崔曉賓

崔曉賓，男，博士，石河子大學醫學院副教授。

基本介紹

• 中文名：崔曉賓
• 畢業院校：華中科技大學
• 學位/學歷：博士
• 職業：教師
• 專業方向：腫瘤的病理診斷與分子診斷學研究、新疆地區食管癌發病機制研究
• 任職院校：石河子大學醫學院

人物經歷

2015年獲華中科技大學同濟醫院腫瘤學博士學位。

兼任中華醫學會病理學分會泌尿男生殖系統學組委員、中國抗癌協會病理專委食管癌協作組委員、中國老年醫學學會病理分會青年委員會委員，中華醫學會病理分會會員，新疆病理學分會會員。

研究方向

腫瘤的病理診斷與分子診斷學研究、新疆地區食管癌發病機制研究。

學術成果

主持課題

PLCE1基因調控miR-106b~25基因簇宿主基因MCM7促進食管鱗癌細胞增殖的作用及分子機制研究（國家自然科學基金 81760436，34萬，2018/01-2021/12，主持）

PLCE1基因在NMBA誘導小鼠食管上皮惡變中的作用及機制研究（石河子大學國際科技合作推進計畫項目 GJHZ201702，30萬，2018/01-2020/12，主持）

PLCE1基因調控炎性NF-кB信號通路在新疆哈族食管癌侵襲轉移中的作用與機制研究（國家自然科學基金 81460362，47萬，2015/01-2018/12，主持）

PLCE1負性調控p53抑制新疆哈族食管癌細胞自噬的作用機制研究（兵團套用基礎研究計畫項目2016AG020，30萬，2016/01 -2018/12，主持）

PLCE1基因對食管癌細胞自噬的作用研究（石河子大學高層次人才科研啟動項目，RCZX201533，5萬，2016/01-2018/12，主持）

PLCE1基因對食管癌細胞自噬抑制的作用機制初步研究（石河子大學傑出青年培育項目，2015ZRKXJQ02，8萬，2016/01 -2018/12，主持，已結題）

聯檢多種腫瘤相關自身抗體對新疆哈族食管癌早期診斷的評價和套用研究（石河子大學重大科技攻關項目，gxjs2014-zdgg06，15萬，2015/01 -2017/12，主持，已結題）

PLCE1及其不同突變體對新疆哈薩克族食管癌侵襲遷移的影響及作用機制（2014/01 -2015/12 石河子大學“優秀青年科技人才培育計畫”聯合資助立項項目，2013ZRKXYQ-YD19，4萬，主持，已結題）

發表文章

1.Ningjing Zou#, Lan Yang#, Ling Chen#(共同第一作者), Tingting Li, Tingting Jin, Hao Peng, Shumao Zhang, Dandan Wang, Ranran Li, Chunxia Liu, Jinfang Jiang, Lianghai Wang, Weihua Liang, Jianming Hu, Shugang Li, Chuanyue Wu, Xiaobin Cui,* Yunzhao Chen,* Feng Li*(共同通訊作者). Heterozygote of TAP1 Codon637 decreases susceptibility to HPV infection but increases susceptibility to esophageal cancer among the Kazakh populations. Journal of Experimental & Clinical Cancer Research, 2015, 34(1):70. (SCI, IF=6.451)

2.Cui X, Chen X, Wang W, Chang A, Yang L, Liu C, Peng H, Wei Y, Liang W, Li S, Wang N, Liu W, Hu J, Zhang W, Wang L, Chen Y, Li F(通訊作者). Epigenetic silencing of miR-203 in Kazakh patients with esophageal squamous cell carcinoma by MassARRAY spectrometry. Epigenetics, 2017, 12(8):698-707. (SCI, IF=4.9)

3.Xiao-bin Cui, Hao Peng, Ran-ran Li, Jian-qin Mu, LanYang, NaLi, Chun-xia Liu, Jian-ming Hu, Shu-gang Li, Yutao Wei, Laibo-Yin,Hong Zhou, Feng Li,and Yun-zhao Chen*(通訊作者). MicroRNA-34a functions as a tumor suppressor by directly targeting oncogenic PLCE1 in Kazakh esophageal squamous cell carcinoma. Oncotarget, 2017,8(54),92454-92469 (SCI, IF=5.168)

4.Cui XB#, Li S#, Li TT#(共同第一作者), Peng H, Jin TT, Zhang SM, Liu CX, Yang L, Shen YY, Li SG, Li N, Li Y, Hu JM, Jiang JF, Suo J, Qi Y, Liang WH, Wang LH, Dang HW, Li L, Cao WW, Wei Y, Laibo-Yin, Wu CY, Yuan XL, Zhou H, Zheng Y, Chen YZ*, Li F*(共同通訊作者). Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma. Oncotarget, 2016, 7(2):1777-1795 (SCI, IF=6.3)

5.Xiao-Bin Cui*, Yan-Xia Tian*, Cai-Pu Chun*, Hao Peng, Chun-Xia Liu, Lan Yang, Jian-Ming Hu, Hua-Hua Xin, Xi Chen, Ning Wang, Yu-Tao Wei, Lai-Bo Yin, Yun-Zhao Chen, Feng Li. Genome-wide screening for genomic aberrations in Kazakh patients with esophageal squamous cell cancer by comparative genomic hybridization.Int J Clin Exp Pathol 2018;11(1):427-437

6.Xiaobin Cui#, Zhimin Zhao#(共同第一作者), Dong Liu, Tao Guo, Su Li, Jianming Hu, Chunxia Liu, Lan Yang, Yuwen Cao, Jinfang Jiang, Weihua Liang, Wei Liu, Shugang Li, Lianghai Wang, Lidong Wang, Wenyi Gu, Chuanyue Wu, Yunzhao Chen*, Feng Li*(共同通訊作者)Inactivation of miR-34a by aberrant CpG methylation in Kazakh patients with esophageal carcinoma. J Exp Clin Cancer Res.2014, 33(1):20. (SCI, IF=4.451)

7.Xiao-bin Cui#, Yao-yuan Shen#, Tingting Jin# (共同第一作者), Su Li, Ting-ting Li, Shu-mao Zhang, Hao Peng, Jian-ming Hu, Chun-xia Liu, Lan Yang, Jing Jin, Jin-Fang Jiang, Wei-hua Liang, Na Li, Zhen-zhu Sun, Shu-gang Li, Chuan-yue Wu, Yun-zhao Chen,* Feng Li*(共同通訊作者). SLC39A6: a potential target for diagnosis and therapy of esophageal carcinoma. J Transl Med, 2015,13:321 (SCI, IF=3.947)

8.Cui XB#, Zhang SM#(共同第一作者), Xu YX, Dang HW, Liu CX, Wang LH, Yang L, Hu JM, Liang WH, Jiang JF, Li N, Li Y, Chen YZ*, Li F*(共同通訊作者). PFN2, a novel marker of unfavorable prognosis, is a potential therapeutic target involved in esophageal squamous cell carcinoma. J Transl Med. 2016, 14(1):137. (SCI, IF=3.947)

9.Cui X, Wang K, Yang X, Peng H, Chen X, Xin H, Tian Y, Chen Y, Li F. Comprehensive bioinformation analysis of the miRNA of PLCE1 knockdown in esophageal squamous cell carcinoma. Mol Cell Biochem,2018,442(1-2):111-127.

10.Xiaobin Cui, Huahua Xin, Hao Peng and Yunzhao Chen*(通訊作者). Comprehensive bioinformatics analysis of the mRNA profile of PLCE1 knockdown in esophageal squamous cell carcinoma. Mol Med Rep, 2017,16(5):5871-5880. (SCI, IF=1.847)

11.Hao Peng, Jie Yu, Feng Li, Xiaobin Cui*(通訊作者), Yunzhao Chen*(通訊作者). Decreased vitamin D receptor protein expression is associated with the progression and prognosis of esophageal squamous cell carcinoma: a multi-ethnic cohort study from the Xinjiang, China. Int J Clin Exp Pathol, 2017, 10(2):2340-2350. (SCI, IF=2.242)

12.Xiao-Bin Cui#, Ran-Ran Li#, Xiao-Li Diao#(共同第一作者), Tao Ren, Hao Peng, Dan-Dan Wang, Bin Wang, Yun-Zhao Chen(通訊作者), Feng Li(通訊作者). Hypermethylation of RASSF1A CpG insland is associated with esophageal squamous cell carcinoma in Kazakh patients. Int J Clin Exp Pathol, 2017,10(2):1765-1773. (SCI, IF=2.242)

13.Xiao-Bin Cui#, Dan-Dan Wang#(共同第一作者), Hai-Yang Zhang, Ting-Ting Li, Ting-Ting Jin, Hao Peng, Shu-Mao Zhang, Bin Wang, Jie Yu, Chun-Xia Liu, Lan Yang, Jing Jin, Su Li, Jin-Fang Jiang, Wei-Hua Liang, Jian-Ming Hu, Shu-Gang Li, Chuan-Yue Wu, Yun-Zhao Chen*, Feng Li*(共同通訊作者). Tumor necrosis factor-αgene 308G/A polymorphism is not associated with esophageal squamous cell carcinoma risk in Kazakh patients. Int J Clin Exp Pathol, 2015, 8(8):9293-9299 (SCI, IF=2.242)

14.Xiaobin Cui#, Hao Peng #,(共同第一作者), Jing Jin, Tingting Li, Shumao Zhang, Tingting Jin, Su Li, Chunxia Liu, Weihua Liang, Feng Li, Yunzhao Chen*. RANK overexpression as a novel esophageal cancer marker: validated immunohistochemical analysis of two different ethnicities.Int J Clin Exp Pathol 2015;8(2):2249-2258.

15.Dong HC#, Cui XB#, Wang LH #(共同第一作者), Li M, Shen YY, Zhu JB, Li CF, Hu JM, Li SG, Yang L, Zhang WJ, Chen YZ, Li F. Type-specific detection of human papillomaviruses in Kazakh esophageal squamous cell carcinoma by genotyping both E6 and L1 genes with MALDI-TOF mass spectrometry. Int J Clin Exp Pathol. 2015, 8(10):13156-65

16.Man Li#, Xiaobin Cui#(共同第一作者), Yaoyuan Shen, Hongchao Dong, Weihua Liang, Yunzhao Chen, Jianming Hu, Shugang Li, Jing Kong, Hongan Li, Jin Zhao*, Feng Li*(共同通訊作者). ORAOV1 overexpression in esophageal squamous cell carcinoma and esophageal dysplasia: a possible biomarker of progression and poor prognosis in esophageal carcinoma. Human Pathology, 2015,46(5):707-715 (SCI, IF=2.769)

17.Xiao-bin Cui#, Xue-lian Pang#(共同第一作者), Su Li, Jing Jin, Jian-ming Hu, Lan Yang, Chun-xia Liu, Li Li, Shu Jun Wen, Wei-hua Liang, Yun-zhao Chen*, Feng Li*(共同通訊作者). Elevated expression patterns and tight correlation of the PLCE1 and NF-κB signaling in Kazakh patients with esophageal carcinoma. Medical oncology, 2014, 31(1):791. (SCI, IF=2.647)

18.Xiaobin Cui, Yunzhao Chen, Lin Liu, Li Li, Jianming Hu, Lan Yang, Weihua Liang, Feng Li*. Heterozygote of PLCE1 rs2274223 increases susceptibility to human papillomavirus infection in patients with esophageal carcinoma among the Kazakh populations.J Med Virol. 2014, 86(4):608-17(SCI, IF=2.3)

19.Xiao-Bin Cui, Yun-Zhao Chen, Xue-lian Pang, Wei Liu, Jian-Ming Hu, Shu-Gang Li, Lan Yang, Wen-Jie Zhang, Chun-xia Liu, Yu-wen Cao, Jin-Fang Jiang, Wen-Yi Gu, James Pang, Lei Yang, Xiang-Lin Yuan, Shi-Ying Yu, Feng Li*. Multiple polymorphisms within the PLCE1are associated with esophageal cancer via promoting the gene expression in a Chinese Kazakh population. GENE, 2013,530(2),315–322 (SCI, IF=2.196)

20.Xiaobin Cui #, Su Li #(共同第一作者), Xuelian Pang, Jing Jin, Jianming Hu, Chunxia Liu, Lan Yang, Jinfang Jiang, Weihua Liang, Jing Suo, Yunzhao Chen*，Feng Li*(共同通訊作者). Significance of elevated ERK expression and its positive correlation with EGFR in Kazakh patients with esophageal squamous cell carcinoma. Int J Clin Exp Pathol.2014,7(4),2382-2391 (SCI, IF=2.242)

21.Xiao-Bin Cui #, Jing Jin #(共同第一作者), Xue-Lian Pang, Su Li, Chun-Xia Liu, Ting-Ting Li, Hao Peng, Shu-Mao Zhang, Li Li, Wei-Hua Liang, Yunzhao Chen*，Feng Li*(共同通訊作者). A case of blastic plasmacytoid dendritic cell neoplasm with ecchymotic lesions on the whole body. Int J Clin Exp Pathol, 2014;7(7):4391-4399 (SCI, IF=2.242)

22.Xiao-Bin Cui, Hao Peng, Su Li, Ting-ting Li, Shu-mao Zhang, Jian-ming Hu, Chun-xia Liu, Liang-hai Wang, Jing Suo, Na Li, Li Li, Wei-hua Liang, Yun-Zhao Chen*, Feng Li*(共同通訊作者). Prognostic Value of PLCE1 Expression in Upper Gastrointestinal Cancer: A Systematic Review and Meta-Analysis. Asian Pac J Cancer Prev, 2014, 15 (22), 9661-9666 (SCI, IF=2.514)