張澤，男，博士，重慶大學生命科學學院副院長，二級教授，博士生導師。
基本介紹
- 中文名：張澤
- 畢業院校：西南農業大學
- 學位/學歷：博士
- 專業方向：進化與功能基因組學
- 職務：重慶大學生命科學學院副院長
人物經歷,研究方向,主講課程,發表論文,
人物經歷
西南農業大學（現西南大學）農學學士學位（1983）、碩士學位（1986）和博士學位（1996）。
1998.10-2000.9日本九州大學生物系遺傳學研究室博士後
2002.02-2004.1日本東京大學農學部生物統計學與生物信息學實驗室JST研究員
2004.02-2006.1英國伯明罕大學生物科學學院研究職員。
2006年全職回國服務，2008年國務院特殊津貼獲得者。
1986年7月-2006年1月西南農業大學農學系講師、副教授、教授
2006年2月-2007年12月西南大學蠶學與系統生物學研究所二級教授、博導；
2008.1至今重慶大學生命科學學院副院長，二級教授，博士生導師。
1998.10-2000.9日本九州大學生物系遺傳學研究室博士後
2002.02-2004.1日本東京大學農學部生物統計學與生物信息學實驗室JST研究員
2004.02-2006.1英國伯明罕大學生物科學學院研究職員。
2006年全職回國服務，2008年國務院特殊津貼獲得者。
1986年7月-2006年1月西南農業大學農學系講師、副教授、教授
2006年2月-2007年12月西南大學蠶學與系統生物學研究所二級教授、博導；
2008.1至今重慶大學生命科學學院副院長，二級教授，博士生導師。
研究方向
進化與功能基因組學
實驗室主要以家蠶為模式研究馴化遺傳學和進化及功能基因組學問題。研究方向：（1）動物馴化性狀差異的分子解析；（2）家蠶脫皮激素代謝途徑調控機制研究；（3）家蠶轉座子的鑑定、功能和比較基因組學研究。目前承擔國家自然科學基金等多項課題。主要成果發表在Science, Mol. Biol. Evol., Genetics, BMC Genomics，BMC Evol. Biol.等國際著名雜誌。歡迎對生命科學基礎研究有濃厚興趣的同學報考本實驗室的研究生。
主講課程
本科生：《生物統計學》，研究生：《分子進化》、《遺傳學研究前沿》
發表論文
1. Wang CF, Zhang Z*, Sun W*. (2018) Ecdysone oxidase and 3-dehydroecdysone-3β-reductase contribute to the synthesis of ecdysone during early embryonic development of the silkworm. Int J Biol Sci 14(11):1472-1482.
2. Qiu CZ, Zhou QZ, Liu TT, Fang SM, Wang YW, Fang X, Huang CL, Yu QY*, Chen CH, Zhang Z. (2018) Evidence of peripheral olfactory impairment in the domestic silkworms: insight from the comparative transcriptome and population genetics. BMC Genomics, 19(1):788.
3. Fu P, Sun W, Lai J, Shen YH, Zhang Z*. (2018) Identification of two isoforms of Pop in the domestic silkworm, Bombyx mori: Cloning, characterization and expression analysis. Gene, 667:101-111.
4. Zhou QZ, Fang SM, Zhang Q, Yu QY, Zhang Z* (2018). Identification and comparison of long non-coding RNAs in the silk gland between domestic and wild silkworms. Insect Sci. doi: 10.1111/1744-7917.12443
5. Zhang Q, Sun W, Sun BY, Xiao Y, Zhang Z* (2017). The dynamic landscape of gene regulation during Bombyx mori oogenesis. BMC Genomics 18: 714
6. Sun W*, Wang CF, Zhang Z (2017).Transcription factor E74A affects the ecdysone titer by regulating the expression of the EO gene in the silkworm, Bombyx mori. BBA-General Subjects 1861:551–558
7. Han MJ#, Zhou QZ#, Zhang HH, Tong X, Lu C, Zhang Z, Dai F* (2016). iMITEdb: the genome-wide landscape of miniature inverted-repeat transposable elements in insects. Database (Oxford) 2016: baw148
8. Yu QY*, Fang SM, Zhang Z, Jiggins CD* (2016). The transcriptome response of Heliconius melpomene larvae to a novel host plant. Mol Ecol 25(19): 4850-4865
9. Zhou QZ, Zhang B, Yu QY, Zhang Z* (2016). BmncRNAdb: a comprehensive database of non-coding RNAs in the silkworm, Bombyx mori. BMC Bioinformatics 17(1): 370
10. Sun W, Shen YH, Zhou LX, Zhang Z* (2016). Ecdysone titer determined by 3DE-3β-reductase enhances the immune response in the silkworm. J Immunol 196(4): 1646-1654
11. Fu P, Sun W, Zhang Z* (2016). Molecular cloning, expression and characterization of acylpeptide hydrolase in the silkworm, Bombyx mori. Gene 580(1): 8-16
12. Sun W, Zhao XW, Zhang Z* (2015). Identification and evolution of the orphan genes in the domestic silkworm, Bombyx mori. FEBS Letters 589: 2731-2738
13. Han MJ, Xiong CL, Zhang HB, Zhang MQ, Zhang HH, Zhang Z* (2015). The diversification of PHIS transposon superfamily in eukaryotes. Mob DNA 6: 12
14. Fang SM#, Hu BL#, Zhou QZ, Yu QY*, Zhang Z (2015). Comparative analysis of the silk gland transcriptomes between the domestic and wild silkworms. BMC Genomics 16: 60
15. Tang Z, Zhang HH, Huang K, Zhang XG, Han MJ, Zhang Z* (2015). Repeated horizontal transfers of four DNA transposons in invertebrates and bats. Mob DNA 6(1): 3
16. Sun W, Shen YH, Han MJ, Cao YF, Zhang Z* (2014). An adaptive transposable element insertion in the regulatory region of the EO gene in the domesticated silkworm, Bombyx mori. Mol Biol Evol 31: 3302-3313
17. Yang SY#, Han MJ#, Kang LF, Li ZW, Shen YH*, Zhang Z (2014). Demographic history and gene flow during silkworm domestication. BMC Evol Biol 14:185
18. Han MJ, Xu HE, Zhang HH, Feschotte C & Zhang Z* (2014). Spy: A new group of eukaryotic DNA transposons without target site duplications. Genome Biol Evol 6(7):1748-57
19. Zhang HH, Feschotte C, Han MJ & Zhang Z* (2014). Recurrent horizontal transfers of Chapaev transposons in diverse invertebrate and vertebrate animals. Genome Biol Evol 6(6): 1375-1386
20. Zhao Q, Han MJ, Sun W & Zhang Z* (2014). Copy number variations among silkworms. BMC Genomics 15: 251
21. Zhang HH, Xu HE, Shen YH, Han MJ & Zhang Z* (2013). The origin and evolution of six miniature inverted-repeat transposable elements (MITEs) in Bombyx mori and Rhodnius prolixus. Genome Biol Evol 5(11): 2020-2031
22. Zhang HH, Shen YH, Xu HE, Liang HY, Han MJ & Zhang Z* (2013). A novel hAT element in Bombyx mori and Rhodnius prolixus: its relationship with miniature inverted repeat transposable elements (MITEs) and horizontal transfer. Insect Mol Biol 22(5): 584-596
23. Han MJ, Shen YH, Xu MS, Liang HY, Zhang HH & Zhang Z* (2013). Identification and evolution of the silkworm Helitrons and their contribution to transcripts. DNA Res 20: 471-484
24. Xu HE, Zhang HH, Xia T, Han MJ, Shen YH & Zhang Z* (2013). BmTEdb: a collective database of transposable elements in the silkworm genome. Database (Oxford) 2013: bat055
25. Zhao Q, Zhu Z, Kasahara M, Morishita S & Zhang Z* (2013). Segmental duplications in the silkworm genome. BMC Genomics 14: 521
26. Hu YG, Shen YH *, Zhang Z & Shi GQ (2013). Melanin and urate act to prevent ultraviolet damage in the integument of the silkworm, Bombyx mori. Arch Insect Biochem Physiol 83(1): 41-55
27. Sun W, Shen YH, Yang WJ, Cao YF, Xiang ZH & Zhang Z* (2012). Expansion of the silkworm GMC oxidoreductase genes is associated with immunity. Insect Biochem Mol Biol 42: 935-945
28. Shi GQ, Yu QY, Shi L & Zhang Z* (2012). Molecular cloning and characterization of peroxiredoxin 4 involved in protection against oxidative stress in the silkworm Bombyx mori. Insect Mol Biol 21: 581-92
29. Zhang YE, Ma HJ, Feng DD, Lai XF, Chen ZM, Xu MY, Yu QY & Zhang Z* (2012). Induction of detoxification enzymes by quercetin in the silkworm. J Econ Entomol 105(3): 1034-42
30. Kang L, Zhu Z*, Zhao Q, Chen L* & Zhang Z (2012). Newly evolved introns in human retrogenes provide novel insights into their evolutionary roles. BMC Evol Biol 12(1): 128
31. Sun W, Yu HS, Shen YH, Banno Y, Xiang ZH & Zhang Z* (2012). Phylogeny and evolutionary history of the silkworm. Sci China Life Sci. 55(6): 483-96
32. Shi GQ, Yu QY & Zhang Z* (2012). Annotation and evolution of the antioxidant genes in the silkworm, Bombyx mori. Arch Insect Biochem Physiol 79(2): 87-103
33. Sun W, Shen YH, Qi DW, Xiang ZH & Zhang Z* (2012). Molecular cloning and characterization of ecdysone oxidase and 3-dehydroecdysone-3α-reductase involved in the ecdysone inactivation pathway of silkworm, Bombyx mori. Int J Biol Sci 8: 125-138
34. Li ZW, Shen YH, Xiang ZH & Zhang Z* (2011). Pathogen-origin horizontally transferred genes contribute to the evolution of Lepidopteran insects. BMC Evol Biol 11: 356
35. Guo Y, Shen YH, Sun W, Kishino H, Xiang ZH & Zhang Z* (2011). Nucleotide diversity and selection signature in the domesticated silkworm, Bombyx mori, and wild silkworm, Bombyx mandarina. J Insect Sci 11:155
36. Yu QY, Fang SM, Zuo WD, Dai FY, Zhang Z & Lu C* (2011). Effect of organophosphate phoxim exposure on certain oxidative stress biomarkers in the silkworm. J Econ Entomol 104(1): 101-106
37. Yu HS, Shen YH, Yuan GX, Hu YG, Xu HE, Xiang ZH & Zhang Z* (2011). Evidence of selection at melanin synthesis pathway loci during silkworm domestication. Mol Biol Evol 28: 1785-1799
38. Han MJ, Shen YH, Gao YH, Chen LY*, Xiang ZH & Zhang Z* (2010). Burst expansion, distribution and diversification of MITEs in the silkworm genome. BMC Genomics 11: 520
39. Xia Q#, Guo Y#, Zhang Z#, Li D#, Xuan Z#, Li Z#, Dai F, Li Y, Cheng D, Li R, Cheng T, Jiang T, Becquet C, Xu X, Liu C, Zha X, Fan W, Lin Y, Shen YH, Jiang L, Jensen J, Hellmann I, Tang S, Zhao P, Xu H, Yu C, Zhang G, Li J, Cao J, Liu S, He N, Zhou Y, Liu H, Zhao J, Ye C, Du Z, Pan G, Zhao A, Shao H, Zeng W, Wu P, Li C, Pan M, Li J, Yin X, Li D, Wang J, Zheng H, Wang W, Zhang X, Li S, Yang H, Lu C, Nielsen R, Zhou Z, Wang J, Xiang ZH* & Wang J* (2009). Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science 326: 433-436 (#: Co-first authors)
40. Li ZW, Li X, Yu QY, Xiang ZH, Kishino H & Zhang Z* (2009). The small heat shock protein (sHSP) genes in the silkworm, Bombyx mori, and comparative analysis with other insect sHSP genes. BMC Evol Biol 9: 215
2. Qiu CZ, Zhou QZ, Liu TT, Fang SM, Wang YW, Fang X, Huang CL, Yu QY*, Chen CH, Zhang Z. (2018) Evidence of peripheral olfactory impairment in the domestic silkworms: insight from the comparative transcriptome and population genetics. BMC Genomics, 19(1):788.
3. Fu P, Sun W, Lai J, Shen YH, Zhang Z*. (2018) Identification of two isoforms of Pop in the domestic silkworm, Bombyx mori: Cloning, characterization and expression analysis. Gene, 667:101-111.
4. Zhou QZ, Fang SM, Zhang Q, Yu QY, Zhang Z* (2018). Identification and comparison of long non-coding RNAs in the silk gland between domestic and wild silkworms. Insect Sci. doi: 10.1111/1744-7917.12443
5. Zhang Q, Sun W, Sun BY, Xiao Y, Zhang Z* (2017). The dynamic landscape of gene regulation during Bombyx mori oogenesis. BMC Genomics 18: 714
6. Sun W*, Wang CF, Zhang Z (2017).Transcription factor E74A affects the ecdysone titer by regulating the expression of the EO gene in the silkworm, Bombyx mori. BBA-General Subjects 1861:551–558
7. Han MJ#, Zhou QZ#, Zhang HH, Tong X, Lu C, Zhang Z, Dai F* (2016). iMITEdb: the genome-wide landscape of miniature inverted-repeat transposable elements in insects. Database (Oxford) 2016: baw148
8. Yu QY*, Fang SM, Zhang Z, Jiggins CD* (2016). The transcriptome response of Heliconius melpomene larvae to a novel host plant. Mol Ecol 25(19): 4850-4865
9. Zhou QZ, Zhang B, Yu QY, Zhang Z* (2016). BmncRNAdb: a comprehensive database of non-coding RNAs in the silkworm, Bombyx mori. BMC Bioinformatics 17(1): 370
10. Sun W, Shen YH, Zhou LX, Zhang Z* (2016). Ecdysone titer determined by 3DE-3β-reductase enhances the immune response in the silkworm. J Immunol 196(4): 1646-1654
11. Fu P, Sun W, Zhang Z* (2016). Molecular cloning, expression and characterization of acylpeptide hydrolase in the silkworm, Bombyx mori. Gene 580(1): 8-16
12. Sun W, Zhao XW, Zhang Z* (2015). Identification and evolution of the orphan genes in the domestic silkworm, Bombyx mori. FEBS Letters 589: 2731-2738
13. Han MJ, Xiong CL, Zhang HB, Zhang MQ, Zhang HH, Zhang Z* (2015). The diversification of PHIS transposon superfamily in eukaryotes. Mob DNA 6: 12
14. Fang SM#, Hu BL#, Zhou QZ, Yu QY*, Zhang Z (2015). Comparative analysis of the silk gland transcriptomes between the domestic and wild silkworms. BMC Genomics 16: 60
15. Tang Z, Zhang HH, Huang K, Zhang XG, Han MJ, Zhang Z* (2015). Repeated horizontal transfers of four DNA transposons in invertebrates and bats. Mob DNA 6(1): 3
16. Sun W, Shen YH, Han MJ, Cao YF, Zhang Z* (2014). An adaptive transposable element insertion in the regulatory region of the EO gene in the domesticated silkworm, Bombyx mori. Mol Biol Evol 31: 3302-3313
17. Yang SY#, Han MJ#, Kang LF, Li ZW, Shen YH*, Zhang Z (2014). Demographic history and gene flow during silkworm domestication. BMC Evol Biol 14:185
18. Han MJ, Xu HE, Zhang HH, Feschotte C & Zhang Z* (2014). Spy: A new group of eukaryotic DNA transposons without target site duplications. Genome Biol Evol 6(7):1748-57
19. Zhang HH, Feschotte C, Han MJ & Zhang Z* (2014). Recurrent horizontal transfers of Chapaev transposons in diverse invertebrate and vertebrate animals. Genome Biol Evol 6(6): 1375-1386
20. Zhao Q, Han MJ, Sun W & Zhang Z* (2014). Copy number variations among silkworms. BMC Genomics 15: 251
21. Zhang HH, Xu HE, Shen YH, Han MJ & Zhang Z* (2013). The origin and evolution of six miniature inverted-repeat transposable elements (MITEs) in Bombyx mori and Rhodnius prolixus. Genome Biol Evol 5(11): 2020-2031
22. Zhang HH, Shen YH, Xu HE, Liang HY, Han MJ & Zhang Z* (2013). A novel hAT element in Bombyx mori and Rhodnius prolixus: its relationship with miniature inverted repeat transposable elements (MITEs) and horizontal transfer. Insect Mol Biol 22(5): 584-596
23. Han MJ, Shen YH, Xu MS, Liang HY, Zhang HH & Zhang Z* (2013). Identification and evolution of the silkworm Helitrons and their contribution to transcripts. DNA Res 20: 471-484
24. Xu HE, Zhang HH, Xia T, Han MJ, Shen YH & Zhang Z* (2013). BmTEdb: a collective database of transposable elements in the silkworm genome. Database (Oxford) 2013: bat055
25. Zhao Q, Zhu Z, Kasahara M, Morishita S & Zhang Z* (2013). Segmental duplications in the silkworm genome. BMC Genomics 14: 521
26. Hu YG, Shen YH *, Zhang Z & Shi GQ (2013). Melanin and urate act to prevent ultraviolet damage in the integument of the silkworm, Bombyx mori. Arch Insect Biochem Physiol 83(1): 41-55
27. Sun W, Shen YH, Yang WJ, Cao YF, Xiang ZH & Zhang Z* (2012). Expansion of the silkworm GMC oxidoreductase genes is associated with immunity. Insect Biochem Mol Biol 42: 935-945
28. Shi GQ, Yu QY, Shi L & Zhang Z* (2012). Molecular cloning and characterization of peroxiredoxin 4 involved in protection against oxidative stress in the silkworm Bombyx mori. Insect Mol Biol 21: 581-92
29. Zhang YE, Ma HJ, Feng DD, Lai XF, Chen ZM, Xu MY, Yu QY & Zhang Z* (2012). Induction of detoxification enzymes by quercetin in the silkworm. J Econ Entomol 105(3): 1034-42
30. Kang L, Zhu Z*, Zhao Q, Chen L* & Zhang Z (2012). Newly evolved introns in human retrogenes provide novel insights into their evolutionary roles. BMC Evol Biol 12(1): 128
31. Sun W, Yu HS, Shen YH, Banno Y, Xiang ZH & Zhang Z* (2012). Phylogeny and evolutionary history of the silkworm. Sci China Life Sci. 55(6): 483-96
32. Shi GQ, Yu QY & Zhang Z* (2012). Annotation and evolution of the antioxidant genes in the silkworm, Bombyx mori. Arch Insect Biochem Physiol 79(2): 87-103
33. Sun W, Shen YH, Qi DW, Xiang ZH & Zhang Z* (2012). Molecular cloning and characterization of ecdysone oxidase and 3-dehydroecdysone-3α-reductase involved in the ecdysone inactivation pathway of silkworm, Bombyx mori. Int J Biol Sci 8: 125-138
34. Li ZW, Shen YH, Xiang ZH & Zhang Z* (2011). Pathogen-origin horizontally transferred genes contribute to the evolution of Lepidopteran insects. BMC Evol Biol 11: 356
35. Guo Y, Shen YH, Sun W, Kishino H, Xiang ZH & Zhang Z* (2011). Nucleotide diversity and selection signature in the domesticated silkworm, Bombyx mori, and wild silkworm, Bombyx mandarina. J Insect Sci 11:155
36. Yu QY, Fang SM, Zuo WD, Dai FY, Zhang Z & Lu C* (2011). Effect of organophosphate phoxim exposure on certain oxidative stress biomarkers in the silkworm. J Econ Entomol 104(1): 101-106
37. Yu HS, Shen YH, Yuan GX, Hu YG, Xu HE, Xiang ZH & Zhang Z* (2011). Evidence of selection at melanin synthesis pathway loci during silkworm domestication. Mol Biol Evol 28: 1785-1799
38. Han MJ, Shen YH, Gao YH, Chen LY*, Xiang ZH & Zhang Z* (2010). Burst expansion, distribution and diversification of MITEs in the silkworm genome. BMC Genomics 11: 520
39. Xia Q#, Guo Y#, Zhang Z#, Li D#, Xuan Z#, Li Z#, Dai F, Li Y, Cheng D, Li R, Cheng T, Jiang T, Becquet C, Xu X, Liu C, Zha X, Fan W, Lin Y, Shen YH, Jiang L, Jensen J, Hellmann I, Tang S, Zhao P, Xu H, Yu C, Zhang G, Li J, Cao J, Liu S, He N, Zhou Y, Liu H, Zhao J, Ye C, Du Z, Pan G, Zhao A, Shao H, Zeng W, Wu P, Li C, Pan M, Li J, Yin X, Li D, Wang J, Zheng H, Wang W, Zhang X, Li S, Yang H, Lu C, Nielsen R, Zhou Z, Wang J, Xiang ZH* & Wang J* (2009). Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science 326: 433-436 (#: Co-first authors)
40. Li ZW, Li X, Yu QY, Xiang ZH, Kishino H & Zhang Z* (2009). The small heat shock protein (sHSP) genes in the silkworm, Bombyx mori, and comparative analysis with other insect sHSP genes. BMC Evol Biol 9: 215
