徐亮，男，1985年10月生，湖北黃岡人，博士，中山大學化學學院教授、博士生導師。
基本介紹
- 中文名：徐亮
- 畢業院校：武漢大學
- 學位/學歷：博士
- 專業方向：有機化學
- 任職院校：中山大學
人物經歷,教育經歷,工作經歷,科研方向,學術成果,
人物經歷
教育經歷
2003年9月‒2007年6月，武漢大學，本科，化學基地班
2007年9月‒2012年6月，武漢大學，博士，有機化學
工作經歷
2012年7月‒2017年3月，加州大學聖地亞哥分校藥學院，博士後
2017年3月‒至今，中山大學化學學院，教授，博士生導師
科研方向
核酸化學生物學，圍繞核酸修飾展開，主要研究內容包括：
(1) 核酸修飾對轉錄回響等生物學過程的分子機制研究；
(2) 發展針對核酸修飾的化學工具，以調控和監測核酸修飾的轉化和功能；
(3) 利用修飾核酸研究核酸結合蛋白的作用機制並發展基因調控的化學工具
學術成果
ØLiang Xu, Wei Wang, Jiabin Wu, Ji Hyun Shin, Pengcheng Wang, Ilona Christy Unarta, Jenny Chong, Yinsheng Wang*, and Dong Wang*. Mechanism of DNA alkylation-induced transcriptional stalling, lesion bypass, and mutagenesis.Proc. Natl. Acad. Sci.,2017,114, E7082–E7091. (*Co-corresponding authors.)
ØWei Wang#,Liang Xu#, Lulu Hu, Jenny Chong, Chuan He, and Dong Wang* Epigenetic DNA Modification N6‑Methyladenine Causes Site-Specific RNA Polymerase II Transcriptional Pausing.J. Am. Chem. Soc.2017,139, 14436-14442. (#Co-first authors.)
ØLiang Xu#, Wei Wang#, Deanna Gotte, Fei Yang, Alissa A. Hare, Timothy R. Welch, Benjamin C. Li, Ji Hyun Shin, Jenny Chong, Jeffrey N. Strathern*, Peter B. Dervan*, and Dong Wang*. RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif.Proc. Natl. Acad. Sci., 2016, 113, 12426-12431.
ØLin-Tai Da#, Fatima Pardo#,Liang Xu#, Daniel-Adriano Silva, Lu Zhang, Xin Gao, Dong Wang*, and Xuhui Huang*.Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue.Nature Commun., 2016,7, 11244.
ØCandy Hwang#,Liang Xu#, Wei Wang, Sébastien Ulrich, Lu Zhang, Jenny Chong, Ji Hyun Shin, Xuhui Huang, Eric Kool, Charles McKenna*, and Dong Wang*. Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution.Nucleic Acids Res.2016,44, 3820-3828.
ØLanfeng Wang#, Yu Zhou#,Liang Xu#, Rui Xiao#, Xingyu Lu, Liang Chen, Jenny Chong, Hairi Li, Chuan He, Xiang-Dong Fu*, and Dong Wang*. Molecular Basis for 5-Carboxycytosine Recognition by RNA Polymerase II Elongation Complex.Nature, 2015,523, 621-625.
ØLiang Xu, Wei Wang, Lu Zhang, Jenny Chong, Xuhui Huang and Dong Wang*.Impact of template backbone heterogeneity on RNA polymerase II transcription.Nucleic Acids Res.2015, 43, 2232-2241.
ØLiang Xu, Ying-Chu Chen, Jenny Chong, Andrea Fin, Lisa S. McCoy, Jun Xu, Chao Zhang, and Dong Wang*. Pyrene-based quantitative detection of the 5-formylcytosine loci symmetry in the CpG duplex content during TET-dependent demethylation.Angew. Chem. Int. Ed.2014,53,11223-11227.
ØLiang Xu, Lu Zhang, Jenny Chong, Jun Xu, Xuhui Huang, and Dong Wang*. Strand-specific (asymmetric) contribution of phosphodiester linkages on RNA polymerase II transcriptional efficiency and fidelity.Proc. Natl. Acad. Sci.2014,111,E3269-76.
ØLiang Xu, Kyle Vincent Butler, Jenny Chong, Jesper Wengel, Eric T. Kool*and Dong Wang*. Dissecting the chemical interactions and substrate structural signatures governing RNA polymerase II trigger loop closure by synthetic nucleic acid analogues.Nucleic Acids Res.2014,42, 5863-5870.
ØLiang Xu, Ying-Chu Chen, Satoshi Nakajima, Jenny Chong, Lanfeng Wang, Li Lan, Chao Zhang*, and Dong Wang*. A chemical probe targets DNA 5-formylcytosine sites and inhibits TDG excision, polymerases bypass, and gene expression.Chem. Sci.2014,5, 567-574.
ØLiang Xu#, Steven W. Plouffe#, Jenny Chong, Jesper Wengel, and Dong Wang*. A chemical perspective on transcriptional fidelity: dominant contributions of sugar integrity revealed by unlocked nucleic acids.Angew. Chem. Int. Ed.2013,52, 12341-12345.
