徐亮，男，博士，四川大學華西藥學院副教授，博士生導師。
基本介紹
- 中文名：徐亮
- 國籍：中國
- 民族：漢族
- 畢業院校：四川大學
- 學位/學歷：博士
- 職務：四川大學博士生導師
- 職稱：副教授
人物經歷,研究方向,研究課題,獲獎記錄,發表論文,
人物經歷
1993～1997 華西醫科大學藥學院獲理學學士學位
1997～2000 華西醫科大學藥學院獲藥物化學碩士學位
2000～2003 四川大學華西藥學院獲藥物化學博士學位, 師從王鋒鵬教授
2003～2005 中科院上海有機化學研究所博士後, 師從林國強院士
2005～2007 美國科羅拉多州立大學化學系博士後, 師從史一安教授
2007～ 2015 四川大學華西藥學院副教授
2015～ 至今 四川大學華西藥學院教授
研究方向
1. 不對稱合成新方法學及其在天然藥物分子合成中的套用
2. 活性天然含氮有機物的全合成研究
研究課題
1. 新型手性氮雜環卡賓配體的合成及其在鈀催化不對稱反應中的套用(國家自然科學基金青年基金，起止日期2010-2012, 負責人)
2. 具有多環稠合複雜結構和高度生物活性的C19-二萜生物鹼-甲基牛扁鹼的全合成研究（國家自然科學基金面上項目，起止日期2013-2016, 負責人）
3. 新型二萜atropurpuran和二萜生物鹼arcutin及其天然衍生物的仿生不對稱全合成（國家自然科學基金面上項目，起止日期2015-2016, 負責人）
4. 二萜生物鹼methyllycaconitine和racemulosine的全合成研究（四川大學優秀青年基金，2013至2016，負責人）
5. 套用代謝組學技術系統研究烏頭鹼類鎮痛藥的體內活性毒性代謝產物（國家自然科學基金青年基金，起止日期2014-2016, 主要參與）
獲獎記錄
1. 2009和2012年度四川大學青年骨幹教師獎
2. 教育部自然科學一等獎：藥用草烏化學成分的系統研究（排名第五）
發表論文
1. Dai-Hui Tang, Ding Ma, Hang Cheng, Yong-Li Li, and Liang Xu*, A bio-inspired synthetic route to the core ring systems of Spiraea atisine-type diterpenoid alkaloids and related diterpenes, Org. Biomol. Chem. 2016, 14, 2716–2722.
2. Min-Li Jiang, Yin-Juan Meng, Wei-Yan Xiong, Liang Xu*, Construction of functionalized ABEF ring system of C20-diterpenoid alkaloid racemulosine, Tetrahedron Lett. 2016, 57, 1610–1612.
3. Hang Cheng, Fan-Hao Zeng, Xue Yang, Yin-Juan Meng, Liang Xu*, and Feng-Peng Wang，Collective Total Syntheses of Atisane-Type Diterpenes and Atisine-Type Diterpenoid Alkaloids: (±)-Spiramilactone B, (±)-Spiraminol, (±)-Dihydroajaconine, and (±)-Spiramines C and D, Angew. Chem. Int. Ed. 2016, 55, 392 –396. (Highlighted by Chin. J. Org. Chem. 2016, 36, 437; Synfacts 2016, 12, 0119).
4. Jie Li, Liang Xu*, Novel C2-symmetric six-membered NHCs for asymmetric copper-catalysed conjugate addition of Grignard reagents to 3-methylhexenone, Tetrahedron 2015, 71, 2858−2862.
5. Ding Ma, Hang Cheng, Chunmei Huang, Liang Xu*, Synthesis of the azatricyclic ACD ring system of calyciphylline A-type Daphniphyllum alkaloids via a nonstabilized azomethine ylide generated by desilylation, Tetrahedron Lett. 2015, 56, 2492–2495.
6. Wei Zhang, Hang Cheng, Yongli Li, Chunmei Huang, Liang Xu*, A new approach toward the bicyclo[3.2.1]octenes via a carbocation-based cyclization from unusually functionalized seven-membered ring precursors, Tetrahedron 2015, 71, 4967−4973.
7. Hang Cheng, Fan-HaoZeng, Ding Ma, Min-Li Jiang, Liang Xu*, and Feng-Peng Wang, Expedient Construction of the ABEF Azatetracyclic Ring Systems of Lycoctonine-Type and 7,17-seco-Type C19-Diterpenoid Alkaloids, Org. Lett. 2014, 16, 2299−2301.
8. Ru-Huai Mei, Zhi-Gang Liu, Hang Cheng, Liang Xu*, and Feng-Peng Wang, Synthesis of the 10-Azatricyclo[3.3.2.04,8]decane Core of C20-Diterpenoid Alkaloid Racemulsonine via Iodine(III) Promoted Transannular Aziridination Reaction, Org. Lett. 2013, 15, 2206−2309.
9. Zhi-Gang Liu, Hang Cheng, Meng-Jia Ge, Liang Xu*, Feng-Peng Wang PIDA-promoted intramolecular transannular aziridination to synthesize bridged azatricyclic amines related to methyllycaconitine, Tetrahedron 2013, 69, 5431-5437.
10. Zhi-Gang Liu, Liang Xu*, Qiao-Hong Chen, Feng-Peng Wang, Construction of A/E/F ring systems of C19-diterpenoid alkaloids with both C-1and C-6 oxygen functions Tetrahedron 2012, 68, 159−165.
11. Hang Cheng, Liang Xu*, De-Lin Chen, Qiao-Hong Chen, Feng-Peng Wang, Construc-tion of functionalized B/C/D ring system of C19-diterpenoid alkaloids via intramolecularDielseAlder reaction followed by Wagner-Meerwein rearrangement Tetrahedron 2012, 68, 1171−1176.
12. Jie Li, Liang Xu*, Feng-Peng Wang, New cytotoxic Myrsinane_typediterpenes from Euphorbia prolifera, Helv. Chim. Acta. 2010, 93, 746.
研究生及博士後期間:
1. Jiang Long, Liang Xu, Haifeng Du, Kai Li and Yian Shi, Mechanistic Studies on a Dipeptide-Promoted Asymmetric Cyclopropanation of Unfunctionalized Olefins, Org. Lett. 2009, 11, 5226–5229.
2. Hong-Fu Lu, Xun Sun, Liang Xu, Li-Guang Lou, Guo-Qiang Lin, Design, synthesis and biological evaluation of novel fluorinated docetaxel analogues，Eur. J. Med. Chem. 2008, doi:10.1016 /j.ejmech.2008.04.004.
3. Liang Xu, Yian Shi, Chiral N-Heterocyclic Carbene-Pd(0) Catalyzed Asymmetric Diamination of Conjugated Dienes and Triene, J. Org. Chem. 2008, 73, 749
4. Liang Xu, Haifeng Du, and Yian Shi, Diamination of Conjugated Dienes and Trienes Catalyzed by N-Heterocyclic Carbene-Pd(0) Complexes. J. Org. Chem. 2007, 72, 7038.
5. Liang Xu, Jian-li Wang, Feng-peng Wang, Novel Rearrangement Products of the Degrated Derivative of Maoecrystal A, An ent-Kaurane-Type Diterpene, J. Asia Nat. Prod. Res. 2007, 9, 239.
6. Liang Xu, Feng-peng Wang, An Attempt to Enlarge the B ring of Maoecrystal B, an ent-Kaurane-type Diterpene, J. Asia Nat. Prod. Res. 2006, 8, 545.
7. Liang Xu, and Feng-Peng Wang, Exhaustive Degradation of the Ring D of 3,20-Epoxy ent-Kaurane-Type Diterpene Maoecrystal A. Tetrahedron, 2005, 61, 4467.
8. Feng-Peng Wang, and Liang Xu, To Seek an Approach Toward the Chemical Conversion of C19- diterpenoid Alkaloids to Taxoids. Tetrahedron, 2005, 61, 2149.
9. Liang Xu, Qiao-hong Chen, Feng-peng Wang, A Novel Skeletal Rearrangement of the A Ring of the Immonium Salt Derived from Norditerpenoid Alkaloid Yunaconitine, Tetrahetron, 2002, 58, 4267.
10. Qiao-hong Chen, Liang Xu, Feng-peng Wang, A Novel Conversion of Norditerpenoid Alkaloids into Aconane-Type Diterpenes, Tetrahetron, 2002, 58, 9431.
11. Qiao-hong Chen, Liang Xu, Feng-peng Wang, A New Access to the Cleavage of the N,19-Bond of Norditerpenoid Alkaloids and Their Derivatives by Formation of Oxaziridines, Heterocycles, 2002, 57, 2357.
12. Zheng-bang Li, Liang Xu, Xi-xianJian and Feng-peng Wang, New Norditerpenoid alkaloids from the roots of Aconitum geniculatum. J. Asia Nat. Prod. Res.2001, 3, 131.
13. Qiao-Hong Chen, Liang Xu,Feng-peng Wang, Preparation of the N,19-seco norditerpenoid alkaloids from norditerpenoid alkaloid yunaconitine, Chin .Chem. Lett, 2003, 14, 147
