chaozheng Li, Shengwen Niu, Linwei Yang, Shaoping weng, Jianguo He, Xiaopeng Xu*. Identification and characterization of an interleukin-16-like gene from pacific white shrimp Litopenaeus vannamei. Dev Comp Immunol. 2017, 74:49-59. （通訊作者）
4.Wei Qiu, Jianhui He, Hongliang Zuo, Shengwen Niu, Chaozheng Li, Shuang Zhang, Shaoping Weng, Jianguo He, Xiaopeng Xu*. Identification, characterization, and function analysis of the NF-kappaB repressing factor (NKRF) gene from Litopenaeus vannamei. Dev Comp Immunol. 2017, 76:83-92.（通訊作者）
5.Jian-Hui He, Muting Yan, Hongliang Zuo, Shengwen Niu, Jia Yuan, Shao-Ping Weng, Jianguo He, Xiaopeng Xu*, High reduced/oxidized glutathione ratio in infectious spleen and kidney necrosis virus-infected cells contributes to degradation of VP08R multimers. Veterinary Microbiology 2017, 207: 19-24. （通訊作者）
6.Jiefeng Gao, Hongliang Zuo, Linwei Yang, Jian-Hui He, Shengwen Niu, Shaoping Weng, Jianguo He*, Xiaopeng Xu*. Long-term influence of cyanobacterial bloom on the immune system of Litopenaeus vannamei. Fish Shellfish Immunol. 2017,61:79-85. （通訊作者）
7.Hongliang Zuo, Jiefeng Gao, Jia Yuan, Hengwei Deng, Linwei Yang, Shaoping Weng, Jianguo He, Xiaopeng Xu*. Fatty acid synthase plays a positive role in shrimp immune responses against Vibrio parahaemolyticus infection. Fish Shellfish Immunol. 2017, 60:282-288. （通訊作者）
8.Xiaopeng Xu, Jia Yuan, Linwei Yang, Shaoping Weng, Jianguo He*, Hongliang Zuo*. The Dorsal/miR-1959/Cactus feedback loop facilitates the infection of WSSV in Litopenaeus vannamei. Fish Shellfish Immunol. 2016, 56:397-401.
9.Hongliang Zuo, Jia Yuan, Yonggui Chen, Sedong Li, Ziqi Su, Erman Wei, Chaozheng Li, Shaoping Weng, Xiaopeng Xu*, Jianguo He*. A microRNA-mediated positive feedback regulatory loop of the NF-κB pathway in Litopenaeus vannamei. Journal of Immunology.2016, 196:3842-3853. （通訊作者）
10.Muting Yan, Jianhui He, Weibin Zhu, Jing Zhang, Qiong Xia, Shaoping Weng, Jianguo He, Xiaopeng Xu*. A microRNA from infectious spleen and kidney necrosis virus modulates expression of the virus-mock basement membrane component VP08R. Virology 2016, 492, 32-37.（通訊作者）
11.Muting Yan, Lihong Liu, Qianhui Liang, Jianhui He, Shaoping Weng, Jianguo He, Xiaopeng Xu*. A mitochondrial outer membrane-localized protein encoded by White spot syndrome virus. Virus Genes. 2016, 52(2):290-293.（通訊作者）
12.Chaozheng Li, Haoyang Li, Yixiao Chen, Yonggui Chen, Sheng Wang, Shaoping Weng, Xiaopeng Xu*, Jianguo He*. Activation of Vago by interferon regulatory factor (IRF) suggests an interferon system-like antiviral mechanism in shrimp. Scientific Reports 2015, 5:15078.（通訊作者）
13.Muting Yan, Junliang Tang, Qianhui Liang, Guohua Zhu, Haoyang Li, Chaozheng Li, Shaoping Weng, Jianguo He*, Xiaopeng Xu*. Daxx from Pacific white shrimp Litopenaeus vannamei is involved in activation of NF-κB pathway. Fish Shellfish Immunol. 2015, 45 (2): 443-453. （通訊作者）
14.Muting Yan, Chaozheng Li, Ziqi Su, Qianhui Liang, Haoyang Li, Shizhong Liang, Shaoping Weng, Jianguo He*, Xiaopeng Xu*. Identification of a JAK/STAT pathway receptor domeless from Pacific white shrimp Litopenaeus vannamei. Fish Shellfish Immunol. 2015, 44(1):26-32. （通訊作者）
15.Hongliang Zuo, Haoyang Li, Erman Wei, Ziqi Su, Jieyao Zheng, Chaozheng Li,Yonggui Chen, Shaoping Weng, Jianguo He*, Xiaopeng Xu*. Identification and functional analysis of a Hemolin like protein from Litopenaeus vannamei. Fish Shellfish Immunol. 2015, 43(1):51-59. （通訊作者）
16.Xiaopeng Xu, Muting Yan, Rui Wang, Ting Lin, Junliang Tang, Chaozheng Li, Shaoping Weng, Jianguo He. VP08R from infectious spleen and kidney necrosis virus is a novel component of the virus-mock basement membrane. J. Virol. 2014, 88(10): 5491-5501.
17.Ming Li, Chaozheng Li, Chunxia Ma, Haoyang Li, Hongliang Zuo, Shaoping Weng, Xiaohan Chen,Digang Zeng, Jianguo He, Xiaopeng Xu*. Identification of a C-type lectin with antiviral and antibacterial activity from pacific white shrimp Litopenaeus vannamei. Dev Comp Immunol. 2014，46:231-240.（通訊作者）
18.Rui Wang, Yang Yi, Lihong Liu, Yanghong Lu, Shaoping Weng,Jianguo He, Xiaopeng Xu*. ORF005L from infectious spleen and kidney necrosis virus is located in the inner mitochondrial membrane and induces apoptosis. Virus Genes. 2014, doi:10.1007/s11262-014-1088-2.（通訊作者）
19.Chaozheng Li, Jiaoting Chai, Haoyang Li, Hongliang Zuo, Sheng Wang, Wei Qiu, Shaoping Weng, Jianguo He, Xiaopeng Xu*. Pellino protein from pacific white shrimp Litopenaeus vannamei positively regulates NF-kappaB activation. Dev Comp Immunol. 2014 44:341-350. （通訊作者）
20.Chaozheng Li, Yixiao Chen,Shaoping Weng,Sedong Li, Hongliang Zuo, Xiaoqiang Yu, Haoyang Li, Jianguo He, Xiaopeng Xu*. Presence of Tube isoforms in Litopenaeus vannamei suggests various regulatory patterns of signal transduction in invertebrate NF-kappaB pathway. Dev Comp Immunol. 2014 42:174-185. （通訊作者）
21.Chaozheng Li, Yi-xiao Chen, Shuang Zhang, Ling Lü, Yi-Hong Chen, Jiaoting Chai, Shaoping Weng, Yong-gui Chen, Jianguo He, Xiaopeng Xu*. Identification, Characterization, and Function Analysis of the Cactus Gene from Litopenaeus vannamei. PLOS ONE, 2012, 7(11): e49711. （通訊作者）
22.Chaozheng Li, Shaoping Weng, Yonggui Chen, Xiaoqiang Yu, Ling Lü, Haiqing Zhang, Jianguo He, Xiaopeng Xu*. Analysis of Litopenaeus vannamei transcriptome using the next-generation DNA sequencing technique. PLOS ONE, 2012, 7(10): e47442. （通訊作者）
23.Xiaopeng Xu, Ting Lin, Lichao Huang, Zhongsheng Li, Qiong Xia, Shaoping Weng ,Ling Lv, Zhongsheng Li, Junliang Tang, Jianguo He. VP15R from infectious spleen and kidney necrosis virus (ISKNV) is a non-muscle myosin II (NM II)-binding protein. Arch. Virol. 2011, 156:53–61.
24.Xiaopeng Xu, Shaoping Weng, Ting Lin, Junliang Tang, Lichao Huang, Jing Wang, Xiaoqian Yu, Ling Lu, Zhijian Huang, and Jianguo He. VP23R of infectious spleen and kidney necrosis virus mediates formation of virus-mock basement membrane to provide attaching sites for lymphatic endothelial cells. J. Virol. 2010, 84(22):11866-11875.
25.Xiaopeng Xu, Lichun Zhang, Shaoping Weng, Zhijian Huang, Jing Lu, Dongming Lan, Xuejun Zhong, Xiaoqiang Yu, Anlong Xu, and Jianguo He. A zebrafish (danio rerio) model of infectious spleen and kidney necrosis virus (ISKNV) infection. Virology,2008,376(1): 1-12. (封面文章)
26.Xiaopeng Xu, Lichao Huang, Shaoping Weng, Jing Wang, Junliang Tang, Ting Lin, Zhongsheng Li, Qingxia Lu, Qiong Xia, Xiaoqiang Yu, and Jianguo He, Tetraodon nigroviridis as a non-lethal model of infectious spleen and kidney necrosis virus (ISKNV) infection. Virology 2010, 406(2):167-175.
27.Xiaopeng Xu, Qingxia Lu, Rui Wang, Ting Lin, Shaoping Weng, Ling Lu, Zhongsheng Li, Xiaoqiang Yu, Junliang Tang, Jianguo He, Identification of the VP92R gene from infectious spleen and kidney necrosis virus. Virus Genes 2010, 41(2):210-217.
28.Xiaopeng Xu, Jing Lu, Qingxia Lu, Hui Zhong, Shaoping Weng, Jianguo He. Characterization of a membrane protein (VP001L) from infectious spleen and kidney necrosis virus (ISKNV). Virus Genes. 2008, 36(1):157-167.
29.Zi-Liang Wang&, Xiao-Peng Xu&, Bai-Liang He, Shao-Ping Weng, Jia Xiao, Li Wang, Ting Lin, Xi Liu, Qing Wang, Xiao-Qiang Yu, and Jian-Guo He. Infectious spleen and kidney necrosis virus ORF48R functions as a new viral vascular endothelial growth factor. J Virol. 2008, 82(9): 4371-4383.（共同第一）
30.Ruiwen Ren&, Xiaopeng Xu&, Ting Lin, Shaoping Weng, Huafang Liang, Mengli Huang, Chuanfu Dong, Yongwen Luo, and Jianguo He. Cloning, characterization, and biological function analysis of the SidT2 gene from Siniperca chuatsi. Dev Comp Immunol. 2011, 35: 692-701. (共同第一)
31.Zhongsheng Li&, Xiaopeng Xu&, Lichao Huang, Jianmin Wu, Qingxia Lu, Zhiming Xiang, Jingjing Liao, Shaoping Weng, Xiaoqiang Yu, Jianguo He. Administration of recombinant IFN1 protects zebrafish (Danio rerio) from ISKNV infection. Fish & Shellfish Immunology，2010, 29(3):399-406. (共同第一)
32.Zhi-Ying Zhao, Zhi-Xin Yin, Xiao-Peng Xu, Shao-Ping Weng, Xia-Yu Rao, Zong-Xian Dai, Yong-Wen Luo, Gan Yang, Zong-Sheng Li, Hao-Ji Guan, Se-Dong Li, Siu-Ming Chan, Xiao-Qiang Yu, and Jian-Guo He. A novel C-type lectin from the shrimp Litopenaeus vannamei possesses anti-WSSV activity. J. Virol.2009, 83(1):347-356.
33.Xiao-Peng Xiong, Chuan-Fu Dong, Xiaopeng Xu, Shao-Ping Weng, Zhao-Yu Liu, Jian-Guo He, Proteomic analysis of zebrafish (Danio rerio) infected with infectious spleen and kidney necrosis virus. Dev Comp Immunol. 2011, 35: 431–440.
34.Xian-De Huang, Li Zhao, Hai-qing Zhang, Xiao-peng Xu, Xiao-ting Jia, Yi-hong Chen，Pei-Hui Wang, Shao-Ping Weng, Xiao-Qiang Yu, Zhi-Xin Yin, Jian-Guo He, Shrimp NF-B Binds to the Immediate-Early Gene ie1 Promoter of White Spot Syndrome Virus and Upregulates Its Activity. Virology 2010, 406(2):176-180.
35.Chuanfu Dong, Shaoping Weng, Xiujuan Shi, Xiaopeng Xu, Nan Shi, Jian-guo He, Development a mandarin fish Siniperca chuatsi fry cell line suitable for the study of infectious spleen and kidney necrosis virus (ISKNV). Virus Research, 2008,135: 273-281.
36.Wei Qiu, Shuang Zhang, Yong-gui Chen, Pei-hui Wang, Xiao-peng Xu, Chao-zheng Li, Yi-Hong Chen, Wen-Zhou Fan, Hui Yan, Shao-Ping Weng, Siuming Francischan, Jian-Guo He. Litopenaeus vannamei NF-kappaB is required for WSSV replication. Dev Comp Immunol. 2014 45:156-162.
專利
1. 湯俊良，徐曉鵬，何建國，翁少萍，嚴慕婷，一種魚類疫苗自動化連續注射裝置，專利號：CN204274713U,授權日期：2016.8.17
2.黃志堅，徐曉鵬，唐晶晶，張颶，何建國；一種利用線粒體DNAD-loop控制區進行魚類遺傳信息分析的方法，專利號：200710028241，授權日期：2010.5
3. 黃志堅，徐曉鵬，唐晶晶，張颶，何建國；魚類線粒體DNA控制區擴增引物及其設計方法和套用，專利號：200710028242，授權日期：2010.6
