張士磊

張士磊，男，蘇州大學藥學院教授，已發表SCI論文30多篇，著作章節1篇，專利2項。

基本介紹

• 中文名：張士磊
• 畢業院校：中國海洋大學
• 職業：教師
• 性別：男
• 職稱：蘇州大學教授

人物經歷

1998.9-2002.7：中國海洋大學化學化工學院海洋化學專業，大學本科

2002.9-2007.7：中國科學院上海藥物研究所，藥物化學，博士學位

2007.7-2008.8：華東理工大學藥學院藥物化學系，講師

2008.10-2012.1：美國新墨西哥大學(University of New Mexico)，有機化學，博士後

2012.2-：蘇州大學醫學部藥學院，教授

研究方向

（1）抗癌藥物和抗菌藥物研究

（2）發展高效的催化方法構建藥物優勢結構

主要貢獻

(1) Xie, H.; Zhang, S.;* Li, H.; Zhang, X.; Zhao, S.; Xu, Z.; Song, X.; Yu, X.;* Wang, W.*“Total Synthesis of Polyene Natural Product Dihydroxerulin by Mild Organocatalyzed Dehydrogenation of Alcohols” Chem. Eur. J. 2012, 18, 2230-2234.

(2) Zhang, S.-L.; Xie, H.-X.; Zhu, J.; Li, H.; Zhang, X.-S.; Li, J.;* Wang, W.* “Organocatalytic enantioselective β-functionalization of aldehydes via oxidation of enamines and their application in cascade reactions” Nature Communications. 2011, 2, 211.

(3) Zhang, S.-L.; Xie, H.-X.; Song, A.-G.; Wu, D.-Y.; Zhu, J.; Zhao, S.-H.; Li, J.; Yu, X.-H.;* Wang, W.* “Efficient preparation of trans α-,β-unsaturated aldehydes from saturated aldehydes by oxidative enamine catalysis” Sci. China. Chem. 2011, 54, 1932-1936.

(4) Xie, H.; Zhang Y.; Zhang, S.; Chen, X.; Wang, W.* “Bifunctional Cinchona Alkaloid Thiourea Catalyzed Highly Efficient, Enantioselective Aza-Henry Reaction of Cyclic Trifluoromethyl Ketimines: Synthesis of Anti-HIV Drug DPC 083” Angew. Chem. Int. Ed. 2011, 50, 11773-11776.

(5) Liu, G.; Zhang, S.; Li, H.; Zhang, T.; Wang W.* “Organocatalytic Enantioselective Friedel-Crafts Reactions of 1-Naphthols with Aldimines” Org. Lett., 2011, 13, 828-831.

(6) Deng, J.; Zhang, S.; Ding, P.; Jiang, H.; Wang, W.;* Li, J.* “Facile Creation of Privileged 3-Indolyl-3-hydroxy-2-oxindoles by an Organocatalytic Enantioselective Friedel-Crafts Reaction of Indoles with Isatins” Adv. Synth. Catal., 2010, 352, 833-838.

(7) Zhang, S.; Li, J;* Zhao, S.; Wang, W.* “1,3-Benzodithiole-1,1,3,3-tetraoxide (BDT) as a versatile methylation reagent in catalytic enantioselective Michael addition reaction with enals” Tetrahedron Lett. 2010, 51, 1766-1769.

(8) Zhang, H.; Zhang, S.; Liu, L.; Luo, G.; Duan, W.-H.;* Wang, W.* “Synthesis of Chiral 3-Substituted Phthalides by a Sequential Organocatalytic Enantioselective Aldol-Lactonization Reaction. Three-Step Synthesis of (S)-(−)-3-Butylphthalide” J. Org. Chem. 2010, 75, 368–374.

(9) Xue, F.; Zhang, S.; Liu, L.; Duan, W.;* Wang, W.* “Organocatalytic Enantioselective Cross-Aldol Reactions of Aldehydes with Isatins: Formation of Two Contiguous Quaternary Centered 3-Substituted 3-Hydroxyindol-2-ones” Chem. Asian J., 2009, 4, 1664-1667.

(10) Zhang,S.; Zhang, Y.; Ji, Y.; Li, H.; Wang, W.* “Catalytic enantioselective conjugate addition of fluorobis(phenylsulfonyl)methane to enals: synthesis of chiral monofluoromethyl compounds” Chem. Commun., 2009, 4886-4888.

(11) Li, H.; Zhang, S.-L.; Yu, C. G.; Song, X.-X.; Wang, W.* “Synthesis of Chiral Fluorinated Quaternary Carbon Containing -Ketoesters by Direct Organocatalytic Asymmetric Conjugate Addition Reactions of Fluoroketoesters with Nitroolefins” Chem. Commun., 2009, 2136-2138.

(12) Zu, L.-S.; Zhang, S.-L.; Xie, H.-X.; Wang, W.* “Catalytic Asymmetric oxa-Michael-Michael Cascade for Facile Construction of Chiral Chromans via an Aminal Intermediate” Org. Lett., 2009, 11, 1627-1630.

(13) Ma, S.; Zhang,S.; Duan, W.;* Wang, W.*“An efficient enantioselective synthesis of (+)-(S)-[n]-gingerol via the L-proline-catalyzed aldol reaction” Bioorg. Med. Chem. Lett., 2009, 19, 3909-3911.

(14) Xue, F.; Zhang, S.-L.;* Duan, W.-H.;* Wang, W.* “A Novel Bifunctional Sulfonamide Primary Amine-Catalyzed Enantioselective Conjugate Addition of Ketones to Nitroolefins” Adv. Synth. Catal., 2008, 350, 2194-2198.

(15) Song, L.; Chen, X.; Zhang, S* Zhang, H.; Li, P.; Luo, G.; Liu, W.; Duan, W.;* Wang, W.* “An Organocatalytic Approach to the Construction of Chiral Oxazolidinone Rings and Application in the Synthesis of Antibiotic Linezolid and Its Analogues”Org. Lett. 2008, 10, 5489-5492.

(16) Mei, K.; Zhang, S.;* He, S.; Li, P.; Jin, M.; Xue, F.; Luo, G.; Zhang, H.; Song.; L.; Duan, W.;* Wang, W. “(S) Pyrrolidine sulfonamide catalyzed asymmetric direct aldol reactions of aryl methyl ketones with aryl aldehydes” Tetrahedron Lett., 2008, 49, 2681-2684.

(17) Zhang, S.; Chen, X.; Zhang, J.; Wang, W.; Duan, W.* “An Enantioselective Formal Synthesis of (R)-(+)--Lipoic Acid by L-Proline-catalyzed Aldol Reaction” Synthesis, 2008, 383-386.

(18) Xu, Y; Zhang S.-L.;* Duan, W.-H.* “A New Radical Way to N,N-Dimethylaniline Hydroperoxide (DMAHP) and Its Application in Organic Synthesis” Chin.Chem.Lett. 2007, 18, 807–810.

(19) Zhao X; Zhang S.-L.;* Duan, W.-H.* “A New Synthetic Method of Natural Product Trichostatin A” Chin. J. Org. Chem. 2007, 27, 1509-1515.

(20) Zhang, S.-L.; Duan, W.-H.;* Wang, W.* “Efficient, Enantioselective Organocatalytic Synthesis of Trichostatin A” Adv. Synth. Catal., 2006, 348, 1228-1234.