張洪鈞，健康科學研究所百人計畫/研究員。
簡歷： |
學習經歷2002-2007：德國慕尼黑大學/馬普學會生物化學研究所 生物化學博士 1994-1997：台灣東吳大學 碩士 1990-1994：台灣東吳大學 學士 工作簡歷 2013-至今：中科院上海生命科學院/上海交通大學醫學院健康科學研究所 研究員 2007-2013：美國麻省理工學院生物系 博士後 1999-2002：台灣中央研究院 研究助理 |
研究方向： |
1)探討抗衰老蛋白Sirtuins的抗腫瘤活性及機制 2)研發以Sirtuin家族蛋白為靶點的糖尿病治療新方法 3)探討生物時鐘與Sirtuins共同調節代謝的機制 |
職稱： |
研究員 |
獲獎及榮譽： |
代表論著： |
Chang, H-C., and Guarente, L.P. SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging.Cell. (in press) Calloni,G., Chen, T., Schermann, S. M.,Chang, H-C., Genevaux, P., Agostini, F., Gian Gaetano Tartaglia, G.G., Hayer-Hartl, M., and Hartl, F.U. (2012). DnaK Functions as a Central Hub in the E. coli Chaperone Network.Cell Reports. 2012, 1: 251–264. Gupta, R., Lakshmipathy, S.K.,Chang, H-C., Etchells, S.A., and Hartl, F.U. Trigger factor lacking the PPIase domain can enhance the folding of eukaryotic multi-domain proteins in Escherichia coli.FEBS Lett. 2010, 584(16):3620-3624. Tang, Y-C*.,Chang, H-C*., Chakraborty, K., Hartl, F.U., and Hayer-Hartl, M. Essential role of the chaperonin folding compartment in vivo.EMBO J. 2008, 27(10):1458-1468. *: Equal contribution Chang, H-C., Tang, Y-C., Hayer-Hartl, M., and Hartl, F. U. SnapShot: Molecular Chaperones, Part I.Cell. 2007, 128(1):212. Tang, Y-C.,Chang, H-C., Hayer-Hartl, M., and Hartl, F. U. SnapShot: Molecular Chaperones, Part II.Cell. 2007, 128(2):412. Lakshmipathy, S.K., Tomic, S., Kaiser, C.M.,Chang, H-C., Genevaux, P., Georgopoulos, C., Barral, J.M., Johnson, A.E., Hartl, F.U., and Etchells, S.A. Identification of nascent chain interaction sites on trigger factor.J. Biol. Chem.2007, 282(16):12186-12193. Kaiser, C. M.,Chang, H-C., Agashe, V. R., Lakshmipathy, S. K., Etchells, S. A., Hayer-Hartl, M., Hartl, F. U., and Barral, M. Real-time observation of trigger factor function on translating ribosomes.Nature. 2006, 444(7118):455-460. Tang, Y-C.,Chang, H-C., Roeben, A., Wischnewski, D., Wischnewski, N., Kerner, M. J., Hartl, F. U., and Hayer-Hartl, M. Structural features of the GroEL-GroES nano-cage required for rapid folding of encapsulated protein.Cell. 2006, 125(5):903-914. Chang, H-C., Kaiser, C. M., Hartl, F. U., and Barral, J. M. De novo folding of GFP fusion proteins: high efficiency in eukaryotes but not in bacteria.J. Mol. Biol.2005, 353(2):397-409. Kerner, M. J*., Naylor, D. J*., Ishihama, Y*., Maier, T*.,Chang, H-C., Stines, A. P., Georgopoulos, C., Frishman, D., Hayer-Hartl, M., Mann, M., and Hartl, F. U. Proteome-wide analysis of chaperonin-dependent protein folding in Escherichia coli.Cell. 2005, 122(2):209-220. *: Equal contribution Shomura, Y., Dragovic, Z.,Chang, H-C., Tzvetkov, N., Young, J. C., Brodsky, J. L., Guerriero, V., Hartl, F. U., and Bracher, A. Regulation of Hsp70 function by HspBP1: structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange.Mol Cell. 2005, 17(3):367-379. Agashe, V. R*., Guha, S*.,Chang, H-C*., Genevaux, P., Hayer-Hartl, M., Stemp, M., Georgopoulos, C., Hartl, F. U., and Barral, J. M. Function of trigger factor and DnaK in multidomain protein folding: increase in yield at the expense of folding speed.Cell. 2004, 117(2):199-209. *: Equal contribution |
