崔京南

崔京南，男，畢業於日本岡山大學，是大連理工大學博士生導師。

基本介紹

• 中文名：崔京南 
• 畢業院校：日本岡山大學
• 學位/學歷：博士
• 專業方向：螢光探針設計、合成及生物酶活性檢測
• 職務：大連理工大學博士生導師

人物經歷

1978-1982年：畢業於東北電力學院、電廠化學專業，學士學位；
1992-1995年：畢業於日本岡山大學、套用化學專業，碩士學位；
1995-1998年：畢業於日本岡山大學、合成有機化學專業，博士學位；
1999-2006年：大連理工大學、精細化工國家重點實驗室，副教授；
2006-2007年：瑞典皇家工學院，化學系，訪問學者；
2007年--至今：大連理工大學、精細化工國家重點實驗室，教授，博士生導師

研究方向

• 螢光分析技術在食品安全和環境污染中微量有害物質快速檢測方法研究
  
• 螢光探針設計、合成及生物酶活性檢測
  

社會兼職

（1）J. Org. Chem.; （2）Tetrahedron Lett.; （3）Bioorg. Med. Chem.; （4）Int. J. Mol. Sci. 等學術期刊審稿人。

著作論文

[1]Feng, Lei,Ma, Xiaochi,Tian, Xiangge,Yu, Zhenlong,Zhao, Xinyu,Sun, Chengpeng,Cui, Jingnan,Ning, Jing,Wang, Chao,Zhang, Baojing.A two-photon ratiometric fluorescent probe for imaging and quantitative analysis of botanic glucosyltransferase: A key enzyme for the biosynthesis of bioactive glycosides[J],SENSORS AND ACTUATORS B-CHEMICAL,2019,282:112-121

[2]Ning, Jing,Huo, Xiaokui,Feng, Lei,Wang, Chao,Sun, Chengpeng,Cui, Jingnan,James, Tony D.,Ma, Xiaochi,Liu, Tao,Dong, Peipei,Wang, Wei,Ge, Guangbo,Wang, Bo,Yu, Zhenlong,Shi, Lei,Tian, Xiangge.Molecular Design Strategy to Construct the Near-Infrared Fluorescent Probe for Selectively Sensing Human Cytochrome P450 2J2[J],JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2019,141(2):1126-1134

[3]Tian, Xiangge,Zhou, Dayong,Wang, Chao,Sun, Chengpeng,Ning, Jing,Ma, Xiaochi,Tian, Zhenhao,Wang, Yan,Hou, Jie,Feng, Lei,Song, Liang,Cui, Jingnan,Huo, Xiaokui,Zhao, Xinyu.A highly selective fluorescent probe for detecting glutathione transferases to reveal anticancer-activity sensitivity of cisplatin in cancer cells and tumor tissues[J],SENSORS AND ACTUATORS B-CHEMICAL,2018,277:423-430

[4]Feng, Lei,Ning, Jing,Ma, Xiao-Chi,Li, Ping,Hou, Jie,Cui, Yong-Lei,Tian, Xiang-Ge,Yu, Zhen-Long,Cui, Jing-Nan,Wang, Chao,Huo, Xiao-Kui.Identification and Isolation of Glucosytransferases (GT) Expressed Fungi Using a Two-Photon Ratiometric Fluorescent Probe Activated by GT[J],ANALYTICAL CHEMISTRY,2018,90(22):13341-13347

[5]Jiao, Long,Song, Fengling,Cui, Jingnan,Peng, Xiaojun.A near-infrared heptamethine aminocyanine dye with a long-lived excited triplet state for photodynamic therapy[J],CHEMICAL COMMUNICATIONS,2018,54(66):9198-9201

[6]Liu, Tao,Wang, Chao,Cui, Jing-Nan,Yan, Qu-Long,Feng, Lei,Ma, Xiao-Chi,Tian, Xiang-Ge,Yu, Zhen-Long,Ning, Jing,Huo, Xiao-Kui,Sun, Cheng-Peng.Isolation of gamma-Glutamyl-Transferase Rich-Bacteria from Mouse Gut by a Near-Infrared Fluorescent Probe with Large Stokes Shift[J],ANALYTICAL CHEMISTRY,2018,90(16):9921-9928

[7]Huo, Xiaokui,Ma, Xiaochi,Tian, Xiangge,Li, Yannan,Feng, Lei,Cui, Yonglei,Wang, Chao,Cui, Jingnan,Sun, Chengpeng,Liu, Kexin.highly selective ratiometric fluorescent probe for real-time imaging of beta-glucuronidase in living cells and zebrafish[J],SENSORS AND ACTUATORS B-CHEMICAL,2018,262:508-515

[8]Li, Pengbo,Wang, Yiru,Zhang, Shufang,Xu, Liang,Wang, Gongchen,Cui, Jingnan.An ultrasensitive rapid-response fluorescent probe for highly selective detection of HSA[J],TETRAHEDRON LETTERS,2018,59(14):1390-1393

[9]Liu, Tao,Zhao, Xinyu,Huo, Xiaokui,Sun, Chengpeng,Cui, Jingnan,Feng, Lei,Ma, Xiaochi,Ning, Jing,Wang, Bo,Dong, Bin,Li, Song,Tian, Xiangge,Yu, Zhenlong,Peng, Yulin,Wang, Chao.Activatable Near-Infrared Fluorescent Probe for Dipeptidyl Peptidase IV and Its Bioimaging Applications in Living Cells and Animals[J],ANALYTICAL CHEMISTRY,2018,90(6):3965-3973

[10]Jin, Yinzhu,Wang, Chao,Ning, Jing,Zhang, Baojing,Feng, Lei,Ma, Xiaochi,Tian, Xiangge,Jin, Lingling,Cui, Yonglei,Liu, Tao,Yu, Zhenlong,Huo, Xiaokui,Cui, Jingnan,Sun, Chengpeng.Highly Specific near-Infrared Fluorescent Probe for the Real-Time Detection of beta-Glucuronidase in Various Living Cells and Animals[J],ANALYTICAL CHEMISTRY,2018,90(5):3276-3283

[11]Zhang Chuanmin,Zhang Shubiao,Zhi Defu,Cui Jingnan.Cancer Treatment with Liposomes Based Drugs and Genes Co-delivery Systems.[J],Current medicinal chemistry,2018,25(28):3319-3332

[12]焦龍,宋鋒玲,崔京南,彭孝軍.A near infrared heptamethine aminocyanine dye with a long-living excited triplet state for photodynamic therapy[J],Chemical Communications, 2018, 54, 9198 – 9201.,2018,54:9198-9201

[13]Lv, Xia,Yang, Ling,Feng, Lei,Ai, Chun-Zhi,Hou, Jie,Wang, Ping,Zou, Li-Wei,Cheng, Jie,Ge, Guang-Bo,Cui, Jing-Nan.A Practical and High-Affinity Fluorescent Probe for Uridine Diphosphate Glucuronosyltransferase 1A1: A Good Surrogate for Bilirubin[J],JOURNAL OF MEDICINAL CHEMISTRY,2017,60(23):9664-9675

[14]Qiao, Qinglong,Liu, Wenjuan,Chen, Jie,Zhou, Wei,Yin, Wenting,Miao, Lu,Cui, Jingnan,Xu, Zhaochao.A naphthalimide-derived fluorogenic probe for SNAP-tag with a fast record labeling rate[J],DYES AND PIGMENTS,2017,147:327-333

[15]Ge, Guang-Bo,Yang, Ling,Feng, Lei,Jin, Qiang,Wang, Yi-Ru,Liu, Zhao-Ming,Zhu, Xin-Yue,Wang, Ping,Hou, Jie,Cui, Jing-Nan.A novel substrate-inspired fluorescent probe to monitor native albumin in human plasma and living cells[J],ANALYTICA CHIMICA ACTA,2017,989:71-79

[16]Jin, Qiang,Yang, Ling,Feng, Lei,Zhang, Shui-Jun,Wang, Dan-Dan,Wang, Fang-Jun,Zhang, Yi,Cui, Jing-Nan,Guo, Wen-Zhi,Ge, Guang-Bo.Real-Time Tracking the Synthesis and Degradation of Albumin in Complex Biological Systems with a near-Infrared Fluorescent Probe[J],ANALYTICAL CHEMISTRY,2017,89(18):9884-9891

[17]Jiao, Long,Song, Fengling,Zhang, Biyou,Ning, Houfu,Cui, Jingnan,Peng, Xiaojun.Improving the brightness and photostability of NIR fluorescent silica nanoparticles through rational fine-tuning of the covalent encapsulation methods[J],JOURNAL OF MATERIALS CHEMISTRY B,2017,5(26):5278-5283

[18]Wang, Yi-Ru,Feng, Lei,Xu, Liang,Hou, Jie,Jin, Qiang,Zhou, Nan,Lin, Yuan,Cui, Jing-Nan,Ge, Guang-Bo.An ultrasensitive and conformation sensitive fluorescent probe for sensing human albumin in complex biological samples[J],SENSORS AND ACTUATORS B-CHEMICAL,2017,245:923-931

[19]Dai, Ziru,Ge, Guang-Bo,Yang, Ling,Feng, Lei,Cui, Jing-Nan,Jin, Qiang.A HIGHLY SELECTIVE RATIOMETRIC TWO-PHOTON FLUORESCENT PROBE FOR HUMAN CYTOCHROME P450 1A1 AND ITS APPLICATION[J],DRUG METABOLISM AND PHARMACOKINETICS,2017,32(1):S37-S37

[20]Jin, Qiang,Feng, Lei,Wang, Dandan,Ge, Guang-Bo,Cui, Jing-Nan,Ling, Yang.A HIGHLY SELECTIVE NEAR-INFRARED FLUORESCENT PROBE FOR CARBOXYLESTERASE 2 AND ITS BIOIMAGING APPLICATIONS IN LIVING SYSTEMS[J],DRUG METABOLISM AND PHARMACOKINETICS,2017,32(1):S22-S22

[21]Lv, Xia,Feng, Lei,Cui, Jing-Nan,Yang, Ling,Ge, Guang-Bo.A TURN ON FLUORESCENT PROBE FOR HUMAN UDP-GLUCURONOSYL TRANSFERASE 1A1 AND BILIRUBIN METABOLISM EVALUATION[J],DRUG METABOLISM AND PHARMACOKINETICS,2017,32(1):S35-S35

[22]宋鋒玲,崔京南,彭孝軍.Improving brightness and photostability of NIR fluorescent silica nanoparticles through rational fine-tuning of the covalent encapsulation methods[J],Journal of Materials Chemistry B,2017,5:5278-5283

[23]Dai, Zi-Ru,Yang, Ling,Feng, Lei,Jin, Qiang,Cheng, Hailing,Li, Yan,Ning, Jing,Yu, Yang,Ge, Guang-Bo,Cui, Jing-Nan.A practical strategy to design and develop an isoform-specific fluorescent probe for a target enzyme: CYP1A1 as a case study[J],CHEMICAL SCIENCE,2017,8(4):2795-2803

[24]丁樂樂,田鎮豪,侯潔,翁仔淼,崔京南,楊凌,葛廣波.基於BODIPY母核的羧酸酯酶1特異性螢光探針底物的設計研發[J],藥學學報,2017,52(1):58-65

[25]Jin, Qiang,Cui, Jing-Nan,Yang, Ling,Feng, Lei,Wang, Dan-Dan,Wu, Jing-Jing,Hou, Jie,Dai, Zi-Ru,Sun, Shi-Guo,Wang, Jia-Yue,Ge, Guang-Bo.A highly selective near-infrared fluorescent probe for carboxylesterase 2 and its bioimaging applications in living cells and animals[J],BIOSENSORS & BIOELECTRONICS,2016,83:193-199

[26]Cui, Jing-Nan,Xu, Liang.A rapid-response fluorescent probe for the sensitive and selective detection of human albumin in plasma and cell culture supernatants[J],CHEMICAL COMMUNICATIONS,2016,52(36):6064-6067

[27]Cui, Jing-Nan.A highly selective marker reaction for measuring the activity of human carboxylesterase 1 in complex biological samples[J],RSC ADVANCES,2016,6(6):4302-4309

[28]Cui, Jing-Nan.A Two-Photon Ratiometric Fluorescent Probe for Imaging Carboxylesterase 2 in Living Cells and Tissues[J],ACS APPLIED MATERIALS & INTERFACES,2015,7(51):28474-28481

[29]Cui, Jing-Nan.A Highly Selective Ratiometric Two-Photon Fluorescent Probe for Human Cytochrome P450 1A[J],JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2015,137(45):14488-14495

[30]Cui, Jing-Nan.An optimized ratiometric fluorescent probe for sensing human UDP-glucuronosyltransferase 1A1 and its biological applications[J],BIOSENSORS & BIOELECTRONICS,2015,72:261-267

[31]Cui, Jing-Nan.A highly selective fluorescent ESIPT probe for the detection of Human carboxylesterase 2 and its biological applications[J],BIOSENSORS & BIOELECTRONICS,2015,65:9-15

[32]Cui, Jingnan.Coumarin 545: an emission reference dye with a record-low temperature coefficient for ratiometric fluorescence based temperature measurements[J],ANALYST,2015,140(4):1008-1013

[33]Cui, Jing-Nan.A ratiometric fluorescent sensor for highly selective detection of human carboxylesterase 2 and its application in living cells[J],SENSORS AND ACTUATORS B-CHEMICAL,2014,205:151-157

[34]Feng, Lei,Liu, Zhao-Ming,Xu, Liang,Lv, Xia,Ning, Jing,Hou, Jie,Ge, Guang-Bo,Cui, Jing-Nan,Yang, Ling.A highly selective long-wavelength fluorescent probe for the detection of human carboxylesterase 2 and its biomedical applications[J],CHEMICAL COMMUNICATIONS,2014,50(93):14519-14522

[35]Cui, Jingnan.A fluorescent probe based on N-butylbenzene-1,2-diamine for Cu(II) and its imaging in living cells[J],JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY,2014,80(3-4):383-390

[36]Liu, Zhao-Ming,Feng, Lei,Ge, Guang-Bo,Lv, Xia,Hou, Jie,Cao, Yun-Feng,Cui, Jing-Nan,Yang, Ling.A highly selective ratiometric fluorescent probe for in vitro monitoring and cellular imaging of human carboxylesterase 1[J],BIOSENSORS & BIOELECTRONICS,2014,57:30-35

[37]Liu, Tianyu,Liu, Xiaogang,Spring, David R.,Qian, Xuhong,Cui, Jingnan,Xu, Zhaochao.Quantitatively Mapping Cellular Viscosity with Detailed Organelle Information via a Designed PET Fluorescent Probe[J],SCIENTIFIC REPORTS,2014,4:5418

[38]崔京南.A highly selective ratiometric fluorescent probe for in vitro monitoring and cellular imaging of human carboxylesterase1[J],Biosensors & Bioelectronics,2014,57(1):30-35

[39]崔京南.A highly selective long-wavelength fluorescent probe for human carboxylesterase 2 and its biomedical applications[J],Chem. Commun,2014,50(50):14519-14522

[40]崔京南.Quantitatively Mapping Cellular Viscosity with Detailed OrganelleInformation via a Designed PET Fluorescent Probe[J],SCIENTIFIC REPORTS,2014,4(5418):1-7

[41]Zou, Chunyan,Qiao, Qinglong,Zhao, Miao,Mao, Deqi,Wang, Danfeng,Feng, Lei,Cui, Jingnan,Xu, Zhaochao.A ratiometric fluorescent probe for fluoride ion based on naphthoimidazolium receptor[J],RSC ADVANCES,2014,4(82):43746-43751

[42]Qiao, Qinglong,Zhao, Miao,Lang, Haijing,Mao, Deqi,Cui, Jingnan,Xu, Zhaochao.A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells[J],RSC ADVANCES,2014,4(49):25790-25794

[43]Song, Xinwei,Liu, Fengyu,Sun, Shiguo,Wang, Jingyun,Cui, Jingnan,Peng, Xiaojun.An NIR dye encapsulated by a supramolecular assembly for imaging mitochondria in living cells with ultrastable photostability[J],RSC ADVANCES,2014,4(18):9326-9329

[44]Liu, Tianyu,Zhang, Xinfu,Qiao, Qinglong,Zou, Chunyan,Feng, Lei,Cui, Jingnan,Xu, Zhaochao.A two-photon fluorescent probe for imaging hydrogen sulfide in living cells[J],DYES AND PIGMENTS,2013,99(3):537-542

[45]Song, Xinwei,Liu, Fengyu,Sun, Shiguo,Cui, Jingnan,Fan, Jiangli,Song, Fengling,Peng, Xiaojun.O-atom effect on the dynamic balance between redox-induced viologen derivative radical and its dimer modulated by cucurbit[8]uril[J],SUPRAMOLECULAR CHEMISTRY,2013,25(7):401-408

[46]Chen, Tao,Zheng, Yi,Xu, Zhaochao,Zhao, Miao,Xu, Yongnan,Cui, Jingnan.A red emission fluorescent probe for hydrogen sulfide and its application in living cells imaging[J],TETRAHEDRON LETTERS,2013,54(23):2980-2982

[47]Wu, Zhiyong,Cui, Jingnan,Qian, Xuhong.Rational design of fluorescent viscosity sensors by the principle of photoinduced electron transfer[J],TETRAHEDRON LETTERS,2013,54(21):2575-2578

[48]Liu, Tianyu,Xu, Zhaochao,Spring, David R.,Cui, Jingnan.A Lysosome-Targetable Fluorescent Probe for Imaging Hydrogen Sulfide in Living Cells[J],ORGANIC LETTERS,2013,15(9):2310-2313

[49]Wu, Zhi-Yong,Cui, Jing-Nan,Qian, Xu-Hong,Liu, Tian-Yu.A 4-aminonaphthalimide based environmentally sensitive fluorescence probe[J],CHINESE CHEMICAL LETTERS,2013,24(5):359-361

[50]王專,崔京南,歐其,吳祖望.三苯二嗪型藍色活性染料研究進展[J],染料與染色,2013,50(1):10-13

[51]Wang, Min,Xu, Zhaochao,Wang, Xu,Cui, Jingnan.A fluorescent and colorimetric chemosensor for nitric oxide based on 1,8-naphthalimide[J],DYES AND PIGMENTS,2013,96(2):333-337

[52]王專,崔京南,歐其,吳祖望.三苯二噁嗪型藍色活性染料研究進展[A],第十二屆全國染料與染色學術研討會暨信息發布會,2012,16-20

[53]王靜,程耀邦,邊悅玲,徐兆超,崔京南.苯萘體系普朔爾環化反應中橋原子與取代基對芳香自由基誘導分子內1,5-氫轉移的影響[J],中國科技論文,2012,6:454-461

[54]Xing, Junling,Cui, Jingnan,Wang, Shuang,Gao, Jin,Zhang, Zhichao.Novel acenaphthopyrazine derivatives as antitumor agents against MCF-7 cells: molecular synthesis, optical properties, and DNA-binding studies[J],MONATSHEFTE FUR CHEMIE,2012,143(2):243-250

[55]Chen, Xiufu,Wang, Jingyun,Cui, Jingnan,Xu, Zhaochao,Peng, Xiaojun.A ratiometric and exclusively selective Cu-II fluorescent probe based on internal charge transfer (ICT)[J],TETRAHEDRON,2011,67(26):4869-4873

[56]Miao, Qingqing,Wu, Liqiong,Cui, Jingnan,Huang, Mingdong,Ma, Tingli.A New Type of Dye-Sensitized Solar Cell with a Multilayered Photoanode Prepared by a Film-Transfer Technique[J],ADVANCED MATERIALS,2011,23(24):2764-2768

[57]楊翠翠,孔志霞,崔京南.用於染料敏化太陽能電池的苊並吡嗪類染料的合成[J],精細化工,2011,28(7):633-638

[58]Xie, Lijuan,Cui, Jingnan,Qian, Xuhong,Xu, Yufang,Liu, Jianwen,Xu, Ruian.5-Non-amino aromatic substituted naphthalimides as potential antitumor agents: Synthesis via Suzuki reaction, antiproliferative activity, and DNA-binding behavior[J],BIOORGANIC & MEDICINAL CHEMISTRY,2011,19(2):961-967

[59]崔京南.Design and synthesis of organic dyes based on acenaphthopyrazine for dye-sensitized solar cells[J],Jingxi Huagong (2011), 28(7), 633-638,2011,28(7):633-638

[60]Wang Xing-yong,Cui Jing-nan,Ren Wei-min,Zhao Guo-quan,Li Feng,Qian Xu-hong.Reductive Metabolism of Nitroaromatic Compounds by Various Liver Microsomes[J],CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2010,26(6):981-985

[61]Wang, Kewei,Qian, Xuhong,Cui, Jingnan.Design, synthesis, and bioactivity of cyanonitrovinyl neonicotinoids as potential insecticides[J],MONATSHEFTE FUR CHEMIE,2010,141(10):1117-1122

[62]Kong, Zhixia,Zhou, Huizhi,Cui, Jingnan,Ma, Tingli,Yang, Xichuan,Sun, Licheng.A new class of organic dyes based on acenaphthopyrazine for dye-sensitized solar cells[J],JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY,2010,213(2-3):152-157

[63]Li, Xiaolian,Wang, Qianqian,Qing, Yang,Lin, Yanjie,Zhang, Yingli,Qian, Xuhong,Cui, Jingnan.Novel DNA intercalators without basic side chains as efficient antitumor agents: Design, synthesis and evaluation of benzo-[c,d]-indol-malononitrile derivatives[J],BIOORGANIC & MEDICINAL CHEMISTRY,2010,18(9):3279-3284

[64]Wang, Lixiao,Wang, Xingyong,Cui, Jingnan,Ren, Weimin,Meng, Nan,Wang, Jingyun,Qian, Xuhong.Preparation of chiral trans-5-substituted-acenaphthene-1,2-diols by baker's yeast-mediated reduction of 5-substituted-acenaphthylene-1,2-diones[J],TETRAHEDRON-ASYMMETRY,2010,21(7):825-830

[65]Xu, Zhaochao,Pan, Jie,Spring, David R.,Cui, Jingnan,Yoon, Juyoung.Ratiometric fluorescent and colorimetric sensors for Cu2+ based on 4,5-disubstituted-1,8-naphthalimide and sensing cyanide via Cu2+ displacement approach[J],TETRAHEDRON,2010,66(9):1678-1683

[66]Xu, Zhaochao,Baek, Kyung-Hwa,Kim, Ha Na,Cui, Jingnan,Qian, Xuhong,Spring, David R.,Shin, Injae,Yoon, Juyoung.Zn2+-Triggered Amide Tautomerization Produces a Highly Zn2+-Selective, Cell-Permeable, and Ratiometric Fluorescent Sensor[J],JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2010,132(2):601-610

[67]崔京南.Design, Synthesis and Bioactivity of Vinylnitro-cyano Neonicotinoids as Potential Insecticides[J],Monatsh. Chem.,2010,141:1117-1120

[68]吳志勇,崔京南.Polarity Sensors Based on Photoinduced Electron Transfer Mechamism[A],The 2nd Workshop on Fluorescence Chemsensors and Bio-imagings,2010,88-89

[69]Wang, Kewei,Qian, Xuhong,Cui, Jingnan.One step from nitro to oxime: a convenient preparation of unsaturated oximes by the reduction of the corresponding vinylnitro compounds[J],TETRAHEDRON,2009,65(50):10377-10382

[70]Xie, Lijuan,Xiao, Yi,Wang, Fang,Xu, Yufang,Qian, Xuhong,Zhang, Rong,Cui, Jingnan,Liu, Jianwen.Novel acenaphtho[1,2-b]pyrrole-carboxylic acid family: Synthesis, cytotoxicity, DNA-binding and cell cycle evaluation[J],BIOORGANIC & MEDICINAL CHEMISTRY,2009,17(21):7615-7621

[71]Xie, Lijuan,Xu, Yufang,Wang, Fang,Liu, Jianwen,Qian, Xuhong,Cui, Jingnan.Synthesis of new amonafide analogues via coupling reaction and their cytotoxic evaluation and DNA-binding studies[J],BIOORGANIC & MEDICINAL CHEMISTRY,2009,17(2):804-810

[72]崔京南.Novel acenaphtho[1,2-b]pyrrole-carboxylic acid family: synthesis, cytotoxicity, DNA-binding and cell cycle evaluation[A],Bioorg. Med. Chem,2009,17(21):7615-7621

[73]Wang, Kewei,Cui, Jingnan,Xie, Lijuan,Qian, Xuhong.Design, synthesis, and Evaluation of Unsymmetrical Difluoro-Boron Complexes with Imidazoline as Potential Fungicides[J],HETEROATOM CHEMISTRY,2009,20(7):418-424

[74]Tong, Lian Peng,Cui, Jing Nan,Ren, Wei Min,Wang, Xing Yong,Qian, Xu Hong.Asymmetric bioreduction of substituted acenaphthenequinones using plant enzymatic systems: A novel strategy for the preparation of (+)- and (-)-mono hydroxyacenaphthenones[J],CHINESE CHEMICAL LETTERS,2008,19(10):1179-1182

[75]Xie, Lijuan,Qian, Xuhong,Cui, Jingnan,Xiao, Yi,Wang, Kewei,Wu, Peichun,Cong, Liying.Novel angular furoquinolinones bearing flexible chain as antitumor agent: Design, synthesis, cytotoxic evaluation, and DNA-binding studies[J],BIOORGANIC & MEDICINAL CHEMISTRY,2008,16(18):8713-8718

[76]佟連鵬,張建偉,孔志霞,崔京南.一種具有變色效應的可在生理pH下檢測Co~(2+)的螢光探針[A],中國化學會第26屆學術年會光化學分會場,2008,1

[77]孔志霞,王興涌,張建偉,崔京南.利用動物肝臟質粒還原芳香硝基類化合物[A],中國化學會第26屆學術年會有機化學分會場,2008,1

[78]Li, Gangyue,Qian, Xuhong,Yan, Shenggang,Cui, Jingnan,Zhang, Rong,Xiao, Yi.Synthesis, herbicidal activity, and structure-bioactivity relationship of pyridyl-containing 2-phenyliminothiazolidines[J],MONATSHEFTE FUR CHEMIE,2008,139(2):169-178

[79]崔京南.一種具有變色效應的可在生理pH下檢測Co2+的螢光探針[A],中國化學會第二十六屆學術年會,2008

[80]邊悅玲,崔京南,程耀邦,徐兆超.以氮為橋原子的芳香自由基誘導的1,5-芳香氫轉移的研究[A],中國化學會第二十五屆學術年會,2006,1

[81]盧春亮,崔京南,徐兆超.一種在生理pH下比例螢光檢測Cd_(2+)的水溶性化學感測器[A],中國化學會第二十五屆學術年會,2006,1

[82]王興涌,崔京南,李峰,任偉民.生物轉化法製備手性5-溴-1,2-二羥基苊[A],中國化學會第二十五屆學術年會,2006,1

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主要成就

相關研究成果在J. Am. Chem. Soc.; Org. Lett.; Chem. Commun; J. Org.Chem.; Sci. Rep; Biosensors and Bioelectronics等雜誌發表論文50餘篇，共被引用700餘次；獲得國家專利授權20餘項；作為項目負責人獲得資助國家自然科學基金面上項目3項、國家科技支撐計畫、國家自然科學基金重大培育計畫、上海市科委科研項目各1項。
1、通過把螢光檢測技術引入食品安全領域，將傳統快速檢測儀器的定性檢測提高至定量檢測，特別是將重金屬離子檢測限由10 mg/L降低至0.05 mg/L；已完成攜帶型食品安全螢光快速檢測儀開發;
2、完成數碼彩色列印專用染料及墨水製備工藝開發，產品打破國外產品壟斷，大幅降低價格，使國外產品基本退出國內市場；成果獲得國家科技發明二等獎（大幅面數碼噴墨染料及其套用，2006年，第二位獲獎人）。
3、開發金屬離子、中性小分子、陰離子、粘度、生物酶（乙醯膽鹼酶、羧酸酯酶、人血清蛋白酶和P450酶）等高選擇性、比例檢測的雙通道螢光探針30餘種；成果獲得上海市自然科學一等獎（生物功能色素及螢光分子感測器，2008年，第三位獲獎人)。

獎勵：

（1）國家技術發明二等獎，2006年，大幅面數碼噴墨染料及其套用，彭孝軍、崔京南、張 蓉、王力成、樊江麗、王力軍；

（2）上海市自然科學一等獎，2008年，生物功能色素及螢光分子感測器，錢旭紅、肖 義、崔京南、徐玉芳；

專利

一種用於識別硫化氫的特異性螢光探針及其套用

一種苯並噻唑類識別硫化氫的螢光探針及其套用

一種用於識別半胱氨酸的特異性螢光探針及其套用

一種以苊並吡嗪為母體的高靈敏性螢光探針、製備及套用

芳雜環基咪唑並萘醯亞胺類化合物及其套用

一類苊並吡嗪染料及其在染料敏化太陽能電池上的套用

一類鄰二氰基苊並吡嗪化合物及其抗腫瘤套用

手性2-羥基苊酮類化合物的製備方法

一種萘醯亞胺螢光染料及其製備和套用

一種染料型中性墨水及其製備方法

科研項目

當前位置: 崔京南>> 科學研究>> 科研項目

人源羧酸酯酶1亞型選擇性螢光探針設計、合成與生物學套用, 國家自然科學基金, 2015/08/18, 進行

制筆行業關鍵材料及製備技術研發與產業化, 國家科技支撐計畫項目, 2011/06/01, 完成

基於剛性、稠環芳香醇的手性分子螢光探針設計與合成, 高等學校博士學科點專項科研基金項目, 2010/12/02, 完成

利用生物轉化法製備剛性、稠環芳香手性醇, 國家自然科學基金, 2008/09/25-2011/12/31, 完成

利用鎘離子比率螢光探針研究鎘誘導的細胞程式化死亡過程中NO的作用機制, 國家自然科學基金, 2007/09/25-2012/12/31, 完成

特色精細化學品及工藝共性技術開發一期項目, 2017/06/13-2021/06/13, 進行

生物分子檢測及醫學診斷用菁螢光標記染料, 遼寧省高等學校科研計畫項目, 2007/01/01-2010/09/17, 完成