岑宇科,男,博士,浙江慈谿人,任職於浙江工業大學生物工程學院副教授,博士生導師,主要研究方向為真菌生物學、分子微生物、代謝工程。
基本介紹
教學課程,科研項目,科研成果,
教學課程
本科
分子生物學、基因工程(全英語)、生物技術製藥、藥學生物學基礎(全英語)
碩士研究生
科技論文寫作、微生物製藥工程
博士研究生
生物催化科學與工程
科研項目
1.“卡泊芬淨與鈣調磷酸酶介導的麥角固醇-法尼醇代謝對光滑念珠菌群體感應與生物被膜的作用機制” 國家自然科學基金項目-面上,2021.01.01-2024.12.31,45萬元,主持
2.“藤倉赤黴菌GPCR-cAMP-PKA通路中信號轉導機制的研究”國家自然科學基金項目-青年,2022.01.01-2024.12.31,30萬元,主持
3. “重要植物天然產物合成途徑的創製”國家重點研發計畫子課題“高產赤黴素酵母細胞工廠構建及赤黴素代謝途徑改造”,2021.01.01-2025.12.31,50萬元,主持
4. “藤倉赤黴菌GPCR-cAMP-PKA信號傳導對赤黴素合成的調控機制研究” 浙江省自然科學基金-青年,2019.01.01-2022.12.31, 9萬元,主持
5. “赤黴素生產菌株改良及發酵過程最佳化”浙江錢江生化有限公司橫向項目,2018.01.01-2022.12.31,150萬元,主持
6.“Gibberella fujikuroi赤黴素外排機制的研究”浙江省教育廳科研項目,2017.06.30-2019.10.01,1萬元,結題,主持
科研成果
1. “Expression of l‑phosphinothricin synthesis enzymes in Pichia pastoris for synthesis of l‑phosphinothricin”. Yu‑Ke Cen, Qi Wang, Huo Gong, Ya‑Ping Xue, Yu‑Guo Zheng, Biotechnology Letters,2022,10.1007/s10529-022-03239-w.
2. “Biosynthesis of l‑phosphinothricin with enzymes from chromosomal integrated expression in E. coli”. Yu‑Ke Cen, Huo Gong, Ya‑Ping Xue, Yu‑Guo Zheng, 3 Biotech,2021,10.1007/s13205-021-03037-7.
3. “The involvement of the Candida glabrata trehalase enzymes in stress resistance and gut colonization”. Mieke Van Ende , Bea Timmermans , Giel Vanreppelen , Sofía Siscar-Lewin ,Daniel Fischer , Stefanie Wijnants , Celia Lobo Romero , Saleh Yazdani , Ona Rogiers , Liesbeth Demuyser , Griet Van Zeebroeck , Yuke Cen, Karl Kuchler, Sascha Brunke & Patrick Van Dijck, Virulence, 2021, 10.1080/21505594.2020.1868825.
4. “The gibberellin producer Fusarium fujikuroi: methods and technologies in the current toolkit”. Yu-Ke Cen, Jian-Guang Lin, You-Liang Wang, Jun-You Wang, Zhi-Qiang Liu, Yu-Guo Zheng, Frontiers in bioengineering and biotechnology, 2020,doi: 10.3389/fbioe.2020.00232.
5. “Enhancement of gibberellic acid production from Fusarium fujikuroi by mutation breeding and glycerol addition” Xiao‑Lun Peng, Wei‑Jun Zhao, Yuan‑Shan Wang, Ke‑Lei Dai, Yu‑Ke Cen, Zhi‑Qiang Liu,Yu‑Guo Zheng,3 Biotech,2020,10.1007/s13205-020-02303-4.
6. “Recent advances in the improvement of enzyme thermostability by structure modification”. Zhe Xu, Yu-Ke Cen, Shuping Zou, Ya-Ping Xue, Yu-Guo Zheng, Critical reviews in biotechnology. 2019, doi: 10.1080/07388551.2019.1682963.
7. “Immobilization of enzymes in/on membranes and their applications”. Yu-Ke Cen, Yu-Xiao Liu, Ya-Ping Xue, Yu-Guo Zheng, Advanced Synthesis & Catalysis. 2019, 10.1002/adsc.201900439.
8. “Colorimetric assay for active biomass quantification of Fusarium fujikuroi”. Yu-Ke Cen, Jian-Guang Lin, Jun-You Wang, Zhi-Qiang Liu , Yu-Guo Zheng, Journal of Microbiological Methods. 2018, doi: 10.1016/j.mimet.2018.11.009.
9. “Comparison of genome engineering using the CRISPR-Cas9 system in C. glabrata wild-type and lig4 strains”. Yuke Cen, Bea Timmermans, Ben Souffriau, Johan M. Thevelein, Patrick Van Dijck, Fungal Genetics and Biology, 2017, doi:10.1016/j.fgb.2017.08.004.
10. “Deletion of the DNA ligase IV gene in Candida glabrata significantly increases gene-targeting efficiency.” Yuke Cen, Alessandro Fiori and Patrick Van Dijck. Eukaryot Cell,2015, doi:10.1128/EC.00281-14.
10.國家發明專利:一種檢測赤黴素發酵液中藤倉赤黴素活性菌體量的方法,ZL 201811300737.X