張銳(中山大學教授)

張銳，男，理學博士，中山大學教授、博士生導師，中山大學“百人計畫”引進人才。

基本介紹

• 中文名：張銳
• 職業：教師
• 畢業院校：中國科學院
• 學位/學歷：博士
• 職務：博士生導師
• 職稱：教授

人物經歷

2003年畢業於四川大學生科院，獲學士學位。2009年於中科院昆明動物所獲得博士學位，在宿兵研究員指導下研究小RNA的進化和功能。

2009年-2011年期間分別在倫敦皇家學會會員Stephen Cohen教授和台灣中研院院士Chung-I Wu教授實驗室從事小RNA進化領域研究工作。
2011年-2015年在美國史丹福大學醫學院遺傳系Jin Billy Li教授實驗室做博士後，通過發展微流控技術、高通量測序相關高新生物技術研究RNA編輯的進化和功能。

講授課程

Evolutionary Biology of Genes and Genomes，本科，逸仙學院

走進幹細胞的世界/ Approaches to stem cells，本科生，公選課

進化基因組學，研究生，生科院

學術成就

目前已在Nature, Science, Nature Methods, Nature Genetics, Cancer Cell, Genome Research, Nature Communications, PNAS, Cell Reports, PLOS Genetics, The EMBO Journal, Genome biology, Molecular Biology and Evolution, Nucleic Acids Research等重要學術雜誌發表多篇論文。榮獲一系列科研獎項，包括Stanford Dean’s Fellowship，中國全國優秀博士學位論文提名獎，中科院優秀博士學位論文獎和中科院院長獎等。

擔任Genome Research, Nature Communications, Trends in Genetics, PLOS Genetics, Molecular Biology and Evolution, Nucleic Acids Research等知名SCI期刊的審稿人，國自然基金評審人。

承擔課題

中山大學百人計畫 (2015 – 2017)，300萬
國家自然基金面上項目(2016 – 2019)，60萬
國家自然基金重大計畫培育項目(2017 – 2019)，100萬
珠江人才計畫創新創業團隊[五個課題組] (2017 – 2021)，2000萬
廣東省重大科技專項（前沿與關鍵技術創新方向）(2017-2019)，300萬
國家重點研發計畫生殖健康及重大出生缺陷防控研究子課題 (2018-2020)，210萬

論文專著

21. Lishi Li *, Yulong Song *, Xinrui Shi, Jianheng Liu, Shaolei Xiong, Wanying Chen, Qiang Fu, Zichao Huang, Nannan Gu#, Rui Zhang# The landscape of miRNA editing in animals and its impact on miRNA biogenesis and targeting. (2017) Genome Research (IF = 14.6).

20. Rui Zhang*,#, Patricia Deng*, Dionna Jacobson, Jin Billy Li# (2017) Evolutionary analysis reveals regulatory and functional landscape of coding and non-coding RNA editing PLOS Genetics (IF = 7.5)
Highlighted by Science: The evolution of edited RNA transcripts

19. Gokul Ramaswami *, Patricia Deng *, Rui Zhang, Mary Anne Carbone, Trudy F.C. Mackay, Li Jin Billy (2015) Genetic mapping uncovers cis-regulatory landscape of RNA editing. Nature Communications. 6:8194. doi: 10.1038/ncomms9194 (IF = 11.5)

18. Leng Han*, Lixia Diao*, Shuangxing Yu*, Xiaoyan Xu*, Jie Li, Rui Zhang, Yang Yang, Henrica M.J. Werner, Karina A. Eterovic, Yuan Yuan, Jun Li, Nikitha Nair, Rosalba Minelli, Yiu-Huen Tsang, Lydia W.T. Cheung, Kang Jin Jeong, Jason Roszik, Zhenlin Ju, Scott Woodman, Yiling Lu, Kenneth L. Scott, Jin Billy Li , Gordon B. Mills, Han Liang (2015) The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers Cancer Cell 28 (4), 515–528 (IF = 23.5)

17. Manuel A Rivas, Matti Pirinen, Donald F Conrad, Monkol Lek, Emily K Tsang, Konrad J Karczewski, Julian B Maller, Kimberly R Kukurba, David S DeLuca, Menachem Fromer, Pedro G Ferreira, Kevin S Smith, Rui Zhang, Fengmei Zhao, Eric Banks, Ryan Poplin, Douglas M Ruderfer, Shaun M Purcell, Taru Tukiainen, Eric V Minikel, Peter D Stenson, David N Cooper, Katharine H Huang, Timothy J Sullivan, Jared Nedzel, Carlos D Bustamante, Jin Billy Li, Mark J Daly, Roderic Guigo, Peter Donnelly, Kristin Ardlie, Michael Sammeth, Emmanouil T Dermitzakis, Mark I McCarthy, Stephen B Montgomery, Tuuli Lappalainen, Daniel G MacArthur (2015) Effect of predicted protein-truncating genetic variants on the human transcriptome Science 348 (6235), 666-669 (IF = 33.6)

16. Yael Baran, Meena Subramaniam, Anne Biton, Taru Tukiainen, Emily K Tsang, Manuel A Rivas, Matti Pirinen, Maria Gutierrez-Arcelus, Kevin S Smith, Kim R Kukurba, Rui Zhang, Celeste Eng, Dara G Torgerson, Cydney Urbanek, Jin Billy Li, Jose R Rodriguez-Santana, Esteban G Burchard, Max A Seibold, Daniel G MacArthur, Stephen B Montgomery, Noah A Zaitlen, Tuuli Lappalainen (2015) The landscape of genomic imprinting across diverse adult human tissues Genome Research, gr. 192278.115 (IF = 14.6)

15. Tomas Babak, Brian DeVeale, Emily K Tsang, Yiqi Zhou, Xin Li, Kevin S Smith, Kim R Kukurba, Rui Zhang, Jin Billy Li, Derek van der Kooy, Stephen B Montgomery and Hunter B Fraser (2015) Genetic conflict reflected in tissue-specific maps of genomic imprinting Nature Genetics 47 (5), 544-549 (IF = 29.3)

14. Anne L. Sapiro, Patricia Deng, Rui Zhang, Jin Billy Li (2015) Cis regulatory effects on A-to-I RNA editing in related Drosophila species. Cell Reports, 11:697-703 (IF = 8.3)

13. Guojing Liu*, Rui Zhang*, Jin Xu, Chung-I Wu and Xuemei Lu (2014) Functional conservation of both CDS- and 3’-UTR-located microRNA binding sites between species Mol Biol Evol doi: 10.1093/molbev/msu323 (IF = 9.1)

12. Kimberly R. Kukurba, Rui Zhang, Xin Li, Kevin S. Smith, David A. Knowles, Meng How Tan, Robert Piskol, Monkol Lek, Michael Snyder, Daniel G. MacArthur, Jin Billy Li and Stephen B. Montgomery (2014) Allelic expression of deleterious protein-coding variants across human tissues PLOS Genetics 10(5):e1004304.doi:10.1371/journal.pgen.1004304 (IF = 7.5)

11. Rui Zhang, Xin Li, Gokul Ramaswami, Kevin S Smith, Gustavo Turecki, Stephen B Montgomery and Jin Billy Li (2014) Quantifying RNA allelic ratios by microfluidic multiplex PCR and sequencing. Nature Methods 11:51–54 (IF = 32)

10. Xin Hong, Hung Thanh Nguyen, Qingfeng Chen, Rui Zhang, Zandra Hagman, P Mathijs and Stephen Cohen (2014) Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnover. EMBO Journal, DOI: 10.15252/embj.201489385 (IF = 10.4)

9. Lily Bazak, Ami Haviv, Michal Barak, Jasmine Jacob-Hirsch, Patricia Deng, Rui Zhang, Farren J Isaacs, Gideon Rechavi, Jin Billy Li, Eli Eisenberg and Erez Y Levanon (2013) A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes Genome Res doi:10.1101/gr.164749.113 (IF = 14.6)

8. Jin Xu*, Rui Zhang*, Yang Shen, Guojing Liu, Xuemei Lu and Chung-I Wu (2013) The evolution of evolvability in microRNA target sites in vertebrates. Genome Res 23:1810-1816 (IF = 14.6)

7. Gokul Ramaswami*, Rui Zhang*, Robert Piskol, Liam P Keegan, Patricia Deng, Mary A O'Connell and Jin Billy Li (2013) Identifying RNA editing sites using RNA sequencing data alone. Nature Methods 10:128–132 (IF = 32)

6. Yang Shen, Yang Lv, Lei Huang, Wensheng Liu, Ming Wen, Tian Tang, Rui Zhang, Eric Hungate, Suhua Shi and Chung-I Wu (2011) Testing hypotheses on the rate of molecular evolution in relation to gene expression using microRNAs. PNAS 108:15942-15947 (IF = 9.2)

5. Wanzhong Ge, Yawen Chen, Ruifen Weng, Singfee Lim, Marita Buescher, Rui Zhang and Stephen M. Cohen (2011) Overlapping functions of microRNAs in control of apoptosis during Drosophila embryogenesis. Cell Death Differ 19:839-846 (IF = 8.2)

4. Xiaodong Fang*, Yanfeng Zhang*, Rui Zhang*, Lixin Yang, Ming Li, Kaixiong Ye, Xiaosen Guo, Jun Wang and Bing Su (2011) Genome sequence and global sequence variation map with 5.5 million SNPs in Chinese rhesus macaque. Genome Biol 12:R63 (IF = 10.8)

3. Rui Zhang, and Bing Su (2008) MicroRNA regulation and the variability of human cortical gene expression. Nucleic Acids Res 36:4621-4628 (IF = 9.1)

2. Rui Zhang, Yinqiu Wang and Bing Su (2008) Molecular evolution of a primate-specific microRNA family. Mol Biol Evol 25:1493-1502 (IF = 9.1)

1. Rui Zhang, Yi Peng, Wen Wang and Bing Su (2007) Rapid evolution of an X-linked microRNA cluster in primates. Genome Res 17:612-617 (IF = 14.6)

*Co-first authors
#Co-corresponding authors