徐凌燕(華東師範大學生命科學學院研究員)

徐凌燕(華東師範大學生命科學學院研究員)

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徐凌燕，華東師範大學生命科學學院研究員、博士生導師，帶領應激與代謝穩態課題組，致力於研究代謝器官回響營養和衰老應激，參與代謝穩態調控的關鍵分子和作用機制。

基本介紹

  • 中文名：徐凌燕
  • 國籍：中國
  • 民族：漢族
  • 畢業院校：中國科學院上海生命科學研究院 
  • 職業：教師
  • 主要成就：上海市 “浦江人才計畫” 
    華東師範大學青年高層次人才計畫“紫江青年學者” 
  • 職稱：研究員
  • 職務：博士生導師 
  • 研究領域：應激與代謝穩態
個人經歷,所獲榮譽,科學研究,研究領域,科研成果,部分發表論文,

個人經歷

2001-2005 復旦大學生命科學學院 生物化學與分子生物學專業理學學士
2005-2010 中國科學院上海生命科學研究院健康科學研究所
生物化學與分子生物學/內分泌代謝病專業 碩博連讀 理學博士
導師：寧光 (中國工程院院士)
2010-2011 中國科學院上海生命科學研究院 內分泌與代謝病實驗室 助理研究員
2011-2016 美國國立衛生研究院 National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 博士後
導師：Elisabetta Mueller (師從哈佛大學醫學院美國國家科學院院士Bruce Spiegelman)
2017- 華東師範大學生命科學學院 生命醫學研究所 研究員

所獲榮譽

入選“上海市浦江人才計畫（A類）”
入選華東師範大學青年高層次人才“紫江學者”項目 “紫江青年學者”

科學研究

研究領域

隨著現代社會生活方式的改變，過度的營養攝入、運動缺乏以及老齡化引起的能量代謝異常和線粒體損傷，在中老年人群中導致“中年發福”現象高發，推動肥胖，糖尿病和脂肪肝等代謝性疾病在世界範圍內快速增長，嚴重危害人類健康。脂肪和肝臟是回響營養和衰老應激，調控機體糖脂代謝變化的重要器官，然而具體的調控分子和機制尚不清晰。因此闡明脂肪和肝臟中關鍵分子的應激回響機制，以及代謝穩態的調控網采獄踏絡，對於防治代謝性疾病具有重要意義。本課題組長期研究脂肪和肝臟回響營養和衰老應激，參與代謝穩態調頁地控的關鍵分子和作用機制：(1) 鑑定並系統解析營養過剩引起的合成增加、分解降低，以及在肥胖和脂肪肝發生髮展中的影響和調控機制；(2) 創新性發現衰老應激中細胞糖脂代謝和能量平衡紊亂的發生機制和內源性調控。

科研成果

近年來發表SCI論文32篇；其中以第一和通訊作者（含共同）身份在Cell Metabolism, PNAS(兩篇), Journal of Hepatology, Hepatology, Aging Cell(兩篇)等國際著名學術期刊發表文章27篇，影響因子合計約180，引用500餘次。2017年於華東師範大學生命科學煮船滲墓學院建立實享匪阿驗室以來，在Journal of Hepatology, Hepatology, Oncogene, Molecular Metabolism (Cover Story) 等國際著名學術期刊發表SCI論文15篇，其中以通訊作者（含共同）身份發表論文9篇。工作受到Nat Med, Nat Rev Endocrinol, Cell Metab, Mol Cell等雜誌引用和評論，F1000 “Exceptional”推薦戶捆肯凳，新聞媒體等亮點報導。入選上海市 “浦江人才計畫堡嬸探”和華東師範大學青年高頌體求層次人才計畫“紫江青年學者”等人才項目。

部分發表論文

1. Liu C*, Zhou B*, Meng M*, Zhao W, Wang D, Yuan Y, Zheng Y, Qiu J, Li Y, Li G, Xiong X, Bian H, Zhang H, Wang H, Ma X#, Hu C#, Xu L#, Lu Y#. FOXA3 induction under endoplasmic reticulum stress contributes to non-alcoholic fatty liver disease. J Hepatol 2021, S0168-8278(21)00090-8.
2. Qiu J*, Zhang Z*, Wang S*, Chen Y*, Liu C, Xu S, Wang D, Su J, Ni M, Yu J, Cui X, Ma L, Hu T, Hu Y, Gu X#, Ma X#, Wang J#, Xu L#. Transferrin Receptor Functionally Marks Thermogenic Adipocytes. Front Cell Dev Biol. 2020, 8:572459.
3. Xu L*, Ma X*, Verma N, Perie L, Pendse J, Shamloo S, Marie Josephson A, Wang D, Qiu J, Guo M, Ping X, Allen M, Noguchi A, Springer D, Shen F, Liu C, Zhang S, Li L, Li J, Xiao J, Lu J, Du Z, Luo J, Aleman JO, Leucht P, Mueller E. PPARγ agonists delay age-associated metabolic disease and extend longevity. Aging Cell. 2020 Nov;19(11):e13267.
5. Guo M*, Qiu J*, Shen F*, Wang S, Yu J, Zuo H, Yao J, Xu S, Hu T, Wang D, Zhao Y, Hu Y, Shen F, Ma X#, Lu J#, Gu X#, Xu L#. Comprehensive analysis of circular RNA profiles in skeletal muscles of aging mice and after aerobic exercise intervention. Aging (Albany NY). 2020 Mar 17;12. doi: 10.18632/aging.102932.
6. Zhou B*, Liu C*, Xu L*, Yuan Y, Zhao J, Zhao W, Chen Y, Qiu J, Meng M, Zheng Y, Wang D, Gao X, Li X, Zhao Q, Wei X, Wu D, Zhang H, Hu C, Zhuo X, Zheng M, Wang H#, Lu Y#, Ma X#. N6-methyladenosine Reader Protein Ythdc2 Suppresses Liver Steatosis via Regulation of mRNA Stability of Lipogenic Genes. Hepatology. 2020 Mar 9. doi: 10.1002/hep.31220.
8. Cheng X*, Qiu J*, Wang S, Yang Y, Guo M, Wang D, Luo Q, Xu L#. Comprehensive circular RNA profiling identifies CircFAM120A as a new biomarker of hypoxic lung adenocarcinoma. Ann Transl Med. 2019;7(18):442.
9. Wang D*, Cheng X*, Li Y, Guo M, Zhao W, Qiu J, Zheng Y, Meng M, Ping X, Chen X, Wang S, Luo J, Luo Q, Ma X#, Xu L#. C/EBPδ-Slug-Lox1 axis promotes metastasis of lung adenocarcinoma via oxLDL uptake. Oncogene. 2020 Jan;39(4):833-848. doi: 10.1038/s41388-019-1015-z.
10. Ma X, Feng D, Lu Y, Sun N, Wang J, Xu L. Editorial: Novel Strategies Targeting Obesity and Metabolic Diseases. Front Physiol. 2019 May 29;10:668. doi: 10.3389/fphys.2019.00668.
11. Yue L*，Zhao W*, Wang D*, Meng M, Zheng Y, Li Y, Qiu J, Yu J, Yan Y, Lu P, Sun Y, Fu J, Wang J, Zhang Q, Xu L#, Ma X#, Silver nanoparticles inhibit beige fat function and promote adiposity. Mol Metab. 2019 Apr;22:1-11. doi: 10.1016/j.molmet.2019.01.005.
12. Ma X, Wang D, Zhao W, Xu L. Deciphering the Roles of PPARγ in Adipocytes via Dynamic Change of Transcription Complex. Front. Endocrinol 2018; 9:473.
13. Xu L, Zhao W, Wang D, Ma X. Chinese Medicine in the Battle against Obesity and Metabolic Diseases.Front Physiol 2018; 9:850.
14.Xu L*, Ma X*, Verma NK, Wang D, Gavrilova O, Proia RL, Finkel T, Mueller E. Ablation of PPARγ in subcutaneous fat exacerbates age-associated obesity and metabolic decline. Aging Cell 2018; 17.
15. Alexaki A, Clarke BA, Gavrilova O, Ma Y, Zhu H, Ma X, Xu L, Tuymetova G, Larman BC, Allende ML, Dunn TM, Proia RL. De Novo Sphingolipid Biosynthesis Is Required for Adipocyte Survival and Metabolic Homeostasis. J Biol Chem 2017; 292:3929-3939.
16.Ma X*, Xu L*, Muller E. Forkhead box A3 Mediates Glucocorticoid Receptor Function in Adipose Tissue. Proc Natl Acad Sci USA 2016; 113:3377-3382.
17. Xu L*, Ma X*, Bagattin A, Mueller E. The transcriptional coactivator PGC1α protects against hyperthermic stress via cooperation with the heat shock factor HSF1. Cell Death & Disease 2016; 7:e2102.
18. Ma X, Xu L, Mueller E. Calorie hoarding and thrifting: Foxa3 finds a way. Adipocyte 2015; 4:325-328.
19. Ma X*, Xu L*, Alberobello AT, Gavrilova O, Bagattin A, Skarulis M, Liu J, Finkel T, Mueller E. Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis.
Cell Metab. 2015; 22:695-708.
20. Ma X*, Xu L*, Gavrilova O, Mueller E. Role of forkhead box protein A3 in age-associated metabolic decline. Proc Natl Acad Sci USA 2014; 111:14289-14294.
21. Xu L*, Panel V*, Ma X*, Du C, Hugendubler L, Gavrilova O, Liu A, McLaughlin T, Kaestner KH, Mueller E. The winged helix transcription factor Foxa3 regulates adipocyte differentiation and depot-selective fat tissue expansion. Mol Cell Biol 2013; 33:3392-3399.
22. Qi Y, Li X, Ma X, Xu L, Zhang X, Jiang X, Hong J, Cui B, Ning G, Wang S. The role of osteopontin in the induction of the CD40 ligand in Graves' disease. Clin Endocrinol (Oxf) 2014; 80:128-134.
23. Li X*, Qi Y*, Ma X*, Huang F, Guo H, Jiang X, Hong J, Lin D, Cui B, Ning G#, Xu L#, Wang S#. Chemokine (C-C motif) ligand 20, a potential biomarker for Graves' disease, is regulated by osteopontin. PLoS One 2013; 8:e64277.
24. Liu R*, Ma X*, Xu L*, Wang D, Jiang X, Zhu W, Cui B, Ning G, Lin D, Wang S. Differential MicroRNA Expression in Peripheral Blood Mononuclear Cells from Graves' Disease Patients. J Clin Endocrinol Metab 2012; 97:E968-E972.
25. Xu L*, Ma X*, Wang Y*, Li X, Qi Y, Cui B, Li X, Ning G, Wang S. The expression and pathophysiological role of osteopontin in Graves' disease. J Clin Endocrinol Metab 2011; 96:E1866-E1870.
26. Ma X*, Xu L*, Wang S, Cui B, Li X, Xu J, Ning G. Deletion of steroid receptor coactivator-3 gene ameliorates hepatic steatosis. J Hepatol 2011; 55:445-452.
27. Xu L*, Ma X*, Cui B, Li X, Ning G, Wang S. Selection of reference genes for qRT-PCR in high fat diet-induced hepatic steatosis mice model. Mol Biotechnol 2011; 48:255-262.
28. Xu L*, Ma X*, Li JL, Li X, Xu J, Ning G, Wang S. SRC-3 deficient mice developed fat redistribution under high fat diet. Endocrine 2010; 38:60-66.
30. Ma X*, Xu L*, Wang S, Chen H, Xu J, Li X, Ning G. Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis. Lab Invest 2009; 89: 903-914.

部分發表論文

1. Liu C*, Zhou B*, Meng M*, Zhao W, Wang D, Yuan Y, Zheng Y, Qiu J, Li Y, Li G, Xiong X, Bian H, Zhang H, Wang H, Ma X#, Hu C#, Xu L#, Lu Y#. FOXA3 induction under endoplasmic reticulum stress contributes to non-alcoholic fatty liver disease. J Hepatol 2021, S0168-8278(21)00090-8.
2. Qiu J*, Zhang Z*, Wang S*, Chen Y*, Liu C, Xu S, Wang D, Su J, Ni M, Yu J, Cui X, Ma L, Hu T, Hu Y, Gu X#, Ma X#, Wang J#, Xu L#. Transferrin Receptor Functionally Marks Thermogenic Adipocytes. Front Cell Dev Biol. 2020, 8:572459.
3. Xu L*, Ma X*, Verma N, Perie L, Pendse J, Shamloo S, Marie Josephson A, Wang D, Qiu J, Guo M, Ping X, Allen M, Noguchi A, Springer D, Shen F, Liu C, Zhang S, Li L, Li J, Xiao J, Lu J, Du Z, Luo J, Aleman JO, Leucht P, Mueller E. PPARγ agonists delay age-associated metabolic disease and extend longevity. Aging Cell. 2020 Nov;19(11):e13267.
5. Guo M*, Qiu J*, Shen F*, Wang S, Yu J, Zuo H, Yao J, Xu S, Hu T, Wang D, Zhao Y, Hu Y, Shen F, Ma X#, Lu J#, Gu X#, Xu L#. Comprehensive analysis of circular RNA profiles in skeletal muscles of aging mice and after aerobic exercise intervention. Aging (Albany NY). 2020 Mar 17;12. doi: 10.18632/aging.102932.
6. Zhou B*, Liu C*, Xu L*, Yuan Y, Zhao J, Zhao W, Chen Y, Qiu J, Meng M, Zheng Y, Wang D, Gao X, Li X, Zhao Q, Wei X, Wu D, Zhang H, Hu C, Zhuo X, Zheng M, Wang H#, Lu Y#, Ma X#. N6-methyladenosine Reader Protein Ythdc2 Suppresses Liver Steatosis via Regulation of mRNA Stability of Lipogenic Genes. Hepatology. 2020 Mar 9. doi: 10.1002/hep.31220.
8. Cheng X*, Qiu J*, Wang S, Yang Y, Guo M, Wang D, Luo Q, Xu L#. Comprehensive circular RNA profiling identifies CircFAM120A as a new biomarker of hypoxic lung adenocarcinoma. Ann Transl Med. 2019;7(18):442.
9. Wang D*, Cheng X*, Li Y, Guo M, Zhao W, Qiu J, Zheng Y, Meng M, Ping X, Chen X, Wang S, Luo J, Luo Q, Ma X#, Xu L#. C/EBPδ-Slug-Lox1 axis promotes metastasis of lung adenocarcinoma via oxLDL uptake. Oncogene. 2020 Jan;39(4):833-848. doi: 10.1038/s41388-019-1015-z.
10. Ma X, Feng D, Lu Y, Sun N, Wang J, Xu L. Editorial: Novel Strategies Targeting Obesity and Metabolic Diseases. Front Physiol. 2019 May 29;10:668. doi: 10.3389/fphys.2019.00668.
11. Yue L*，Zhao W*, Wang D*, Meng M, Zheng Y, Li Y, Qiu J, Yu J, Yan Y, Lu P, Sun Y, Fu J, Wang J, Zhang Q, Xu L#, Ma X#, Silver nanoparticles inhibit beige fat function and promote adiposity. Mol Metab. 2019 Apr;22:1-11. doi: 10.1016/j.molmet.2019.01.005.
12. Ma X, Wang D, Zhao W, Xu L. Deciphering the Roles of PPARγ in Adipocytes via Dynamic Change of Transcription Complex. Front. Endocrinol 2018; 9:473.
13. Xu L, Zhao W, Wang D, Ma X. Chinese Medicine in the Battle against Obesity and Metabolic Diseases.Front Physiol 2018; 9:850.
14.Xu L*, Ma X*, Verma NK, Wang D, Gavrilova O, Proia RL, Finkel T, Mueller E. Ablation of PPARγ in subcutaneous fat exacerbates age-associated obesity and metabolic decline. Aging Cell 2018; 17.
15. Alexaki A, Clarke BA, Gavrilova O, Ma Y, Zhu H, Ma X, Xu L, Tuymetova G, Larman BC, Allende ML, Dunn TM, Proia RL. De Novo Sphingolipid Biosynthesis Is Required for Adipocyte Survival and Metabolic Homeostasis. J Biol Chem 2017; 292:3929-3939.
16.Ma X*, Xu L*, Muller E. Forkhead box A3 Mediates Glucocorticoid Receptor Function in Adipose Tissue. Proc Natl Acad Sci USA 2016; 113:3377-3382.
17. Xu L*, Ma X*, Bagattin A, Mueller E. The transcriptional coactivator PGC1α protects against hyperthermic stress via cooperation with the heat shock factor HSF1. Cell Death & Disease 2016; 7:e2102.
18. Ma X, Xu L, Mueller E. Calorie hoarding and thrifting: Foxa3 finds a way. Adipocyte 2015; 4:325-328.
19. Ma X*, Xu L*, Alberobello AT, Gavrilova O, Bagattin A, Skarulis M, Liu J, Finkel T, Mueller E. Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis.
Cell Metab. 2015; 22:695-708.
20. Ma X*, Xu L*, Gavrilova O, Mueller E. Role of forkhead box protein A3 in age-associated metabolic decline. Proc Natl Acad Sci USA 2014; 111:14289-14294.
21. Xu L*, Panel V*, Ma X*, Du C, Hugendubler L, Gavrilova O, Liu A, McLaughlin T, Kaestner KH, Mueller E. The winged helix transcription factor Foxa3 regulates adipocyte differentiation and depot-selective fat tissue expansion. Mol Cell Biol 2013; 33:3392-3399.
22. Qi Y, Li X, Ma X, Xu L, Zhang X, Jiang X, Hong J, Cui B, Ning G, Wang S. The role of osteopontin in the induction of the CD40 ligand in Graves' disease. Clin Endocrinol (Oxf) 2014; 80:128-134.
23. Li X*, Qi Y*, Ma X*, Huang F, Guo H, Jiang X, Hong J, Lin D, Cui B, Ning G#, Xu L#, Wang S#. Chemokine (C-C motif) ligand 20, a potential biomarker for Graves' disease, is regulated by osteopontin. PLoS One 2013; 8:e64277.
24. Liu R*, Ma X*, Xu L*, Wang D, Jiang X, Zhu W, Cui B, Ning G, Lin D, Wang S. Differential MicroRNA Expression in Peripheral Blood Mononuclear Cells from Graves' Disease Patients. J Clin Endocrinol Metab 2012; 97:E968-E972.
25. Xu L*, Ma X*, Wang Y*, Li X, Qi Y, Cui B, Li X, Ning G, Wang S. The expression and pathophysiological role of osteopontin in Graves' disease. J Clin Endocrinol Metab 2011; 96:E1866-E1870.
26. Ma X*, Xu L*, Wang S, Cui B, Li X, Xu J, Ning G. Deletion of steroid receptor coactivator-3 gene ameliorates hepatic steatosis. J Hepatol 2011; 55:445-452.
27. Xu L*, Ma X*, Cui B, Li X, Ning G, Wang S. Selection of reference genes for qRT-PCR in high fat diet-induced hepatic steatosis mice model. Mol Biotechnol 2011; 48:255-262.
28. Xu L*, Ma X*, Li JL, Li X, Xu J, Ning G, Wang S. SRC-3 deficient mice developed fat redistribution under high fat diet. Endocrine 2010; 38:60-66.
30. Ma X*, Xu L*, Wang S, Chen H, Xu J, Li X, Ning G. Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis. Lab Invest 2009; 89: 903-914.

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