尹靖東，男，生於1970年10月，蒙古族，中國民盟盟員，博士，中國農業大學動物科技學院研究員，博士生導師，教育部新世紀優秀人才，中國畜牧獸醫學會動物營養學分會秘書長，中國畜牧雜誌副主編，Asia-Australian Journal of Animal Science的編委。研究方向為動物營養與飼料科學、動物分子營養與營養基因組學、動物肌肉與脂肪發育的營養調控。
基本介紹
- 中文名：尹靖東
- 民族：蒙古族
- 出生日期：1970年10月
- 代表作品：動物肌肉生物學與肉品科學
- 性別：男
人物經歷,主要成就,主持項目,出版著作,專利,
人物經歷
2012至2013 加利福尼亞大學洛杉磯分校（UCLA），幹細胞分化機制，訪問學者
2007 入選教育部新世紀優秀人才
2004至今 中國農業大學農業部飼料工業中心 研究員 博士生導師
2002至2004 中國農業大學動物營養博士後流動站工作，動物分子營養，博士後
1995 西北農林科技大學，動物遺傳育種碩士學位
1992 內蒙古民族大學，學士學位
主要成就
先後主持了5項國家自然基金面上項目和1項北京市自然基金項目，主持了1項國家973項目課題（2013CB127302），1項國家科技支撐計畫項目課題，1項國家863課題，合作主持國家自然基金聯合資助項目（廣東省聯合基金）重點項目1項，是國家重點基礎研究項目（973）(2004CB117500、2012CB124700)的學術骨幹和項目辦公室主任，國家“985”平台研究骨幹，在國內外發表學術論文50餘篇，其中第一作者或通訊作者發表的SCI收錄文章25篇；獲得並轉讓了3項國家發明專利授權；指導和合作指導博碩士研究生20餘名，2015年指導的研究生獲畜牧獸醫學會優秀論文獎。
主持項目
在研項目
1、 課題主持人，[題目 ] RyR1介導的鈣離子信號通路在肌肉間充質細胞成肌成脂分化中的作用及其調節，[來源]國家自然科學基金委，[起止時間]2017.1-2020.12，[項目編號]31672431。
2、 課題主持人，[題目 ]豬肌肉充質幹細胞成脂分化的分子機制及其與肌內脂肪生成的關係，[來源]國家自然科學基金委，[起止時間]2013.1-2016.12，[項目編號]31272452。
3、 課題主持人，[題目 ]小腸黏膜結構、功能與氮營養素吸收利用，[來源]國家973計畫，[起止時間]2013.1-2017.12，[項目編號]2013CB127302。
已結題項目
4、 研究骨幹，項目辦主任，[題目]豬肌纖維發育與肌內脂肪沉積的機制與營養調控，[項目編號]2012CB124700,[來源]國家973計畫，[起止時間]2012.1-2016.12。
5、 課題主持人，[題目] 氯離子胞內通道基因在豬肌內脂肪沉積中的作用及其調控途徑的研究，[編號]30972113，[來源]國家自然科學基金委，[起止時間]2010.1-2012.12。
5、課題主持人，[題目] 鋅介導的腦腸肽分泌及其對仔豬生長調控的機理，[編號] 30371042，[來源]國家自然科學基金面上項目，[起止時間] 2004.1-2004.12。
6、課題主持人，[題目] 氧化鋅介導的胃腸調節肽分泌及其在仔豬生長調控中的生物學意義，[編號] 30571343，[來源] 國家自然科學基金面上項目，[起止時間] 2006.1-2008.12。
7、作為項目辦主任和學術骨幹，參與了國家重點基礎研究項目（973），[題目] 畜禽肉品質形成的規律及其營養調控，[編號] 2004CB117503，[起止時間] 2004.10-2009.10。
8、課題主持人，[題目] 榮昌豬肌內脂肪超級沉積的分子機制及主效基因的鑑別，[編號]2008AA10Z141,[來源]科技部863項目，[起止時間]2008.3-2010.12。
9、課題副主持人，[題目]藍塘豬肉質性狀形成的分子機理及其在豬肉質改良中的意義，[編號] u0731004，[來源]國家自然科學基金委，[起止時間]2008.1-2011.12。
10、課題主持人，[題目]榮昌豬特色性狀研究與優勢性狀基因的篩選和鑑定，[編號]2007BAD51B02 [來源]科技部國家科技支撐計畫，[起止時間]2007.7-2010.12。
11、課題主持人， [題目] 共軛亞油酸對豬肌內前脂肪細胞分化的調控機理，[編號] 6072016，[來源]北京市自然基金委項目，[起止時間] 2007.1-2009.12。
12、 獲教育部新世紀優秀人才基金支持計畫資助，[題目]豬肌內脂肪沉積的生物學基礎及其對營養調控的差異性回響[編號] NCET-06-0115，[來源]教育部，[起止時間] 2007.1-2009.12。
出版著作
編著《動物肌肉生物學與肉品科學》（主編）、《豬的營養》（副主編）、《豬的可持續營養》（主譯）。
發表文章:
1. Qin CF, Qiu K, Sun W, Jiao N, Zhang X, Che L†, Zhao H, Shen H, Yin JD†.2016. A proteomic adaptation of small intestinal mucosa in response to dietary protein limitation. Sci Rep. | 6:36888 | DOI: 10.1038/srep36888
2. Zhou Q, Sun W, Liu X, Wang X, Xiao Y, Bi D, Yin JD†, Shi D†. 2016. Third- generation sequencing and analysis of four complete pig liver esterase gene sequences in clones identified by screening BAC library. PLoS One. Oct 3;11(10):e0163295. doi: 10.1371/journal.pone.0163295.
3. Qiu K*, Qin CF*, Luo M, Zhang X, Sun WJ, Jiao N, Li DF, Yin JD†.2016. Protein restriction with amino acid-balanced diets shrinks circulating pool size of amino acid by decreasing expression of specific transporters in the small intestine. PLoS One. Sep 9;11(9):e0162475. doi: 10.1371/journal.pone.0162475.
4. Qin CF, Huang P, Qiu K, Sun WJ, Xu L, Zhang X, andYin JD†. 2015. Influences of dietary protein sources and crude protein levels on intracellular free amino acid profile in the longissimus dorsi muscle of inishing gilts. J Anim Sci Biotech.7（2）184-193. 6:52 DOI 10.1186/s40104-015-0052-x
5. Liu Y, Lv W, Yu B, Ju T, Yang F, Jiang M, Liu Z, Xu L, Sun W, Huang J, Li D, Yin JD†. 2013. S-Adenosylmethionine-induced adipogenesis is accompanied by suppression of Wnt/β-catenin and Hedgehog signaling pathways. Mol Cell Biochem. 382(1-2):59-73.
6. Yu G, Xiang H, Tian J, Yin JD, Pinkert CA, Li Q, Zhao X.2015.Mitochondrial haplotypes influence metabolic traits in porcine transmitochondrial cybrids. Sci Rep. Aug 19;5:13118. doi: 10.1038/srep13118.
7. Liu Y, Chen F, Odle J, Lin X, Zhu H, Shi H, Hou Y, Yin JD†. 2013. Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge. J Nutr. 143(8):1331-9.
8. Chen J, Fu R, Cui Y, Li YS, Pan JR, Liu JL, Luo HS, Yin JD, Li DF, Cui S. 2013. LIM-homeodomain transcription factor Isl-1 mediates the effect of leptin on insulin secretion in mice. J Biol Chem. 288(17):12395-405.
9. Fu R, Liu JL, Fan JJ, Li RG, Li DF, Yin JD†,Cu S†. 2012. Evidence that testosterone promotes cell proliferation and differentiation via G protein-coupled receptors in the rat L6 skeletal muscle myoblast cell line. J. Cell Physiol. 227: 98–107.
10. Lv W, Ju T, Dong B, Yu B, Yin JD†.2012. Effect of dietary stable isotopic ratios of carbon and nitrogen on the extent of their incorporation into tissues of rats. J Anim Sci Biotechnol., 3(1):14.
11. Yang HS, Li FN, Kong XF, Yuan XX, Lian GQ, Geng MM, Li TJ, Yin JD†, and Yin YL†. 2012. Molecular cloning, tissue distribution and ontogenetic expression of Xiang pig Chemerin and its involvement in regulating energy metabolism through Akt and ERK1/2 signaling pathways. Mol Biol Rep., 39(2):1887-94.
12. Wang Q, Ji C, Huang JX, Yang FY, Zhang HY, Liu L, Yin JD†.2011. The mRNA of lipin1 and its isoforms are differently expressed in the longissimus dorsi muscle of obese and lean pigs.Mol Biol Rep. 38(1):319-325.
13. Li FN, Yin JD†, Ni JJ, Liu L, Zhang HY, and Du M. 2010. Chloride intracellular channel 5 modulates adipocyte accumulation in skeletal muscle by inhibiting preadipocytes differentiation.J Cell Biochem. 110 (4): 1013-1021
14. Peng Y, Ren F, Yin JD†, Fang Q, Li F N, and Li DF. 2010. Transfer of conjugated linoleic acid from the sows to their offspring and its impact on the fatty acid profiles of plasma, muscle, and subcutaneous fat in piglets. J Anim Sci. 88:1741-1751.
15. Li FN, Yin JD †, Yue T, Liu L and Zhang HY. 2010. The chloride intracellular channel 5 (CLIC5) involved in C2C12 myoblasts proliferation and differentiation. Cell Biol Internat. 34（4）:379-384.
16. Yue T, Fang Q, Yin JD†, Li FN. 2010. High glucose induces differentiation and adipogenesis in porcine muscle satellite cells via mTOR. BMB reports. 43(2): 140-145.
17. Liu L, Yin JD†, Li W, Liu K, Peng Y, Tan PP, Ma RLZ†. 2010. Construction of a Bacterial Artificial Chromosome Library for the Rongchang Pig Breed and its Use for the Identification of Genes Involved in Intramuscular Fat Deposition. Biochem Bioph Res Co.，391: 1280–1284.
18. Yue T, Qian F, Yin JD†, Li DF, Li W. 2010. S-adenosylmethionine stimulates fatty acid metabolism-linked gene expression in porcine muscle satellite cells.Mol Biol Rep., 37(7):3143-3149. Epub 2009 Oct 14.
19. Fang Q, Yin JD†, Li FN, Zhang JX, Watford M. 2010. Characterization of methionine adenosyltransferase 2b gene expression in skeletal muscle and subcutaneous adipose tissue from obese and lean pigs. Mol Biol Rep, 37:2517–2524.
20. Du M, Yin JD, Zhu MJ. 2010. Cellular signaling pathways regulating the initial stage of adipogenesis and arbling of skeletal muscle. Meat Sci. 2010: 86(1):103-109.
21. Han P, Ma X, Yin JD. 2010. The effects of lipoic acid on soybean beta-conglycinin- induced anaphylactic reactions in a rat model. Arch Anim Nutr, 64(3):254-264.
22. Yu J, Yin P, Yin JD, Liu F, Zhu X, Cheng G, Guo K, Yin Y, Xu J.2010. Involvement of ERK1/2 signalling and growth-related molecules' expression in response to heat stress-induced damage in rat jejunum and IEC-6 cells. Int J Hyperthermia, 26(6): 538-555.
23. Yin JD†, Li XL, Li DF,Yue T, Fang Q, Ni JJ,Zhou X, and Wu G. 2009. Dietary supplementation with zinc oxide stimulates ghrelin secretion from the stomach of pigs. J Nutr Biochem, 20 (10):783-790.
24. Liu FH, Yin JD, Du M., Yan P, Xu JQ, Zhu X, and Yu J. 2009. Heat-stress-induced damage to porcine small intestinal epithelium associated with downregulation of epithelial growth factor signaling1.J Anim Sci., 87(6): 1941-1949.
25. Yin JD and Li DF. 2009. Nutrigenomics Approach-A Strategy in Identification of Nutrition Responsive Genes Influencing Meat Edible Quality Traits in Swine. Asian- Austr J Anim Sci, 22 (4):605-610.
26. Wang X, Ou D, Yin JD, Wu G, Wang J. 2009. Proteomic analysis reveals altered expression of proteins related to glutathione metabolism and apoptosis in the small intestine of zinc oxide- supplemented piglets. Amino Acids, 37(1):209-218.
27. Zhang JX, Yin JD†, Zhou X, Li FN, Ni JJ, Dong B. 2008. Effects of lower dietary lysine and energy content on carcass characteristics and meat quality in growing-finishing pigs. Asian- Austr J Anim Sci， 21(12):1785-1793.
28. Yin JD, Shang XG, Li DF, Wang FL, Guang YF, Wang ZY. 2008. Effects of Dietary Conjugated Linoleic Acid on the Fatty Acid Profile and Cholesterol Content of Egg Yolks from Different Breeds of Layers. Poult Sci, 87:284-290.
29. Li ZJ, Yi GF, Yin JD†, Sun P, Li DF and Chris Knight. 2008. Effects of organic acids on growth performance, gastrointestinal pH, intestinal microbial populations and immune responses of weaned pigs. Asian-Austr J of Anim Sci, 21:252-261.
30. Lu P, Zhang LY, Yin JD, Everts AKR, Li DF*. 2008. Effects of soybean oil and linseed oil on fatty acid compositions of muscle lipids and cooked pork flavour. Meat Sci, 80: 910-918.
31. Zhang HW, Yin JD, Li DF，Zhou X and Li XL. 2007. Tryptophan enhances ghrelin expression and secretion associated with increased food intake and weight gainin weaning pigs. Domest Anim Endocrinol, 33(1):47-61.
32. Lu P, Defa Li , Yin JD, Liying Zhang, Zongyi Wang. 2007. Flavour differences of cooked longissimus muscle from Chinese indigenous pig breeds and hybrid pig breed (Duroc * Landrace * Large White). Food Chem, 107: 1529-1537.
33. Zhou X, Li DF*, Yin JD†, Ni JJ, Dong B, Zhang JX and Du Min. 2007. Conjugated linoleic acid differently regulates adipogenesis in stromal vascular cells from subcantenous adipose tissue and skeletal muscle of neonatal pigs. J Lipid Res, 48(8):1701-1709.
34. Ou DY, Li DF*, Cao YH, Li XL, Yin JD†, Qiao SHY and Wu GY*.2007. Dietary supplementation with zinc oxide decrease expression of the stem cell factor in the small intestine of weaning pigs.J Nutr Biochem, 18(12)：820-827.
35. Chen XJ, Li DF*, Yin JD†, Ding YH, Zhang HL and Yi GF.2006. Regulation of dietary energy level and oil source on leptin and its long form receptor mRNA expression of the adipose tissues in growing pigs. Domest Anim Endocrinol, 31(3):269-283.
36. Li XL, Yin JD, Li DF, Chen XJ, Zang JJ and Zhou X. 2006. Dietary supplementation with zinc oxide increases IGF-I and IGF-I receptor gene expression in the small intestine of weanling piglets. J Nutr, 136 (7): 1786-1791.
37. Lai CHH, Yin JD, Li DF, Zhao LD, Piao XSH and Xing JJ.2005. Conjugated linoleic acid attenuates the production and gene expression of proinflammatory cytokines in weaned pigs with lipopolysaccharide. J Nutr, 135(2):239-244.
38. Lai CHH, Yin JD, Li DF, Zhao LD, Chen XJ. 2005. Effects of dietary conjugated linoleic acid supplementation on performance and immune function of weaned pigs. Arch Anim Nutr, 59:41-51.
39. Zhao LD, Yin JD, Li DF, Lai CHH, Chen XJ and Ma D. 2005. Conjugated linoleic acid can prevent tumor necrosis factor gene expression by inhibiting nuclear factor binding activity in peripheral blood mononuclear cells from weaned pigs challenged with lipopolysaccharide. Arch Anim Nutr, 59(6):429-438.
40. Shang XG, Wang FL, Li DF, Yin JD, Li XJ and Yi GF.2005. Effect of dietary conjugated linoleic acid on the fatty acid composition of egg yolk, plasma and liver as well as hepatic stearoyl-coenzyme A desaturase activity and gene expression in laying hens. Poult Sci, 84 (12):1886-1892.
41. Zhu YZ, Li DF, WANG FL, Yin JD and Jin H.2004. Nutritional assessment and fate of DNA of Soybean meal from Roundup ready or conventional soybeans using rats. Arch Anim Nutr, 58:295-310.
42. Shang XG, Wang FL, Li DF, Yin JD and Li JY. 2004. Effects of dietary conjugated linoleic acid on the productivity of laying hens and egg quality during refrigerated storage. Poult Sci, 83 (10):1688-1695.
43. Yin JD, Qi GH, Zheng JJ and Huo QG. 2002. Influence of dietary isoflavnoids on stability of egg yolk lipids, Agri Sci China, 1(10):1180-1184.
44. 王嘉為，張蕾，祝皎月，王宇波，尹靖東†，朱偉雲†. 2016.飼糧中添加苜蓿草粉對生長豬結腸微生物區系及其代謝產物的影響. 動物營養學報，28(9): 2715-2723
45. 姜美華， 巨婷婷，劉 洋，許玲，孫文娟，趙泮峰，尹靖東†.2013.成肌細胞成脂過程中PPARγ、C/EBPa和Myogenin基因啟動子的甲基化變化. 中國農業科學,46(14)：3010-3021.
46. 巨婷婷，呂文濤，於渤洋，劉洋，姜美華，許玲，趙澤平，尹靖東†.2012.小鼠胞內氯離子通道5基因啟動子核心功能區域鑑定及轉錄調控分析.中國農業大學學報.17(5):137-143
47. 於渤洋，呂文濤，巨婷婷，劉 洋，姜美華，尹靖東†.2012.腺苷甲硫氨酸對成肌細胞成脂分化及脂肪沉積的影響. 中國農業科學,45(18)：3841—3848.
48. 朱元招，尹靖東†，李德發，王鳳來.2005. 生長豬對轉基因豆粕外源DNA的代謝的研究. 畜牧獸醫學報，36（10）：1083-1086.
49. 尹靖東，齊廣海，張萍，霍啟光．2004．大豆黃酮對雞蛋膽固醇及其耐氧化性的影響，中國農業科學，37（5）：756-761．
50. 尹靖東，齊廣海，鄭君傑，霍啟光．2003．類黃酮雞蛋蛋黃脂質穩定性的影響及其機理研究，中國農業科學，36（4）：438-442．
51. 尹靖東，齊廣海，霍啟光．2002．類黃酮對蛋雞脂類代謝的影響．畜牧獸醫學報，33（3）：215-220．
52. 尹靖東，齊廣海，霍啟光．2001．日糧中添加微量組分對雞蛋膽固醇含量的影響．西北農林科技大學學報(自然科學版)，29（3）：13-18．
專利
1、豬肌內脂肪沉積主效基因及其分子標記 A major gene and its marker for intramuscular fat content in pigs（專利號:ZL200910077822.9 IPC主分類號：C12N15/12(2006.01)I主分類號:C12N15/12(2006.01)I （專利分類號:C12N15/12(2006.01)I; C12N15/11(2006.01)I; C12Q1/68(2006.01)I）；
2、與豬肌內脂肪沉積相關的氯離子通道基因片段及其套用 Association of DNA Fragment of the chloride intracellular channel 5 with intramuscular fat deposition in pigs.（專利號：ZL200910076200.4；IPC主分類號：C12N15/12(2006.01)I）；
3、一種與肌內脂肪沉積量相關的DNA片段及其套用 An application of DNA sequence associated with intramuscular fat content in pigs.（專利號：ZL200910076199.5；IPC主分類號：C12N15/12(2006.01)I）
獲獎情況
2015年獲國家科技進步二等獎“榮昌豬品種資源保護與開發利用”（2015-J-203-2-01-R04），個人排第4名，單位第二名
2012年獲重慶市政府科技進步一等獎，“榮昌豬品種資源開發關鍵技術研究與產業化示範（2011-J-1-04-R03)”，個人排名第三，（單位排名第二）
2011年獲陝西省政府科技進步三等獎
2006年獲湖北省政府科技進步三等獎
2005年陝西省政府科學技術進步三等獎
