張齊好

張齊好，畢業於中山大學，博士學位 ，暨南大學生命科學技術學院研究員。

基本介紹

• 中文名：張齊好
• 國籍：中國
• 畢業院校：中山大學
• 學位/學歷：博士
• 職業：教師
• 專業方向：金屬對生殖系統和神經系統損傷的機制研究等

人物經歷

學習經歷

2013/03-2014/03，墨爾本大學，訪問學者，神經生物學

2004/07-2007/06，中山大學，博士學位，病理學

2000/07-2003/06，暨南大學，碩士學位，病理生理學

1994/07-2000/06，暨南大學，學士學位，臨床醫學

工作經歷

2018/10至今，暨南大學生命科學技術學院細胞生物學系/生物醫藥研究院，研究員

2011/10-2018/09，暨南大學生命科學技術學院細胞生物學系/生物醫藥研究院，副研究員

2010/11-2011/09，暨南大學生命科學技術學院細胞生物學系/生物醫藥研究院，助理研究員

2008/04-2010/10，暨南大學，博士後，生物學

2003/07-2004/09，暨南大學醫藥生物技術研究開發中心

研究方向

1. 重金屬對生殖系統和神經系統損傷的機制研究

2. 重組蛋白藥物治療神經退行性疾病的機制研究

學術成就

主要論文

1.Jianfeng Feng, Shaomin Chen, Youjin Wang, Qunxing Liu, Mengqi Yang, Xin Li, Chuan Nie, Jianxiang Qin, Hongxia Chen, Xiaohui Yuan, Yadong Huang, Qihao Zhang.Maternal exposure to cadmium impairs cognitive development of male offspring by targeting the Coronin-1a signaling pathway.Chemosphere, 2019 (A1, IF 4.43, doi:10.1016/j.chemosphere.2019.03.094,通訊作者).

2. Zhiliang Li, Teng Li, Yang Leng, Shaomin Chen, Qunxing Liu, Jianfeng Feng, Hongxia Chen, Yadong Huang, Qihao Zhang*. Hormonal changes and folliculogenesis in female offspring of ratsexposed to cadmium during gestation and lactation.Environmental Pollution, 2018, 238: 336-347 (A1, IF 5.01,通訊作者).

3. Huajian Tian, Shaomin Chen, Yang Leng, Teng Li, Zengli Li, Hongxia Chen, Yadong Huang, Qihao Zhang. Exposure to cadmium during gestation and lactation affects development and function of Leydig cells in male offspring. Environmental Toxicology, 2017, DOI: 10.1002/tox.22522 (A2, IF 3.001,通訊作者).

4.Tian Meng, Qin Cao, Peng Lei, Ashley I Bush, Qi Xiang, Zhijian Su, Xiang He, Jack T Rogers, Ing-Ming Chiu, Qihao Zhang, Yadong Huang. Tat-haFGF14–154Upregulates ADAM10 to Attenuate the Alzheimer Phenotype of APP/PS1 Mice through the PI3K-CREB-IRE1α/XBP1 Pathway.Mol Ther Nucleic Acids., 2017 Jun., 16 (7): 439-452 (A1, IF 6.392,通訊作者).

5.Yang PH, Zhu JX, Huang YD, Zhang XY, Lei P, Bush AI, Xiang Q, Su ZJ, Zhang QH.Human Basic Fibroblast Growth Factor Inhibits Tau Phosphorylation via the PI3K/Akt-GSK3β Signaling Pathway in a 6-Hydroxydopamine-Induced Model of Parkinson's Disease.Neurodegener Dis., 2016 May, 16(5-6): 357-369 (A2, IF2.842,通訊作者).

6.Gao X, Feng J, He Y, Xu F, Fan X, Huang W, Xiong H, Liu Q, Liu W, Liu X, Sun X, He QY, Zhang Q, Liu L. hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells. Sci Rep., 2016 Mar., 14(6):22999 (A1, IF4.259,通訊作者).

7.Ji X, Li Z, Chen H, Li J, Tian H, Li Z, Gao X, Xiang Q, Su Z, Huang Y, Zhang Q. Cytotoxic mechanism related to dihydrolipoamide dehydrogenase in Leydig cells exposed to heavy metals. Toxicology, 2015 Aug 6; 334: 22-32(A1, IF 3.582,通訊作者).

8.Chen H, Li S, Meng T, Zhang L, Dai T, Xiang Q, Su Z, Zhang Q, Huang Y. HSP27 as a biomarker for predicting skin irritation in human skin and reconstructed organotypic skin model. Toxicol Lett., 2014 Apr, 226(2):124-131(A1, IF 3.858,通訊作者).

9.Lou G#,Zhang Q#, Xiao F, Xiang Q, Su Z, Zhang L, Yang P, Yang Y, Zheng Q, Huang Y. Intranasal administration of TAT-haFGF(14-154) attenuates disease progression in a mouse model of Alzheimer's disease. Neuroscience. 2012 Oct, 223:225-37(A1, IF 3.277,共同第一作者).

10.Qihao Zhang, Ping Zou, Haichao Zhan, Minjing Zhang, Lei Zhang, Ren-shan Ge,Yadong Huang.Dihydrolipoamide dehydrogenase and cAMP are associated with cadmium-mediated Leydig cell damage. Toxicology Letters, 2011, 205 (2): 183-189(IF 3.86).

11.Qihao Zhang, Taoli Dai, Lei Zhang, Minjing Zhang, Xue Xiao, Hao Hu, Ping Zou,Xia Liu, Qi Xiang, Zhijian Su, Yadong Huang, Qing-Yu He. Identification of Potential Biomarkers for Predicting Acute Dermal Irritation by Proteomic Analysis. Journal of Applied Toxicology, 2011, 31(8): 762-772(IF 3.16).

12.Qihao Zhang, Lei Zhang, Xue Xiao, Zhijian Su, Ping Zou, Hao Hu, Yadong Huang, Qing-Yu He, Heavy Metals Chromium and Neodymium Reduced Phosphorylation Level of Heat Shock Protein 27 in Human Keratinocytes. Toxicology in Vitro, 2010, 24(4): 1098-1104(IF 2.87).

13.Lou G, Zhang Q, Xiao F, Xiang Q, Su Z, Huang Y. Intranasal TAT-haFGF Improves Cognition and Amyloid-βPathology in an AβPP/PS1 Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016 Feb, 51(4): 985-990 (A1, IF3.731,第二作者).

14.Li Y, Xiang Q, Zhang Q, Huang Y, Su Z. Overview on the recent study of antimicrobial peptides: origins, functions, relative mechanisms and application. Peptides. 2012 Oct, 37(2): 207-15 (A1, IF 2.778,他引次數95,第三作者).

15.Lei P, Ayton S, Moon S, Zhang Q, Volitakis I, Finkelstein DI, Bush AI. Motor and cognitive deficits in aged tau knockout mice in two background strains. Mol Neurodegener. 2014 Aug, 9: 29 (A1, IF 6.78,第四作者).

16.Ning X, Yang Y, Deng H, Zhang Q, Huang Y, Su Z, Fu Y, Xiang Q, Zhang S.Development of 17β-hydroxysteroid dehydrogenase type 3 as a target in hormone-dependent prostate cancer therapy.Steroids. 2017May, 121: 10-16 (A2, IF2.282,第四作者).

17.Zhang Y, Meng T, Zuo L, Bei Y, Zhang Q, Su Z, Huang Y, Pang J, Xiang Q, Yang H.Xyloketal B Attenuates Fatty Acid-Induced Lipid Accumulation via the SREBP-1c Pathway in NAFLD Models.Mar Drugs. 2017 Jun.,15(6). pii: E163(A2, IF3.503).

18.Yang Y, Li Z, Wu X, Chen H, Xu W, Xiang Q, Zhang Q, Chen J, Ge RS, Su Z, Huang Y.Direct Reprogramming of Mouse Fibroblasts toward Leydig-like Cells by Defined Factors.Stem Cell Reports. 2017 Jan.,8(1):39-53.(A1, IF7.338)

19.Xiao X, Zhang C, Liu D, Bai W, Zhang Q, Xiang Q, Huang Y, Su Z. Prevention of gastrointestinal lead poisoning using recombinant Lactococcus lactis expressing human metallothionein-I fusion protein. Sci Rep. 2016 Apr, 6: 23716 (A1, IF4.259).

20.Xu J, Xiang Q, Su J, Yang P, Zhang Q, Su Z, Xiao F, Huang Y. Evaluation of the safety and brain-related tissues distribution characteristics of TAT-HaFGF via intranasal administration. Biol Pharm Bull. 2014;37(7):1149-57 (A2, IF 1.683).

21.Zhang L, Wang H, Yang Y, Liu H, Zhang Q, Xiang Q, Ge R, Su Z, Huang Y. NGF induces adult stem Leydig cells to proliferate and differentiate during Leydig cell regeneration. Biochem Biophys Res Commun. 2013 Jun 28;436(2):300-5 (A2, IF 2.466).

22.Yang Y, Su Z, Xu W, Luo J, Liang R, Xiang Q, Zhang Q, Ge RS, Huang Y. Directed mouse embryonic stem cells into leydig-like cells rescue testosterone-deficient male rats in vivo. Stem Cells Dev. 2015 Feb 15;24(4):459-70 (A1, IF 3.562).

23.Gao X, Xu F, Zhang HT, Chen M, Huang W, Zhang Q, Zeng Q, Liu L.PKCα-GSK3β-NF-κB signaling pathway and the possible involvement of TRIM21 in TRAIL-induced apoptosis.Biochem Cell Biol. 2016 Jun,94(3):256-264 (A2, IF1.895).

24.Cai C, Dai X, Zhu Y, Lian M, Xiao F, Dong F, Zhang Q, Huang Y, Zheng Q.A specific RAGE-binding peptide biopanning from phage display random peptide library that ameliorates symptoms in amyloid β peptide-mediated neuronal disorder.Appl Microbiol Biotechnol. 2016 Jan,100(2):825-35 (A1, IF3.42).

25.Su J, Chang C, Xiang Q, Zhou ZW, Luo R, Yang L, He ZX, Yang H, Li J, Bei Y, Xu J, Zhang M, Zhang Q, Su Z, Huang Y, Pang J, Zhou SF.Xyloketal B, a marine compound, acts on a network of molecular proteins and regulates the activity and expression of rat cytochrome P450 3a: a bioinformatic and animal study.Drug Des Devel Ther. 2014 Dec,8:2555-2602 (A2, IF2.822).

26.Liu H, Yang Y, Zhang L, Liang R, Ge RS, Zhang Y, Zhang Q, Xiang Q, Huang Y, Su Z.Basic fibroblast growth factor promotes stem Leydig cell development and inhibits LH-stimulated androgen production by regulating microRNA expression.J Steroid Biochem Mol Biol. 2014 Oct,144 Pt B:483-491 (A1, IF4.561).

27.Hu H, Xiang Q, Liu H, Qu H, Tang X, Xiao X, Zhang Q, Su Z, Huang Y.Expression, purification, and biological activity of the recombinant pramlintide precursor.Appl Microbiol Biotechnol. 2014 Sep,98(18):7837-7844 (A1, IF3.42).

28.Yuan X, Li H, Bai H, Su Z, Xiang Q, Wang C, Zhao B, Zhang Y, Zhang Q, Chu Y, Huang Y.Synthesis of novel curcumin analogues for inhibition of 11β-hydroxysteroid dehydrogenase type 1 with anti-diabetic properties.Eur J Med Chem. 2014 Apr,77:223-30 (A1, IF4.519).

29.Dai X, Cai C, Xiao F, Xiong Y, Huang Y, Zhang Q, Xiang Q, Lou G, Lian M, Su Z, Zheng Q.Identification of a novel aFGF-binding peptide with anti-tumor effect on breast cancer from phage display library.Biochem Biophys Res Commun. 2014 Mar,445(4):795-801(A2, IF2.466).

30.Sun J, Bai S, Bai W, Zou F, Zhang L, Su Z, Zhang Q, Ou S, Huang Y.Toxic mechanisms of 3-monochloropropane-1,2-diol on progesterone production in R2C rat leydig cells.J Agric Food Chem. 2013 Oct,61(41):9955-9960 (A1, IF3.154).

31.Zhang M, Qiu Z, Li Y, Yang Y, Zhang Q, Xiang Q, Su Z, Huang Y.Construction and characterization of a recombinant human beta defensin 2 fusion protein targeting the epidermal growth factor receptor: in vitro study.Appl Microbiol Biotechnol. 2013 May,97(9):3913-3923 (A1, IF3.42).

承擔課題

1. 類膠原肽的安全性評價，橫向課題，30萬元，2017.10-2019.10（主持）
2. 以神經元微環境調控為靶點治療神經退行性疾病的藥物研究開發，廣東省對外科技合作項目，2013B051000063,25萬元，2014.01-2016.12（主持）
3. FGFs突破血腦屏障治療帕金森病新型給藥系統的研究開發，廣東省重大科技專項，2012A080201010，150萬，2012.01-2014.12（主持）；
4. 重金屬鎘暴露影響子代睪丸Leydig細胞發育的線粒體相關機制研究，國家自然科學基金面上項目，31271607，75萬，2013.01-2016.12（主持）；
5. 線粒體作為重金屬毒性靶點在睪丸Leydig細胞中的研究，國家自然科學青年基金，31000663，20萬，2011.01-2013.12（主持）；
6. 套用蛋白組學技術篩選評價Leydig細胞的重金屬毒性生物標記，中國博士後科學基金，20090450882，3萬，2010.01-2011.10（主持）；
7. 以11β-羥甾脫氫酶為靶點治療II型糖尿病藥物——薑黃素衍生物的研發，暨南大學科研培育與創新基金項目，21611508，8萬，2011.1-2011.12（主持）；
8. aFGF改構體調控神經元微環境拮抗Αβ神經毒性治療AD的分子機制研究，廣東省自然科學基金重點項目，2015A03031101，30萬，2015.08-2018.08（副主持）；
9. 緩控釋細胞生長因子新型智慧型生物材料技術體系的建立及套用研究，廣州市產學研協同創新重大專項，20150802001，100萬，2015.01-2017.12（副主持）。
10. bFGF和IGF1對成年睪丸間質幹細胞增殖和分化、最佳化的調節機制研究，國家自然科學基金，81070477，31萬，2011.01-2013.12（第二負責人）；

講授課程

高級生物化學，生物製藥。