張欣(安徽農業大學生命科學學院講席教授)

張欣，女，博士，教授，安徽農業大學生命科學學院講席教授、博士生導師。

基本介紹

• 中文名：張欣
• 畢業時間：1993年
• 畢業地點：吉林大學
• 職稱：講席教授、博士生導師

人物經歷

1993年畢業於吉林大學，2000年獲中國科學院長春套用化學研究所碩士學位，2002年赴法國留學，在斯特拉斯堡第一大學（路易·巴斯德大學，Université Louis Pasteur, Strasbourg, France）藥學院攻讀博士學位，2005年獲法國國家博士學位；2006年6月至2008年9月在美國紐約阿爾伯特·愛因斯坦醫學院（Albert Einstein College of Medicine, NY, USA）分子藥理系擔任研究助理。2008年底回國，2009年6月起被聘為安徽農業大學生命科學學院講席教授。

研究方向

主要研究方向為一直從事環境因子對天然產物成分的影響及神經肽的質譜學分析等方面的研究，在有機化學、分析化學、天然產物的分離與分析等基礎研究領域具有專長，科研能力強。

主要貢獻

發表SCI論文20篇，多項研究成果具有重要的科學價值和套用前景，達到本領域國際先進水平。申請二項中國專利並均已進入公開初審階段。

科研領域

1. 功能小分子結構及其生理活性的研究：分離製備天然有機功能小分子及其衍生物，研究其化學結構，並運用一系列體內體外模式生物分析相關生理活性，探討其作用機理。
2.多肽組學研究：開展與植物生理、病理等性狀相關的具有生物活性的多肽組學研究。

科研項目

國家自然科學基金項目（21072002）：植物甾醇單體氧化物的製備及其細胞毒性的研究（主持）
教育部留學回國人員科研啟動基金（教外司留(2011)1568號）：Δ7-植物甾醇氧化物的合成及生物效應研究（主持）

論文論著

1. Junlan Gao, Qiulin Yue, Yishun Ji, Beijiu Cheng, Xin Zhang*, Novel synthesis strategy for preparation of individual phytosterol oxides, Journal of Agricutural and Food Chemistry, 2013, 61, 982-988.

2. Dongqing Cai, Longhai Wang, Xin Zhang*, Zhengyan Wu*, Controlling pesticide loss by natural porous micro/nano composites: straw ash-based biochar and biosilica, ACS Applied Materials & Interfaces, in press.

3. Qiulin Yue, Xiuhong Zhou, Qianli Leng, Lele Zhang, Beijiu Cheng, Xin Zhang*, 7-Ketocholesterol-induced caspase-mediated apoptosis in Saccharomyces cerevisiae, FEMS Yeast Research, accepted.

4. Xin Zhang, Hui Pan, Bonnie Peng, Donald F. Steiner, John E. Pintar, Lloyd D. Fricker, Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neuropeptide biosynthesis, Journal of Neurochemistry, 2010, 112, 1168-1179.

5. Jonathan H. Wardman, Xin Zhang, Sandra Gagnon, Leandro M. Castro, Xiaorong Zhu, Donald F. Steiner, Robert Day, Lloyd D. Fricker, Analysis of peptides in prohormone convertase 1/3 null mouse brain using quantitative peptidomics, Journal of Neurochemistry, 2010, 114, 215-225.

6. Sebastian Tanco, Xin Zhang, Cain Morano, Francesc X. Avilés, Julia Lorenzo, Lloyd D. Fricker, Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing, Journal of Biological Chemistry, 2010, 285, 18385-18396.

7. Denise A. Berti, Cain Morano, Lilian C. Russo, Leandro M. Castro, Fernanda M. Cunha, Xin Zhang, Juan Sironi, Clécio F. Klitzke, Emer S. Ferro, Lloyd D. Fricker, Analysis of intracellular substrates and products of thimet oligopeptidase (EC 3.4.24.15) in human embryonic kidney 293 cells, Journal of Biological Chemistry, 2009, 284, 14105-14116.

8. Xin Zhang, Fan-Yun Che, Iryna Berezniuk, Kemal Sonmez, Lawrence Toll, Lloyd D. Fricker, Peptidomics of Cpefat/fat mouse brain regions: Implications for neuropeptide processing, Journal of Neurochemistry, 2008, 107, 1596-1613.

9. Cain Morano, Xin Zhang (co-first author), Lloyd D. Fricker, Multiple isotopic labels for quantitative mass spectrometry, Analytical Chemistry, 2008, 80, 9298–9309.

10. Fa-yun Che, Xin Zhang, Iryna Berezniuk, Myrasol Callaway, Jihyeon Lim, Lloyd D. Fricker, Optimization of neuropeptide extraction from the mouse hypothalamus, Journal of Proteome Research, 2007, 6, 4667-4676.

11. Stamatiki Roussi, Francine Gossé, Dalal Aoudé-Werner, Xin Zhang, Eric Marchioni, Philippe Geoffroy, Michel Miesch, Francis Raul, Mitochondrial perturbation, oxidative stress and lysosomal destabilization are involved in 7β-hydroxysitosterol and 7β-hydroxycholesterol triggered apoptosis in human colon cancer cells, Apoptosis, 2007, 12, 87-96.

12. Xin Zhang, Diane Julien-David, Michel Miesch, Francis Raul, Philippe Geoffroy, Dalal Aoudé-Werner, Saïd Ennahar, Eric Marchioni, Quantitative analysis of β-sitosterol oxides in vegetable oils induced by natural sunlight, artificially generated ultraviolet light and irradiation, Journal of Agricutural and Food Chemistry, 2006, 54, 5410-5415.

13. Xin Zhang, Amandine Cambrai, Michel Miesch, Stamatiki Roussi, Francis Raul, Dalal Aoudé-Werner, Eric Marchioni, Separation of 5- and 7-phytosterols by adsorption chromatography and semi-preparative RP-HPLC for quantitative analysis of phytosterols in foods, Journal of Agricutural and Food Chemistry, 2006, 54, 1196-1202.

14. Stamatiki Roussi, Francine Gossé, Dalal Aoudé-Werner, Xin Zhang, Philippe Geoffroy, Michel Miesch, Eric Marchioni, Francis Raul, Perturbation of polyamine metabolism and its relation to cell death in human colon cancer cells treated by 7β-hydroxycholesterol and 7β-hydroxysitosterol, International Journal of Oncology, 2006, 29, 1549-1554.

15. Xin Zhang, Diane Julien-David, Michel Miesch, Philippe Geoffroy, Francis Raul, Stamatiki Roussi, Dalal Aoudé-Werner, Eric Marchioni, Identification and quantitative analysis of β-sitosterol oxides in vegetable oils by capillary gas chromatography-mass spectrometry, Steroids, 2005, 70, 896-906.

16. Xin Zhang, Philippe Geoffroy, Michel Miesch, Diane Julien-David, Francis Raul, Dalal Aoudé-Werner, Eric Marchioni, Gram-scale chromatographic purification of β-sitosterol: Synthesis and characterization of β-sitosterol oxides, Steroids, 2005, 70, 886-895.

17. Stamatiki Roussi, Annelise Winter, Francine Gossé, Dalal Aoudé-Werner, Xin Zhang, Eric Marchioni, Philippe Geoffroy, Michel Miesch, Francis Raul, Different apoptotic mechanisms are involved in the antiproliferative effects of 7β-hydroxysitosterol and 7β-hydroxycholesterol in human colon cancer cells, Cell Death & Differentiation, 2005, 12, 128-135