研究方向
個人經歷
2013年取得中山大學理學博士學位;
2013年至2016年,中山大學 博士後;
2022年至今,中山大學生命科學學院 教授
講授課程
RNA生物學、新生研討課、生物科學綜合實驗、細胞生物學實驗、生命科學導論實驗
學術成就
發掘農藝性狀調控基因是現代育種關鍵步驟,而新型基因資源非編碼RNA在作物中的功能還不清楚。圍繞非編碼RNA與作物性狀調控,獲得主要學術成績:(1)在國際上報導了首例正調控水稻產量的microRNA,揭示了非編碼RNA也可作為遺傳資源被用於作物育種;研究成果發表於Nature Biotechnology(IF5:45.1,第一作者,亮點論文,F1000、Nature China等點評收錄)、PNAS(IF5:12.30,第一作者)等刊物,並於2018年申請並獲得廣東省科技獎勵自然科學類一等獎(2/7);(2)闡明作物生殖階段特有相位小RNA作用機制,揭示了相位小RNA是保證水稻雄配子體發育的關鍵因子,維持水稻結實率和產量;研究成果發表於Nature Communications(IF5:15.8,第一作者)、The Plant Cell(IF5:12.1,共同通訊作,封面故事論文)等刊物;(3)率先在水稻中開展長鏈非編碼RNA和染色質結合RNA鑑定,發現調控胚乳發育、體細胞重編程和植株再生的長鏈非編碼RNA;研究成果發表於Genome Biology(IF5:17.4,第一作者,封面故事論文)、Nature Communications(IF5:15.8,共同第一作者,特色論文)、Nucleic Acid Research(IF5:15.5,共同第一作者)等刊物。研究成果發現了一個新層面上的作物性狀調控方式,為作物的遺傳育種套用提供新思路和基因資源。受邀合作為Annual Review of Cell and Development Biology撰寫綜述(IF5:17.4,共同第一作者),編寫書籍;獲國家發明專利4項。
承擔課題
廣東省傑出青年項目;
廣東省特支計畫科技創新青年拔尖人才項目;
廣州市珠江科技新星。
論文專著
第一作者或通訊作者論文:
(1) Zhang YC*; Zhou YF*; Cheng Y*; Huang JH; Lian JP; Yang L; He RR; Lei MQ; Liu YW; Yuan C; Zhao WL; Xiao S; Chen YQ ; Genome-wide analysis and functional annotation of chromatin-enriched noncoding RNAs in rice during somatic cell regeneration, Genome Biology, 2022, 23(1) ( IF5:17.4)
(2) Zhang YC*; Lei MQ*; Zhou YF; Yang YW; Lian JP; Yu Y; Feng YZ; Zhou KR; He RR; He H; Zhang Z; Yang JH; Chen YQ ; Reproductive phasiRNAs regulate reprogramming of gene expression and meiotic progression in rice, Nature Communications, 2020, 11(1) ( IF5:15.8)
(3) Lian JP; Yang YW; He RR; Yang L; Zhou YF; Lei MQ; Zhang Z; Huang JH; Cheng Y; Liu YW; Zhang YC#; Chen YQ# ; Ubiquitin-dependent Argonauteprotein MEL1 degradation is essential for rice sporogenesis and phasiRNA target regulation, The Plant Cell, 2021, 33(8): 2685-2700 ( IF5:12.1)
(4) Zhou YF*; Zhang YC*; Sun YM; Yu Y; Lei MQ; Yang YW; Lian JP; Feng YZ; Zhang Z; Yang L; He RR; Huang JH; Cheng Y; Liu YW; Chen YQ ; The parent-of-origin lncRNA MISSEN regulates rice endosperm development, Nature Communications, 2021, 12(1) ( IF5:15.8)
(5) Zhang YC; He RR; Lian JP; Zhou YF; Zhang F; Li QF; Yu Y; Feng YZ; Yang YW; Lei MQ; He H; Zhang Z; Chen YQ*; OsmiR528 regulates rice-pollen intine formation by targeting an uclacyanin to influence flavonoid metabolism, Proceedings of the National Academy of Sciences of the United States of America, 2019,117(1): 727-732. ( IF5:10.6)
(6) Zhang F#; Zhang YC#*; Liao JY; Yu Y; Zhou YF; Feng YZ; Yang YW; Lei MQ; Bai M; Wu H; Chen YQ*; The subunit of RNA N6-methyladenosine methyltransferase OsFIP regulates early degeneration of microspores in rice , PLoS Genetics, 201 9, 15(5): 0-e1008120. ( IF5:6.3)
(7) Liao JY#*; Yang B#; Zhang YC#; Wang XJ; Ye YS; Peng JW; Yang ZZ; He JH; Zhang Y; Hu KS; Lin DC*; Yin D*; EuRBPDB: a comprehensive resource for annotation, functional and oncological investigation of eukaryotic RNA binding proteins (RBPs). , Nucleic Acids Research, 2019, 48(D1): D307-D313. ( IF5:15.5)
(8) Yu Y#; Zhang YC#; Chen XM*; Chen YQ*; Plant Noncoding RNAs: Hidden Players in Development and Stress Responses, Annual Review of Cell and Developmental Biology, 2019, 35: 407-431. ( IF5:17.4)
(9) Zhang F#; Zhang YC#; Zhang JP; Yu Y; Zhou YF; Feng YZ; Yang YW; Lei MQ; He H; Lian JP; Chen YQ*; Rice UCL8, a plantacyanin gene targeted by miR408, regulates fertility by controlling pollen tube germination and growth, Rice, 2018, 11(60): 10.1186/s12284-018. ( IF5:4.6)
(10) Zhang JP#; Yu Y#; Feng YZ; Zhou YF; Zhang F; Yang YW; Lei MQ; Zhang YC*; Chen YQ*; MiR408 Regulates Grain Yield and Photosynthesis via a Phytocyanin Protein , Plant Physiology, 2017, 175(3): 1175-1185. ( IF5:7)
(11) Yu Y; Li QF; Zhang JP; Zhang F; Zhou YF; Feng YZ; Chen YQ; Zhang YC*; Laccase-13 Regulates Seed Setting Rate by Affecting Hydrogen Peroxide Dynamics and Mitochondrial Integrity in Rice , Frontiers in Plant Science, 2017, 8:0-1324. ( IF5:4.9)
(12) Zhang YC; Chen YQ*; Epigenetic Regulation by Noncoding RNAs in Plant Development, Springer, 2017.
(13) Zhang YC#; Liao JY#; Li ZY; Yu Y; Zhang JP; Li QF; Qu LH; Shu WS; Chen YQ*; Genome-wide screening and functional analysis identify a large number of long noncoding RNAs involved in the sexual reproduction of rice., Genome Biology, 2014, 15(12). ( IF5:17.4)
(14) Zhang YC; Yu Y; Wang CY; Li ZY; Liu Q; Xu J; Liao JY; Wang XJ; Qu LH; Chen F; Xin PY; Yan CY; Chu JF; Li HQ; Chen YQ*; Overexpression of microRNA OsmiR397 improves rice yield by increasing grain size and promoting panicle branching , Nature Biotechnology, 2013, 31(9): 848-852. ( IF5:50.5)
(15) Zhang YC; Chen YQ*; Long noncoding RNAs: New regulators in plant development , Biochemical and Biophysical Research Communications, 2013, 436(2): 111-114. ( IF5:2.6)