帥惠萍，1990年1月出生，廣東廣州人，香港大學微生物學部門助理研究教授。研究領域是新發傳染病。
基本介紹
研究方向,主要成就,科研成果,學術成果,所獲榮譽,
研究方向
新出現的冠狀病毒，包括嚴重急性呼吸系統綜合徵冠狀病毒1型、MERS-CoV和嚴重急性呼吸綜合徵冠狀病毒2型的差異致病性和宿主嗜性的體內比較研究；病毒-宿主相互作用的研究與體內多組學分析；新型疫苗接種策略和小分子抗病毒藥物在感染動物模型中的療效評估。
主要成就
科研成果
長期專注於嚴重急性呼吸系統綜合徵冠狀病毒1型及2型（SARSCoV-1，SARS-CoV-2）、中東呼吸道綜合徵病毒（MERS-CoV）和高致病性禽流感等烈性呼吸道病原體的研究，以第一作者在《自然》（Nature）雜誌首先報導奧密克戎變異株的複製能力以及致病性均弱於其他關注變異株，為奧密克戎變異株針對性的疫苗和治療藥物研究提供了重要科學依據。此研究揭示了新冠病毒致病力逐漸減弱的演化路徑，警示全球仍需加強對新冠病毒的監測與防控。在國內及國際核心期刊發表論文26篇。
學術成果
代表論文
Shuai H*, Chan JF*, Hu B*, Chai Y*, Yuen TT*, Yin F*, Huang X, Yoon C, Hu JC, Liu H, Shi J, Liu Y, Zhu T, Zhang J, Hou Y, Wang Y, Lu L, Cai JP, Zhang AJ, Zhou J, Yuan S, Brindley MA, Zhang BZ, Huang JD, To KK, Yuen KY, Chu H. Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron. Nature. 2022 Jan 21.
Shuai H*, Chan JF*, Yuen TT*, Yoon C, Hu JC, Wen L, Hu B, Yang D, Wang Y, Hou Y, Huang X, Chai Y, Chan CC, Poon VK, Lu L, Zhang RQ, Chan WM, Ip JD, Chu AW, Hu YF, Cai JP, Chan KH, Zhou J, Sridhar S, Zhang BZ, Yuan S, Zhang AJ, Huang JD, To KK, Yuen KY, Chu H. Emerging SARS-CoV-2 variants expand species tropism to murines. EBioMedicine. 2021 Oct 21;73:103643.
Shuai H*, Chu H*, Hou Y*, Yang D, Wang Y, Hu B, Huang X, Zhang X, Chai Y, Cai JP, Chan JF, Yuen KY. Differential immune activation profile of SARS-CoV-2 and SARS-CoV infection in human lung and intestinal cells: implications for treatment with IFN-β and IFN inducer. Journal of Infection. 2020 Oct;81(4):e1-e10.
Quan BX*, Shuai H* (co-first author), Xia AJ*, Hou Y*, Zeng R*, Liu XL*, Lin GF*, Qiao JX, Li WP, Wang FL, Wang K, Zhou RJ, Yuen TT, Chen MX, Yoon C, Wu M, Zhang SY, Huang C, Wang YF, Yang W, Tian C, Li WM, Wei YQ, Yuen KY, Chan JF#, Lei J#, Chu H#, Yang S#. An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron. Nature Microbiology. 2022 May;7(5):716-725. (*co-first author)
Chu H*, Shuai H* (co-first author), Hou Y, Zhang X, Wen L, Huang X, Hu B, Yang D, Wang Y, Yoon C, Wong BH, Li C, Zhao X, Poon VK, Cai JP, Wong KK, Yeung ML, Zhou J, Au-Yeung RK, Yuan S, Jin DY, Kok KH, Perlman S, Chan JF, Yuen KY. Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity. Science Advances. 2021 Jun 16;7(25):eabf8577.
Shuai H *(co-first author), Chu H*, Hou Y*, Yang D, Wang Y, Hu B, Huang X, Zhang X, Chai Y, Cai JP, Chan JF, Yuen KY. Differential immune activation profile of SARS-CoV-2 and SARS-CoV infection in human lung and intestinal cells: Implications for treatment with IFN-β and IFN inducer. Journal of Infection. 2020 Oct;81(4):e1-e10.
Chu H*, Chan JF*, Yuen TT*, Shuai H*(co-first author), Yuan S, Wang Y, Hu B, Yip CC, Tsang JO, Huang X, Chai Y, Yang D, Hou Y, Chik KK, Zhang X, Fung AY, Tsoi HW, Cai JP, Chan WM, Ip JD, Chu AW, Zhou J, Lung DC, Kok KH, To KK, Tsang OT, Chan KH, Yuen KY. Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study. Lancet Microbe. 2020 May;1(1):e14-e23.
Zhang BZ*, Chu H*#, Han S*, Shuai H*(co-first author), Deng J, Hu YF, Gong HR, Lee AC, Zou Z, Yau T, Wu W, Hung IF, Chan JF, Yuen KY, Huang JD. Cell Research. 2020 Oct;30(10):928-931.
Chu H, Hou Y, Yang D, Wen L, Shuai H, Yoon C, Shi J, Chai Y, Yuen TT, Hu B, Li C, Zhao X, Wang Y, Huang X, Lee KS, Luo C, Cai JP, Poon VK, Chan CC, Zhang J, Yuan S, Sit KY, Foo DC, Au WK, Wong KK, Zhou J, Kok KH, Jin DY, Chan JF, Yuen KY. Coronaviruses exploit a host cysteine-aspartic protease for replication. Nature. 2022 Aug. (In press)
Chu H, Hu B, Huang X, Chai Y, Zhou D, Wang Y, Shuai H, Yang D, Hou Y, Zhang X, Yuen TT, Cai JP, Zhang AJ, Zhou J, Yuan S, To KK, Chan IH, Sit KY, Foo DC, Wong IY, Ng AT, Cheung TT, Law S, Au WK, Brindley MA, Chen Z, Kok KH, Chan JF, Yuen KY. Host and viral determinants for efficient SARS-CoV-2 infection of the human lung. Nature Communications. 2021 Jan 8;12(1):134.
所獲榮譽
2023年4月，入選“未來女科學家計畫”。
